Cetilistat for Treatment of Obesity: All the Things You Need To Know
What Is Cetilistat
Cetilistat, also known by the brand names Kilfat, Checkwt, Cetislim, Celistat is the new weight loss drug on our shelves. It was developed by Alizyme, a biopharmaceutical company, together with Takeda pharmaceutical. Cetilistat (282526-98-1) is still considered an experimental drug as research on it is still on-going in Europe, Japan, the U.S, and other parts of the world.
Why We Need Cetilistat?
Today, obesity is the most prevalent nutritional disorder worldwide. It is caused by the accumulation of fats in the body following the consumption of fatty foods. When one is obese, they get predisposed to some conditions like diabetes, certain cancers like colorectal and breast as well as cardiovascular diseases. There has been an increase in type 2 diabetes incidences as a result of rising obesity cases for the past few years.
Going by the statistics, 70% of both men and women aged between 55-60 years are obese, with increasing rates of childhood obesity being reported. It is for such reasons that obesity should be treated just like any other ailment and drugs prescribed for its treatment. Everyone may not notice results with exercise and clean eating; hence may need to use Cetilistat to fight obesity.
How Does Cetilistat Work?
Unlike other weight loss drugs that work through the brain by reducing one’s appetite,such as sibutramine and lorcaserin HCL. Cetilistat works by blocking the breakdown and absorption of fat. It does this through the prevention of the formation of pancreatic lipase whose function is to break down triglycerides in the intestines. Once the triglycerides cannot be absorbed as fatty acids in the body, they undergo excretion.
Consequently, there is reduced energy intake leading to weight loss. It is therefore known to act peripherally by causing no significant absorption as long as it is in the gastrointestinal tract.
Cetilistat Benefits and Weight Loss
There are many weight loss drugs out there, but what makes Cetilistat stand out is its benefits. Here are a few;
· Helps you lose weight maintain a healthy lifestyle
Cetilistat is one of the best Weight loss supplements as well as obesity treatments. Other than helping you lose weight, Cetilistat helps you maintain a healthy lifestyle. That is through assisting you in maintaining a healthy BMI.
· It is well-tolerated
As much as people always go for what is effective, it is always good to consider the drug’s tolerance in one’s body. Cetilistat offers both in loads as studies done on it show that it is effective and, most importantly, very well tolerated. That means that it is safe and will rarely cause severe side effects. In this case, majority of the effects are manageable and may go away with time.
· Provides results within a short time
If anyone told you that you will achieve your body goals in three months, would you believe it? It may sound like magic, but Cetilistat gives you that bikini body within twelve weeks. So if your wedding or vacation is around the corner, then you could give it a try.
Cetilistat Research Result
After its development by Alizyme in collaboration with Takeda Pharmaceutical, Cetilistat’s global rights were transferred to “NORGINA BV” after Alizyme moved to administration.
In December 2008, Takeda in Japan undertook a Phase III clinical study on Cetilistat (282526-98-1). The results showed that Cetilistat is well tolerated in patients suffering from obesity clinically. Following the pivotal Phase III trials, the Phase ll clinical trials were encouraged.
In August 2003, Takeda evaluated the Phase ll European data. Together with Alizyme, they decided to solely develop, manufacture, and distribute this weight loss drug in Japan.
In October 2012, Takeda submitted a New Drug Application to Japan’s ministry of health, labor, and welfare for Cetilistat to be considered as an obesity treatment. Today, its use has grown just like that of Sibutramine HCL and Lorcaserin HCL.
Usually, Cetilistat is the active ingredient in commonly marketed as Cetislim tablet. It has the following features;
- Molecular weight -401.591 g/mol
- MESH names 2-(hexadecyloxy)-6-methyl-4H-3, 1-benzoxazine-4-one
- IUPAC name 2-hexadecoxy-6-methyl-3, 1-benzoxazine-4-one
- Molecular formula: C25H39NO3
- Salt -60mg
How To Use Cetilistat
Usually, Cetilistat powder is sold in the form of 60mg capsules that are taken orally. That makes it convenient to use as all you got to do is take it during your meals and voila! The absorption of fat is minimized. Some people will prefer to take it after mealtime, but you should never exceed an hour post mealtime.
For some, a dosage of up to 100mg works or them, but what is essential is to always listen to your body. Start with a low dosage and observe your body’s tolerance towards the drug. If there are no severe side effects, you could increase the Cetilistat dosage gradually. If your health worsens, you should stop the usage of this drug immediately.
When using this drug, take a healthy diet to fasten the results. You could cut back on starches and sugars and eat more proteins and vegetables. You could also use it and increase your physical activity as this helps you burn more fat. While doing all this, you will be shocked at how fast you shed the pounds.
What Happen If Miss Dose
Missing a dose is very common, and you should never panic once you miss it. However it is always advisable that you stick to the dosage schedule strictly. That is because missing some could make you not reap all the expected Cetilistat benefits. You could also develop some signs of withdrawal if you are used to missing doses.
If you have missed a dose, there are two things you ought to consider; how late you are and when your next schedule is. In case you remember that you just missed a dose, take it as soon as you notice.
If your next schedule is very close, skip the missed Cetilistat dose and resume your regular dosing schedule. Never use an additional dose to make up for a missed dose, as this will only lead to an overdose. If you feel like recalling when to take your drugs is becoming a task, you can always set the alarm or ask one of your friends or family members to remind you.
What Happen If Over Dose
A Cetilistat overdose could occur accidentally or out of your own will. One thing you need to know is that a high Cetilistat (282526-98-1) dosage does not mean that its effectiveness increases or you achieve more exceptional results quickly. It leads to severe adverse effects that could poison your system. Even worse, such an overdose could be fatal.
It is good to be familiar with signs of Cetilistat overdose as you could sometimes take a higher dosage accidentally. If you notice that you just had an overdose, do not take any other medication as it would only increase the severity of the poisoning side effects. Instead, contact your doctor immediately and give all the necessary information.
Always ensure that you have the correct dosage information on Cetilistat before taking it.
Cetilistat Side Effects
Most of the Cetilistat side effects are gastro and digestive tract related.
- Reduced level of bet
- Reduction in vitamin E and D levels
- Subcutaneous abnormalities
- Renal stones
- Gall stones
- Nutrient deficiencies
- Malabsorption of vitamins
- Oily stools
- Fatty stools
- Rectal discharge
- Defecation urgency
- Fecal incontinence
Other side effects may include;
- Change in consciousness
- Abdominal pains, stomach-ache, and cramps
- Difficulty walking, thinking or speaking
- Difficulty breathing
- Shaking of hands and feet
- Redness of the neck, arms, face and occasionally, upper chest
- Pain or discomfort in the neck, back, jaw and arms
- Tingling or numbness in the legs
- Increased frequency of urinating
- Irregular heartbeat
- Dry mouth
- Difficulty or painful urination
- Chest pain or discomfort
- Severe mental change
- Hearing or seeing things that are not there
Does Cetilistat Really Work?
Many people who have heard about weight loss drugs have termed it to be a scam. However, people are successfully losing weight with their use. Although they may not work on everyone, most of the Cetilistat reviews are positive.
Also, most of the Cetilistat reviews have noted that they used a healthy diet as well as physical exercise to achieve in combination with the obesity drug. As for the Cetilistat side effects, it matters with the person. Some have had a fair share of the side effects, while some have experienced none. It all depends on how your body reacts to Cetilistat use and your Cetilistat dosage. The higher the dosage, the more the likelihood of suffering from the effects.
The drug is also a short term drug and may not be the best to control weight for the rest of your life. In case it is used for a very long time, it could lead to addiction as well as gastrointestinal issues.
Cetilistat is, however, seen to be tolerated in a better way as compared to other weight loss drugs like Orlistat. For instance, when comparing the Cetilistat vs Orlistat side effects, you will notice that those of Cetilistat are very mild, some moderate, and very few are severe. Most of the Orlistat side effects are severe. That is because the Cetilistat structure is different from that of Orlistat. Their weight loss results and mechanism of action are similar since both of them are lipase inhibitors.
Who Can Use Cetilistat?
You may consider using Cetilistat (282526-98-1) in case you want to lose weight. It could also be important for you if you meet any of the following;
- Your BMI is more than 27, and you are suffering from an obesity-related health problem such as high blood pressure and diabetes.
- Your BMI is higher than 27.
However, it is vital to note that not everyone with these conditions should take this weight loss drug. For instance, it is not safe for expectant women. That is because it could put the unborn child at risk. One should, therefore, avoid when trying to conceive too.
Children are also advised not to take this weight loss drug, especially while undergoing puberty, as they could alter their height and growth.
It is also commended that those who are breastfeeding not to take the drug as it could be passed to the infant through breast milk.
Anyone who does not suffer from any of the following conditions can use Cetilistat.
- Chronic malabsorption
Your dosage determines the Cetilistat (282526-98-1) price you are going to pay. For instance, if you decide to start with the 60mg Cetilistat tablet during the first week and increase it 100mg during the second week, then the price will go high. Our Cetilistat price is, however, very affordable, and you will not need to break a bank to purchase them.
Weight loss can be stressing, particularly if you have been trying, and nothing seems to work. Using Cetilistat looks like the perfect option as it saves you from all the buying and trying out. All you got to do is to be consistent with your Cetilistat dosage and maintain a healthy, nutritious diet. Who said that you have to fast to lose weight? Maintaining a proper diet will help your body remain healthy as you shed the extra weight.
Do you intend to buy Cetilistat? Well, this should not be a hustle either; we are here for you.
- Anti-Obesity Drug Discovery and Development, Volume 3, edited by Atta-ur Rahman, M. Iqbal Choudhary, page 22-25
- Clinical Obesity in Adults and Children, written by Peter G. Kopelman, Ian D. Caterson, William H. Dietz, page 335
- Handbook of Obesity, Two-Volume Set, edited by George A. Bray, Claude Bouchard, page 248