Best Nootropic Choline Source Citicoline Vs. Alpha GPC


Choline and Nootropic Dietary Supplement

Citicoline Sodium and Alpha GPC are two of the most popular nootropic supplements that are known to contain generous amounts of choline.  Choline is one of the crucial chemicals that play an important role in maintaining proper brain function. Choline was officially recognized as a vital nutrient in 1998 by the Institute of Medicine (IOM).

Our brains depend on choline to work properly. Choline is a precursor to a neurotransmitter known as Acetylcholine. This is one of the numerous neurotransmitters in the central nervous system. One of its many functions is that it plays an important role in boosting focus and sustaining attention. Lack of Acetylcholine has been linked to memory deficits and depression.

So, what’s the difference between the Citicoline and Alpha GPC? Well, we have prepared this in-depth guide to help you understand all the important aspects about Citicoline and Alpha GPC that you should know.  


What Is Citicoline Sodium (CDP Choline Sodium)

Citicoline sodium (Cytidine diphosphocholine), also referred to as CDP choline, is a compound that has neuro-protective properties. It is made up of choline and cytidine. As a bountiful source of choline, citicoline aids in the transportation of dopamine, augmenting its release into the brain. While choline helps with brain function, cytidine becomes useful when it is converted to uridine.

Citicoline is available in two forms: as citicoline sodium, which is a prescription medication for treating neurological disorders, and as citicoline free-base, which is a dietary supplement. Supplementation with citicoline nootropic is believed to boost cognitive dysfunction and improve neurological recovery in various conditions.

Citicoline is said to have been originally developed in Japan as a cure for stroke. Currently, it is used in many parts of the world as an ingredient for Dietary Supplements. The most popular citicoline brand name is Ceraxon. It is also sold under other brand names, including Cebroton, Cidilin, and Cognizin, among others.  Citicoline sodium cas no is Citicoline Sodium (CDP Choline Sodium) powder (33818-15-4).


How Does Citicoline Sodium Work?

Citicoline Sodium Powder is a rich Choline Source. To understand how citicoline works, it is important that you first understand how choline works.

Choline is one of the crucial chemicals that play an important role in maintaining proper brain function. That’s why eating foods and supplements that are rich in choline is highly encouraged, as it has positive effects on Brain Development.

Citicoline occurs in the cell membrane through a biochemical process. Research has found that CDP chlorine enhances brain activity by the mechanism of supporting the citicoline synthesis. Citicoline increases the brain chemical known as phosphatidylcholine, which is important for brain function. It also decreases brain tissue damage in case of a brain injury.


What is CDP Choline Sodium used for?

One of the desirable aspects about Citicoline is that there are many Citicoline Sodium uses. The Citicoline Nootropics is used to cure diseases like Alzheimer’s, head trauma, other types of dementia, cerebrovascular diseases such as stroke, Parkinson’s disease, age-related memory loss, glaucoma, attention deficit hyperactive disorder (ADHD). The following are the common Citicoline Sodium uses:


  • It may help prevent memory impairment2019 Best Nootropic Choline Source Citicoline Vs Alpha GPC

Citicoline is believed to be effective in Improving memory. Therefore, age-related memory loss, brought about by old age between can be rectified by consuming citicoline. If you have an aging parent or relative whose memory is declining with age, you should consider adding citicoline supplement in his/her diet.


  • It may help speedy recovery after a stroke

Research has shown that citicoline aids in stroke recovery. If you take the citicoline within 24 hours after experiencing a stroke, you are more likely to recover completely within a few months. This is according to a study that comprised a randomized (3 doses of citicoline to 1 placebo) vehicle-controlled double-blind trial at 21 US centers.

Treatment using citicoline sodium salt was to be started within 24 hours of stroke onset and was continued for 6 weeks. Its outcome assessments were at 12 weeks. NIH stroke scale was used as a covariate. Both the 500 mg citicoline group and the 2,000 mg citicoline group had a significant improvement in terms of the percent of patients who had a favorable outcome on the Barthel Index at 90 days. The study concluded that oral Citicoline sodium powder can be used safely with minimal side effects in acute stroke treatment.


  • May enhance learning capacity

One of the biggest advantages of supplementing with citicoline nootropic is that it leads to a better functioning brain. It does so by increasing blood flow and the energy production in your brain. Moreover, choline helps to keep the pathways in your brain clear of dregs so that you can recall information faster. This can help to enhance learning capacity in learners.

There are many citicoline sodium benefits to look forward to. The most common benefit is the possibility of amplifying the impact of other nootropics. As a result, many people consider citicoline Sodium powder a definite addition in many supplementation programs.


Does Citicoline Increase Dopamine?

Dopamine is important for optimal mental function, as well as for many of our daily habits and behavior. It plays an important role in the movement, food preference, habits, attention, and mood.

Dopamine is normally triggered when the brain expects a reward from certain behaviors. It also alerts and motivates us to pursue the things that meet our needs and desires. Lack of adequate dopamine levels can limit cognitive performance and cause a bad case of the blues.

One of the major components in Citicoline, DP chlorine, encourages the release of dopamine and increases the overall dopamine levels by the mechanism of acting as the dopamine agonist, as well as inhibiting dopamine reuptake.

Citicoline Sodium (CDP Choline Sodium) powder (33818-15-4) salt, being a water-soluble substance, is readily absorbed into the bloodstream. This not only gives a 90% bioavailability rate, but it also increases its effectiveness. Uridine, along with Cdp choline dopamine, promotes the growth of new dopamine receptors in the brain by activating D1 and D2 receptor signaling, helping to prevent dopamine receptor burn out.


What Is the Difference Between Choline and Citicoline?

Let’s look at citicoline vs choline and see how they compare. CDP Choline and Citicoline are one and the same thing. They refer to a psychostimulant or nootropic that research has found to be effective in boosting focus and mental energy.


How to Take Citicoline

Currently, there is no standardized citicoline dosage nootropic. However, most of the research points to 250 mg to 500 mg to be the optimal citicoline dosage nootropic.

Citicoline appears to improve functional outcomes and reduce the neurologic deficit with 500 mg of citicoline appearing to be the optimal citicoline nootropic dose. The recommended dosage for optimal Cognitive Ability is between citicoline 500 mg to 2000mg per day in two divided doses (250mg to 1000mg per dose).

The following doses have been studied in scientific research:


By mouth

  • Decline in thinking skills due to age: 1000-2000 mg of citicoline per day.
  • The ongoing disease of the blood vessels that serve the brain (chronic cerebrovascular disease): 600 mg of citicoline per day.
  • Immediate treatment of stroke due to a clot (ischemic stroke): the recommended citicoline dose in stroke is 500 mg to 2000 mg per day starting within 24 hours of a stroke.



  • Healthcare providers give citicoline intravenously (by IV) for age-related decline in thinking skills or chronic cerebrovascular disease.

Through injection

  • Healthcare providers give citicoline by shot for chronic cerebrovascular disease


Is It Safe to Take Citicoline?

A citicoline nootropic dose is regarded enormously effective. When taken alongside other supplements, citicoline is found to be relatively powerful. There’s growing evidence of its benefits for Enhancing Cognition, improving nerve function, and possibly in addiction recovery.

Besides being effective, citicoline is well documented to be safe. It has been found to have a very low toxicity profile in both animals and humans. In one study, high doses of citicoline in the 2000mg per day range were tested and still found no harmful effects.

Research has found citicoline to be safe when taken by mouth in the short run-up to 90 days. The safety of long-term use is still to be concluded. Rarely has any person using citicoline reported to experience problematic Citicoline Side Effects.

Even though not many people experience severe citicoline side effects, there is still a possibility that some side effects can occur. A few users for instance reported to experience citicoline anxiety.

Here are the symptoms that can indicate that you are experiencing the side effects of citicoline:

  • Insomnia
  • Headaches
  • Diarrhea
  • Nausea
  • Chest pains
  • Blurred vision

There is not enough reliable information regarding the safety of taking the supplement for pregnant women or breastfeeding women. Therefore, pregnant women and breastfeeding mothers should not use citicoline.


2019 Best Nootropic Choline Source Citicoline Vs Alpha GPC


What is Alpha GPC

Alpha GPC is a Nootropic Compound that is known to improve physical performance and boost brain function. Alpha gpc nootropic happens to be one of the most effective sources of choline; which is useful in our bodies, as it is used to make a neurotransmitter that aids in memory and contraction of muscles.

Alpha GPC  is powerful enough to be used as a medicine, yet gentle enough to be used as a supplement. It is known to improve memory and brain power output. Following this, it is viewed as a very promising dietary supplement for athletes, and anyone else who wants to support their brain and at the same time foster their physical strength.


How does Alpha GPC Work?

Alpha GPC is found to increase acetylcholine, which is a chemical in our brain that aids in improving memory and increasing learning capacity.


Alpha GPC benefits

  • It improves brain function

Alpha brain nootropic is widely known for cognitive improvement due to its capability to reach the brain, which is made possible by its choline form. Most of Alpha GPC uses focus on the mind and muscles. An alpha brain nootropic review posted online by an experienced user proved that this drug is a must have to anyone who want to enhance his/her brain function.


  • It may boost physical performance

Studies have established that alpha gpc growth hormone is effective in increasing lower body force production after six days of supplementation. Therefore, fitness enthusiasts and athletes can consider adding Alpha GPC powder to their diet to enhance their muscle performance and boost their isometric strength. Alpha gpc pre workout regime have proved to take physical performance to a whole new level among many sports men.


2019 Best Nootropic Choline Source Citicoline Vs Alpha GPC


  • It may improve intellectual skills

Developing study propose that taking 1200 mg of Alpha brain nootropic per day meaningfully improves intellectual skills in Alzheimer’s patients in 3 to 6 months of treatment. It’s also believed that taking 1000 mg of Alpha GPC daily as a shot help improving symptoms of vascular dementia. Alpha gpc dopamine also improves patient mood, behavior, and intellectual skills.


  • It may help stroke patients recover

Patients suffering from transient ischemic attack (TIA) and who receive alpha GPC before the lapse of 10 days have been found to have a better recovery. Research suggests that patients who gets a 1200 mg of Alpha GPC injection daily for a period of 28 days, followed by an oral Alpha GPC dosage three times a day for 6 months, have a chance of recovering intellectually.


How to take Alpha GPC

Alpha GPC nootropic is either taken orally, or through injection. When taking it orally, you can take alpha GPC with or without food. What surprise many people is that alpha gpc powder taste is pretty sweet.

Alpha GPC dosage varies depending on whether you are using it for physical or mental performance.

To boost Fat burning and growth hormone, you should take approximately 600 mg of Alpha GPC, 30 to 60 minutes prior to working out.

To increase mental performance, you can take a small dose of 200 mg to 600 mg. You can increase the dose gradually to see what dose makes you feel the best. Alpha gpc nootropic stack with another drug from Racetam family will also give amazing results.

You can take multiple Alpha GPC doses in a day. However, you should keep the doses at a minimum, i.e. 200 mg – 600 mg, and ensure that you space the doses at least four hours apart. Although it is not a must, it is recommended taking Alpha GPC along with dietary fatty acids for better absorption. You can also learn more on how to take the drug from alpha brain nootropic reddit forums where experienced users shares information on how they have used the drug successfully.


Alpha GPC side effects

To data, no serious side effects of Alpha GPC powder (28319-77-9) have been recorded. When used appropriately, this dietary supplement seems to be very safe according to alpha gpc reviews that are available online. Some Alpha brain nootropic side effects that have been reported so far include:

  • Headaches
  • Insomnia
  • Dizziness
  • skin rashes
  • heartburn

Some people have reported brain fog and lethargic side effects, and on few incidences, a spike in libido. They both seem to be related to a high inclusive dosage of choline.

If you experience any of these Alpha brain nootropic side effects, it is advisable to opt for a lesser Alpha GPC dosage and observe if the symptoms will go away. If symptoms persist or become severe even after reducing the Alpha GPC dosage, it is best to seek medical attention right away.

At present, there’s limited research on usage of Alpha GPC during pregnancy and while breastfeeding. Therefore, there is no way of knowing whether citicoline can cause harm to the baby. Therefore, it is advisable not to use it if this applies to your case to be on the safer side.


What Foods are Rich with Choline

Just like Citicoline, choline is one of the alpha brain Nootropic ingredients. High choline foods include:

  • Lean chicken
  • Lean pork
  • Fish (salmon)
  • Oyster mushrooms
  • Eggs
  • Beef
  • Shrimp
  • Shell fish
  • Beans
  • Broccoli
  • Cauliflower
  • Green peas
  • Low-fat milk
  • Spinach
  • Pickled beets
  • Wheat
  • Nuts
  • Flax seeds
  • Sweet corn


2019 Best Nootropic Choline Source Citicoline Vs Alpha GPC


Citicoline Vs Alpha GPC: Which one is good?

Let’s now see how Alpha GPC powder (28319-77-9) vs choline compares. Both Citicoline Sodium (CDP Choline Sodium) powder (33818-15-4) and Alpha GPC are great sources of choline, which makes their supplementation in our diet an added advantage. They however seem to do the same thing when it comes to improving overall brain function and mental acuity.

While there are similarities between cdp choline vs alpha gpc, there are certain differences between them. For instance, both compounds have different metabolism processes. As alpha GPC breaks down, acetylcholine is released as a byproduct. On the other hand, citicoline serves as a derivative of the same chemical.

Alpha GPC may also have some positive effects that are not common with citicoline. For instance, consuming alpha GPC could result in enhanced vitality, improved strength, and even help muscles recover quickly after strenuous workouts. Alpha GPC increases the production of growth hormone in the human body while at the same time acting as something of a weak stimulant.

Since citicoline and Alpha GPC have their unique strengths, we can’t say that one supplement is better than the other. Whether you will benefit from either of the supplements depends on what your intended use for it is.


Nootropic Choline Source

While you may get choline from the foods that you eat, it is best to add supplements that contain this beneficial compound. Using citicoline or Alpha GPG supplements is a great way of getting choline into your system.

Since citicoline and Alpha GPC powder buy are safe, there are no legal restrictions on these supplements. This means that you can find them in most citicoline nootropics depot, supplement shops, grocery stores, and online vendors.

If you want to buy citicoline and Alpha GPG GNC conveniently from an online seller, it is important that you verify that the vendor has a reputation for selling genuine products. Buying authentic Alpha GPG amazon will ensure that you will get to enjoy all the benefits that are associated with the use of the dietary supplement. High quality alpha gpc powder for sale is also readily available on at an affordable price. They also process alpha gpc powder bulk orders and deliver them faster to your preferred address.



Citicoline and Alpha GPC are among the most-studied nootropics to date. They have powerful benefits for brain health and physical performance. If you are an adult looking for a mental edge, citicoline will most likely give you a mental boost. If you are an athlete who wants faster and better results in the gym, Alpha GPC will work for you.



  1. US National Library of Medicine National Institute of Health, Gatti G, Barzaghi N, Acuto G, Abbiati G, Fossati T, Perucca E., 1992 Sep;30(9):331-5.
  2. Doggrell SA & Evans S; Evans (Oct. 2003). “Treatment of dementia with neurotransmission modulation”. Expert Opinion Investigating Drugs. 12 (10): 1633–1654.
  3. Parnetti, Lucilla; et al. (2007). “Cholinergic precursor in the treatment of cognitive impairment: Ineffective approaches or need for re-evaluation?”. Journal of the Neurological Sciences. 257 (1–2): 264–9.





2019-10-22 Nootropics
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