Coluracetam Review: A Powerful New Nootropic Powder

Coluracetam is a new racetam family drug belonging to nootropic class. It has gained massive popularity over the years in various countries, including the United States. Although the drug was initially made for the treatment of Alzheimer’s disease, it has with time been scientifically proved to have a myriad of benefits. The benefits include long-term and working memory boosting, better colour and sound perception and depression relief.

In the United States, Coluracetam powder (135463-81-9) is legal and sold as a supplement for diet. However, its legal status differs from a country to another.


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What is Coluracetam?

Coluracetam nootropic, which is also called BCI-540, or MKC-231 and belongs to coluracetam nootropics depot (135463-81-9), is regarded by many as the best nootropic powder or most effective and safe nootropic drug. In case you don’t know, a Nootropic is a “smart drug” that’s an alternative to orthodox medication for enhancing the cognitive health of a person.

Coluracetam powde 135463-81-9 was initially manufactured in the year 2005 in Japan by Mitsubishi Tanabe Pharma Corporation. The first experiment that was done on this drug was to establish its ability to treat Alzheimer’s disease.

Later on, BrainCells Inc. in-licensed the development of the coluracetam nootropics depot 135463-81-9 for development for depressive disorder treatment. The research which involved over 100 people with serious anxiety and depression symptoms revealed the supplement’s benefits in the relief of major depressive disorder (MDD).

The nootropic powder can be dissolved in fats and oils and this coluracetam solubility makes it (the supplement) have higher potency as compared to phenylpiracetam powder. Due to the high coluracetam solubility, the drug is quickly effective as its takes about 30 minutes to reach high-level plasma cells. As such, its dosage amount should be smaller than that of the rest of the nootropics belonging to racetam class.

How does coluracetam work in the brain? Coluracetam Review A Powerful New Nootropic Powder in 2019

In human brain, choline plays a significant role for the organ’s health as nerves use the nutrient to make acetylcholine, a neurotransmitter that has a remarkable influence on a person’s memory and cognition. Coluracetam benefits the brain by influencing acetylcholine and choline in various ways, including:

Supporting high-affinity choline uptake

As it is with the case with all racetams, Coluracetam 135463-81-9 works by stimulating the receptors that are associated with acetylcholine to activate the production of the neurotransmitter. However, unlike other racetams, Coluracetam works specifically with high-affinity choline uptake (HACU) system in the neurons of the brain to increase choline intake by the brain.

When a person takescoluracetam supplement, the drug increases the uptake of choline by the nerve cells, consequently increasing the production of acetylcholine in the brain. As a result, the high-affinity choline transporter 1 (CHT1) increases and this causes an increase of choline which helps in Acetylcholine synthesis. Acetate is also paramount for the process.

HACU system is the key channel of choline transportation into the system. In case the system develops a breakdown, a person experiences brain fog, memory problems and learning issues. However, you are less likely to experience such problems even when there are damages in your HACU system because coluracetam supplement the increased free choline in the blood plasma makes the system to work more efficiently. The increase of acetylcholine caused by the drug leads to improved memory, better decision-making ability as well as improved reasoning.

Improves the potentiation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA).

Scientifically, Coluracetam (135463-81-9) has been found to improve AMPA potentiation. Glutamate affects AMPA receptors and thus influences the biological learning and memory foundation known as Long-term potentiation (LTP).

Serotonin Selective Reuptake Inhibitors (SSRIs), which are the most widely consumed drug for the relief of mood disorders and depression, affect the brain’s serotonin levels. As such, the medication causes numerous adverse side effects.

On the other hand, Coluracetam (135463-81-9) doesn’t interrupt the serotonin levels like SSRIs. Instead, it can improve a mood disorder without causing any side effect through improving the choline uptake as well as AMPA potentiation. Research shows that Coluracetam is capable of assisting in the treatment of key disorders related to depression and anxiety without causing serotonin-disruption-related side effects by increasing glutamate effectiveness.

Coluracetam anxiety and depression relief capability without triggering adverse side effects are among the things that make the supplement among the best solutions for the disorders.

Shielding N-methyl-D-aspartate (NMDA ) receptors from the harmfulness of glutamate

 NMDA receptor damage as a result of glutamate toxicity is the leading cause of brain diseases, Alzheimer’s disease, stroke and traumatic brain injury, among other illnesses and disorders. Fortunately, when a takes pure nootropics coluracetam, he/she will have his/her NMDA receptors protected by the drug from the toxicity of glutamate. There’s enough scientific proof showing the ability of coluracetam supplement to offer such protection.

It is important to note that coluracetam half life is the shortest among all racetams. Coluracetam half life is about three hours. After taking the nootropic powder supplement or sublingual solution, you’ll most likely experience its effects almost immediately; within about five to ten minutes. The effects will last for two to three hours or even longer because of the short coluracetam half life.

Coluracetam Vs aniracetam, fasoracetam, pramiracetam, what is the difference? 

Coluracetam vs Aniracetam

Aniracetam, just like coluracetam, is a nootropic supplement belonging to the racetam family. Discovered in the early 1970s, courtesy of by Hoffman-LaRoche, a Swiss pharmaceutical company, aniracetam is capable of enhancing memory and mood, improving focus, reducing anxiety and offering a depression relief in a person.

Besides, quite a good number of personal accounts show that the medication boots creativity. Similarly to coluracetam, aniracetam functions by altering brain cell (including neotransmitter) production and release.

However, comparing coluracetam vs aniracetam, coluracetam enhances contrast and details while Aniracetam leads to great colour saturation. On the downside, Aniracetam’s mood enhancement capability is slightly lower than of coluracetam.

Coluracetam vs Fasoracetam

Fasoracetam, another nootropics was synthesized for the first time in the 1960s. However, its use as a nootropic medication began just recently, with preliminary research supporting the usage. Besides, research is ongoing to establish the effectiveness of the medication as a deficit hyperactivity disorder (ADHD) treatment.

However, many people are unable to draw a clear line between coluracetam vs fasoracetam because of various factors. First, like coluracetam, fasoracetam improves the brain areas that handle intelligence and memory. Besides, it prevents harmful factors from interfering with normal brain function.

Comparing coluracetam vs fasoracetam, the major difference between is the rate of acetylcholine production. Coluracetam produces acetylcholine more quickly by improving the system responsible for choline uptake as compared to fasoracetam. That’s why just one dose of the former (Coluracetam) can decrease learning deficit. Also, unlike coluracetam whose ability to improve mood has been scientifically proven, fasoracetam potentially does so; it’s not been fully confirmed yet.

Coluracetam vs. Pramiracetam

Pramiracetam similarly to Coluracetam can increase focus and memory. However, it has an additional benefit of being a stimulant. Nevertheless, unlike coluracetam, pramiracetam can’t reduce anxiety and isn’t a potential motivation booster. Therefore, if you are looking for a racetam that can help you to focus better and have your memory improved without interfering with your mood or anxiety, you might not go wrong with pramiracetam.


Coluracetam Review A Powerful New Nootropic Powder in 2019


10 Potential benefits of Coluracetam

Following various documented human studies, user self-reports, user feedbacks such as coluracetam bluelight reviews, as well as animal tests, findings show numerous coluracetam benefits to the body, minds and senses. Here are some of the major potential coluracetam benefits:

1. Working Memory improvement

A Japanese Iwate Medical University study was done on mice to establish the influence of coluracetam supplement on the deficits of working memory as well as reduced hippocampal acetylcholine (ACh) content when administered acutely and chronically. The choline uptake system of the mice has been damaged as a result of nerve toxin administration.

The researchers found out that coluracetam nootropics increased the release of the HACU and Ach, improving the toxin-created working memory deficit and ACh depletion. They observed a remarkable acetylcholine deficit reversal as a result of the administration of the supplement.

2. Improved Learning

People with health issues like Alzheimer’s disease and Schizophrenia normally have abnormally low Acetylcholine levels. As a result, they may experience mind-related symptoms like poor memory and learning. To alleviate the symptoms, something has to be done to increase their levels of acetylcholine, and this is where coluracetam comes in handy.

A Tottori University’s study from the institution’s Department of Neuropsychiatry involved administering recreational drug PCP to inhibit the enzyme that produces acetylcholine and then giving them Coluracetam to see if the supplement would have any effect on the acetylcholine level.

They eventually found out that coluracetam increased ChAT, thus repairing the learning function deficit. As such, they concluded that Coluracetam can be used as a therapeutic drug for those who have learning difficulty due to Schizophrenia or Alzheimer’s disease.

3. Improved memorization and recall abilities

In case you have been experiencing difficulties in comprehending anything you read or memorize things, coluracetam could be of great help for you. Any authentic coluracetam psychonaut will tell you that coluracetam can improve your short-term memory and free recall ability remarkably.

Many users on online threads such as coluracetam bluelight reviews indicate that their coluracetam experience included better memorization, recall capability and reading comprehension. Also, the feedbacks suggest that Coluracetam also boosts information retention, learning speed and thinking ability.

4. Long-term Cognition Improvement

A Yokohama Research Center’s study notes that coluracetam changes choline transporter regulation system, and as a result, positive precognitive affects which last for numerous days after a dose. The effects last for a long time even when the concentration of the nootropic is negligible.

5. Likely to minimize depression that’s resistant to antidepressants

Coluracetam anxiety and treatment-resistant depression relief

Brain Cells Inc. conducted a double-blind randomized controlled trial aimed at establishing coluracetam depression relief capability. The research involved 101 101 people whose depression couldn’t get better even after taking at least two antidepressants. The subjects were given a coluracetam dosage of 80 mg three times per day.

After the trial period, the researchers observed that the subjects responded positively to the supplement as the severity of their depression symptoms had reduced significantly. Being a mood booster by reducing the toxicity of glutamate, coluracetam supplement can be very helpful for people with major depressive disorder (MDD).

From a study similar to the aforementioned but still by Brain Cells Inc. but involving people with comorbid generalized anxiety disorders, coluracetam anxiety relief capability was established. After an 80 mg coluracetam dosage three times a day, the people who were used in the trial had responded positively to the supplement, as their symptoms had reduced.


Coluracetam Review A Powerful New Nootropic Powder in 2019


6. Potential Neurogenesis promotion

In layman’s language, neurogenesis is simply the generation of neurons from the neural stem cells. In other words, it’s a process through which new brain cells are created. The process strongly influences a person’s cognitive capabilities as well as brain function.

In case your cognitive ability is deteriorating or have a brain dysfunction, using coluracetam nootropics daily for a couple of weeks might help you recover your mental and brain health by promoting the production of brain cells. This benefit is possibly due to the fact that the supplement increases in hippocampal acetylcholine levels.

7. Can improve Mental Disability

People with mental disabilities such as Alzheimer’s disease and Schizophrenia might get better following the recommended use of coluracetam. This is because supplement boosts acetylcholine activity by empowering the enzyme responsible for the production of acetylcholine. Mental disabilities usually impair the enzyme.

8. May Improve Vision

Besides helping in memory and concentration, coluracetam nootropics also promote the growth of nerves for people with degenerative diseases which affect the eye’s retina.

Many people who have had personal coluracetam experience report that their eyesight got sharper and had a better colour vision and enhanced shape recognition after taking the supplement.

9. Irritable Bowel Syndrome symptom improvement

Irritable bowel syndrome (IBS) is a common large intestine disorder which mostly results from poorly regulated choline transporter 1 (CHT1), a protein cell membrane transporter which transports choline into the neurons that synthesize acetylcholine.

According to a 2018 research done by researchers from Renin Hospital of Wuhan University, the researchers observed that coluracetam improved CHT1 regulation in people with Irritable Bowel Syndrome, consequently improving the symptoms of the disorder.

10. Coluracetam recreational use

If you just want to get rid of that “buzzed” or “wired” feeling and feel more lively and with a clearer mind, you can tap in to the coluracetam recreational benefits by combining the supplement with a stimulant. Coluracetam recreational benefits doesn’t include energy boost and that’s why the supplement works well with stimulant.

Also, coluracetam bodybuilding benefit has also made the drug popular, especially among bodybuilders. The supplement activates human growth hormone for bodybuilding. 

Coluracetam Dosage, Stack, side effects

Coluracetam dosage

Similarly to other racetam nootropics, the coluracetam nootropic doesn’t have a defined universally accepted dosing guideline, for oral or sublingual administration. Nevertheless, there is some recommendation that gives a coluracetam psychonaut an idea of the suitable dosage range.

According to the recommendations, the most suitable coluracetam dosage for an average person ranges from 2.5mg to 3mg per body weight kilogram. As such, the recommended daily dose for an adult is approximately 200mg to 240mg per day, which should be divided equally and taken in 3 regular intervals daily.

Many user reviews suggest that a person who’s just starting out with the supplement should begin with a low dose of about 10mg to 20mg thrice a day, and then increase it gradually with time as your body adjusts to the medication. People who’ve used coluracetam within the dosage range rarely experience negative coluracetam effects.

However, to achieve maximum coluracetam benefits and avoid undesired coluracetam effects, users are advised to consult their healthcare service providers before they begin to use the supplement.

Nonetheless, depending on a health care expert’s judgment, a coluracetam dosage which is as high as 100 mg may be recommended to be taken three times a day for a person with Major Depressive Disorder. The dosage may be prescribed for people with a General Anxiety Disorder as well.

Nearly everyone finds Coluracetam powder taste very unpleasant, many referring to it as gummy. To avoid the Coluracetam powder taste, the capsule form of the drug is preferred.

Coluracetam nootropic stack

Just like the majority of solution or powder nootropic supplements, especially the racetams, Coluracetam nootropic stack well with choline sources like alpha GPC and CDP choline for better results.

In case you want a Coluracetam nootropic stack with alpha GPC, the recommended supplemental choline dose is 300 to 600 mg per day and 250–750 mg per day in case you opt to stack with CDP choline.

Patricianly, it is safe for stacking with a wide range of nootropic stacks including noopept, modafinil, piracetam and other nootropics such as phenylpiracetam powder, tianeptine powder, pramiracetam powder and tianeptine sulfate powder.

Coluracetam possible side effects

Although Coluracetam nootropic stack or pure nootropics coluracetam is not toxic and well tolerated, thus safe for general consumption, the medication can cause some adverse reactions. However, the side effects are rare and mostly occur as a result of overdosing the supplement.

Possible adverse coluracetam effects include:

  • Brain fog : Coluracetam users say that they feel confused and disoriented after taking the supplement. That’s brain fog coluracetam effect. Fortunately, brain fog coluracetam effect disappears with continued use of the supplement within the correct dosage.
  • Low mood: The supplement is expected to enhance a person’s mood, it can lead to low mood, especially at the beginning of use or if taken in larger quantities than recommended.
  • Suicidal thoughts: Some cases, the resulting low mood can lead to suicidal thoughts.
  • Irritability
  • Low mood caused by the supplement can also make a person quite irritable.
  • Nausea: In case you overdose the drug, you are likely to experience nausea
  • Daytime Coluracetam sleep feeling; An overdose of the supplement cause coluracetam sleeps feeling or dizziness, even daytime when you need to be alert.
  • Anxiety
  • Headaches
  • Disturbed night sleep

Fortunately, a coluracetam user can avoid these among other possible side effects by:

  • Co-supplementing the supplement with choline sources
  • Avoiding taking the supplement close to bedtime
  • Always sticking to the recommended coluracetam dosage
  • Drinking a lot of water

Who can use coluracetam?

Anybody can buy coluracetam powder or solution supplement and use it for various benefits. However, pregnant women and people with certain medical issues are advised not to use the supplement.

People with memory disorders and/or cognition deficits resulting from age or illnesses such as Alzheimer’s disease and Schizophrenia, among other memory-deficit-causing factors are likely to benefit big time from coluracetam. As earlier mentioned, the supplement increases the acetylcholine levels, thus offsetting memory deficits and improving one’s focus and concentration,

The drug is also suitable for those with anxiety or depression as its acetylcholine increase effect leads to a jollier mood with better reasoning ability.

People with health issues like Alzheimer’s disease and Schizophrenia normally have abnormally low Acetylcholine levels. As a result, they may experience mind-related symptoms like poor memory and learning. To alleviate the symptoms, something has to be done to increase their levels of acetylcholine.

People with not-so-clear vision also stand to benefit from coluracetam. After taking the supplement with the right prescription, one gains a clearer vision with brighter colors, more intense contrast and more radiant lights. It improves the damaged retinal and optical nerves.

The supplement can also be beneficial to people suffering IBS because it improves CHT1 regulation, thus improving the symptoms of the disorder.

Learners who want to boost their free recall and comprehension capabilities can benefit from the drug. Besides, the also coluracetam bodybuilding benefit suits bodybuilders.

Buy Coluracetam Nootropic Powder

Now you can buy coluracetam powder or solution online hassle-free. However, it’s important for you to know that there are many coluracetam buy places, but only a handful of them are reliable. If you’d like to buy pure nootropics coluracetam, we’d advise you to source from wisepowder. It is the most convenient and reliable place where you can buy coluracetam powder.


Although Coluracetam is a new family member of racetam nootropic class, it’s popularity is growing significantly, thanks to its myriad of benefits which include depression and anxiety symptom relief, cognition boost and improved vision. Besides, the supplement has minimal side effects which rarely occur.

However, you can avoid the side effects by sticking to the recommended dose and drinking lots of water, among the aforementioned measures. If you want to buy the supplement, ensure that you buy it from a reputable source .



Barlow, C., Carter, T., Morse, A., Treuner, K., Lorrain, K., Gitnick, D., & Pires, J. (2007). U.S. Patent Application No. 11/683,982.

Patel, S. J., Patel, K. K., Patel, M. S., Rupak, M. A., Patel, Y. B., Sanyal, A. P., … & Sen, D. J. (2016). Neuro stimulants cognitive enhancers as nootropics in multi task hectic schedule. World Journal of Pharmaceutical Research, 3(5), 570-590.

Phillips, I. D. J. (2009). U.S. Patent Application No. 12/315,255.

Reggente, N. Coluracetam’s Pharmacological Mechanisms: A Perspective Piece.

Squier, A. H., & Fisk, N. (2013). Becoming a nootropics user: how online communities enable cognitive enhancement.




2019-09-24 Nootropics
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