Blog

Flibanserin (Addyi): Is It Female Viagra?

 

What Is Flibanserin?

Flibanserin, also known as Flibanserin HCL, is a new non-hormonal medication used for the treatment of Hypoactive sexual disorder (HSDD) among premenopausal women. Some people call this drug a “female Viagra”.

However, the pink pill doesn’t fit Female Viagra name because unlike Viagra which works on the genital’s blood flow, Flibanserin Hydrochloride affects the brain neurons of a woman. Besides, contrary to Viagra, Flibanserin doesn’t have any hormone, be it estrogen or testosterone.

Sprout Pharmaceuticals trades the FDA-approved drug under the brand name Addyi and Flibanserin generic. Those who speak Spanish call it flibanserina.

How Does Flibanserin Work?

The manufacturer of Flibanserin (147359-76-0) (Addyi) appreciated the fact that sexual drive is psychological, especially in women. As such, flibanserina or Flibanserin is designed to work on dopamine, norepinephrine as well as serotonin.

The three are very vital brain chemicals as they facilitate the communication of signals from the brain to other body parts and vice versa via the nervous system.

Dopamine and norepinephrine trigger sexual excitement; the former enhances sexual desire while the latter promoted sexual arousal. On the other hand, serotonin promotes sexual inhibition which might lead to reduced sex drive.

So, when the levels of serotonin are extremely higher as compared to that of dopamine and norepinephrine, a person might experience reduced sex drive.

So, to maintain the right balance of the three chemicals thus promote sexual desire, Flibanserin works by increasing dopamine and norepinephrine levels into the cerebral cortex and at the same time, reduce serotonin activity. This results to increased sex desire.

Flibanserin Mechanism of action

Hypothetically, Flibanserin boosts sexual functioning by stimulating postsynaptic 5HT1A receptors thus increasing dopamine and norepinephrine downstream release. At the same time, it blocks postsynaptic 5HT2A receptors, consequently cutting down on the release of serotonin.

The latter happens in the brain circuits responsible for the mediation of low sexual desire symptoms (prefrontal cortex). As a result, a premenopausal woman with reduced sexual interest and desire to start yearning for sex again.

 

Flibanserin (Addyi) Is It Female Viagra

 

What Is Flibanserin Used For?

Flibanserin (Addyi) is used for the treatment of a sexual dysfunction known as hypoactive sexual desire disorder (HSDD). Chronic HSDD makes a woman to lose interest in sex, and this is a problem that can’t be traced to any other medical issue. a woman suffering from HSSD also feels mysteriously distressed due to the condition.

HSDD is not the only cause of reduced Sex desire among women. Pregnancy, drug side effects and menopause can also make a woman fail to feel the urge to have sex. In case low sex drive is due to another factor apart from HSDD, Flibanserin shouldn’t be used as a treatment to improve the desire.

Flibanserin Benefits

Women with HSDD feel unsatisfied when they can’t enjoy sex with their partner. It is a problem that, if not addressed, can lead to more hurting problems such as infidelity and divorce.

Therefore, besides restoring the urge to enjoy coitus with her romantic partner, a woman can regain her happiness in marriage or relationship as a result of using the medication. The Flibanserin cost is indeed worth if you are a HSDD victim, considering the benefits.

How Long Does It Take for Flibanserin to Work?

According to relevant scientific studies and Flibanserin Reddit user reviews, among other Flibanserin reviews, the drug mostly starts working within the initial four weeks of treatment.  However, the best results will start to show roughly from about the eighth to twelfth week.

In some cases, the drug might not work at all. Its success rate is nearly 50%. Unfortunately, you can’t know if it will work on you unless you try it.

But it’s not logical to try it forever. A maximum of 12 weeks is enough. If you’ve been using the drug for 12 weeks and haven’t noticed any improvement on your sexual desire, consider dropping it off. Most likely, you aren’t a responder.

Is Flibanserin a Hormone?

No, Flibanserin (147359-76-0) is not a hormone. Unlike erectile dysfunction(ED) medications such as Viagra, among other libido-boosting drugs, Addyi doesn’t have any kind of hormone, be it estrogen or testosterone. It is just a psychotropic drug as its action is limited to serotonergic brain neurons, although it has an indirect influence on dopamine and norepinephrine levels.

What Women Can Benefit from Flibanserin?

It’s evident that women with HSDD are the ones who stand to benefit from Flibanserin. However, it’s not easy to establish the exact factors that influence the success of the drug in these women. This is because the clinical studies that were conducted on the medication involved women who were suffering from “generalized, acquired HSDD.”

All of the women used as respondents in the study were committed in long-term, one-to-one and stable relationships. They had a normal sexual desire in the past but lost it with time. At an average, each of the women has lived with the sexual disorder for five tears.

A woman with such a profile (like that of the women used in the clinical trials) has a chance of about 46 to 60% to reclaim meaningful level of her sexual desire following the use of Flibanserin. However, different symptom patterns like lifetime lack of sexual desire or desiring to have sex with other people but not the main partner might require a different approach. This is because the effectiveness of Flibanserin in such cases hasn’t been established yet.

 

Who can use it?Flibanserin (Addyi) Is It Female Viagra

Although pre-menopausal women suffer from HSDD just like their post-menopausal counterparts, currently the use of Flibanserin in the post-menopausal group is off-label. However, the clinical trials done on post-menopausal indicate that the drug is effective for women in the age group as well.

As for men, there’s no Flibanserin for males. This drug is exclusively mean to benefit women who no longer desire to have sex, yet they had the urge in the past. As long as the sexual desire loss is due to HSDD and the woman is pre-menopausal, Flibanserin is likely to do what it does best.

Does Flibanserin Really Work?

Yes, but not for everyone. In recent randomized placebo-control clinical trials to establish the effectiveness of Flibanserin HCL, 46% to 60% of women who received the treatment reported significant sexual desire boost by the end of the trial periods.

So, if you are planning to use the drug, be open-minded that it might work for you or not and the possibility versus impossibility is 50/50.

How to Use Flibanserin

Whether you are dealing with Flibanserin liquid or tablet, you should take care to avoid overdosing or underdoing. The recommendedFlibanserin dosage is 100mg, which should be taken once per day. Preferably, it should be taken at bedtime and through the mouth (orally).

ADDYI taken during working g hours makes the consumer more likely to develop low blood pressure somnolence or sedation, syncope and cause accidental injuries. That’s why bed-time is the best time to take your Flibanserin dosage.

We’ve seen Flibanserin Amazon reviews showing what different users do in case they miss a dose of the drug. While some of them defy the standard directions of use, the truth of the matter is that ADDYI dose shouldn’t be made up.

In case you fail to take your ADDYI dose on time, it’s advisable to assume no mistake happened. continue with the rest of the dosages without trying to make up for the missed dose, for instance by doubling the next dose.

As earlier mentioned, Flibanserin Hydrochloride doesn’t work on everyone. However, you need to be patient with the drug and see if you’re going to experience any improvement following its use. Take the drug religiously for the first eight weeks after which it is advisable to discontinue the medication in case you don’t experience any improvement.

In case you want to start using Flibanserin Hydrochloride after CYP3A4 inhibitor use (whether strong or moderate), begin the ADDYI treatment two weeks after the day of the last CYP3A4 inhibitor dose.

Flibanserin Form

Flibanserin for sale in pharmacies or consumer use comes in the form of oval, pink, film-coated tablets weighing 100 mg, each. One side of Flibanserin over the counter tablet is debossed “f100” while the other side is blank. The Flibanserin over the counter tablets come in bottles, each with 30 tablets.

 Is It Safe to Use Flibanserin?

The data of the clinical trials of Flibanserin submitted to Food and Drug Administration (FDA), the United States’ agency of the Department of Health and Human Services, comprised results from more than 11,000 HSDD patients. This is among the largest data submitted to the agency in its entire history.

FDA and the scientists behind the development of this drug have evaluated its safety in a more stringent way as compared to the majority of the drugs that have been approved by the agency recently. However, just like any other medication that has been approved recently, there are still some things that are yet to be known about Flibanserin for sale or use.

As such, some of the serious side effects of the drug are likely to be established years after its approval, and that’s where we are. The safety and the side effects are still accumulating as prescribers keep a close eye on the treatment effects of their patients who are on the medication.

Before approval by the FDA, there were concerns that the drug could cause sedation to its consumers. Although many people who were used as samples in the clinical trials experienced sedation, the side effect was mild.

It was so mild that a woman could comfortably and safely drive the following day after taking the medication. That was the case even when a woman experienced sedation due to the use of the drug. Interestingly, people who’d taken Flibanserin had better driving performance as compared to those who had not used it

Flibanserin Side Effects

Prior to the approval of Flibanserin, the FDA seriously focused on two (supposedly) side effects of the drug. The two were sedation and dizziness/fainting, the latter occurring as a result of low blood pressure.

  • Sedation

Although mild, the incidences of sedation were frequent in the clinical trials of Addyi. Fortunately, an affected woman shouldn’t worry much about the side effect because it won’t interfere much with her daily activities. For instance, one can drive safely even the second day after taking the drug, when sedation is likely to take a toll on you.

  • Dizziness/convulsion

Dizziness, or fainting when on Flibanserin is usually as a result of low blood pressure. However, the two side effects were few, yet many subjects in the clinical trials, especially those involved in “challenge studies” had reduced blood pressure.

The “challenge studies” participants had volunteered to take Flibanserin alongside two to four shots of liquor every morning or blood pressure boosting medications. The researchers observed that many respondents of this study experienced dizziness or convulsions due to reduced blood pressure.

Considering the Flibanserin side effects, FDA issued a “black-box warning” which requires any woman taking the drug or is intending to take it to avoid using medications that elevate blood pressure level while on Flibanserin. Also, one should stay away from alcohol while taking Addyi to prevent dizziness and/or convulsion.

According to Flibanserin reviews such as Flibanserin Reddit reviews, other side slightly common effects the drug include: Drowsiness, nausea and tiredness. Seek urgent medical attention in case any of the side effects persist or worsens.

Although this happens rarely, a woman can develop an allergic reaction after using Addyi. The symptoms you need to watch out concerning Flibanserin include tongue, throat and/or facial rash swelling or itching. Severe dizziness and breathing difficulty could also indicate an allergic reaction. Seek urgent medical help in case you spot any of the serious allergic reaction symptoms.

 

Flibanserin (Addyi) Is It Female Viagra

 

Buy Flibanserin

Be on the lookout when making a Flibanserin buy so that you don’t fall into the trickery of the fraudulent pharmacies that try to sell counterfeit and possibly unsafe Flibanserin generic. The same case applies to the brand-name Addyi.

Avoid all the doubts about being deceived online; make a genuine Flibanserin buy from a reputable and licensed online seller.

Conclusion

Although some Flibanserin (147359-76-0) Amazon and Flibanserin Reddit reviews, depict Flibanserin as a female Viagra name, Flibanserin Hydrochloride is quite different from Viagra. Its action is psychological as opposed to the genital blood flow enhancement benefit provided by Viagra. If you are a woman with lost sexual desire due to HDSS, Flibanserin could be the best solution to your problem.

 

References:

  • Derogatis LR, Komer L, Katz M, Moreau M, Kimura T, Garcia M, Jr, et al. Treatment of hypoactive sexual desire disorder in premenopausal women: efficacy of flibanserin in the VIOLET study. J Sex Med. 2012;9:1074–1085.
  • Jaspers L, Feys F, Bramer WM, Franco OH, Leusink P, Laan ET, et al. Efficacy and safety of flibanserin for the treatment of hypoactive sexual desire disorder in women: A Systematic review and meta-analysis. JAMA Intern Med. 2016;176:453–62.
  • Kim MJ, Kim TH, Lee HH. G-protein coupled estrogen receptor (GPER/GPR30) and womens health. J Menopausal Med. 2015;21:79–81.
  • Pollack A. ‘Viagra for Women’ gets push for F.D.A. approval. New York, NY: The New York Times Company; 2015. [cited by 2015 June 24]. Available from:
  • Thorp J, Simon J, Dattani D, Taylor L, Kimura T, Garcia M, Jr, et al. Treatment of hypoactive sexual desire disorder in premenopausal women: efficacy of flibanserin in the DAISY study. J Sex Med. 2012;9:793–804.
  •  Woloshin S, Schwartz LM. US food and drug administration approval of flibanserin: Even the score does not add up. JAMA Intern Med. 2016;176:439–42.
2019-11-20 Nootropics
About wisepowder

Leave a Reply

Your email address will not be published. Required fields are marked *