A Comprehensive Comparison of Weight Loss Drug Lorcaserin vs Orlistat For Treatment of Obesity


Lorcaserin HCL 846589-98-8 Orlistat 96829-58-2

What is Lorcaserin HCL?

Lorcaserin (belviq) is a serotonin 2C

receptor agonist which is used for the treatment of obesity in adults with a BMI

(body mass index) of 30 and above as an additional treatment to body exercise and reduced

calorie diet.

What is Orlistat?

Orlistat powder is a reversible inhibitor of lipase and more specifically, intestinal lipases, which is highly recommended by FDA

for treatment of obesity. Orlistat powder is used to help in weight loss or to aid

lower the risk of regaining the weight already lost.

How does Lorcaserin HCL work?

Lorcaserin hcl functions by controlling appetite ie. making you feel full faster thereby lowering the amount of food you take through activation of a serotonin receptor known as 5-HT2C receptor found in the region of brain known as hypothalamus which controls appetite.  Serotonin is a neurotransmitter which elicits feelings of satisfaction and satiety. Serotonin 2C receptors are involved also in the regulation of mood; a majority of antidepressant drugs functions through blocking the serotonin reuptake and maintaining your brain receptors bathed in the chemical and so is lorcaserin hydrochloride. So, in short lorcaserin is one of the best appetite suppressant medications

because it works by suppressing your appetite.

How does Orlistat work?

Orlistat powder functions simply by blocking the active absorption of fats from the diet we take. Orlistat weight loss pills works by actively blocking more than 25% of fat in the diet from being absorbed in the body and is used to reduce weight to adults who are 18 years and above. It should be taken along with a low fat and reduced calorie diet.





Lorcaserin HCL Brand Names

The other brand names for lorcaserin includes; BELVIQ XR, lorcaserin hcl, lorcaserin

hcl hemihydrate, belviq, Lorcaserin HCL 846589-98-8, lorcaserin hydrochloride,

lorcaserin hcl powder.


Orlistat Brand Names

The other brand names for orlistat include Alli, Orlistat Polpharma, Orlistat Farmandina, Orlistat Apotex, O rlistat Aurovitas, Orlistat Stada, Orlistat Serral, Orlistat Amneal, Orlistat HEXAL,  Pharex Orlistat, Orlistat-Mepha 120mg, Orlistat Sandoz 120mg, Orlistat

La Santé, Orlistat EG, Orlistat MK, Orlistat 123ratio, Orlistat Teva, Orlistat Sandoz, Axcel Orlistat, Orlistat Spirig HC 120mg,

Lorcaserin HCL Half Life

The half-life of any drug is the amount of time taken for its plasma concentration to reduce to 50% its original value. The

half-life for lorcaserin hcl hemihydrate is 11 hours.

Orlistat Half Life

The half life for Orlistat is 13.5 hours.


Lorcaserin HCL Dosage

The suggested lorcaserin hydrochloride dosage is one 10 mg tablet taken orally two times a day.

The suggested dose for BELVIQ XR is one 20 mg tablet taken orally one time per day.


Orlistat Dosage

Usual Orlistat dosage for people aged 18 years and above for prescription strength (Xenical[R]) is 120 mg orally three times per day with each major meal containing fat.


The usual dosage for over the counter Alli[R] is 60 mg orally three times per day with each major meal containing fat.

Lorcaserin Price

High Quality Lorcaserin HCl (BELVIQ) for weight loss CAS: 846589-98-8 costs around  $2-3/g. The minimum order is 10g.

Each tablet of lorcaserin cost around $5.37(contain 10mg lorcaserin powder).  You’ll need around 60 tablets to complete the dose. The total lorcaserin hcl price therefore adds up to around $322.28.

Orlistat Price

High quality 99% Purity CAS No. 96829-58-2 costs around $2/g.

Each Xenical capsule of orlistat costs $6.9 to $8.06 depending on the store or website you buy. You’ll need 90 capsules for a complete dose. The total orlistat cost is therefore between $621.4 and $725.48.


How to use Lorcaserin HCL?

For best results, users are encouraged to use lorcaserin hydrochloride together with a healthy diet and fat burning exercises.You can take BELVIQ XR/BELVIQ with or without food. Swallow BELVIQ XR tablets wholly and don’t divide, crush, or chew.









How to use Orlistat?

This weight loss drug should be taken up to one hour after meals or during meals. If a meal contains no fat or is skipped, the dose can be skipped.

During treatment, one should take a nutritionally balanced, calorie-reduced diet containing around 30 percent of calories from fat.

A patient should take a vitamin supplement containing fat-soluble vitamins while taking this fat burning pills. This is because orlistat may make it hard for the body to absorb particular vitamins and you may therefore need to take a mineral supplement and a vitamin when taking this drug.

Patients should not take this drug at the same time as their usual multivitamin. All the other drugs should also be taken separately.

One should not take this weight loss medication if breastfeeding, pregnant, or have chronic malabsorption syndrome.


How much can you lose with lorcaserin?

According to the clinical trial data submitted to the FDA by the drug manufacturer, almost 50% of the dieters who used the drug, lost at least 12 lbs in average or 5 percent of their starting weight.

It is recommended that you discontinue using the drug if you fail to lose 5 percent of your body weight after 12 weeks.

How much can you lose with orlistat?

Health experts and medical doctors attest to the efficiency of orlistat. It have been proved that when used correctly and combined with a healthy lifestyle and the right meal, Orlistat can assist you lose 10 to 20 percent of your body weight within a span of as little as 3-6 months.

What are the side effects of Lorcaserin HCL?

Although lorcaserin is very beneficial, some side effects may occur. However, these side effects are not bound to occur ie. They may occur to some people and fail to occur in others.  Lorcaserin hcl side effects include: usual weakness or tiredness, excess or unexpected milk flow from the breasts, sore throat, sneezing, faster or slow heart rate, shakiness, runny nose, nightmares, nausea, nasal congestion, loss of voice, increased hunger, headache, frequent urge to urinate, fever, dizziness, confusion, cold sweats, cough, anxiety, and blurred vision.

What are the side effects of Orlistat?

Along with it’s benefits, orlistat may come with some unwanted effects. Some of these side effects may show up while others may fail to show up. However, if these side effects show up, you may need medical attention.

Orlistat side effects include unusual weakness or tiredness, vomiting, trouble sleeping, sweating, sore throat, sneezing, shivering, runny nose, nausea, nasal congestion, loss of voice, loss of appetite, discomfort, fever, ear congestion, difficulty with breathing, diarrhea, cough, chills,  and bladder pain.

Lorcaserin HCL reviews

After researching online to find out what is the drug’s user experience, we were thrilled to learn that many users are happy with lorcaserin hcl for the treatment of obesity results. Here are some of lorcaserin reviews that we came along:


One lorcaserin user by the name Famwen had this to say, “Hi, I’ve been on Belviq 20mg of XR once a day. I’ve been on it for 3 weeks and 2 days. Only side effect I’ve noticed, so far, are headaches, but they are becoming less frequent. I’ve been strictly adhering to the high protein, low fat, 1,500 calorie per day, diet given to me by my dietitian. I started at 288 lbs and am now 271. I am 72 years old. On this drug, I have virtually no appetite. Which, for me, is amazing. In fact, sometimes I have to force myself to eat so as not to go below 1,000 calories per day. I do record every calorie I eat, in a spreadsheet, and the lowest calorie count for a single day was 536 calories. Anyway, I would definitely recommend you give this drug a try.”


Another Belvic user had this to say about the drug “Started on Belviq in May 2018 @ 485, bought scale, started seeing nutritionist, and started to track my food. Stopped drinking all soda and juice, eating out, ordering in, any pizza, pasta, etc and started drinking only water or a home-made skinny latte I make. Started using a local meal service that delivered my meals freshly made weekly. As of today I am @ 343lb. No surgery, almost all eating habit changes, and staying on Belviq.”


Another user had this to say about Belviq: “I struggled with weight loss after spine surgery. I was at 177 lbs. Took Belviq for 3 months along with walk about walking 3 miles a day, I loss 40lbs. I am able to keep the weight down by walking everyday and eating better. No excessive eating.”


According to the above lorcaserin hydrochloride reviews, it is evident that lorcaserin is working great in the treatment of obesity and management of weight loss.

Orlistat reviews

As you’ll see from the following orlistat reviews, many users of orlistat diet are happy with the drug’s results.


An Orlistat user by the name Gurlo had this to say about  Xenical (orlistat) for Obesity: “I am female, started off 99kg/217lbs (I’m 5’7). At first, I was looking for a quick fix but realistically when it comes to weight loss there isn’t one. I gained 70lbs in the last four years and finally realized how unhappy I was. 20 days in and I have lost 14lbs/6kg. I am strict on my diet, though to be honest haven’t done the recommended exercise. So I can only imagine how much I would have lost in that time. As for the oily orange stools, I haven’t had any uncontrollable accidents, you can see it in the toilet bowl but haven’t had any embarrassing moments as of yet, but I am keeping within the recommended daily allowance of fats. I would recommend Orlistat to anyone who needs a helping hand, I have found that it has made me really determined to make better choices regarding my health and weight. Co workers and family have noticed a difference in my body and I can feel it in my clothes so I’m really happy.”


Another user by the name Chris had these to say:  “When I started taking orlistat I was 235lbs and in a matter of 4 weeks, my weight cane down to 220lbs! 15lbs in a month!! I did not even exercise, so imagine how much more is possible if I did. One thing to be careful with is leakage. It makes it easy to leak orange fats when farting, so be careful with that since it’s oily!”


Another user had this to say about the drug: “This medicine is a life saver. I was up to 200 lbs, in January 2019. Today I’m down to 174. Plus I struggled with severe constipation for years. I now just go once a day. This medicine is wonderful.”





Buy Lorcaserin HCL

You can make a perfect lorcaserin buy online if you take your time to research well. Always make sure that you’re buying from a reliable and legit lorcaserin hcl supplier because the illegal versions of this medication can be very dangerous and highly unsafe for your health.


Buy Orlistat

Well, it is possible to buy orlistat 60mg over the counter but the high strength generic orlistat or Xenical contain 120mg of orlistat and you can only obtain it with a doctor’s prescription. So, if you want higher strength orlistat 120mg, the best and hassle-free way is to buy it online from a legit supplier. If you’re looking to order orlistatpowder, we recommend that you buy it from one of the best and trustworthy orlistat powder manufacturers such as


 A Comprehensive Comparison of Weight Loss Drug Lorcaserin vs Orlistat For Treatment of Obesity


Lorcaserin vs sibutramine

As earlier stated, lorcaserin induces a  feeling of satisfaction through activation of a serotonin receptor known as 5-HT2C receptor found in the region of brain known as hypothalamus. On the other hand, sibutramine is also an appetite suppressant but it acts as a centrally acting serotonin-norepinephrine reuptake inhibitor. Sibutramine is considered to be less safer compared to lorcaserin because of increased risk of strokes and heart attacks.

Lorcaserin vs Orlistat For Treatment of Obesity: Which one is better?

Lorcaserin works as an appetite suppressant natural because as mentioned above it functions by controlling appetite. The drug actually works by making you feel full faster thereby lowering the amount of food you take. On the other hand, orlistat mechanism of action is through blocking the active absorption of fats from the diet we take.

It is important to note that you’ll need to take a vitamin supplement containing fat-soluble vitamins while taking orlistat since the drug may make it hard for the body to absorb particular vitamins. On the other hand, you won’t need such a supplement when taking lorcaserin appetite suppressants. You’ll only need to combine the drug with fat burning workouts and a healthy diet and that’s all. However, if you don’t have any problem taking a vitamin supplement, orlistat fat burning pills may also work great for you.

According to the clinical trial data submitted to the FDA by the drug manufacturer, dieters who used lorcaserin only lost around 5 percent of their starting weight. On the other hand, one can lose as much as 10-20 percent of their starting weight when using orlistat. But orlistat is also slightly more expensive compared to lorcaserin. One dose of lorcaserin hydrochloride buy costs around $323 while that of orlistat costs between $621.4 and $725.48.

So what’s the bottom line on Lorcaserin vs orlistat?

Both Lorcaserin and orlistat seems to work in a heathy way and deciding which is better among them sorely depends on your choice. However, if higher price and use of additional vitamin supplement isn’t a problem for you, then orlistat will be your best bet.


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How to choose weight loss drug?

The first step to choose the appropriate weight loss drug is to know and understand your body and how it can respond to various weight loss medications. For instance, if you know that controlling your appetite have been a major challenge in your weight loss journey, then you’ll need to go for appetite suppressants such as lorcaserin.

On the other hand, if you have been experiencing crazy cravings on food rich in fats such as chocolate and fast foods, then, you’ll need to go for the fat burning diet medications such as orlistat. You can also check the side effects of each drug and avoid the drug which might bring more adverse effects to you.


With the availability of safe fat burning medications such as orlistat and lorcaserin, we don’t find any reason whatsoever for anyone to go for weight loss surgery. Combining these drugs with the suitable fat burning foods will help you to achieve a perfect body shape that you have always desired. Just choose one of these weight loss drugs and start your journey to a lean and attractive body shape.



  1. National Center for Biotechnology Information, U.S. National Library of Medicine, Safetyassessment of FDA-approved (orlistat and lorcaserin) anti-obesity medications, Department of Endocrinology and Metabology, Obesity Group , 462 cj 72-73.
  2. Zhi J, Melia AT, Eggers H, Patel IH (1995). “Review of limited systemic absorption of orlistat, a lipase inhibitor, in healthy human volunteers”. J Clin Pharmacol. 35 (11): 1103–8.
  3. Spreitzer, Helmut (2010). “Lorcaserin”. Österreichische Apothekerzeitung (in German). 64 (19): 1083.
  4. Peng-Yu, Yang (2009). “Activity-Based Proteome Profiling of Potential CellularTargets of Orlistat -An FDA-Approved Drug”. Journal of the American Chemical Society. 132 (2): 656–66.





2019-09-26 Nootropics
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