A Comprehensive Overview On Nootropics Supplements Phosphatidylserine


What is Phosphatidylserine?

Phosphatidylserine may sound like a complicated word, but in the real sense, it is one of the commonest compounds that offer nootropic benefits in the body. Having been discovered in the early 1940s by Howard A. Schneider and Jordi Folch, Phosphatidylserine powder (51446-62-9) has become more popular and is one of the world’s most sought after nootropic today.

You will be suprised to learn that Phosphatidylserine is an amino acid derivative and aminophospholipid that our bodies produce naturally. It is a phospholipid that makes up a massive part of the brain. So why would you need to supplement it? Most of the foods we take today may not offer sufficient Phosphatidylserine to the body.

Also, studies have shown that the Phosphatidylserine levels decrease as you age; hence, you have to keep yourself armed with the Phosphatidylserine best source. There are various reasons why you should be taking Phosphatidylserine, including for the proper functioning of the nerve cells in the brain. It also assists in the transmission of messages between them.

Phosphatidylserine as well works as a signaling agent for apoptosis. That is the process of cell death which contributes to an organism’s growth and development.

In the past Phosphatidylserine, was manufactured from cow brains until a health concern arose on its risk in causing infections like mad cow disease. Today, it is mostly made from cabbage or soy.


How does phosphatidylserine work?

So far, Phosphatidylserine has undergone extensive research indicating that it works through the nerve cell membranes. It assists in the optimization of the functions of the cell, including homeostatic, maintenance, and specialized processes that are unique to the nerve cell.

Phosphatidylserine and other phospholipids help in holding the cell membranes together. They are packed side to side, forming a two-layer structure that holds proteins and other membrane constituents in place. Studies done on rodents showed that Phosphatidylserine works by;

  • Rejuvenating adaptive behaviors, including learning.
  • It improves glucose utilization and synaptic efficiency in the body.
  • Reversal of the EEG patterns.
  • Works by reversing the nerve network decline.
  • It boosts the nerve transmitters, i.e., acetyl-choline, tyrosine hydroxylase activity, dopamine release, and catecholamine turnover.
  • It resets lagging circadian and estrus rhythms.

Phosphatidylserine is usually present in every cell type, and although it has proven to work best in the nerve cells, it also helps in improving one’s immunity. That is by facilitating the recycling of old cells. Usually, red blood cells become less rigid, and this makes them incapable of passing through the narrow capillaries, making them need replacement.

Consequently, membrane enzymes transfer Phosphatidylserine from its normal position, which is the inner half of the membrane to the outer half. That acts as a signal to the circulating immune cells to get rid of the aged red blood cells from circulation.

Phosphatidylserine has also been linked with membrane phenomena which are involved in the bone matrix formation, signal transduction in the heart, testicular function and secretion by the adrenal glands.


A Comprehensive Overview On Nootropics Supplements Phosphatidylserine


Does phosphatidylserine help you sleep?

Yes, phosphatidylserine help sleep. Sleep is one of the most valued gifts that you can give to your body. Wondering why? Good sleep leads to greater wellbeing, more happiness, lower disease rate, sharper mental capabilities, and less fatigue.

Although most of us yearn to have a sound sleep, not all of us can achieve that naturally. Today, almost six out of ten people are suffering from sleeplessness and insomnia for at least a few days a week globally.

The bad news is that abnormal sleep patterns could lead to a higher risk of suffering from cardiovascular disease and multiple types of cancer. It could also lead to lower testosterone output and a higher risk of type 2 diabetes.

Well, in a bid to get a cool and a longer nap many people are going for natural ways to improve their sleep quality including maintaining regular sleep times, making their rooms darker and sleeping in cooler rooms. The tricky part is that this may only work for a day and leave you glaring at the roof for the rest of the week. So what do you do?

The Phosphatidylserine sleep benefits are so substantial that you might forget you ever struggled to have a good nap. It does this through the Phosphatidylserine cortisol effect. Cortisol is a chemical produced by the adrenal glands in a circadian rhythm. That means that its production peaks in the morning and that’s what makes you wake up. In the evening, it gradually decreases, giving you some sound sleep.

However, due to the ups and downs in the world we live in today, cortisol levels could stay high for many people. Subsequently, there is desensitization in two parts of the brain; the hypothalamus and the hippocampus which act as cortisol’s shut off valves.

Once the desensitization takes place, the cortisol levels go high up. Phosphatidylserine has proven to re-sensitize the hypothalamus and the hippocampus, which in turn lower the cortisol levels back in line with the circadian rhythm.

What makes it a great option as a sleep supplement is that it is natural (it is not synthesized from human-made chemicals found in the lab). It also works through a natural mechanism which is the lowering of the cortisol levels. All this sets it apart from other human-made sleep medications that may only end up giving you severe side effects and also make you suffer from addiction.

Next time you feel like your sleep is playing games on you; you could try Phosphatidylserine for deep and refreshing sleep.


Is phosphatidylserine the same as phosphatidylcholine?

Both the Phosphatidylserine and Phosphatidylcholine are phospholipids that assist in the formation of the cell membrane.  That allows for the transfer of fat and water-soluble molecules hence keeping the membrane flexible, healthy, and fluid. In other words, these phospholipids help in keeping the cells healthy, which translates to healthy overall wellbeing.

Both of them share a function which is to aid in neurotransmitter production, which helps with memory and concentration. This role is very vital, especially as we age as it slows down the decline in the cognitive ability and the risk of dementia.

Although they sound similar, the Phosphatidylserine structure is different from that of Phosphatidylcholine. Phosphatidylcholine adds a positively-charged group that is choline to the phosphate head group of phosphatidic acid whereas phosphatidylserine is made of the phosphatidic acid and a negatively charged phosphate group attached to the serine at the hydroxyl end.

Phosphatidylserine only comprises about 10% of the total cell membrane phospholipids and is mostly situated in the inner monolayer. On the other hand, Phosphatidylcholine is one of the largest phospholipids found in the cellular membranes and could make up to 50% of the total membrane phospholipid composition. It is mostly found in the outer part of the membranes.



A Comprehensive Overview On Nootropics Supplements Phosphatidylserine


What foods are high in phosphatidylserine?

It is good to note that Phosphatidylserine is mostly found in the food that we eat. Some of the common Phosphatidylserine sources include; chicken heart, Atlantic mackerel, soy lecithin, cabbage, egg yolk, bovine brain, and Atlantic herring. If you are not a food enthusiast, then you could save yourself the hustle by buying Phosphatidylserine supplement.


Phosphatidylserine health benefits

Reverse the age-related mental decline

Aging is inevitable, but there is always something you can do to age gracefully. As age piles on us, our mental capability decreases. It is for such reasons that you have seen older adults struggle to live a healthy life. Luckily, you do not have to feel like you are powerless and can do nothing concerning aging.

With the help of Phosphatidylserine, you can improve your language skills, attention, and memory which may have reduced due to aging.


Improve athletic performance

If you are into cycling, jogging, training, or running for long distances, then you can admit that any product that promises to boost your performance could help you achieve your goals fast. In this case, Phosphatidylserine powder (51446-62-9) helps in reducing muscle soreness even after strenuous training. It does this by providing relief to the sore muscles and also reducing inflammation of the joints.

Additionally, Phosphatidylserine offers protection against the increase in the cortisol levels, which frequently occurs due to overtraining. Consequently, you are likely to enjoy more significant physical achievements without feeling all the pain and fatigue.


Helps with depression

Depression is one of the severe illnesses that many people around the globe suffer from. Sometimes it may be characterized by intense sadness and anxiety that seem to take away one’s purpose in living. Although there are many depression treatments, medication is not recommended and only comes as a last resort. What else could you use to reduce the symptoms and treat depression?

Phosphatidylserine is one of the natural supplements that you could use to fight depression. It is said to play a role in the regulation of one’s mood. In a study done on people over the age of sixty-five and who suffered from major depression, those that took Phosphatidylserine in combination with omega-3 fatty acids EPA and DHA three times daily for three weeks, observed improvement on the symptoms.


Aids in memory loss

One of the most devastating things one would undergo as you age is memory loss. It gets heartbreaking when you notice that you now forget even the obvious stuff like your name, what day of the week it is etc. What could you do to stave off memory loss?

Phosphatidylserine has been used in the past to slow age-related memory loss. In 2010, a study was conducted on seventy-eight older adults who had mild cognitive impairment. They were administered with Phosphatidylserine for six months. It was observed that those who had low memory scores experienced considerable improvement in their memory.


Helps in the management of ADHD

ADHD is a disorder that has an impact on the brain and one’s behavior. So far, there is no known cure, but there are several options that could help counter the hyperactive behavior. The Phosphatidylserine ADHD effect has helped in the management of its symptoms effectively.

When taken in combination with omega-3 fatty acids, Phosphatidylserine has proven to aid in the treatment of ADHD, especially in children. A study was done on two hundred children with ADHD, and they were assigned on a fifteen weeks treatment with Phosphatidylserine and omega-3 fatty acids. The results showed that they experienced a significantly higher reduction in impulsive behavior.


Improving thinking ability

Our thinking ability may sometimes become slow due to reasons like age, anxiety, and stress. That does not, however, mean that you sit there and watch your thinking skills and the efficiency of your brain go down the drain; there are ways you could deal with it.

One of the Phosphatidylserine benefits is that it enhances your thinking ability by improving your cognitive brain functioning and by sharpening your thinking skills too.

So if you are looking for a product that will help you with faster learning, sharper thinking, good memory and out of the box problem-solving, then you can trust in the Phosphatidylserine nootropic. It will make you feel like a genius in no time.


Aid in the treatment of Alzheimer’s disease

Alzheimer’s disease is a progressive condition which leads to the degeneration and ultimate death of the brain cells. This disorder is known to cause dementia; a condition that leads to the decline in one’s thinking ability, behavioral and social skills that could result in the disruption in a person’s ability to function self-reliably.

While some of the symptoms include severe memory impairment and the inability to carry out everyday tasks, as usual, the Phosphatidylserine Alzheimer’s effect comes as a new dawn to patients suffering from it. The essential brain nutrient helps in improving some of the Alzheimer’s disease symptoms within six to twelve weeks of treatment.

It has, however, been observed that Phosphatidylserine works best in people with less severe symptoms. After the first sixteen weeks of treatment, this nootropic may not offer any more benefit on the progression of Alzheimer’s disease.


How should I take phosphatidylserine?

What is the appropriate Phosphatidylserine dosage? Is there any risk of taking too much? These are some of the critical questions that many people ask. Since we have already dealt on the Phosphatidylserine benefits, let us learn a little more on how much of this supplement you should be taking every day.

The recommended Phosphatidylserine dosage is 100mg taken three times a day. However, you could play around with the dosage to know what works for you best. The 100mg should be your starting point as you gradually increase the dosage. That will help you understand your reaction towards it before testing the depth of the water with both feet.

Never take more than 500mg in a day as it may increase the chance of suffering from Phosphatidylserine side effects as rare and minor as they may seem.

Phosphatidylserine stack

You may decide to stack Phosphatidylserine with other nootropics to achieve better results. The most popular choices that people prefer to use are pramiracetam and Noopept. That is because they offer different effects from those that Phosphatidylserine give; hence, their combination could give very nice synergistic effects. You could, however, choose any other nootropic that suits you since Phosphatidylserine is safe and well-tolerated in the body.

If you stack Phosphatidylserine, then you may want to use less than 100mg especially if it synergizes well with the other nootropics.

Although some people stack Phosphatidylserine, it doesn’t mean that it is not potent on its own. You could use it purely on its own and still reap the fruits. To get the best out of it, do not take it only when you want to hack your brain, instead, use it with a long term goal of achieving the overall health of both the mind and the body.


What are the side effects of phosphatidylserine?

Phosphatidylserine is considered to be a safe nootropic as many people rarely react to soy-derived supplements. The Phosphatidylserine side effects are, therefore, less likely to occur. They may include;

  • Trouble while sleeping
  • Stomach upset
  • Gas

To prevent yourself from suffering from this, always take the right dosage and avoid drugs that interact with it, e.g., blood thinners, anti-inflammatory medicines, and performance-enhancing drugs or supplements.


A Comprehensive Overview On Nootropics Supplements Phosphatidylserine


Buy phosphatidylserine online

Getting the right Phosphatidylserine supplier can be a hustle, especially if quality is your thing. The fact that 85% of the supplements on the market contain additives makes it even harder to settle for any Phosphatidylserine manufacturer.

There is some little hope left, though. The legit Phosphatidylserine manufacturers that offer nothing else other than excellent quality. It is no wonder all the Phosphatidylserine reviews from our clients have been positive.

Additionally, buy phosphatidylserine supplements online comes with a bunch of benefits. Other than the convenience it will offer you; you can choose the quantity you want in a short period. Why walk around physical stores when your favorite supplement is a click away?



As seen in the article, Phosphatidylserine is no ordinary supplement. It is what every person should be taking for a longer and quality life. With all the benefits it brings on the table, it comes as a surprise that it does not offer all this at the expense of your body’s wellbeing. That means that with the correct dosage, you will never suffer from any adverse effect.

Furthermore, it has undergone a large number of studies; hence, you already know what to expect. Why not try it today and unleash the great potential in your overall health?



Kannan, Muthukumar; Riekhof, Voelker, Dennis R. (2015). “Transport of Phosphatidylserine from  Endoplasmic Reticulum to  Site of Phosphatidylserine Decarboxylase2 in Yeast”.  16 (2): 123–134.

Solomon TM, Leech J, DeBros G, Budson A,. A randomized, double-blind, placebo controlled, , efficacy study of alpha BRAIN® administered orally. Journal of the International Society of Sports Nutrition. 2015;12(S1):P54.

EFSA Panel on Dietetic Products, Nutrition and Allergies . “Scientific Opinion on health claims related to phosphatidyl serine, pursuant to Article 13(1) of Regulation (EC) “. EFSA Journal8 (10): 1749.

Jäger R, Purpura M, et al. The effects of phosphatidylserine on the golf performance. Journal of the International Society of Sport Nutrition. 2007;4(1):23




2019-09-11 Supplements
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