Nmn powder (1094-61-7)

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β-Nicotinamide Mononucleotide powder

β-Nicotinamide Mononucleotide powder can be used as an activator or booster of NAD. NAD is a coenzyme responsible for homeostasis and equilibrium in the body. Reduction of this coenzyme is responsible for most of the effects of aging as it balances the effects of all organ systems.

What is β-Nicotinamide Mononucleotide powder?

Nicotinamide mononucleotide, is a nucleotide that is found naturally in certain fruits and vegetables. It is a derivative of Vitamin B3 or niacin, that is especially known for its use as an anti-aging supplement.

NMN powder, once ingested, converts to NAD+, a potent coenzyme necessary for homeostasis in the body. This coenzyme is believed to play an important role in the energy production process in the body, which only adds to the importance of NAD+. A significant reduction in the levels of NAD+ is seen with aging, which would, to an extent, explain the lack of energy, fatigue, and tiredness seen with aging. It is the ability of NMN to convert into NAD+ that is hypothesized to be the reason for its use as an anti-aging compound.

NMN discovery as an anti-aging supplement is still under process but it has the potential to take over the use of Nicotinamide riboside (NR) as anti-aging supplements. NR also converts into NAD+ in the body and this compound has been thoroughly studied with supplementation of NR being labeled as safe for humans.

Once ingested, NMN powder is absorbed from the gut into the blood in approximately fifteen minutes with the process starting within two to three minutes of ingestion. After absorption, it is stored in skeletal muscles, mostly, after it has been converted to NAD+. NMN in general has poor bioavailability, which hinders its potential. The conversion of the NMN into NAD+ is needed because once in the periphery, the compound is degraded by CD38, resulting in no net increase in NAD+ levels and hence, no anti-aging effects of NMN powder.

Mechanism of Action of NMN Powder

NMN is a naturally occurring nucleotide that, once ingested, gets immediately converted into another compound, Nucleotide riboside or NR. NR itself is often used as a supplement but NMN supplements may replace NR supplements almost completely.

NMN is converted into NR in the body because it cannot cross the cell membrane as itself and needs to be converted into a smaller structure that is able to cross the cell membrane easily. After NMN enters the cell as NR, it is converted into NMN again before being metabolized into the coenzyme NAD+. While it is not clear as to which enzyme is responsible for the initial, extracellular conversion of NMN into NR, it is known that the enzyme responsible for intracellular conversion is nicotinamide ribose kinase or NRK.

Intracellularly, NMN contributes to the energy production process in the mitochondria of the cell, although indirectly, in the form of NAD+. The main mechanism of action of the compound is energy production by replenishing the levels of the vital coenzyme, NAD+. The same mechanism of action is responsible for the various other benefits of NMN powder.

Uses of NMN Powder

NMN powder is widely used as a supplement for several purposes, however, the most common use of the compound is as an anti-aging supplement. People also use NMN powder for its ability to suppress several age-related changes such as weight gain, decreased insulin sensitivity, and worsening of vision. Moreover, it can be used for the prevention of age-related changes in gene expression, which is responsible for the genetic alteration that is required for the pathogenesis of several disorders.

Benefits of NMN Powder

Initially, it was believed that the benefits of NMN powder are limited to the age-related benefits of the compound but further research is being performed to prove that if taken in youth, it may help treat several other conditions that are not directly related to aging.

The most common benefits of NMN powder that are backed by scientific evidence are mentioned below, along with the research studies that support them.

Management of obesity

A recent study that was performed on animal models found that NMN supplementation significantly increased the satiety hormones and metabolism rates in the mice. NMN powder resulted in a marked increase in genetic expression which is needed to suppress the appetite-inducing hormones, such as leptin and sirtuin. This led the researchers to believe that NMN can combat obesity in older individuals, which is especially beneficial, as obesity in this age group is often associated with comorbidities.

Furthermore, NMN is also stored in the fat cells as NAD+, which proves to be beneficial as NAD+ in adipose tissue is responsible for increasing the metabolism rate, resulting in a net decrease in fat levels in the body. The ability of the compound to increase metabolism rates and suppress appetite is one of the main reasons why people use the supplement for weight loss purposes, even if they do not suffer from age-associated obesity.

Management of diabetes

NMN powder is hypothesized to have several positive effects with regards to diabetes such as glucose tolerance and insulin sensitization, especially in peripheral cells.

A recent study performed on animal models found that NMN supplementation increased the levels of NAD+, which in the pancreas helps improve beta-cell function. As the impaired function of these pancreatic cells is the main reason behind the pathogenesis of the metabolic disorder by altering insulin levels, this function of NMN powder is highly important in the treatment of diabetes. In a different study focused on the same subject, it was found that NMN’s ability to digest fat is also effective against fatty liver. There is an increase in lipid oxidation in the liver as a result of NMN supplementation, which not only decreases fat levels in the body but also helps increase the sensitization of cells to insulin.

An important note here is that although these mechanisms of action are proven to work against diabetes mellitus, hence, helping manage the disorder, these effects may also be effective against other metabolic disorders that may develop as a result of aging.

Increased blood flow

Researchers have found that many endothelial cells in blood vessels could be activated and their functioning could be improved in a significant manner with NMN supplementation. This could help treat vascular disorders, especially as they constrict blood flow and result in severe, life-threatening conditions or medical emergencies.

Enhance cognitive function

NAD+ is important for the protection and survival of neurons in the brain. Supplementation with NMN powder has been found to improve cognitive function by increasing NAD+ levels. To test this theory, a study was performed where animal models with traumatic brain injury were treated with P7C3-A20, an NMN-producing compound. It was found that not only cognition was improved in these mice, but also further neurodegeneration was completely stopped. Traumatic brain injury is often progressive and the mental status of patients keeps worsening usually, however, treatment with P7C3-A20 stopped the progress of TBI almost completely. It also improved the survivability of the cells and reversed the damage, to a certain extent.

Another benefit of NMN powder on the brain is its stabilizing and protective benefit on the blood-brain barrier, which is important for the prevention of medications, toxins, and infections from passing into the brain from the bloodstream.

Increased endurance and athletic abilities

This benefit of NMN is a derivative of NMN’s energy-producing benefit. As the energy levels increase in the body, the ability to perform physical activities along with the required stamina increases significantly. These effects of NMN powder were studied in research that found that athletes taking the supplement had a higher aerobic capacity than those not taking the supplement. Furthermore, these athletes were able to endure high-intensity training easier than their counterparts.

Immune booster

NMN supplementation was hypothesized to have an immune-boosting effect on the human body and given that the research into the compound began during the COVID-19 pandemic, this theory was tested against this virus. A study performed on this topic found that NMN after conversion into NAD+ has an immune-boosting effect that not only is effective against COVID-19 but also against other viruses.

The study found that older individuals, as a result of physiological aging, suffer from the decreased functioning ability of their immune system. This results in increased infections in this age group which is why they are asked to receive vaccinations against specific pathogens. However, NMN supplementation in this age group was found to boost the immune system so that it is sufficient in fighting off pathogens and reducing the incidence of infections.

Moreover, NMN reduces comorbidities that develop as a result of aging or obesity, which further decreases the risk of mortality with COVID-19 in older individuals. This is a benefit of NMN supplementation specific to this age group and the virus.

Improved fertility in females

Studies have found that a detrimental change in the quality of oocytes is because of an imbalance in NAD+ levels in the mitochondria, resulting in point mutations and altered gene expression. This is why researchers concluded that NMN supplementation could significantly improve the quality of the oocytes and improve fertility in women over the age of 30 years to 35 years.

Side Effects of NMN Powder

β-Nicotinamide Mononucleotide is a naturally occurring compound that is derived from niacin. β-Nicotinamide Mononucleotide powder is labeled as safe for human use because of its widespread availability in nature and a clear lack of reported toxicities and adverse effects.

There are certain side effects associated with NMN powder if it isn’t stored properly in a cold and dry place, away from sunlight. Apart from that, the product has no side effects associated with it. An important point here is to be careful of the doses and timing of the compound as regular use of NMN powder can reduce the potency of the compound.

Why buy NMN Powder from our Manufacturer Factory?

Our manufacturer factory produces NMN powder that is manufactured with all safety guidelines and protocols in place. The utmost regard is given to preventing contamination of the NMN powder with any toxins or contaminants that can cause more harm than good to the human body. The products are tested for quality control, during and after the manufacturing process. Products are also labeled with quality control trackers to make the process of recall, if necessary, easy and efficient.

Moreover, the NMN powder at our manufacturer factory, as mentioned above, is stored in the appropriate conditions that are also maintained during the transportation of the supplements.

References

1. Yoshino, J., Baur, J. A., & Imai, S. I. (2018). NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell metabolism, 27(3), 513–528. https://doi.org/10.1016/j.cmet.2017.11.002
2. Chen, X., Amorim, J. A., Moustafa, G. A., Lee, J. J., Yu, Z., Ishihara, K., Iesato, Y., Barbisan, P., Ueta, T., Togka, K. A., Lu, L., Sinclair, D. A., & Vavvas, D. G. (2020). Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment. Aging, 12(24), 24504–24521. https://doi.org/10.18632/aging.202453
3. Miao, Y., Cui, Z., Gao, Q., Rui, R., & Xiong, B. (2020). Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes. Cell reports, 32(5), 107987. https://doi.org/10.1016/j.celrep.2020.107987
4. Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., Redpath, P., Migaud, M. E., Apte, R. S., Uchida, K., Yoshino, J., & Imai, S. I. (2016). Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell metabolism, 24(6), 795–806. https://doi.org/10.1016/j.cmet.2016.09.013
5. Uddin, G. M., Youngson, N. A., Sinclair, D. A., & Morris, M. J. (2016). Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice. Frontiers in pharmacology, 7, 258. https://doi.org/10.3389/fphar.2016.00258
6. Everything You Need to Know About Nicotinamide Riboside Chloride
7. Nicotinamide Mononucleotide(NMN): Benefits, Dosage, Supplement, Research

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