Nmn powder (1094-61-7)

Nicotinamide mononucleotide powder video

 

Nmn powder Base Information

Name	NMN powder
CAS	1094-61-7
Purity	98%
Chemical name	beta-Nicotinamide mononucleotide nicotinamide mononucleotide 1094-61-7 beta-NMN nicotinamide ribonucleotide
Synonyms	3-Carbamoyl-1-[5-O-(hydroxyphosphinato)-β-D-ribofuranosyl]pyridinium
Molecular Formula	C11H15N2O8P
Molecular Weight	334.221 g/mol
Melting Point	>96°C
InChI Key	DAYLJWODMCOQEW-TURQNECASA-N
Form	Solid
Appearance	white powder
Half Life
Solubility	soluble in water
Storage Condition	Hygroscopic, -20˚C Freezer, Under Inert Atmosphere
Application	Nicotinamide mononucleotide (“NMN”, “NAMN”, and “β-NMN”) is a nucleotide derived from ribose and nicotinamide.
Testing Document	Available

 

General Description

beta-Nicotinamide mononucleotide powder (1094-61-7) is a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice.

It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.

 

History

Beta-Nicotinamide mononucleotide (NMN) powder  is an intermediate of NAD+ biosynthesis produced from nicotinamide through nicotinamide phosphoribosyltransferase (NAMPT) and also referred to as NMN or nicotinamide ribotide. In recent studies of NMN applications to prevention and diagnosis of age-dependent diseases such as diabetes, neurodegenerative disorder, cardiac disease etc., it has become one of hottest biomarkers on discussion for anti-aging, lately.

 

Of Action

beta-Nicotinamide mononucleotide (β-NMN) is a biosynthetic precursor of nicotinamide adenine dinucleotide (NAD+) known to promote cellular NAD+ production and counteract age-associated pathologies associated with a decline in tissue NAD+ levels.

 

Application

Aging cells. Indeed, past work in Imai’s lab has shown that giving beta-Nicotinamide mononucleotide to older mice has beneficial effects on metabolism throughout the body, including positive effects in skeletal muscle, liver function, bone density, eye function, insulin sensitivity, immune function, body weight, and activity levels.

 

More research

Aging cells. Indeed, past work in Imai’s lab has shown that giving beta-Nicotinamide mononucleotide to older mice has beneficial effects on metabolism throughout the body, including positive effects in skeletal muscle, liver function, bone density, eye function, insulin sensitivity, immune function, body weight, and activity levels.

 

Reference

• 1, Bogan, KL; Brenner, C (2008). “Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition”. Annual Review of Nutrition. 28: 115–30. doi:10.1146/annurev.nutr.28.061807.155443. PMID 18429699.
• 2, Brazill, JM; Li, C; Zhu, Y; Zhai, RG (June 2017). “NMNAT: It’s an NAD+ synthase… It’s a chaperone… It’s a neuroprotector”. Current Opinion in Genetics & Development. 44: 156–162. doi:10.1016/j.gde.2017.03.014. PMC 5515290. PMID 28445802.
• 3,  “Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice”. Cell Metabolism. 13 December 2016.
• 4, Stipp, David (March 11, 2015). “Beyond Resveratrol: The Anti-Aging NAD Fad”. Scientific American Blog Network.
• Everything You Need to Know About Nicotinamide Riboside Chloride
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