Fasoracetam powder (110958-19-5)

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Molecular Formula:  C10H16N2O2

STORAGE:Store in a cool and dry place. Keep away from direct sunlight and heat.

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Fasoracetam powder (110958-19-5) video


Fasoracetam powder Base Information

Name Fasoracetam powder
CAS 110958-19-5
Purity 98%
Chemical name (R)-1-((5-Oxo-2-pyrrolidinyl)carbonyl)piperidine
Synonyms Fasoracetam; N-(5-Oxo-D-prolyl)piperidine; NS-105; NFC-1; LAM-105.
Molecular Formula C10H16N2O2
Molecular Weight 196.25 g/mol
Melting Point 57 °C
Form Solid
Appearance White powder
Half Life 1.5 hours
Solubility Soluble in DMSO
Storage Condition Store in dry, dark conditions at 0 – 4 °C for short-term (day/weeks), and – 20°C for long term storage.
Application Agonist of all three metabotropic glutamate receptors (mGluRs) with potential antidepressant action, that has been used in clinical trials for vascular dementia and attention deficit disorder
Testing Document Available


Fasoracetam: What is it? What are its Uses?

Fasoracetam is a nootropic and one of the newest additions to the racetam family. It is a compound that is being researched for its ability to enhance cognition. It may also have benefits in treating anxiety and cognitive problems.


What is Fasoracetam?

Fasoracetam is a nootropic of the racetam family. Nootropics are known for their cognitive enhancing abilities. Fasoracetam may be able to relieve anxiety, better memory, and improve cognition. It works by acting on three receptors: acetylcholine,gamma-aminobutyric acid (GABA), and glutamate.

Fasoracetam was first developed by a Japanese pharmaceutical company, Nippon Shinyaku. It was made with the hope of being the treatment for dementia. They conducted a clinical trial to see its efficacy, but it failed to make it past phase 3. In the end, due to the lack of efficacy, it was abandoned.

NeuroFix bought Fasoracetam in 2013. It then passed to Aevi Genomic Medicine. After this, clinical trials to see its abilities started. The first one was conducted in 2016 to treat children with attention deficit hyperactivity disorder (ADHD).

Fasoracetam powder has shown effectiveness as a potential treatment for ADHD treatment and is currently in phase 2 trials.

It has not been approved officially for any use by the FDA. Therefore, it is used as a research chemical for now.


How Does Fasoracetam work?

To understand how Fasoracetam powder works, we must first talk about its parent class, nootropics.

Nootropics, also called smart drugs, are a group of drugs that can enhance mental capability or performance. These drugs can better the learning and memory of the users. They do this action by blocking calcium channels. They also inhibit the action of acetylcholine esterase, allowing for acetylcholine to last longer. They also increase the antioxidant levels, act as a neuroprotective agent, and increase the synaptic and mitochondrial response genes.

Fasoracetam is a comparatively new nootropic of the racetam family. Its mechanism of action is not fully understood. However, the studies have shown that it works both on cholinergic and GABA functioning.

Fasoracetam can increase the amount of acetylcholine in the cerebral cortex. Acetylcholine is one of the major neurotransmitters in the body. It can dilate blood vessels, increase bodily secretions, slow down the heart rate and contract smooth muscles. In the brain, it acts as a neurotransmitter and a neuromodulator. Acetylcholine can play an important role in activities like alertness, memory, mood, arousal, and motivation. Fasoracetam not only increases the amount of acetylcholine in the brain but also inhibits its breakdown. It also encourages its uptake by the cholinergic receptors. This is how it works on the cholinergic system. In conditions where acetylcholine levels decrease in the body, Fasoracetam may help to increase its amount.

Fasoracetam also works on gamma-aminobutyric acid (GABA) by increasing the number of receptors for the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). GABA (B) receptors are present in the whole of the nervous system. When activated, it can block neurotransmissions. It can also stop the excessive excitation of the nervous system. Thus, it can help the neurons to rest and calm the system down, allowing for a state of relaxation. This activity can especially help in conditions like anxiety, sleep disorders, and depression. Fasoracetam on the GABA (B) receptor via receptor antagonism. It also upregulates the GABA (B) receptors.

However, Fasoracetam does not seem to affect adrenoreceptors, serotonergic or dopaminergic receptors.

Fasoracetam also appears to agonize all three groups of metabotropic glutamate receptors (mGluRs). These receptors are involved in memory, anxiety, learning, and pain perception. The mutation of mGluRs occurs more in frequency in children with ADHD. Fasoracetam can act on these mGluRs and may restore the glutamatergic activity to normal in ADHD patients.


Uses of Fasoracetam

The workings and potential of Fasoracetam have not been finalized yet. It is still under study. However, it has shown potential as an effective drug for cognition, attention, memory improvement, etc in trials and research.

Here are some of the possible uses of Fasoracetam:


Effect on ADHD

Fasoracetam may be effective in improving the condition of attention deficit hyperactivity disorder or ADHD.

ADHD is a neurodevelopmental disorder. The afflicted person will have poor impulse control, poor focus, inattention, hyperactivity, etc. A group of genes called metabotropic glutamatergic network (mGluR) was discovered to be significantly higher in frequency in children with ADHD. The control number variation (CNV) of these genes in ADHD was also found to be higher compared to normal.

To show its effectiveness in ADHD, Fasoracetam was provided for five weeks in a study involving 30 adolescents of ages 12 to 17year. It especially showed improvement in cases with mGluR Tier 1 variants [1].

It means Fasoracetam could be effective in patients with ADHD who have variants of these genes.


Effect on Depression and Anxiety

Fasoracetam has some effects on depression and anxiety which may help to tackle these conditions.

The neurotransmitter GABA  works as an agent in the neurogenesis and maturation of neurons. This activity is vital to regulate normal nervous system functions [2]. A decrease in the amount of GABA and its receptors in the brain is one of the common characteristics of depression.

Fasoracetam can work as a cognitive enhancer as well as a proper anxiolytic agent. It can improve anxiety by acting on glutamate and gamma-aminobutyric acid (GABA). It can increase the amount of GABA in the brain and suppresses the excess production of glutamate, an excitatory neurotransmitter. Fasoracetam can help bring calmness and relaxation.

A study was conducted on rats with behavioral disturbance of learned helplessness to show the effects of Fasoracetam on depression [3]. It showed that after the rats were given doses of this drug, their moods increased, and they were able to escape danger, an action they were unable to do before being given this drug. Thus, it was attributed that this is because of an increase in the number of GABA(B) receptors in the cerebral cortex.

Its benefit over other anxiolytics is that its anxiolytic action lasts for a longer duration. It has a high chance of being non-addictive and does not cause lethargy, drowsiness, or sedation.


Effect on Memory and Cognition

Fasoracetam may be able to decrease the decline in memory and cognition.

A study was conducted on rats with memory disruption. Their memory disruption was due to electroconvulsive therapy, cerebral ischemia, baclofen use, scopolamine use, and electrolytic lesion of nucleus basalis {4]. After Fasoracetam was provided to the rats, they began to show memory improvement. Thus, it may be possible for Fasoracetam to improve memory and cognition by acting on the cholinergic system and GABA(B) mediated responses.


Effect on Creativity and Motivation

Fasoracetam may also provide improvements in creativity and motivation in the users. It may also enhance mood because of the actions of the neurotransmitter acetylcholine, which is responsible for cognition and learning.


Side Effects of Fasoracetam

  • Fatigue
  • Headache
  • Digestive discomfort
  • Reduced libido
  • Loss of motivation
  • Loss of balance
  • Possible memory loss
  • Nervousness
  • Drowsiness
  • Disorientation
  • Sedation


How to Buy Fasoracetam?

Fasoracetam comes in a white powder form. It comes in a package of 1kg per bag or 25kg per drum. If you want  to buy Fasoracetam powder, the best way is to contact the Fasoracetam powder manufacturer factory. Only the best materials are used to prepare this powder, under the watchful eye of the experts in the field. They are made and packaged following strict safety guidelines. Hence, this product is of high quality and potency. The customization of the orders is possible as per the user’s need.

Fasoracetam powder needs to be stored in dry and dark conditions with a cold temperature of 0 to 4°C and -20°C for the long term. It is to prevent it from reacting with other chemicals or from spoiling.




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