J-147 powder is a new experimental drug that is being developed as a possible treatment for Alzheimer’s disease. So far, the tests done on mice show a lot of promise. J147 has reported effects in reversing the effects of dementia and Alzheimer’s in mouse models. J147 takes a different approach compared to several other Nootropics and Alzheimer’s drugs. J147 tries to remove plaque deposits in the brain. Researchers also note that J147 has the potential of addressing several other biological aging issues, not just memory loss. The drug may help to prevent leakage of blood from microvessels, as shown through mice trials done so far. The drug was first developed in 2011. Ever since, tests have been conducted on mice but we haven’t seen any broad human-based clinical trials. However, some research published last year paints a very good picture of how J147 works within the human brain. According to the paper, the drug binds to protein mitochondria. The Mitochondria cells are often responsible for generating energy. The action of J147 on them enhances cell regeneration. This regeneration is crucial in reversing memory loss and enhancing overall cognitive health.
Manufacture: Batch Production
Package: 1KG/bag, 25KG/drum
02 J147 powder (1146963-51-0) video
03 J147 powder Base Information
|Chemical name||2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide|
|Molecular Weight||350.341 g/mol|
|Appearance||White of off-white powder|
|Half Life||1.5 hrs in plasma and 2.5 hrs in brain|
|Solubility||Soluble to 100 mM in DMSO and to 100 mM in ethano|
|Storage Condition||Store at +4°C|
|Application||Experimental drug with reported effects against both Alzheimer’s disease and ageing in mouse models of accelerated aging.|
04 What is J147 powder?
As we have already noted above, J-147 powder is an experimental drug. In other words, it is not yet available on a mass scale in the market and there are still so many aspects of it yet to be established. J147 is seen as a possible treatment for Alzheimer’s but can also be marketed as an overall anti-aging supplement.
J147 has been under development since 2011. Research on the workings of the drug is still very scanty. But we know that it helps to regenerate cells in the brain by binding to protein mitochondria. Additionally, all studies done on the effects of J147 have been on mouse models. Until there are full J147 human trials, there’s still a lot of potential to be uncovered. J147 synthesis is still ongoing and the drug is available online for purchase.
05 How Does J147 Work
Although research on the function of J147 as Nootropics is still coming out slowly, scientists have already been able to show that it works by manipulating ATP, a form of protein found in the mitochondria. According to researchers, when J147 was introduced into the mitochondria, neurons in the brain were protected from toxins often associated with aging. Researchers also found that J147 triggers enhanced production of ATP in the body. The drug may also help to stabilize the mitochondria, a factor that is essential in anti-aging.
The significance of these actions is important for one reason. This is because the single biggest cause of Alzheimer’s, dementia, and other cognitive ailments is aging. Finding a way to slow down or reverse the effects of aging in the brain could have massive positive effects in treating Alzheimer’s. J147 has also been used to target the buildup of the protein beta-amyloid. High accumulation of this protein in Alzheimer patients has been reported in previous research.
There is also evidence linking this acclamation to degenerative brain disorders including Alzheimer’s, Parkinson’s disease and others. J147 Nootropic aims to remove the beta-amyloid plaque accumulation, which in turn may help reverse or prevent the progression of Alzheimer’s and other cognitive issues. What really makes J147 a very promising drug is the fact that it can treat all forms of degenerative brain disorders.
At the moment, you’d probably need different medications for different neurodegenerative brain disorders. In essence, you would have a prescription for Alzheimer’s, Parkinson’s, and others. But J147 could be a treatment for all these diseases. One single type of drug that may treat several neurodegenerative disorders could be a game-changer, and J147 looks like it may actually do it.
06 J147 Benefits and Uses
J147 has several potential benefits. The drug is currently being developed as a treatment for Alzheimer’s but it offers additional positive benefits as well.
Here they are:
May Reverse Degenerative Brain Disorders
J147 has shown a lot of promise in reversing the effects of neurodegenerative brain disorders like Alzheimer’s and others. In tests done on mouse models so far, the drug has shown very positive effects in dealing with these conditions.
J147 works by helping cells in the brain regenerate, making them younger and more functional than older cells. However, it is important to note that no human trials have been done on the effects of J147. Hopefully, that will happen soon but the drug is still available for sale as a powder in selected online vendors.
Improves Mitochondria Action and Longevity
J147 works by binding into the mitochondria, the cells that are responsible for generating energy in our bodies. The action of J147 helps to prevent oxidative stress in mitochondria cells, leading to better cell function and longevity.
J147 also helps to reduce toxic metabolites that may cause cell excitotoxicity, the process through which cells die by getting too over excited. This allows your cells to remain new and healthier for a longer time. In fact, some trails done on animal subjects showed that the administration of J147 on fruit flies prolonged their lifespan by 9.5 to 12.8%.
J147 has also shown a lot of promise among test mouse models in enhancing memory. The drug even helped to reverse severe cognitive deficits in older test subjects during research studies.
Researchers believe that these effects can be replicated in human subjects. There is also some evidence suggesting that J147 could be explored as a possible treatment for spatial memory.
Protects Neurons and Helps the Brain Grow
J147 also has neuroprotective properties that prevent oxidative action within cells. This helps to protect neurons from possible damage. J147 may also be a trigger for brain growth. J147 may also improve synaptic plasticity in the brain, leading to growth.
07 How to Use J147
Since J147 is still an experimental drug, there is no way of knowing the perfect dosage so far. There is also no way of knowing how to make J147. Besides, we have not seen any J147 clinical trials on humans.
However, the drug is an orally active supplement, meaning that it is supposed to be ingested through the mouth. In the J147 trial tests done on mice, the test subjects were treated with a J147 dosage of 10 mgs for a kilogram of body weight for a day. This is by no means a standard dose. It would be better to consult with your doctor before starting to use J147.
08 J147 and Curcumin
J147 is actually a modified version of curcumin, a molecule that is found in turmeric. Curcumin has been in the past linked with improved brain function. The molecules are responsible for enhancing the levels of BDNF, a brain-derived Nootropic factor that may be essential in reversing cognitive ailments.
09 The Latest Research on J147
One of the more recent research on J147 looks at the actions of the drug at a cellular level. A paper published in 2018 established that J147 works by binding into a protein in the mitochondria.
This action was reported to have regenerative abilities on brain cells. Some research has also been done on mouse models with regards to J147 and its potential to treat Alzheimer’s and other degenerative brain disorders. It was very promising.
10 J147 Powder Buy
Curcumin derivative J147 is available as a powder in selected online wisepowder supplier. However, it is important to take extra care just to get the right product. Nootropics powder suppliers that have been selling for a while should be top of your list.
Check out the reviews of other users as well. You want to buy from vendors that have plenty of positive reviews over the last 12 months or so. J147 price also varies from one seller to the next.
11 J147 (1146963-51-0) Reference
- “Experimental drug targeting Alzheimer’s disease shows anti-aging effects”(Press release). Salk Institute. 12 November 2015. Retrieved November 13, 2015.
- Joshua Goldberg et al. The mitochondrial ATP synthase is a shared drug target for aging and dementia. Aging Cell, 2018 DOI: 10.1111/acel.12715
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