02 RAD140 powder (1182367-47-0) video
03 RAD140 powder (1182367-47-0) Base Information
|Molecular Weight||393.831 g/mol|
|Appearance||White to Off-white powder|
|Half Life||16-20 hours|
|Solubility||Organic solvents such as ethanol,DMSO and Dimethyl Formamide(DMF)|
|Storage Condition||Store at room temperature, in a sealed airtight container, keep the air out, protected from heat, light and humidity.|
|Application||RAD140 is an investigational and non-steroidal selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.|
04 RAD140 (1182367-47-0) powder History
Testolone or RAD140 is an investigative drug that is being developed by Radius Health and is being researched for potential therapeutic applications.
It is a fairly recent addition to the world of SARMS, considering that the first animal studies were conducted in 2011. However, it is already being considered by many as one of the most promising new developments.
Like most other SARMS, RAD140 powder has a strong affinity for the androgen receptor and it stimulates an effect in the body that is very identical to anabolic steroids. However, it does not affect the prostate gland in men or cause androgenic symptoms in women.
Also, going by anecdotal evidence provided by users, it seems to have a much stronger effect (affinity) than other SARMS. The only other SARM that can rival it in terms of potency is said to be YK-11 and that stuff’s toxic.
So, if you are looking to wet your toes in SARMS with something that’s strong and extremely powerful, Testolone is one of your best bets.
05 RAD140 (1182367-47-0) Mechanism of action
SARMs work by binding to androgen receptors that are found in different areas of the body. Normally these receptors interact with androgens, which are a group of steroid hormones. Androgens like testosterone, dihydrotestosterone, and androstenedione are naturally produced by the body.
RAD-140 produces anabolic processes by targeting androgen receptors in your skeletal muscles. Skeletal muscles are the ones you can willingly control, such as your biceps, pectoral muscles, deltoid, and so on. Basically, these are the muscles you activate while working out, plus the leg ones.
RAD-140 does not aromatize, and it does not convert to DHT, just like any other SARM.
06 RAD140 (1182367-47-0) Application
Researchers have found that RAD-140 prevents the production of ESR1 protein, one of the compounds catalyzing breast cancer. It suppresses cancer growth by blocking the effect estrogen may have on surrounding tissue.
RAD-140 also protects brain nerves by blocking amyloid beta proteins. These proteins are responsible for the development of Alzheimer’s disease. It also increases learning and memory capacity by affecting brain cell growth.
Moreover, a type of cancer called cachexia is treated with RAD-140. This type of cancer is causing muscle loss, so the beneficial effects of RAD-140 are more than clear.
Furthermore, it also stimulates seminal vesicles, increasing sperm count.
Medical experts use RAD-140 in testosterone replacement therapy (TRT). This therapy is beneficial for treating hypogonadism and other signs of low Testosterone count, such as erectile dysfunction, low libido, and prostate problems.
Doctors use RAD-140 in low dosages which means that there is no risk of virilization — the biological process that develops male secondary characteristics. That means it is perfectly safe for women too.
Of course, you don’t need to have a medical problem in order to use RAD-140. This is, after all, the most popular SARM in the fitness community. The root of RAD-140’s popularity lies in the fact that it does not aromatize. That means the users will not experience gynecomastia after consuming the substance.
07 RAD140 (1182367-47-0) More Research
RAD140 is considered to be one of the best mass building SARMs out there. The great thing about SARMS is that they are very selective in its actions. It mean they cause specific growth and development in area’s of the muscle and bones without messing up biological systems like hormone production. So basically, Great results and MINIMAL side effects.
 Hamson, D. K.; Wainwright, S. R.; Taylor, J. R.; Jones, B. A.; Watson, N. V.; Galea, L. a. M. (September 2013). “Androgens Increase Survival of Adult-Born Neurons in the Dentate Gyrus by an Androgen Receptor-Dependent Mechanism in Male Rats”. Endocrinology. 154 (9): 3294–3304. doi:10.1210/en.2013-1129. ISSN 0013-7227. PMID 23782943.
 Chris Miller; Maysoun Shomali; C Richard Lyttle; Gary Hattersley (24 June 2012). A Selective Androgen Receptor Modulator (RAD140) Induces Inflammation in Rat Right Heart Ventricle: Evidence for an Androgen-Specific, Species-Specific Mechanism. Roles of Androgen & Glucocorticoid Receptors in Physiology & Disease (Translational). Meeting Abstracts. The Endocrine Society. pp. SUN–525-SUN-525. doi:10.1210/endo-meetings.2012.nrsh.9.sun-525.
 Miller, Chris P.; Shomali, Maysoun; Lyttle, C. Richard; O’Dea, Louis St. L.; Herendeen, Hillary; Gallacher, Kyla; Paquin, Dottie; Compton, Dennis R.; Sahoo, Bishwabhusan; Kerrigan, Sean A.; Burge, Matthew S.; Nickels, Michael; Green, Jennifer L.; Katzenellenbogen, John A.; Tchesnokov, Alexei; Hattersley, Gary (February 2011). “Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140”. ACS Medicinal Chemistry Letters. 2 (2): 124–129. doi:10.1021/ml1002508. PMC 4018048. PMID 24900290.