Tianeptine hemisulfate monohydrate (THM) powder (1224690-84-9)

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Name:Tianeptine hemisulfate monohydrate

CAS:1224690-84-9

Molecular Formula:C42H56Cl2N4O14S3

STORAGE:Store in a cool and dry place. Keep away from direct sunlight and heat.

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THM powder (1224690-84-9) video

 

 

THM powder (1224690-84-9) Base Information

Name Tianeptine hemisulfate monohydrate (THM) powder
CAS 1224690-84-9
Purity 98%
Chemical name Tianeptine hemisulfate monohydrate; 1224690-84-9; Heptanoic acid,
Synonyms Tianeptine hemisulfate monohydrate

1224690-84-9

7-((3-Chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanoic acid compound with sulfuric acid (2:1) dihydrate

Tianeptine sulfate;Tianeptine-d4

BCP30653

Molecular Formula C42H56Cl2N4O14S3
Molecular Weight 1008.01
Melting Point 1800℃
InChI Key KVVMXNNJBVTOSX-UHFFFAOYSA-N
Form Powder
Appearance white crystalline powder
Half Life Unknow
Solubility Freetly soluble In water and methanol and dichloromethane
Storage Condition Tianeptine hemisulfate monohydrate powder is stable for at least four years when stored unopened and desiccated at −20 °C.
Application Anti-ulcer and anti-emetic properties. Antidepressant
Testing Document Available

 

THM powder (1224690-84-9) General Description

Tianeptine sulfate is used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. Chemically it is a tricyclic antidepressant (TCA), but it has different pharmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity.

Tianeptine sulfate has antidepressant and anxiolytic (anti-anxiety) properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects, thus suggesting it is particularly suitable for use in the elderly and in those following alcohol withdrawal; such persons can be more sensitive to the adverse effects of psychotropic drugs. Recent results indicate possible anticonvulsant (anti-seizure) and analgesic (painkilling) activity of tianeptine via immediate or downstream modulation of adenosine A1 receptors (as the effects could be experimentally blocked by antagonists of this receptor).

 

THM powder (1224690-84-9) History

Tianeptine sulfate (Tianeptine Hemisulfate Monohydrate(THM))is classified as a selective serotonin reuptake enhancer (SSRE) used to treat depression. Tianeptine was developed in France in the 1960s and has been used throughout the last part of the 2000s. There are Tianeptine sulfate, Tianeptine sodium, and Tianeptine acid.

is classified as a selective serotonin reuptake enhancer (SSRE) used to treat depression. Tianeptine was developed in France in the 1960s and has been used throughout the last part of the 2000s. There are Tianeptine sulfate, Tianeptine sodium, and Tianeptine acid.

 

THM powder (1224690-84-9) Mechanism Of Action

Unlike many antidepressants, Tianeptine has few negative side effects; Tianeptine is showing promise as an alternative to traditional antidepressants and their addictive nature and long-list of side effects.While the majority of antidepressant users do not abuse or misuse the medication, they are prescribed, that does not speak to the rest of the public. Antidepressants are a very popular and dangerous recreational activity. For people who do not need them, the taking of such drugs can come with many negative side effects and potential addictive properties. Tianeptine may be a much safer alternative to many of the antidepressants on the market today. The listing of side effects that are associated with are minor and tolerable, they include drowsiness, dry-mouth, insomnia, dizziness, constipation, bouts of low blood pressure, and some patients describe unusually vivid dreams.

 

THM powder (1224690-84-9) Application

Tianeptine medication for the treatment of mental disorders, studies have shown that tianeptine not only a good antidepressant effect and adverse reactions was significantly less than conventional antidepressant tricyclic drugs, almost no adverse effect on the cardiovascular system, blood , liver and kidney functions were not hurt, nor do I have a calming effect. Tianeptine is not only effective for depression and depressive neurosis, chronic alcoholism and depression after alcohol is also effective. Long-term use can prevent relapse

 

THM powder (1224690-84-9) More research

Magnesium taurate has been studied in rats for delaying the onset and progression of cataract.

Tianeptine is also used to treat anxiety disorders, asthma and even irritable bowel syndrome.

the Science Behind it:

this is a deceptive question because Tianeptine sulfate is a relatively new compound that needs, and deserves, much more money invested in it for testing.

what we do know is that Tianeptine Sulfate is closely related to Tianeptine Sodium, and acts in a very similar way. this is mainly due to the similarities in chemical structure, as can be seen in the figure on the right.

for those of you familiar with Tianeptine Sodium, you may know it under the trade name & lsquo; Coaxil ‘through Europe and Asia or as & lsquo; Stablon ‘and & lsquo; Tatinol ‘through Latin America. it is currently approved for medical use in 20 countries.

curiously, though, scientists aren’t 100% positive about how Tianeptine actually & lsquo; it works. Initial theories were that it acted as a Selective Serotonin Re-absorption Enhancer (SSRE) however more recent studies have shown that long-term actually have no effect on extracellular administration can serotonin levels.

Newer point theories towards Tianeptine work as an anti-sedative through alteration of indirect glutamate receptor activity and the release of BDNF (brain derived neurotrophic factor) which could in turn affect neural plasticity.

there was also new research in July 2014 which found that Tianeptine is a direct agonist of the Mu and Delta Opioid Receptors. since selective Mu-Opioid receptors have been linked to euphoric effects, this has been recommended as a reason for Tianeptine’s function as an anti-sedative.

 

THM powder (1224690-84-9) Reference

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