PQQ disodium salt powder (122628-50-6)

PQQ disodium salt powder or Pyrroloquinoline quinone disodium salt powder, is a water-soluble quinone compound that has a strong anti-oxidant capacity. A previous study in rats fed a PQQ-depleted diet showed that elevated levels of serum triglyceride (TG) decreased after PQQ supplementation.

Manufacture:  Batch Production
Package:  1KG/bag, 25KG/drum
Wisepowder has the capability to produce and supply large quantity. All production under cGMP condition and strict quality control system, all testing documents and sample available.

PQQ disodium salt powder (122628-50-6) video


PQQ disodium salt powder Base Information

Name PQQ disodium salt powder
CAS 122628-50-6
Purity 98%
Chemical name Disodium 4,5-dihydro-4,5-dioxo-1H-pyrrolo(2,3-f)quinoline-2,7,9-tricarboxylate
Synonyms Methoxatin Disodium

Methoxatin disodium salt

Methoxatin (disodium salt)

Pyrroloquinoline quinone disodium salt

Molecular Formula C14H4N2Na2O8
Molecular Weight 374.17 g/mol
Melting Point /
Form Powder
Appearance Reddish orange to Reddish Brown Fine Powder
Half Life /
Storage Condition Store at room temperature, in a sealed airtight container, keep the air out, protected from heat, light and humidity.
Application PQQ pyrroloquinoline quinone disodium salt powder is widely used for dietary supplement and nutraceuticals.
Testing Document Available


PQQ disodium salt General Description

pyrroloquinoline quinone disodium salt is a bit of a mouthful, so most people prefer to use the abbreviation PQQ disodium salt or PQQ. It’s also called methoxatin. So what is PQQ disodium salt? PQQ disodium salt is the disodium form of PQQ, PQQ was thought to be a type of vitamin, but after further studies, researchers determined that while it has some vitamin-like qualities, it was only a related nutrient. can act as a cofactor, or enzyme booster, in the REDOX process(Reduction Oxidation). Because of its involvement in REDOX,  PQQ offers certain anti-oxidative effects. PQQ is most commonly found in kiwi, green peppers, and parsley, but many people choose to incorporate it in their diets through PQQ supplements.


PQQ disodium salt powder (122628-50-6) History

Many people have noticed that supplement companies are selling products called PQQ but have PQQ disodium salt listed in the ingredients, which is technically a different compound. So it is a thoughtful question to ask “Does the chemical form of PQQ make a difference?”It is a great question and applies to many other compounds commonly found in supplements as well.Pyrroloquinoline quinone disodium salt Vs pyrroloquinoline quinone, as usual, there is an important caveat, but the short answer is for the forms of PQQ currently used in supplements, there is probably little difference between the variability of nutritional availability (or relative potency if you will).


PQQ disodium salt Mechanism Of Action

Pyrroloquinoline quinone (PQQ) is a small quinone molecule, which has a redox effect, can reduce oxidant (antioxidant); it then is recovered into the active form by glutathione. It seems relatively stable because it can undergo thousands of cycles before depletion, and it is new because it is related to the protein structure of cells (some antioxidants, main carotenoids such as beta-carotene and astaxanthin, are located in specific areas of cells, where they play more antioxidant roles proportionally). Because of proximity, PQQ seems to play a role near proteins such as carotenoids on cell membranes.

These redox functions can alter protein functions and signal transduction pathways. Although there are many promising studies in vitro (outside living models), some promising results of PQQ supplementation are mainly related to altering some signal transduction pathways or their benefits to mitochondria. (Produce more and improve efficiency).

It’s a coenzyme in bacteria (so for bacteria, it’s like B-vitamins), but it doesn’t seem to extend to humans. Since this does not apply to humans, a 2003 article in Nature, a scientific journal, argues that the idea that PQ is a vitamin compound is outdated and at best considered as a “vitamin-like substance.”

Perhaps most notable is the effect of PQQ on mitochondria, which provide energy (ATP) and regulate cell metabolism. Researchers have extensively observed the impact of PPQ on mitochondria and found that PQQ can increase the number of mitochondria and even improve the efficiency of mitochondria. This is an important reason why PPQ is so useful. Enzymes containing PQQ are known as glucose dehydrogenase, a quinoa protein that is used as a glucose sensor.


PQQ disodium salt powder Application

PQQ naturally exists in most vegetable foods, fruits, and vegetables (trace), and relatively high levels of PQQ can be detected in fermented soybean products, such as kiwifruit, lychee, green beans, tofu, rapeseed, mustard, green tea (camellia), green pepper, spinach, etc. Pyrroloquinoline quinone disodium salt (pqq) complex, the best form of PQQ is powder form. The benefits of taking PQQ disodium salt powder may include:


Since mitochondria produce energy for the cell, and PQQ helps mitochondria work more efficiently, there is an overall increase of energy within your cells. The unused cellular energy is transferred to other parts of your body. If you struggle to have energy to make it through the day, or you experience fatigue or lethargy, this added boost of energy from PPQ will be important to you. One study found that participants who reported having problems with their energy, experienced a noticeable decrease in their fatigue after taking PQQ. If you’re looking for a boost to your energy, PQQ may help with that.


Participants in the study mentioned above also reported that they were able to sleep better after taking PQQ for 8 weeks. Prior to beginning the study, these patients had been experiencing sleeping problems. PQQ seems to reduce the amount of cortisol, or stress hormone, within patients and improve their sleep. While PQQ’s benefits to sleep haven’t been studied thoroughly, these initial results seems promising.


With a reduced amount of stress, researchers have begun to see improvements to memory. In this case, the combination of PQQ and CoQ10 may lead to memory enhancement and promoting cognitive health. CoQ10, like PQQ, is another nutrient that can offer support to the body’s mitochondria. Many patients often look at PQQ and CoQ10 as an either/or option, but taking one and ignoring the other may result in missing out on some big benefits.


In addition to the three main benefits listed above, PQQ provides other less, well-known benefits. PQQ may promote Nerve Growth Factor (NGF) synthesis, which can lead to more neuronal growth and survival. PQQ may also be able to improve fertility, though more studies are still needed to draw conclusive results. Further benefits from taking PQQ may be discovered as more research is conducted.


PQQ disodium salt powder More research

Maybe you will ask “Is PQQ dangers?”

If you are worried about PQQ side effects, the good news is the current data for PQQ’s safety is excellent — at least for limited or short-term use in humans and longer-term use in animals. Long-term (multiple-year) safety in humans still needs to be assessed.  However, based on pyrroloquinoline quinone direct to market sales, it may be concluded that hundreds of individuals now take PQQ.  Some of these users tend to be aggressive about supplementation, so the chance that an interaction with PQQ may be adverse seems highly unlikely based on the lack of any published reports.


PQQ disodium salt powder (122628-50-6) Reference

  • [1]Ameyama M, Matsushita K, Ohno Y, Shinagawa E, Adachi O (1981). “Existence of a novel prosthetic group, PQQ, in membrane-bound, electron transport chain-linked, primary dehydrogenases of oxidative bacteria”. FEBS Lett. 130 (2): 179–83. doi:10.1016/0014-5793(81)81114-3. PMID 6793395.
  • [2]Haft DH (2011). “Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners”. BMC Genomics. 12: 21. doi:10.1186/1471-2164-12-21. PMC 3023750. PMID 21223593.
  • [3]Ames, Bruce (15 October 2018). “Prolonging healthy aging: Longevity vitamins and proteins”.
  • [4]Ameyama M, Matsushita K, Shinagawa E, Hayashi M, Adachi O (1988). “Pyrroloquinoline quinone: excretion by methylotrophs and growth stimulation for microorganisms”. BioFactors. 1 (1): 51–3. PMID 2855583.


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