Coluracetam powder (135463-81-9)

$14.99
Free shipping for order over US$249 (USA and Asia)
Free shipping for order over US$349 (Europe)
5-10 hours(in business day) fast shipping
Clear
Only 13 left! 110 people are viewing this and 17 people have it in their cart.
No your quantity? Click here
Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. Keep out of reach of children.
Category: SKU: N/A

Name:Coluracetam

CAS:135463-81-9

Molecular Formula:C19H23N3O3

STORAGE:Store in a cool and dry place. Keep away from direct sunlight and heat.

How To Place Order?
[1]. Choose quantity you need, then add to cart

[2]. Proceed to check out

[3]. Fill in your detail information, the *is required, choose your payment method. There are different payment methods include:
-Direct Bank Transfer
-Coinpayments: Bitcoin,Ether,USDT
Then click “Place order”
Tips: the email address must correct, the tracking information will keep update through email notice

[4]. If choose “Coinpayment”, after click “Place order”, then will show as below to pay

[5]. If Choose “Direct Bank Transfer”, after click “Place order”, then will show as below, will appear the bank account details, after make bank transfer (please use your order number as the reference), send a bank slip to us

[6]. Payment confirmed
[7]. Parcel send out about 5-10 hours (in business day)
[8]. Tracking number provided
[9]. Parcel arrived
[10]. Re-order

Coluracetam powder (135463-81-9) video

 

Coluracetam powder Base Information

Name Coluracetam powder
CAS 135463-81-9
Purity 98%
Chemical name N-(2,3-dimethyl-5,6,7,8-tetrahydrofuro[2,3-b]quinolin-4-yl)-2-(2-oxopyrrolidin-1-yl)acetamide

MKC-231

bci-540

Synonyms Coluracetam; BCI-540; MKC-231; BCI 540; MKC 231; BCI540; MKC231.
Molecular Formula C19H23N3O3
Molecular Weight 341.411 g/mol
Melting Point
InChI Key PSPGQHXMUKWNDI-UHFFFAOYSA-N
Form Solid powder
Appearance white crystalline powder
Half Life
Solubility Soluble in DMSO
Storage Condition Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years)
Application Coluracetam (MKC-231) is a synthetic racetam drug purported to be a nootropic compound. It does not have a large body of evidence investigating it, but the mechanisms of action (as well as structute) appear to be very distinct from other racetam compounds like Piracetam or Aniracetam.
Testing Document Available

 

Coluracetam powder General Description

Coluracetam powder, with CAS 135463-81-9, is also known as BCI-540 and MKC-231. Coluracetam was invented in Japan and only first registered in 2005 by the Mitsubishi Tanabe Pharmaceutical Corporation, and then its patent has been transfer to BrainCells Inc.

Coluracetam powder is a brain supplement for cognitive enhancer, memory improvement as well as also treats Major Depressive Disorder(MDD) and also anxiety problems.

 

Coluracetam powder (135463-81-9) History

Coluracetam (INN) (code name BCI-540; formerly MKC-231) powder is a nootropic agent of the racetam family. It was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer’s disease. After the drug failed to reach endpoints in its clinical trials it was in-licensed by BrainCells Inc for investigations into major depressive disorder (MDD), which was preceded by being awarded a “Qualifying Therapeutic Discovery Program Grant” by the state of California.

Findings from phase IIa clinical trials have suggested that it would be a potential medication for comorbid MDD with generalized anxiety disorder (GAD). BrainCells Inc is currently[when?] out-licensing the drug for this purpose.[full citation needed] It may also have potential use in prevention and treatment of ischemic retinopathy and retinal and optic nerve injury.[medical citation needed]

Coluracetam has been shown to reverse the loss of choline acetyltransferase production in the medial septal nucleus of rats exposed to phencyclidine (PCP), and is considered a potential therapeutic drug for schizophrenia.

 

Coluracetam (135463-81-9) Mechanism Of Action

Coluracetam enhances high-affinity choline uptake (HACU), which is the rate-limiting step of acetylcholine (ACh) synthesis. Studies have shown coluracetam to improve learning impairment on a single oral dose given to rats which have been exposed to cholinergic neurotoxins. Subsequent studies have shown that it may induce long-lasting procognitive effects in cholinergic neurotoxin-treated rats by changing the choline transporter regulation system.

 

Benefits of Coluracetam (135463-81-9)

Coluracetam is a nootropic compound in the racetam family, with a unique enhancing effect on high affinity choline uptake.
Coluracetam can improve memory, learning, anxiety, depression, and eyesight. It has potential use in prevention and treatment of ischemic retinopathy and retinal and optic nerve injury. It also can improve learning impairment on a single oral dose given to rats which have been exposed to cholinergic neurotoxins.
It may induce long-lasting procognitive effects in cholinergic neurotoxin-treated rats by changing the choline transporter regulation system. Coluracetam is also shown to improve AMPA potentiation, which is a process that triggers cognitive function and alertness.

 

Coluracetam (135463-81-9) side effect

Additionally, standard racetam side effects also apply to users of Coluracetam. Some people struggle with a headache due to a lack of acetylcholine (remedied by alpha GPC or citicoline). Other people have Colurracetam side effects such as overstimulation or jitteriness, nausea, or irritability.

 

Coluracetam (135463-81-9) Reference

  • Takashina K, Bessho T, Mori R, Kawai K, Eguchi J, Saito K. MKC-231, a choline uptake enhancer: (3) Mode of action of MKC-231 in the enhancement of high-affinity choline uptake. J Neural Transm (Vienna). 2008 Jul;115(7):1037-46. doi: 10.1007/s00702-008-0049-0. PubMed PMID: 18461273.
  • Bessho T, Takashina K, Eguchi J, Komatsu T, Saito K. MKC-231, a choline-uptake enhancer: (1) long-lasting cognitive improvement after repeated administration in AF64A-treated rats. J Neural Transm (Vienna). 2008 Jul;115(7):1019-25. doi: 10.1007/s00702-008-0053-4. PubMed PMID: 18461272.
  • Takashina K, Bessho T, Mori R, Eguchi J, Saito K. MKC-231, a choline uptake enhancer: (2) Effect on synthesis and release of acetylcholine in AF64A-treated rats. J Neural Transm (Vienna). 2008 Jul;115(7):1027-35. doi: 10.1007/s00702-008-0048-1. PubMed PMID: 18446264.
  • Shirayama Y, Yamamoto A, Nishimura T, Katayama S, Kawahara R. Subsequent exposure to the choline uptake enhancer MKC-231 antagonizes phencyclidine-induced behavioral deficits and reduction in septal cholinergic neurons in rats. Eur Neuropsychopharmacol. 2007 Sep;17(9):616-26. PubMed PMID: 17467960.
  • Coluracetam Review: A Powerful New Nootropic Powder in 2020
  • 2020 L-theanine Nootropics: Everything You Need To Know About
  • 2020 The Best Nootropics Noopept Powder: Effects, Dosage
  • Buy the Best Nootropics Fasoracetam Powder in 2020

Reviews

There are no reviews yet.

Be the first to review “Coluracetam powder (135463-81-9)”

Your email address will not be published. Required fields are marked *

Login

Lost your password?

Cart

Your cart is currently empty.