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Flibanserin Hydrochloride powder (147359-76-0)
01 Overview
Flibanserin powder is a serotonergic antidepressant used to treat hypoactive sexual desire disorder. Flibanserin Hydrochloride has been associated with a low rate of minor serum aminotransferase elevations during treatment, but has not been linked to instances of clinically apparent acute liver injury.
02 Flibanserin Hydrochloride powder (147359-76-0) video
03 (147359-76-0) Base Information
Name | Flibanserin Hydrochloride powder |
CAS | 147359-76-0 |
Purity | 98% |
Chemical name | Flibanserin Hydrochloride |
Synonyms | BIMT 17 Hydrochloride; BIMT 17BS Hydrochloride; 1-(2-(4-(3-(Trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)-one Hydrochloride |
Molecular Formula | C20H21F3N4O.ClH |
Molecular Weight | 426.863 |
Melting Point | >225°C |
InChI Key | XGAGFLQFMFCIHZ-UHFFFAOYSA-N |
Form | Solid |
Appearance | White to Pale Yellow |
Half Life | ≈11 hours |
Solubility | DMSO (Slightly), Methanol (Slightly) |
Storage Condition | Room Temperature |
Application | Flibanserin Hydrochloride is a 5-HT1A agonist and 5-HT2A antagonist that is developed for the treatment of hypoactive sexual desire disorder in women (1,2). |
Testing Document | Available |
04 Flibanserin Hydrochloride General Description
Flibansetrin Hydrochloride powder has high affinity for serotonin receptors in the brain: it acts as an agonist on 5-HT1A and an antagonist on 5-HT2A. In vivo, flibanserin Hydrochloride binds equally to 5-HT1A and 5-HT2A receptors. However, under higher levels of brain 5-HT (i.e., under stress), flibanserin Hydrochloride may occupy 5-HT2A receptors in higher proportion than 5-HT(1A) receptors. It may also moderately antagonize D4 (dopamine) receptors and 5-HT2B and 5-HTB2C. Its action on neurotransmitter receptors may contribute to reduction in serotonin levels and increase in dopamine and norepinephrine levels, all of which may play part in reward processing. Flibanserin Hydrochloride is sold under the trade name Addyi and indicated for the treatment of premenopausal women with acquired, generalized hypoactive sexual desire disorder (HSDD) as characterized by low sexual desire that causes marked distress or interpersonal difficulty
05 Flibanserin Hydrochloride powder History
Flibanserin powder is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder drug by Sprout Pharmaceuticals.
06 Flibanserin Hydrochloride Mechanism Of Action
Flibansetrin has high affinity for serotonin receptors in the brain: it acts as an agonist on 5-HT1A and an antagonist on 5-HT2A. In vivo, flibanserin binds equally to 5-HT1A and 5-HT2A receptors. However, under higher levels of brain 5-HT (i.e., under stress), flibanserin may occupy 5-HT2A receptors in higher proportion than 5-HT(1A) receptors. It may also moderately antagonize D4 (dopamine) receptors and 5-HT2B and 5-HTB2C. Its action on neurotransmitter receptors may contribute to reduction in serotonin levels and increase in dopamine and norepinephrine levels, all of which may play part in reward processing.
07 Flibanserin Hydrochloride Application
For the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women.
08 Flibanserin Hydrochloride More research
Adverse events are more common among women taking flibanserin. The majority of adverse events were mild to moderate. The most commonly reported adverse events included dizziness, nausea, feeling tired, sleepiness, and trouble sleeping.
Drinking alcohol while on flibanserin may result in severely low blood pressure (low blood pressure that produced symptoms after 2 glasses of wine occurred in 17%).
09 Flibanserin Hydrochloride Document Download
COA
10 Flibanserin Hydrochloride Reference
- Gelez, H., et. al.: (2013) Psychopharmacology 230 :639-52.
- Katz, M., et. al.: (2013) J. Sex. Med. 10, 1807-15
- Flibanserin (Addyi): Is It Female Viagra?
- Product Catalog
Sections
- 01. Overview
- 02. Flibanserin Hydrochloride powder (147359-76-0) video
- 03. (147359-76-0) Base Information
- 04. Flibanserin Hydrochloride General Description
- 05. Flibanserin Hydrochloride powder History
- 06. Flibanserin Hydrochloride Mechanism Of Action
- 07. Flibanserin Hydrochloride Application
- 08. Flibanserin Hydrochloride More research
- 09. Flibanserin Hydrochloride Document Download
- 10. Flibanserin Hydrochloride Reference