pinoline powder (20315-68-8)

Pinoline powder is a methoxylated tryptoline (5-methoxytryptoline) long claimed to be produced in the pineal gland during the metabolism of melatonin, however its pineal occurrence remains controversial. Its IUPAC name is 6-methoxy-1,2,3,4-tetrahydro-β-carboline, usually abbreviated as 6-MeO-THBC, and its more common name is a combination of “pineal beta-carboline”. The biological activity of this molecule is of interest as a potential free radical scavenger, also known as an antioxidant, and as a monoamine oxidase A inhibitor.

Manufacture:  Batch Production
Package:  1KG/bag, 25KG/drum
Wisepowder has the capability to produce and supply large quantity. All production under cGMP condition and strict quality control system, all testing documents and sample available.

pinoline powder (20315-68-8) video


pinoline powder (20315-68-8) Base Information

Name pinoline powder
CAS 20315-68-8
Purity 98%
Chemical name 6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole
Synonyms 20315-68-8





Molecular Formula C12H14N2O
Molecular Weight 202.257 g/mol
Melting Point 216- 224 °C
Form Solid
Half Life
Storage Condition
Application Pinoline is a methoxylated tryptoline (5-methoxytryptoline) long claimed to be produced in the pineal gland during the metabolism of melatonin,
Testing Document Available


pinoline powder General Description

Pinoline (6-methoxy-tetrahydro-beta-carboline) powder can be formed in the mammalian body under physiological conditions from 5-hydroxytryptamine or as a tricyclic metabolite of melatonin. Both melatonin and pinoline inhibited lipid peroxidation and showed comparable activity in a total antioxidant status test.  These results support the importance of the indolic part of the molecule and the 5-methoxy group common to both compounds in terms of the ability of these molecules to quench the hydroxyl radicals.


pinoline (20315-68-8) More research

As pinoline has been shown to exert an antidepressant-like effect in behavioral experiments and has been reported to have a low toxicity, this compound should be further studied as a potential antidepressant with pronounced antioxidative effects. These results further support the importance of pineal gland in antioxidative protection.


pinoline (20315-68-8) Reference

  1. Schiller, Erich; Bartsch, H. (2003). Free Radicals and Inhalation Pathology: Respiratory System, Mononuclear Phagocyte System, Hypoxia and Reoxygenation, Pneumoconioses, and Other Granulomatoses, Cancer (Google Books, page view). Springer. p. 107. ISBN 978-3-540-00201-7. Retrieved 2009-02-14.
  2.  Airaksinen, M. M., Huang, J. T., Ho, B. T., Taylor, D., and Walker, K. (1978). “The Uptake of 6-Methoxy-1,2,3,4-Tetrahydro-β-carboline and its Effect on 5-Hydroxytryptamine Uptake and Release in Blood Platelets”. Acta Pharmacol Toxicol. 43 (5): 375–380. doi:10.1111/j.1600-0773.1978.tb02281.x.
  3. Bartels, S. P. (2006) U.S. Patent No. 20,060,292,202 Washington, DC: U.S.
  4. { Mario de la Fuente et al. 2015 “Neurogenic Potential Assessment and Pharmacological Characterization of 6-Methoxy-1,2,3,4-tetrahydro-β-carboline (Pinoline) and Melatonin–Pinoline Hybrids”}


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