Glucoraphanin, the bioprecursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, it has antioxidant activity, it induces phase-I xenobiotic metabolizing enzymes and increases free radical generation in rat liver. Glucoraphanin powder can ameliorates obesity and insulin resistance through adipose tissue browning and reduction of metabolic endotoxemia in mice. Glucoraphanin powder and Glucoerucin effectively act as antagonists for the aryl hydrocarbonreceptor, and this may contribute to their established chemoprevention potency. WISEPOWDER holds The Exclusive Patent Of Manufacturing 30% Pure Glucoraphanin Powder.
02 Glucoraphanin powder (21414-41-5) video
03 Glucoraphanin powder Base Information
|Synonyms||β-D-1-thio-Glucopyranose 1-[5-(Methylsulfinyl)valerohydroximate] NO-(Hydrogen Sulfate); 4-Methylsulfinylbutyl Gucosinolate; Glucorafanin; Sulforaphane Glucosinolate|
|Molecular Weight||437.50672 g/mol|
|Solubility||Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.|
|Storage Condition||Store it in the cool and dry place.Keep it from strong light and heat.|
|Application||Glucoraphanin powder is a natural glycoinsolate found in cruciferous vegetables. Glucophanin (Sulforaphane), is a bioactive component in brocolli and is digested by gut bacteria to produce chemopreventive agents.|
04 Glucoraphanin powder General Description
Glucoraphanin powder, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects.
Glucoraphanin powder reduces weight gain and increases energy expenditure in HFD-fed mice. Glucoraphanin can improves insulin sensitivity and glucose tolerance in HFD-fed mice. However, Glucoraphanin does not exert antiobesity and insulin-sensitizing effects in Nrf2−/− Mice. Glucoraphanin blocks HFD-induced reduction of Ucp1 protein levels in white adipose depots of wild-type mice but not in Nrf2−/− mice. Glucoraphanin powder alleviates HFD-induced hepatic steatosis and oxidative stress. Glucoraphanin suppresses HFD-induced proinflammatory activation of macrophages in liver and adipose tissue. Glucoraphanin also decreases circulating LPS and the relative abundance of proteobacteria in the gut microbiomes of HFD-fed mice. Mice with pellets including 0.1% Glucoraphanin (GF) significantly attenuates the decreased social avoidance time in stressed mice. In the 1% sucrose preference test (SPT), treatment with pellets including 0.1% GF significantly attenuates the decreased sucrose preference of stressed mice.
05 Glucoraphanin powder (21414-41-5) History
06 Glucoraphanin powder Mechanism Of Action
07 Glucoraphanin powder (21414-41-5) Application
08 Glucoraphanin powder (21414-41-5) More research
Glucoraphanin is converted to sulforaphane by the enzyme myrosinase. In plants, sulforaphane deters insect predators and acts as a selective antibiotic. In humans, sulforaphane has been studied for its potential affects in neurodegenerative and cardiovascular diseases.
Due to the potential health benefits, a variety of broccoli has been bred to contain two to three times more glucoraphanin than standard broccoli.
09 Glucoraphanin powder Document Download
10 Glucoraphanin powder (21414-41-5) Reference
. Nagata N, et al. Glucoraphanin Ameliorates Obesity and Insulin Resistance Through Adipose Tissue Browning and Reduction of Metabolic Endotoxemia in Mice. Diabetes. 2017 May;66(5):1222-1236.
. Yao W, et al. Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice. Sci Rep. 2016 Jul 29;6:30659.
. James, D.; Devaraj, S.; Bellur, P.; Lakkanna, S.; Vicini, J.; Boddupalli, S. (2012). “Novel concepts of broccoli sulforaphanes and disease: Induction of phase II antioxidant and detoxification enzymes by enhanced-glucoraphanin broccoli”. Nutrition Reviews. 70 (11): 654– doi:10.1111/j.1753-4887.2012.00532.x. PMID 23110644.
- 01. Overview
- 02. Glucoraphanin powder (21414-41-5) video
- 03. Glucoraphanin powder Base Information
- 04. Glucoraphanin powder General Description
- 05. Glucoraphanin powder (21414-41-5) History
- 06. Glucoraphanin powder Mechanism Of Action
- 07. Glucoraphanin powder (21414-41-5) Application
- 08. Glucoraphanin powder (21414-41-5) More research
- 09. Glucoraphanin powder Document Download
- 10. Glucoraphanin powder (21414-41-5) Reference