Conjugated linoleic acid (CLA) (2420-56-6)

CLA (Conjugated Linoleic Acid) is a naturally occurring free fatty acid which is found in small amounts mainly in dairy and meat products. It’s become one of the most widely researched fat loss ingredients in recent years due to its ability to favourable interfere with the enzyme called lipoprotein lipase which in turn restricts the fat cells from getting any bigger. This coupled with the research that shows it can increase the amount of stored fat the body is able to use as energy has meant CLA(Conjugated Linoleic Acid) has become one of the most widely used fat loss supplements in sports nutrition.

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Conjugated linoleic acid (CLA) video


Conjugated linoleic acid (CLA) Base Information

Name Conjugated linoleic acid
CAS 2420-56-6
Purity 95%
Chemical name Conjugated linoleic acid
Synonyms octadeca-10,12-dienoic acid
Molecular Formula C18H32O2
Molecular Weight 280.4455
Melting Point Not Available
Form liquid
Appearance liquid
Half Life Not Available
Solubility 0.00015 g/L
Storage Condition 2-8°C
Application A potential antioxidant
Testing Document Available


Conjugated linoleic acid General Description

Conjugated Linoleic Acid(CLA) are a family of fatty acids originating in animal products, including meat and dairy. Conjugated Linoleic Acid(CLA) contain omega-6 fatty acids. They are polyunsaturated fat, which the American Heart Association (AHA) say can have beneficial effects on the heart.

Conjugated Linoleic Acid(CLA) are also technically trans fats, which, in most cases, are unhealthful fats. However, Conjugated Linoleic Acid(CLA) powder is a natural form of trans fat and does not seem to have the same negative health effects as artificially produced, industrial trans fats. The AHA has linked artificial trans fats to a higher risk of heart disease.

While there is a large amount of evidence Trusted Source to show that industrial trans fats are harmful, the research on natural trans fats and their effects is limited and inconclusive.


Conjugated linoleic acid History

The biological activity of Conjugated Linoleic Acid(CLA) was noted by researchers in 1979 who found it to inhibit chemically induced cancer in mice and research on its biological activity has continued.

In 2008, the United States Food and Drug Administration categorized Conjugated Linoleic Acid(CLA) as generally recognized as safe (GRAS).


(2420-56-6) Mechanism Of Action

Conjugated Linoleic Acid(CLA) might help reduce body fat deposits and improve immune function.


Conjugated linoleic acid (CLA) Application

Many people use Conjugated Linoleic Acid(CLA) , believing that it can be used for reducing blood pressure and helping decrease body fat(which have special effects on bodybuilding).

Reduce High blood pressure: Taking conjugated linoleic acid powder along with the blood pressure drug ramipril seems to reduce blood pressure more than ramipril alone in people with uncontrolled high blood pressure.

Treat Obesity: Taking conjugated linoleic acid by mouth daily might help decrease body fat in adults. Also, conjugated linoleic acid might reduce feelings of hunger, but it’s not clear if this leads to reduced food intake. Conjugated linoleic acid does not seem to decrease body weight or body mass index (BMI) in most people. Also, taking conjugated linoleic acid does not seem to prevent weight gain in previously obese people who lost some weight. Adding conjugated linoleic acid to fatty foods does not seem to promote weight loss. However, adding conjugated linoleic acid to milk might help decrease body fat in obese adults. In children, taking 3 grams of conjugated linoleic acid daily seems to help reduce body fat.


(2420-56-6) More research

Most studies of Conjugated Linoleic Acid(CLA) have used a mixture of isomers wherein the isomers c9,t11-CLA (rumenic acid) and t10,c12-CLA were the most abundant. More recent studies using individual isomers indicate that the two isomers have very different health effects

Conjugated Linoleic Acid(CLA) is both a trans fatty acid and a cis fatty acid. The cis bond causes a lower melting point and ostensibly also the observed beneficial health effects. Unlike other trans fatty acids, it may have beneficial effects on human health. Conjugated Linoleic Acid(CLA) is conjugated, and in the United States, trans linkages in a conjugated system are not counted as trans fats for the purposes of nutritional regulations and labeling.[citation needed] Conjugated Linoleic Acid(CLA) and some trans isomers of oleic acid are produced by microorganisms in the rumens of ruminants. Non-ruminants, including humans, produce certain isomers of Conjugated Linoleic Acid(CLA) from trans isomers of oleic acid, such as vaccenic acid, which is converted to Conjugated Linoleic Acid(CLA) by delta-9-desaturase.


Conjugated linoleic acid Reference

  • 1 Shultz, T.D., Chew, B.P., Seaman, W.R., et al. Inhibitory effect of conjugated dienoic derivatives of linoleic acid and β-carotene on the in vitro growth of human cancer cells. Cancer Lett 63 125-133 (1992). 2 Houseknecht, K.L., Vanden Heuvel, J.P., Moya-Camarena, S.Y., et al. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun 244 678-682 (1998).
  • Banni S (June 2002). “Conjugated linoleic acid metabolism”. Current Opinion in Lipidology. 13 (3): 261–6. doi:10.1097/00041433-200206000-00005. PMID 12045395.
  • Talbott SM, Hughes K (2007). “Conjugated linoleic acid”. The Health Professional’s Guide to Dietary Supplements. Lippincott Williams & Wilkins. pp. 14–. ISBN 978-0-7817-4672-4.
  • Conjugated Linoleic Acid (CLA): Benefits, Dosage, Side Effects


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