Norharmane acts powder as a co-mutagen. Norharmane is a natural β-carboline first isolated from plants of the Zygophyllaceae family. It is a heterocyclic amine (HCA) that may also be found in fried meats, tobacco smoke, and coffee. Harman and norharmane are aminocarbolines known as “co-mutagens” because they do not show mutagenicity to Salmonella serovar typhimurium
|Name||beta carboline powder|
|Synonyms||Norharmane; β-Carboline; 2-Azacarbazole.|
|Molecular Weight||168.2 g/mol|
|Melting Point||200.0 to 203.0 deg-C|
|Solubility||Soluble in DMSO, not in water|
|Storage Condition||Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).|
|Application||The compund has cytotoxic effects.|
Norharmane powder is a β-Carboline alkaloid that is widespread in plants and animals, and frequently act as benzodiazepine inverse agonists. Norharmane showed a potent inhibition against α-glucosidase enzyme in a concentration dependent manner with an IC50 value of 0.27 mM for maltase and 0.41 mM for sucrase, respectively. A Lineweaver-Burk plot revealed that norharman inhibited α-glucosidase enzyme uncompetitively, with a Ki value of 0.13 mM.
Norharmane powder is an inhibitor of indoleamine 2,3-dioxygenase. Norharmane is a heterocylce that can be used as a matrix for analysis cyclodextrins. Has cytotoxic effects.also known as norharmane, is a nitrogen containing heterocycle. It is also the prototype of a class of compounds known as β-carbolines.
Norharmane is a natural β-carboline first isolated from plants of the Zygophyllaceae family. It is a heterocyclic amine that may also be found in fried meats, tobacco smoke, and coffee.1,2 While not mutagenic by itself, norharmane is described as a co-mutagen, as it induces or enhances the mutagenicity of other compounds, commonly forming DNA adducts.
A natural β-carboline that may be found in fried meats, cigarette smoke, and coffee; described as a co-mutagen, as it induces or enhances the mutagenicity of other compounds
Norharmane is a natural β-carboline first isolated from plants of the Zygophyllaceae family. It is a heterocyclic amine that may also be found in fried meats, tobacco smoke, and coffee. While not mutagenic by itself, norharmane is described as a co-mutagen, as it induces or enhances the mutagenicity of other compounds, commonly forming DNA adducts.
Beta-carboline is the parent compound of the beta-carbolines, a tricyclic structure comprising an indole ring system ortho- fused to C-3 and C-4 of a pyridine ring. It has a role as a marine metabolite and a fungal metabolite. It is a member of beta-carbolines and a mancude organic heterotricyclic parent.
Harman and norharmane with concentrations of 0.275 uM and 0.9 uM respectively might inhibited MAO-A and MAO-B. In adult male rats, a novel cocktail of cigarette smoke constituents, containing five minor alkaloids (nornicotine, cotinine, myosmine, anatabine, and anabasine), two β-carbolines (harman and norharmane), and acetaldehyde, did not significantly enhance nicotine self-administration.
Norharmane matrix enhances detection of endotoxin，by MALDI-MS for simultaneous profiling of pathogen,for host–pathogen interaction studies by mass spectrometry imaging; we emphasize the
improved detection of pathogen-specific lipids (endotoxin) achievable only with norharmane (NRM), an underutilized matrix substance facilitating，The discovery of novel pathogenic mechanisms engaged during bacterial infections requires the evolution of advanced
techniques. Here, we evaluate the dual polarity matrix norharmane (NRM) to improve detection of bacterial lipid A
(endotoxin), from host and vector tissues infected with Francisella novicida (Fn).
1: Wojtowicz E, Zawirska-Wojtasiak R, Przygoński K, Mildner-Szkudlarz S. Bioactive β-carbolines norharman and harman in traditional and novel raw materials for chicory coffee. Food Chem. 2015 May 15;175:280-3. doi: 10.1016/j.foodchem.2014.11.143. Epub 2014 Nov 29. PubMed PMID: 25577081.
2: Wabaidur SM, Lee SH, Alothman ZA, Siddiqui MR, Alam SM. Second derivative synchronous fluorimetric method for simultaneous determination of harman and norharman in coffee samples. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Jun;110:179-84. doi: 10.1016/j.saa.2013.03.045. Epub 2013 Mar 16. PubMed PMID: 23563636.
3: Esmaeili MH, Movahedi M, Faraji A, Haghdoost-Yazdi H. Intracerebral injection of low amounts of norharman induces moderate Parkinsonism-like behavioral symptoms in rat. Neurotoxicol Teratol. 2012 Sep-Oct;34(5):489-94. doi: 10.1016/j.ntt.2012.07.001. Epub 2012 Jul 9. PubMed PMID: 22789434.
4: Tan C, Wu S, Lai S, Wang M, Chen Y, Zhou L, Zhu Y, Lian W, Peng W, Ji L, Xu A. Synthesis, structures, cellular uptake and apoptosis-inducing properties of highly cytotoxic ruthenium-Norharman complexes. Dalton Trans. 2011 Sep 14;40(34):8611-21. doi: 10.1039/c1dt10084j. Epub 2011 Jul 29. PubMed PMID: 21804968.
5: Thatcher RJ, Douthwaite RE. β-Carboline (norharman). Acta Crystallogr C. 2011 Jul;67(Pt 7):o241-3. doi: 10.1107/S0108270111021706. Epub 2011 Jun 23. PubMed PMID: 21727633.
6: Haghdoost-Yazdi H, Hosseini SS, Faraji A, Nahid D, Jahanihashemi H. Long term exposure to norharman exacerbates 6-hydroxydopamine-induced parkinsonism: possible involvement of L-type Ca2+ channels. Behav Brain Res. 2010 Dec 20;215(1):136-40. doi: 10.1016/j.bbr.2010.07.011. Epub 2010 Jul 16. PubMed PMID: 20638417.