02 (2521-07-5) video
03 (2521-07-5) Base Information
|Molecular Weight||182.226 g/mol|
|Melting Point||105.0 – 109.0 °C|
|Application||9-Methyl-9H-pyrido[3,4-b]indole (cas# 2521-07-5) is a useful research chemical.|
04 (2521-07-5) General Description
In vitro studies with dopaminergic neuron cell cultures demonstrated increased expression of tyrosine hydroxylase and associated transcription factors, increased neurite outgrowth, regeneration of neurons after chronic rotenone administration, and reduced expression of inflammatory cytokines. In studies of primary mesencephalic dopaminergic neuron cell cultures, the substance increased the number of differentiated dopaminergic neurons and produced higher levels of transcription factors associated with dopaminergic differentiation. 9-Me-BC also inhibited the oxidation of the neurotoxin precursor MPTP to the dopaminergic neurotoxin MPP+ in vitro.
Rodent studies in vivo demonstrated elevated hippocampal dopamine levels, improved spatial learning performance in a radial maze test, and increased dendrite outgrowth in the dentate gyrus of the hippocampus, as well as restoration of the number of tyrosine hydroxylase expressing neurons in the left striatum after an injection of MPP+ had reduced the number of such cells by 50% in an animal model of Parkinsonism.
05 (2521-07-5) History
06 (2521-07-5) Mechanism Of Action
β-Carbolines (BCs) belong to the heterogenous family of carbolines, which have been found exogenously, that is, in various fruits, meats, tobacco smoke, alcohol and coffee, but also endogenously, that is, blood, brain and CSF. These exogenous and endogenous BCs and some of their metabolites can exert neurotoxic effects, however, an unexpected stimulatory effect of 9-methyl-β-carboline (9-me-BC) on dopaminergic neurons in primary mesencephalic cultures was recently discovered. The aim of the present study was to extend our knowledge on the stimulatory effects of 9-me-BC and to test the hypothesis that 9-me-BC may act as a cognitive enhancer. We found that 10 days (but not 5 days) of pharmacological treatment with 9-me-BC (i) improves spatial learning in the radial maze, (ii) elevates dopamine levels in the hippocampal formation, and (iii) results after 10 days of treatment in elongated, more complex dendritic trees and higher spine numbers on granule neurons in the dentate gyrus of 9-me-BC-treated rats. Our results demonstrate that beyond its neuroprotective/neurorestorative and anti-inflammatory effects, 9-me-BC acts as a cognitive enhancer in a hippocampus-dependent task, and that the behavioral effects may be associated with a stimulatory impact on hippocampal dopamine levels and dendritic and synaptic proliferation.
07 (2521-07-5) Application
9-Methyl-9H-beta-carboline (9-Me-BC) amethrocyclic amine of the beta-carboline family, and the research methods. It derived the origin of β-carboline methylated with C12H10N molecules. It may be one was organized by the Eschweiler-Clarke’s repair of β-carboline deficiency (norharmane).
9-Methyl-9H-beta-carboline is a novel, dopaminergic, well-developed. It is designed to improve the (dopamine, focusing on life, concentrations, predictions and awakening) by leading to the development of the dopaminergic solution of hippocampal. In hippocampus, it is a memory memory and storage memory location. In addition, 9-Methyl-9H-beta-carboline also has some bacterial infections. 9-Methyl-9B-Carboline is a major development. It works primarily by upgrading, contrasting and strongly influencing dendrities and synapses whenever optimizing doping calls.
08 (2521-07-5) More research
9-Me-BC is a known inhibitor of monoamine oxidase A and monoamine oxidase B, and has been proposed for further investigation in the treatment of Parkinson’s disease.
It may also possess photosensitizing effects.
09 (2521-07-5) Document Download
10 (2521-07-5) Reference
- Polanski, W; Enzensperger, C; Reichmann, H; Gille, G (2010). “The exceptional properties of 9-methyl-beta-carboline: stimulation, protection and regeneration of dopaminergic neurons coupled with anti-inflammatory effects”. J Neurochem. 113 (6): 1659– doi:10.1111/j.1471-4159.2010.06725.x. PMID 20374418.
- Hamann, J; Wernicke, C; Lehmann, J; Reichmann, H; Rommelspacher, H; Gille, G (2008). “9-Methyl-beta-carboline up-regulates the appearance of differentiated dopaminergic neurones in primary mesencephalic culture”. Neurochem. Int. 52 (4–5): 688– doi:10.1016/j.neuint.2007.08.018. PMID 17913302.
- Herraiz, T; Guillén, H (2011). “Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors”. Food Chem. Toxicol. 49 (8): 1773– doi:10.1016/j.fct.2011.04.026. hdl:10261/63126. PMID 21554916.