Methylselenocysteine powder 26046-90-2

Methylselenocysteine powder Chemical Base Information

Methylselenocysteine powder 26046-90-2 General Description

Selenium is an essential trace mineral. Antioxidant enzymes often contain selenium and protect cells against oxidative damage. Se-methylseleno-L-cysteine (commonly known as methylselenocysteine) is found naturally in vegetables such as garlic and broccoli and used for a nutrient supplement. Studies in animal models have shown that Se-methylseleno-L-cysteine (Methylselenocysteine) is effective for chemoprevention of cancer. Its mechanism of action is reported to be through inhibiting reactive oxygen species.

Methylselenocysteine Mechanism Of Action, Methylselenocysteine Benefits

Powder Methylselenocysteine is a selenoamino acid found naturally in vegetables such as garlic and broccoli. It is a bioavailable and safe form of the essential trace mineral nutrient, selenium. Selenium in the form of Selenocysteine is an essential component of antioxidant enzymes such as glutathione peroxidase and is also found in several proteins in the body.

Antioxidant enzymes containing selenium, protect cells against oxidative damage. Studies in animal models have shown that the benefits of Methylselenocysteine is effective in cancer chemoprevention. The mechanism of action of methylselenocysteine in these models, is believed to be through the generation of monomethylated selenium species by endogenous enzymes. These in turn generate superoxide and induce apoptosis (programmed cell death) by the inhibition of proliferation of cancer cell. Methylselenocysteine is not incorporated into body proteins, making it completely bioavailable for chemoprevention, and the synthesis of selenium-containing enzymes such as glutathione peroxidase.

Selenium is an essential micronutrient for the well being of humans. Inadequate selenium intake results in deficiency leading to a variety of disease conditions. Selenium is present naturally in several plant and animal foods. Brazil nuts, walnuts, grains, meat and seafood are good sources of selenium. Dietary exposure from these sources varies with geographical location, depending upon the selenium content in the soil. Situations where adequate amounts of selenium cannot be obtained from natural resources warrant the use of selenium supplements.

Research reveals that a monomethylated selenium metabolite is needed for the chemopreventive benefits of selenium compounds. A recent study hypothesizes that gamma-glutamylmethylselenocysteine found in high selenium garlic, serves primarily as a carrier of Methylselenocysteine, which has been demonstrated to be a potent cancer chemopreventive agent in animal carcinogenesis bioassays.

Methylselenocysteine is therefore potentially useful in preventive health maintenance. The immunological role of selenium is well documented. Additionally, adequate selenium nutrition offers a line of defense against viral infections and chronic diseases as well. Methylselenocysteine in light of its bioavailability and natural occurrence in food sources, is an efficacious selenium supplement.

Methylselenocysteine Supplements Dosage

Methylselenocysteine is a more active form of selenium which functions primarily as a component of the antioxidant enzyme, glutathione peroxidase. Glutathione peroxidase activity, which requires selenium for activity, facilitates the recycling of vitamins C and E, in optimizing the performance of the antioxidant system. Low levels of selenium have been linked to a higher risk for cancer, cardiovascular disease, inflammatory diseases, and other conditions associated with free radical damage, including aging and cataract formation. Selenium is also essential for healthy cell-mediated immune function, stimulating immune properties of lymphocytes. Selenium is also needed for the activation of thyroid hormones.

Chronic low selenium intake is associated with an increased risk for heart disease, cancer and depressed immune function. Selenium appears to provide protection against heart disease and stroke. Selenium supplementation (100 ugm/day) increases the ratio of HDL to LDL and inhibits platelet aggregation.  Selenium and glutathione peroxidase activity are low in patients with rheumatoid arthritis, eczema, psoriasis and most inflammatory conditions. This is related to the increased synthesis of proinflammatory prostaglandins and leukotrienes. Immune system function is enhanced by selenium, by contributing to higher natural killer cell (NKC) activity. Natural killer cells have the ability to destroy cancer cells and bacterial and viral agents. Heavy metal toxicity symptoms may be alleviated by selenium, acting as an antagonist. Selenium deficiency may also contribute to male infertility.

Selenium is safe at the level generally used for supplementation (100-200 mcg/day). However, taking more than 750 mcg of selenium per day may cause toxicity Reactions such as loss of fingernails, skin rash, and neurological aberrations. In the presence of iodine deficiency goiter, selenium supplementation has been reported to exacerbate low thyroid function. Selenium is available in several different forms. Studies indicate that inorganic salts like sodium selenite are less effectively absorbed and not as biologically active as organic forms of selenium, such as selenomethionine or high-selenium content yeast.

Methylselenocysteine powder 26046-90-2 Application

Nutrient supplement,dietary supplements

What Foods Are Rich In selenium?

Righest sources of dietary selenium are found in:

Wheat Germ

Bran

Brazil Nuts

Red Swiss Chard

Whole Wheat Bread

Oats

Brown Rice

Turnips

Se-Methylselenocysteine(Methylselenocysteine) Clinical Trial

Methylselenocysteine powder 26046-90-2 Reference

1. Speciation of selenoamino acids and organoselenium compounds in selenium-enriched yeast using high-performance liquid chromatography-inductively coupled plasma mass spectrometry
2. M. Bird, P. C. Uden, J. F. Tyson, E. Block, E. Denoyer, J. Anal. At. Spectrom. 1997, 12, 785.
3. In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical forcancer chemoprevention
4. Ip, H. J. Thompson, Z. Zhu, H. E. Ganther, Cancer Res. 2000, 60, 2882.
5. Ellis DR, Sors TG, Brunk DG, Albrecht C, Orser C, Lahner B, Wood KV, Harris HH, Pickering IJ, Salt DE (2004) Production of Se-methylselenocysteine in transgenic plants expressing selenocysteine methyltransferase. BMC Plant Biol 4:1–11
6. Kristal AR, Darke AK, Morris JS, Tangen CM, Goodman PJ, Thompson IM, Meyskens FL Jr, Goodman GE, Minasian LM, Parnes HL, Lippman SM, Klein EA (2014) Baseline selenium status and effects of selenium and vitamin e supplementation on prostate cancer risk. J Natl Cancer Inst 106(3):djt456