02 Cyclofenil powder (2624-43-3) video
03 Cyclofenil powder (2624-43-3) Base Information
|Chemical name||4,4′-(Cyclohexylidenemethylene)diphenol diacetate ester|
|Synonyms||Cyclofenil; H 3452; F 6066; AI3-52271|
|Molecular Weight||364.441 g/moll|
|Half Life||>48 hours|
|Solubility||Soluble in DMSO|
|Storage Condition||Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).|
|Application||Cyclofenil is a weak nonsteroidal estrogen with ovulation induction properties.|
04 Cyclofenil powder General Description
Cyclofenil powder is a gonadal stimulant and inducer of ovulation. It is used in the treatment of infertility and amenorrhea, but is thought to be less effective than CLOMIPHENE.
05 Cyclofenil powder (2624-43-3) History
Cyclofenil powder (INN, USAN, BAN) (brand names Fertodur, Menopax, Ondonid, Ondogyne, Sexovid, others) is a selective estrogen receptor modulator (SERM) used as a gonadotropin stimulant which is or has been marketed in Europe, South Korea, Mexico, and Brazil, among other countries.
Cyclofenil was first introduced in 1970 under the brand name Ondogyne in France. Subsequently, it was introduced under the brand names Sexovid in Japan in 1972, Ondonvid in the United Kingdom in 1972, and Fertodur in West Germany in 1972 and Italy in 1974. It was also marketed as Sexovid in Sweden, Neoclym in Italy, and Klofenil in Turkey.
Cyclofenil was studied in the 1970s as an agent to induce ovulation in infertile women. It was then investigated as a possible treatment for scleroderma in the 1980s, but was found to be ineffective. Later study of its efficacy in treating Raynaud’s phenomenon in people with scleroderma also found no statistically significant benefit.
06 Cyclofenil powder (2624-43-3) Mechanism Of Action
Cyclofenil powder is a nonsteroidal antiestrogen that is used in the treatment of menstrual disturbances and anovulatory infertility due to hypothalamic-pituitary insufficiency
07 Cyclofenil (2624-43-3) Application
Cyclofenil is an analytical reference standard categorized as an anti-estrogen. 1,2 Anti-estrogens, including cyclofenil, have been used as performance-enhancing drugs in sports doping. This product is intended for research and forensic applications
08 Cyclofenil (2624-43-3) More research
Cyclofenil is a anti-estrogen drug developed for the treatment of female infertility and for induction of ovulation. Cyclofenil exerts its action by binding to estrogen receptor beta and demonstrates agonism or antagonism depending on tissues type.
09 Cyclofenil (2624-43-3) Document Download
10 Cyclofenil (2624-43-3) Reference
1: Thompson LA, Barratt CL, Thornton SJ, Bolton AE, Cooke ID. The effects of clomiphene citrate and cyclofenil on cervical mucus volume and receptivity over the periovulatory period. Fertil Steril. 1993 Jan;59(1):125-9. PubMed PMID: 8419199.
2: Clarke B, Sykakis E, Parmar DN. Cyclofenil as a possible cause of non-arteritic anterior ischaemic optic neuropathy. BMJ Case Rep. 2012 Dec 20;2012. pii: bcr2012007825. doi: 10.1136/bcr-2012-007825. PubMed PMID: 23264159; PubMed Central PMCID: PMC4544974.
3: Bhathena RK, Patel RH, Varma TR. The effects of Cyclofenil on the Cervical Mucus Score (Insler). Int J Gynaecol Obstet. 1986 Feb;24(1):17-9. PubMed PMID: 2874064.
4: Gärtner P, Hofbauer K, Reichel C, Geisendorfer T, Gmeiner G. Synthesis and identification of hydroxylated metabolites of the anti-estrogenic agent cyclofenil. J Mass Spectrom. 2008 Jul;43(7):958-64. doi: 10.1002/jms.1462. PubMed PMID: 18576435.
- 01. Overview
- 02. Cyclofenil powder (2624-43-3) video
- 03. Cyclofenil powder (2624-43-3) Base Information
- 04. Cyclofenil powder General Description
- 05. Cyclofenil powder (2624-43-3) History
- 06. Cyclofenil powder (2624-43-3) Mechanism Of Action
- 07. Cyclofenil (2624-43-3) Application
- 08. Cyclofenil (2624-43-3) More research
- 09. Cyclofenil (2624-43-3) Document Download
- 10. Cyclofenil (2624-43-3) Reference