Indapamide powder is a thiazide-like diuretic generally used in the treatment of hypertension, as well as decompensated heart failure. Combination preparations with perindopril (an ACE inhibitor antihypertensive) are also available. benzamide-sulfonamide-indole. It is called a thiazide-like diuretic but structure is different enough (lacking the thiazo-ring) , indapamide has a longer duration of action and controls blood pressure better than most other diuretics. Second, indapamide has been shown to work better than other types of high blood pressure drugs at preventing heart failure. Finally, a large clinical study showed that the combination of indapamide and another blood pressure medicine (perindopril) reduced the risk of heart attack, stroke, and death in people with type 2 diabetes.
02 Indapamide powder (26807-65-8) video
03 Indapamide powder Base Information
|Synonyms||Indapamide, Noranat, Fludex, Natrilix, Tertensif|
|Molecular Weight||365.8345 g/mol|
|Appearance||White to light yellow crystalline powder.|
|Half Life||14 hours|
|Solubility||Soluble in DMSO, not in water|
|Storage Condition||Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).|
|Application||Indapamide is a thiazide-like diuretic generally used in the treatment of hypertension|
04 Indapamide powderGeneral Description
Indapamide powder belongs to a class of drugs called diuretics (water pills). A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.
Indapamide makes your body get rid of extra water and salt through your urine. This results in less swelling and lowered blood pressure.
05 Indapamide powder (26807-65-8) History
Indapamide is a diuretic (also called a “water pill”) approved by the FDA in 1983. Indapamide acts on the kidneys to boost the elimination of sodium, potassium, and water in the urine. This results in increased urination, which lowers blood pressure by reducing the fluid in blood vessels and body tissues. Indapamide also opens up blood vessels, further reducing the blood pressure and easing stress on the heart.
06 Indapamide (26807-65-8) Mechanism Of Action
Indapamide is a diuretic (water pill) that is used primarily for the treatment of high blood pressure. It works by preventing the kidney from reabsorbing (retaining in the body) salt and water that is destined to be eliminated in the urine. This results in increased urine output (diuresis). Indapamide also is thought to reduce the salt in the smooth muscle of the walls of blood vessels. (The salt ultimately is eliminated in the urine.) The loss of salt from the muscle causes the muscle to relax, and the relaxation of the vessels results in reduced blood pressure.
07 Indapamide (26807-65-8) Application
Diuretics play a pivotal role in the management of hypertension. A large experience has been accumulated with indapamide , a long-acting thiazide-like diuretic that lowers blood pressure (BP) primarily through its natriuretic diuretic effect. Some of its long-term antihypertensive efficacy may be due to calcium antagonist-like vasorelaxant activities. Indapamide has protecting effects in a variety of conditions associated with high cardiovascular risk, such as diabetes, left ventricular hypertrophy, nephropathy and stroke. It is highly effective in lowering BP, whether given alone or in combination. Indapamide is well tolerated and has the advantage of having no adverse impact on glucose and lipid metabolism. Today, thiazide-like diuretics are regarded more and more as preferred drugs, when diuretic therapy is required to lower BP.
08 Indapamide (26807-65-8) More research
Indapamide oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.
Also indapamide is specifically contraindicated in patients with sulfonamide hypersensitivity. Although thiazide-type diuretics such as indapamide are sulfonamide derivatives, sulfonamide cross-sensitivity has been rarely documented. Until further data are available, indapamide should be used with caution in patients with sulfonamide hypersensitivity. Indapamide does not contain the N4-aromatic amine or the N1-substituent which are present in sulfonamide antibiotics.
09 Indapamide (26807-65-8) Document Download
10 Indapamide (26807-65-8) Reference
- 1: Roush GC, Ernst ME, Kostis JB, Tandon S, Sica DA. Head-to-head comparisons of hydrochlorothiazide with indapamide and chlorthalidone: antihypertensive and metabolic effects. Hypertension. 2015 May;65(5):1041-6. doi: 10.1161/HYPERTENSIONAHA.114.05021. Epub 2015 Mar 2. Review. PubMed PMID: 25733245.
- 2: DiNicolantonio JJ, Bhutani J, Lavie CJ, O’Keefe JH. Evidence-based diuretics: focus on chlorthalidone and indapamide. Future Cardiol. 2015 Mar;11(2):203-17. doi: 10.2217/fca.14.83. Review. PubMed PMID: 25760879.
- 3: Waeber B, Rotaru C, Feihl F. Position of indapamide, a diuretic with vasorelaxant activities, in antihypertensive therapy. Expert Opin Pharmacother. 2012 Jul;13(10):1515-26. doi: 10.1517/14656566.2012.698611. Review. PubMed PMID: 22725706.
- 4: de Leeuw PW. Combination perindopril/indapamide for the treatment of hypertension: a review. Expert Opin Pharmacother. 2011 Aug;12(11):1827-33. doi: 10.1517/14656566.2011.585638. Epub 2011 Jun 9. Review. PubMed PMID: 21651456.
- 01. Overview
- 02. Indapamide powder (26807-65-8) video
- 03. Indapamide powder Base Information
- 04. Indapamide powderGeneral Description
- 05. Indapamide powder (26807-65-8) History
- 06. Indapamide (26807-65-8) Mechanism Of Action
- 07. Indapamide (26807-65-8) Application
- 08. Indapamide (26807-65-8) More research
- 09. Indapamide (26807-65-8) Document Download
- 10. Indapamide (26807-65-8) Reference