6-Paradol powder (27113-22-0)

Paradol, also known as 6-Paradol, is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta or grains of paradise). It is also found in ginger. Paradol has been found to have antioxidant and antitumor promoting effects in a mouse model. It is used in flavors as an essential oil to give spiciness.

Manufacture:  Batch Production
Package:  1KG/bag, 25KG/drum
Wisepowder has the capability to produce and supply large quantity. All production under cGMP condition and strict quality control system, all testing documents and sample available.

6-Paradol powder (27113-22-0) video



6-Paradol powder Base Information

Name 6-Paradol powder
CAS 27113-22-0
Purity 50%
Chemical name 6-Paradol;Paradol; 1-(4-Hydroxy-3-methoxyphenyl)decan-3-one;


Synonyms 6-Paradol; Paradol
Molecular Formula C17H26O3
Molecular Weight 278.392
Melting Point 31 – 32 °C
Form Solid powder
Appearance white powder
Half Life
Solubility Soluble in DMSO
Storage Condition Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Application Used in medicine, health products, food, beverage, cosmetics, biological and chemical reagents and other industries.
Testing Document Available


6-Paradol powder General Description

The 6-Paradol, with the CAS registry number 27113-22-0, is also known as 3-Decanone, 1-(4-hydroxy-3-methoxyphenyl)-. Its EINECS registry number is 248-228-1. This chemical’s molecular formula is C17H26O3 and molecular weight is 278.38654. What’s more, its IUPAC name is 1-(4-Hydroxy-3-methoxyphenyl)decan-3-one. This chemical’s classification code is Drug / Therapeutic Agent.In addition, 6-Paradol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta). And the seed is also known as Grains of paradise. Besides, this chemical has been found to have antioxidative and antitumor promoting effects. And it is used in flavors as an essential oil to give spiciness.Paradol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta). Theseed is also known as Grains of paradise. Paradol has been found to have antioxidative andantitumor promoting effects


6-Paradol powder (27113-22-0) Application

Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site.

Paradol induces apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. Paradol induces apoptosis through a caspase-3-dependent mechanism.


6-Paradol powder More research

Magnesium taurate has been studied in rats for delaying the onset and progression of cataract.

Function of 6-Paradol

  1. Weight loss

In a related clinical trial, researchers of the Japanese Society of Nutrition have found that aframomum melegueta has the ability to lower body fat percentage, and decreased waisthip ratio without any harmful side effects. Recently, further studies onaframomum melegueta have reported its 6 paradol chemical constituent to be biologically significant beyond its medicinal value.

  1. Bodybuilding benefits

Aframomum melegueta extract has been established to be beneficial in bodybuilding purposes as it obtains intense anti-estrogenic properties and promotes an increase in body weight and  levels in serum by more than 300%.

  1. Increase t level as a Aphrodisiac

This benefit of aframomum melegueta is not proofed by the scitific evidences. But many guys believe it works when take a few weeks


6-Paradol powder (27113-22-0) Reference

  • 1: Setoguchi S, Watase D, Nagata-Akaho N, Haratake A, Matsunaga K, Takata J. Pharmacokinetics of Paradol Analogues Orally Administered to Rats. J Agric Food Chem. 2016 Mar 9;64(9):1932-7. doi: 10.1021/acs.jafc.5b05615. Epub 2016 Feb 24.
  • 2: Gaire BP, Kwon OW, Park SH, Chun KH, Kim SY, Shin DY, Choi JW. Neuroprotective effect of 6-paradol in focal cerebral ischemia involves the attenuation of neuroinflammatory responses in activated microglia. PLoS One. 2015 Mar 19;10(3):e0120203. doi: 10.1371/journal.pone.0120203. eCollection 2015. PubMed PMID: 25789481;
  • 3: Haratake A, Watase D, Setoguchi S, Terada K, Matsunaga K, Takata J. Relationship between the acyl chain length of paradol analogues and their antiobesity activity following oral ingestion. J Agric Food Chem. 2014 Jul 2;62(26):6166-74. doi: 10.1021/jf500873a. Epub 2014 Jun 18.


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