Paradol, also known as 6-Paradol, is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta or grains of paradise). It is also found in ginger. Paradol has been found to have antioxidant and antitumor promoting effects in a mouse model. It is used in flavors as an essential oil to give spiciness.
Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Used in medicine, health products, food, beverage, cosmetics, biological and chemical reagents and other industries.
6-Paradol powder General Description
The 6-Paradol, with the CAS registry number 27113-22-0, is also known as 3-Decanone, 1-(4-hydroxy-3-methoxyphenyl)-. Its EINECS registry number is 248-228-1. This chemical’s molecular formula is C17H26O3 and molecular weight is 278.38654. What’s more, its IUPAC name is 1-(4-Hydroxy-3-methoxyphenyl)decan-3-one. This chemical’s classification code is Drug / Therapeutic Agent.In addition, 6-Paradol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta). And the seed is also known as Grains of paradise. Besides, this chemical has been found to have antioxidative and antitumor promoting effects. And it is used in flavors as an essential oil to give spiciness.Paradol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta). Theseed is also known as Grains of paradise. Paradol has been found to have antioxidative andantitumor promoting effects
6-Paradol powder (27113-22-0) Application
Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site.
Paradol induces apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. Paradol induces apoptosis through a caspase-3-dependent mechanism.
6-Paradol powder More research
Magnesium taurate has been studied in rats for delaying the onset and progression of cataract.
Function of 6-Paradol
In a related clinical trial, researchers of the Japanese Society of Nutrition have found that aframomum melegueta has the ability to lower body fat percentage, and decreased waisthip ratio without any harmful side effects. Recently, further studies onaframomum melegueta have reported its 6 paradol chemical constituent to be biologically significant beyond its medicinal value.
Aframomum melegueta extract has been established to be beneficial in bodybuilding purposes as it obtains intense anti-estrogenic properties and promotes an increase in body weight and levels in serum by more than 300%.
Increase t level as a Aphrodisiac
This benefit of aframomum melegueta is not proofed by the scitific evidences. But many guys believe it works when take a few weeks
6-Paradol powder (27113-22-0) Reference
1: Setoguchi S, Watase D, Nagata-Akaho N, Haratake A, Matsunaga K, Takata J. Pharmacokinetics of Paradol Analogues Orally Administered to Rats. J Agric Food Chem. 2016 Mar 9;64(9):1932-7. doi: 10.1021/acs.jafc.5b05615. Epub 2016 Feb 24.
2: Gaire BP, Kwon OW, Park SH, Chun KH, Kim SY, Shin DY, Choi JW. Neuroprotective effect of 6-paradol in focal cerebral ischemia involves the attenuation of neuroinflammatory responses in activated microglia. PLoS One. 2015 Mar 19;10(3):e0120203. doi: 10.1371/journal.pone.0120203. eCollection 2015. PubMed PMID: 25789481;
3: Haratake A, Watase D, Setoguchi S, Terada K, Matsunaga K, Takata J. Relationship between the acyl chain length of paradol analogues and their antiobesity activity following oral ingestion. J Agric Food Chem. 2014 Jul 2;62(26):6166-74. doi: 10.1021/jf500873a. Epub 2014 Jun 18.