Coenzyme Q10 (CoQ10) powder (303-98-0)
Coenzyme Q10 (COQ10) powder, also well known as ubidecarenone, helps generate energy in your cells. Coenzyme Q10 (COQ10) powder is a naturally occurring benzoquinone important in electron transport in mitochondrial membranes. Coenzyme Q10(COQ10) functions as an endogenous antioxidant; deficiencies of this enzyme have been observed in patients with many different types of cancer and limited studies have suggested that coenzyme Q10 may induce tumor regression in patients with breast cancer. This agent may have immunostimulatory effects.
Manufacture: Batch Production
Package: 1KG/bag, 25KG/drum
COENZYME Q10 (CoQ10) powder (303-98-0) video
1.What is Coenzyme Q10 (COQ10)?
Coenzyme Q10 (or CoQ10) is a quinone, a substance that aids in providing energy to cells in all oxygen-breathing organisms. Researchers first discovered CoQ10 in 1957, naming it ubiquinone – the quinone found in every cell of the body (ubi = everywhere). Ubiquinones are lipophilic, water-insoluble substances that deliver electrical charges to the mitochondria, or powerhouses of the cells, to produce energy and sustain life. CoQ10 plays an important role as the coenzyme for at least three mitochondrial enzymes (complexes I, II and III) as well as enzymes in other parts of the cell.
Coenzyme Q10 is a pseudo vitamin that acts as a coenzyme in the body to facilitate a variety of critical functions. CoQ10 is crucial to synthesis adenosine triphosphate (ATP), which serves as the primary energy source for cells. ATP drives a number of biological processes including muscle contraction and the production of protein. Coenzyme Q10 is also a powerful antioxidant that supports a robust immune system.
Reindeer, beef, and pork hearts are the richest sources of Coenzyme Q10(COQ10), followed by oily fish. About a hundred different food sources can provide Coenzyme Q10(COQ10), but it is difficult to get a significant serving with some of the more appetizing ones.
Your body produces CoQ10 naturally, but its production tends to decrease with age. Fortunately, you can also get CoQ10 through supplements or foods.
Health conditions like heart disease, brain disorders, diabetes, and cancer have been linked to low levels of CoQ10. It is not clear whether low levels of CoQ10 cause these diseases or are a result of them.
One thing is for certain: plenty of research has revealed CoQ10’s wide range of health benefits.
2.COENZYME Q10 (CoQ10) Powder BasicInformation
Coenzyme Q10 powder
40% (water solubility), 98%
The pharmacokinetic properties may vary between different brandsbut studies have reported a half life of ubidecarenone of 21.7 h.
water solubility: Sparingly soluble
Store in a sealed airtight container, keep the air out, protected
from heat, light and humidity.
CoQ10 acts as an antioxidant, which protects cells from damage and plays an important part in the metabolism.
3.COENZYME Q10 (CoQ10) History
In 1950, G. N. Festenstein was the first to isolate a small amount of CoQ10 from the lining of a horse’s gut at Liverpool, England. In subsequent studies the compound was briefly called substance SA, it was deemed to be quinone and it was noted that it could be found from many tissues of a number of animals.
In 1957, Frederick L. Crane and colleagues at the University of Wisconsin–Madison Enzyme Institute isolated the same compound from mitochondrial membranes of beef heart and noted that it transported electrons within mitochondria. They called it Q-275 for short as it was a quinone. Soon they noted that Q-275 and substance SA studied in England may be the same compound. This was confirmed later that year and Q-275/substance SA was renamed ubiquinone as it was a ubiquitous quinone that could be found from all animal tissues.
In 1958, its full chemical structure was reported by D. E. Wolf and colleagues working under Karl Folkers at Merck in Rahway. Later that year D. E. Green and colleagues belonging to the Wisconsin research group suggested that ubiquinone should be called either mitoquinone or coenzyme Q due to its participation to the mitochondrial electron transport chain.
In 1966, A. Mellors and A. L. Tappel at the University of California were the first to show that reduced CoQ6 was an effective antioxidant in cells.
In 1960s Peter D. Mitchell enlarged upon the understanding of mitochondrial function via his theory of electrochemical gradient, which involves CoQ10, and in late 1970s studies of Lars Ernster enlargened upon the importance of CoQ10 as an antioxidant. The 1980s witnessed a steep rise in the number of clinical trials involving CoQ10.
4.How Coenzyme Q10 (COQ10)Works
Coenzyme Q10 is an important component of the cells’ mitochondria. The mitochondria are considered the power plants in your cells, responsible for producing adenosine triphosphate (ATP), the energy-rich molecule that fuels essentially everything you do. ATP can be produced through the foods you eat and through oxygen in the process known as cellular respiration.
Coenzyme Q10 plays an important role in the creation of ATP, particularly in the electron transfer chain. Studies suggest that up to 95 percent of the energy generated in the human body from cellular respiration.
5.Coenzyme Q10 Benefits and Uses
（1）May Help Treat Heart Failure
Heart failure is often a consequence of other heart conditions, such as coronary artery disease or high blood pressure.
These conditions can lead to increased oxidative damage and inflammation of the veins and arteries.
Heart failure occurs when these problems affect the heart to the point that it is unable to regularly contract, relax or pump blood through the body.
To make matters worse, some treatments for heart failure have undesirable side effects, such as low blood pressure, while others could even further reduce CoQ10 levels.
In a study of 420 people with heart failure, treatment with Coenzyme Q10(COQ10) supplement for two years improved their symptoms and reduced their risk of dying from heart problems.
Also, another study treated 641 people with CoQ10 or a placebo for a year. At the end of the study, those in the CoQ10 group had been hospitalized less frequently for worsening heart failure and had fewer serious complications.
It seems that treatment with CoQ10 could assist with restoring optimal levels of energy production, reduce oxidative damage and improve heart function, all of which can aid the treatment of heart failure.
（2）Could Help With Fertility
Female fertility decreases with age due to a decline in the number and quality of available eggs.
CoQ10 is directly involved in this process. As you age, CoQ10 production slows, making the body less effective at protecting the eggs from oxidative damage .
Supplementing with CoQ10 seems to help and may even reverse this age-related decline in egg quality and quantity.
Similarly, male sperm is susceptible to the effects of oxidative damage, which may result in reduced sperm count, poor sperm quality and infertility.
Several studies have concluded that supplementing with Coenzyme Q10 supplement may improve sperm quality, activity and concentration by increasing antioxidant protection.
（3）Might Help Keep Your Skin Young
Coenzyme Q10 is important for skin care. It plays a vital role in the production of collagen and other proteins that make up the extracellular matrix. When the extracellular matrix is disrupted or depleted, skin will lose its elasticity, smoothness, and tone which can cause wrinkles and premature aging. Coenzyme Q10 can help to maintain overall skin integrity and reduce the signs of aging.
By functioning as an antioxidant and free radical scavenger, Coenzyme Q10 can enhance our natural defense system against environmental stress. Coenzyme Q10 can also be useful in sun care products. Data has demonstrated a reduction of wrinkles with long-term use of Coenzyme Q10 in skin care products.
Coenzyme Q10 is not derived from animal source. It is derived from a microbial fermentation process.
（4）Could Reduce Headaches
Abnormal mitochondrial function can lead to an increased calcium uptake by the cells, the excessive production of free radicals and decreased antioxidant protection. This can result in low energy in the brain cells and even migraines.
Since CoQ10 lives mainly in the mitochondria of the cells, it has been shown to improve mitochondrial function and help decrease the inflammation that may occur during migraines .
In fact, a study showed that supplementing with CoQ10 was three times more likely than a placebo to reduce the number of migraines in 42 people.
Additionally, CoQ10 deficiency has been observed in people suffering from migraines.
One larger study showed that 1,550 people with low CoQ10 levels experienced fewer and less severe headaches after treatment with CoQ10.
What’s more, it seems that CoQ10 not only helps treat migraines but may also prevent them.
（5）Could Help With Exercise Performance
Oxidative stress can affect muscle function, and thus, exercise performance.
Similarly, abnormal mitochondrial function can reduce muscle energy, making it hard for muscles to contract efficiently and sustain exercise.
CoQ10 can help exercise performance by decreasing oxidative stress in the cells and improving mitochondrial functions.
In fact, one study investigated the effects of CoQ10 on physical activity. Those supplementing with 1,200 mg of CoQ10 per day for 60 days showed decreased oxidative stress.
Moreover, supplementing with CoQ10 can help increase power during exercise and reduce fatigue, both of which can improve exercise performance.
（6）Could Help With Diabetes
Oxidative stress can induce cell damage. This can result in metabolic diseases like diabetes.
Abnormal mitochondrial function has also been linked to insulin resistance.
CoQ10 has been shown to improve insulin sensitivity and regulate blood sugar levels.
Supplementing with CoQ10 might also help increase CoQ10 concentrations in the blood by up to three times in people with diabetes who typically show low levels of this compound.
Also, one study had people with type 2 diabetes supplement with CoQ10 for 12 weeks. Doing so significantly reduced fasting blood sugar levels and hemoglobin A1C, which is the average of blood sugar levels over the past two to three months.
Lastly, CoQ10 might help prevent diabetes by stimulating the breakdown of fats and reducing the accumulation of fat cells that could lead to obesity or type 2 diabetes.
（7）Might Play a Role in Cancer Prevention
Oxidative stress is known to cause cell damage and affect their function.
If your body is unable to effectively fight oxidative damage, the structure of your cells can become damaged, possibly increasing the risk of cancer.
CoQ10 may protect cells from oxidative stress and promote cellular energy production, promoting their health and survival.
Interestingly, cancer patients have been shown to have lower levels of CoQ10.
Low levels of CoQ10 have been associated with up to a 53.3% higher risk of cancer and indicate a poor prognosis for various types of cancer.
What’s more, one study also suggested that supplementing with CoQ10 may help reduce the chance of cancer recurrence.
（8）Good for the Brain
Mitochondria are the main energy generators of brain cells.
Mitochondrial function tends to decrease with age. Total mitochondrial dysfunction can lead to the death of brain cells and diseases like Alzheimer’s and Parkinson’s.
Unfortunately, the brain is very susceptible to oxidative damage due to its high fatty acid content and its high demand for oxygen.
This oxidative damage enhances the production of harmful compounds that could affect memory, cognition and physical functions.
CoQ10 may reduce these harmful compounds, possibly slowing the progression of Alzheimer’s and Parkinson’s disease.
（9）Could Protect the Lungs
Of all your organs, your lungs have the most contact with oxygen. This makes them very susceptible to oxidative damage.
Increased oxidative damage in the lungs and poor antioxidant protection, including low levels of CoQ10, can result in lung diseases like asthma and chronic obstructive pulmonary disease (COPD).
Furthermore, it has been shown that people suffering from these conditions present lower levels of CoQ10.
A study demonstrated that supplementing with CoQ10 reduced inflammation in individuals who had asthma, as well as their need for steroid medications to treat it.
Another study showed improvements in exercise performance in those suffering from COPD. This was observed through better tissue oxygenation and heart rate after supplementing with CoQ10.
6.Coenzyme Q10(CoQ10)Dosage and Side Effects
CoQ10 comes in two different forms — ubiquinol and ubiquinone.
Ubiquinol accounts for 90% of the CoQ10 in the blood and is the most absorbable form. Thus, it’s recommended to choose from supplements containing the ubiquinol form.
If you want to buy a CoQ10 supplement containing the ubiquinol form, you can have a check on wisepowder.
The standard dose of CoQ10 ranges from 90 mg to 200 mg per day. Doses up to 500 mg seem well tolerated, and several studies have used even higher doses without any serious side effects.
Because CoQ10 is a fat-soluble compound, its absorption is slow and limited. However, taking CoQ10 supplements with food can help your body absorb it up to three times faster than taking it without food.
Additionally, some products offer a solubilized form of CoQ10, or a combination of CoQ10 and oils, to improve its absorption.
Your body does not store CoQ10. Therefore, its continued use is recommended to see its benefits.
Supplementing with CoQ10 appears to be well tolerated by humans and have low toxicity.
In fact, participants in some studies showed no major side effects taking daily doses of 1,200 mg for 16 months.
However, if side effects appear, it is recommended to divide the daily dose into two to three smaller doses.
7.Why do we use Coenzyme Q10Powder in formulations?
Coenzyme Q10 (Ubiquinone) is primarily included in formulations for its anti-oxidant, skin conditioning, and anti-aging properties.
8.How to Work with Coenzyme Q10?
Pre-dispersed liquid versions can be easier to work with as Coenzyme Q10 (Ubiquinone) is not very enthusiastically oil soluble.
Lotion Crafter recommends including powdered Coenzyme Q10 (Ubiquinone) in the heated oil phase of emulsions to ensure proper incorporation.
We would recommend adding pre-dispersed liquid Coenzyme Q10 (Ubiquinone) products in the cool down phase given the low usage rate, but defer to your supplier recommendations for the precise product you are using.
9.Some Formulations that Use Coenzyme Q10 (Ubiquinone)
Rosehip Oat Solid Oil Serum
Argan Plum Body Oil
Summer Stone Fruit Facial Oil Serum
Passionfruit Facial Glow Oil
Brightening Gel Serum
Cranberry Orange Facial Serum
Cacti Q10 Ageless Facial Serum
10.Coenzyme Q10(COQ10) and DHEA
Treatment of patients with diminished ovarian reserve (DOR) is one of the biggest challenges in assisted reproductive therapeutics. Dehydroepiandrosterone (DHEA) and Coenzyme Q10 (CoQ10) are supplements that have been purported to have a beneficial effect in these patients. Combined DHEA and CoQ10 supplementation significantly increases the AFC compared to DHEA alone, which lead to a higher ovarian responsiveness during both COH and IVF, but without a difference in pregnancy rate.
11.Coenzyme Q10(COQ10) and Quercetin
Coenzyme Q10(COQ10) and Quercetin are two popular heart and longevity supplements , the former being an abundant dietary flavonoid and the latter an endogenous antioxidant. Consumers often mistake quercetin and coenzyme Q10 as being the same (likely due to their putative synergy as cardioprotective supplements). Though these micronutrients provide similar disease-mitigating properties and antioxidant effects in mitochondria, they are distinct molecules with unrelated chemical structures.
Then there are many people want to take quercetin and Coenzyme Q10 together. Taking quercetin is a practical way to reap the antioxidant effects of this essential dietary flavonoid. While there is only limited data investigating synergy between coenzyme Q10 and quercetin supplements, there’s a plausible crossover between the mechanisms of action of these micronutrients. In fact, recent evidence suggests quercetin can act as a “coenzyme Q10-mimetic”.
With that in mind, Transparent Labs Vitality and CoQ10 Capsules make an excellent tandem for active men that want to improve their energy levels, reduce oxidative stress, support heart health, boost testosterone levels, and enhance athletic performance.
Indeed, preliminary findings indicate that taking quercetin and CoQ10 can bolster musculoskeletal and cardiovascular functions. We can expect further studies to provide insights into the ergogenic and health-promoting applications of quercetin and CoQ10.
12. Where to Buy Coenzyme Q10Powder?
Wisepowder offers the best Coenzyme Q10 powder with the most competitive price. And its Coenzyme Q10 bulk and wholesale powder has been lab-tested and verified for both product purity and identity.
What’s more, wisepowder provide Coenzyme Q10 powder in bulk order or wholesale according to your need.