Citicoline(CDP Choline) Sodium powder (33818-15-4)

Citicoline Sodium powder is a complex organic molecule that functions as an intermediate in the biosynthesis of cell membrane phospholipids. CiticolineSodium is also known as CDP-choline  Sodium and Cytidine 5′-diphosphocholine sodium. CDP-choline  Sodium belongs to the group of biomolecules in living systems known as “nucleotides” that play important roles in cellular metabolism. CDP-choline  Sodium is composed of ribose, pyrophosphate, cytosine (a nitrogenous base), and choline. Exogenous citicoline research in animal experiments and human clinical trials provides evidenceof its cholinergic and neuroprotective actions. As a dietary supplement, citicoline appears useful for improving both the structural integrity and functionality of the neuronal membrane that may assist in membrane repair. Animal and clinical studies indicate the potential of citicoline to improve cognitive deficits, stroke rehabilitation, brain and spinal cordinjuries, neurological diseases, and eye conditions.

This supplement is also catered towards preventing or treating memory impairments associated with aging because both of the molecules it confers are neuroprotective and potentially enhance learning. This effect mayalso benefit younger populations as well. It appears to be more efficientthan phosphatidylcholine (PC) itself in this role, in part due to also increasing PC synthesis in the brain.

Citicoline Sodium (CDP Choline Sodium) is a brain chemical that occursnaturally in the body. As a medicine, it is taken by mouth as a supplement or given by IV or as a shot. Citicoline Sodium (CDP Choline Sodium) is used for Alzheimer’s disease and other types of dementia, head trauma, cerebrovascular disease such as stroke, age-related memory loss, Parkinson’s disease, attention deficit-hyperactive disorder (ADHD), and glaucoma. Citicoline Sodium (CDP Choline Sodium) was originally developed in Japan for stroke.It was later introduced as a prescription drug in many European countries. In these countries it is now frequently prescribed for thinking problems related to circulation problems in the brain. In the US, Citicoline Sodium (CDP Choline Sodium) is marketed as a dietary supplement.

Citicoline is the generic name of the pharmaceutical substance that chemically is cytidine-5′-diphosphocholine (CDP-choline), which is identical to the natural intracellular precursor of phospholipid phosphatidylcholine.Following injection or ingestion, citicoline is believed to undergo quick hydrolysis and dephosphorylation to yield cytidine and choline, which then enter the brain separately and are used to resynthesize CDP-choline inside brain cells.  Citicoline seems to increase a brain chemical called phosphatidylcholine. This brain chemical is important for brain function. Citicoline might also decrease brain tissue damage when the brain is injured.

Citicoline Sodium (CDP Choline Sodium) powder is a neuroprotective agent. It acts by enhancing cellular communication, stimulating the synthesis of SAMe, and increasing glucose metabolis. Citicoline Sodium (CDP Choline Sodium) powder is a naturally occurring nucleotide; intermediate in the major pathway of lecitin biosynthesis. Neuroprotective. It is used in the treatment of ischemic stroke and head trauma. Neuroprotectiveproduct. Citicholine exhibits protective effects in cerebral ischemia, traumatic brain injury, and memory disorders. Recently showed efficacy against dementia when given with AchEIs (Acetylcholinesterase inhibitor). Depicts Neuroprotective, acnticonvulsant activity and sedative effect at a dose of 150mg/kg in rats.  Showed protection against aluminum induced cognitive impairment in rats reducing elevated glutamate level, oxidativestress and NO overproduction in the hippocampus.

Citicoline Sodium (CDP-choline; cytidine 5′-diphosphocholine) has a broad spectrum of benefits for conditions associated with symptoms of neurological dysfunction shows promise of clinical efficacy in elderly patients with cognitive deficits, inefficient memory, and early-stage Alzheimer’s disease. Citicoline Sodium has also been investigated as a therapy in stroke patient. Despite it was approved in some countries for treatment Traumatic Brain Injury (TBI), the use of this drug for acute TBI seems to have no field of support anymore, whereas it may have some benefits in improving the neuro-cognitive state in chronic TBI patients. It’s also recommended to keep in mind acute interventions like Psychological First Aid (PFA) during acute TBI management. Citicoline Sodium plays several important roles in human physiology, including enhancement of structural integrity and signaling for cell membranes, support of acetylcholine synthesis, and synthesisof betaine, a methyl donor. The precise mechanism of action of Citicoline Sodium to treat disease is unknown, but was confirmed, that drug might increase phosphatidylcholine (PtdCho) synthesis and might reverse PtdCho loss. In addition, was shown, that citicolinemodulates phospholipids metabolism and neurotransmitter levels and appears to improve cognition insome central nervous system disorders such as bipolar disorder and cocaine dependence.

COA

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• Liu Y, Wang J, Xu C, Chen Y, Yang J, Liu D, Niu H, Jiang Y, Yang S, Ying H. Efficient multi-enzyme-catalyzed CDP-choline production driven by an ATP donor module. Appl Microbiol Biotechnol. 2017 Feb;101(4):1409-1417. doi: 10.1007/s00253-016-7874-0. Epub 2016 Oct 13. PubMed PMID: 27738720.
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