Monosialotetrahexosyl ganglioside Sodium(GM1) powder (Pig Brain) (37758-47-7)

Monosialotetrahexosyl ganglioside Sodium(GM1) (37758-47-7) video

 

Monosialotetrahexosyl ganglioside Sodium(GM1) (37758-47-7) Base Information

Name	Monosialotetrahexosyl ganglioside Sodium(GM1)
CAS	37758-47-7
Purity	98%
Chemical name	Ganglioside GM1 Sodium Salt (pig brain)
Synonyms	Ganglioside G4 Sodium Salt; GM1 Sodium Salt; GM1-Ganglioside Sodium Salt; Ganglioside A2 Sodium Salt; Ganglioside GGtet1 Sodium Salt; Ganglioside GI Sodium Salt; Ganglioside GM1a Sodium Salt; Ganglioside M1 Sodium Salt; Sialosylganglio-N-tetraosylceramide Sodium Salt; Sygen Sodium Salt;
Molecular Formula	C73H134N4O31
Molecular Weight	1546.822299
Melting Point	207-230ºC
InChI Key	QPJBWNIQKHGLAU-IQZHVAEDSA-N
Form	powder
Appearance	Off-White Solid
Half Life	/
Solubility	DMSO (Slightly), Methanol (Slightly)
Storage Condition	-20ºC
Application	Ganglioside GM1 Sodium Salt (pig brain) is a specific receptor for cholera toxin.
Testing Document	Available

 

Monosialotetrahexosyl ganglioside Sodium(GM1) (37758-47-7) General Description

Monosialotetrahexosylganglioside Sodium (GM1) powder pig brain extracted from pig brain. Useful as an antigen and receptor for cholera toxin, as a growthinhibition marker in fibroblasts, and as a marker for lymphoid subpopulations.Monosialotetrahexosylganglioside Sodium powder, one of the glycosphingolipids widely distributed in all tissues, occurs in highest concentrations in the central nervous system. It is primarily located in the outer surface of the mammalian cell’s plasma membrane and in synaptic membranes of the CNS. Monosialotetrahexosylganglioside Sodium modulates a number of cell surface and receptor activities as well as neuronal differentiation and development, protein phosphorylation and synaptic function. In addition, it exerts anti-excitotoxic activity, prevents necrosis, and improves neuronal recovery and function. Check for active clinical trials using this agent.

 

Monosialotetrahexosyl ganglioside Sodium(GM1) (37758-47-7) History

The study of GM1 powder and its role in neuroprotection dates back to 1970s. Since then, research scientists have shown interest in the compound by carrying out cell cultures and animal studies. All the experiments focused on establishing the significance of GM1 in neurodegenerative disorders.

In 1986, through TRB S.A, Monosialotetrahexosylganglioside sodium was officially launched under the trade name, GM-1. Given that the results on animal studies were promising, the US clinicians set out to investigate Monosialotetrahexosylganglioside sodium (GM1) effects on human. The subjects of the study were patients with CNS damage due to injury of the spinal cord, stroke, Parkinson’s disease, and Alzheimer.

Since then, states such as Argentina and Italy have approved its therapeutic application as a prescription drug for the treatment of neurological conditions.

 

Monosialotetrahexosyl ganglioside Sodium(GM1) (37758-47-7) Mechanism Of Action

Monosialotetrahexosyl ganglioside powder works in several ways. The molecule is an epicenter of most of the physiological activities of the nervous system.

In the cell membrane of the brain, Monosialotetrahexosylganglioside functions to maintain the ion balance within and outside the membranous tissue. Not only does it enhance impermeability, but it also evens out sodium and calcium ions pump.

In the case of nerve injury, Monosialotetrahexosylganglioside sodium (GM1) powder comes in to protect the membranous structure. It trims down the activity of phospholipase A2, moderates the calcium ion influx, and cuts down the formation of free radicals.

Brain traumas amplify the activity of protein kinase in the cells, which may be responsible for apoptosis. GM1 inhibits and reverses this process by holding the metabolism of proteins within the cytoplasm and nucleus.

Within the mitochondrion, Monosialotetrahexosylganglioside works to upregulate the production of ATP and its synthase activity. It repairs possible damages on the electron transport chain and improves the oxidative phosphorylation. As a result, the brain’s mitochondrial respiratory function remains healthy.

Monosialotetrahexosylganglioside sodium injection stimulates axonal sprouting by concentrating the growth factors to their specific receptors. This activity regenerates the nerve fibers and promotes rapid neurological recovery. In the case of secondary degeneration, probably due to dopamine neuron damage, Monosialotetrahexosylganglioside will stabilize the effect and enhance the survival of these neurons.

 

Monosialotetrahexosyl ganglioside Sodium(GM1) (37758-47-7) Application

Ganglioside GM1 Sodium Salt (pig brain) is a Specific receptors for cholera toxin that accumulate in the brain in late infantile lipidosis.

 

Monosialotetrahexosyl ganglioside Sodium(GM1) (37758-47-7) More research

Therapeutic applications

Because of GM1’s close role in neurotrophic repair mechanisms, it has been investigated as a potential method to potentially slow or even reverse the progression of a wide range of neurodegenerative conditions. Controlled phase II studies have indicated that GM1 can ease the symptoms of Parkinson’s disease, presumably by countering degeneration of the substantia nigra, and a similar methodology has been pursued to try and limit cellular damage from necrosis and apoptosis occurring after acute spinal cord injury.

 

Monosialotetrahexosyl ganglioside Sodium(GM1) (37758-47-7) Reference

• Mocchetti I (2005). “Exogenous gangliosides, neuronal plasticity and repair, and the neurotrophins”. Cell. Mol. Life Sci. 62 (19–20): 2283–
• Chen JC, Chang YS, Wu SL, et al. (September 2007). “Inhibition of Escherichia coli heat-labile enterotoxin-induced diarrhea by Chaenomeles speciosa”. J Ethnopharmacol. 113 (2): 233–
• Fishman, P.H., et al.: J. Membr. Biol., 69, 85-97 (1982); Vlasova, I., et al.: Zh. Evol. Biokhim. Fiziol., 45, 465-471 (2009);