7,8-Dihydroxyflavone powder

7,8-Dihydroxyflavone, also known as tropoflavin, is a naturally occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves.[2][3][4] It has been found to act as a potent and selective small-molecule agonist of the tropomyosin receptor kinase B (TrkB) (Kd ≈ 320 nM), the main signaling receptor of the neurotrophin brain-derived neurotrophic factor (BDNF). Tropoflavin is both orally bioavailable and able to penetrate the blood–brain barrier. A prodrug of tropoflavin with greatly improved potency and pharmacokinetics, R13 (and, formerly, R7), is under development for the treatment of Alzheimer’s disease.

Wisepowder has the capability to produce and supply large quantity. All production under cGMP condition and strict quality control system, all testing documents and sample available.

7,8-Dihydroxyflavone powder Chemical Base Information

CAS 38183-03-8
Purity 98%
Chemical name 7,8-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one
Synonyms 7,8-DHF; 7,8-DIHYDROXYFLAVONE;7,8-dihydroxy-2-phenyl-4-benzopyrone; DIHYDROXYFLAVONE, 7,8-(RG); 7,8-Dihydroxyflavone hydrate; 7,8-dihydroxy-2-phenyl-1-benzopyran-4-one; 8-Dihydroxyflavone; 7,8-DIHYDROXYFLAVONE 7,8-DIHYDROXYFLAVONE; 7,8-dihydroxy-2-phenyl-4h-1-benzopyran-4-on
Molecular Formula C15H10O4
Molecular Weight 254.24
Boling Point 494.4° C at 760 mmHg
Form solid
Appearance Yellow powder
Half Life /
Solubility DMSO : ≥ 100 mg/mL (393.33 mM)

Soluble in DMSO, ethanol, and methanol.

Storage Condition room temp
Application 7,8-Dihydroxyflavone is a TrkB agonist that inhibits glutamate-triggered apoptosis
Testing Document Available


7,8-Dihydroxyflavone powder General Description

7,8-Dihydroxyflavone (7,8-DHF) is a monophenolic flavone with diverse effects. It acts as an agonist of the neurotrophic tyrosine kinase receptor TrkB (Kd = 320 nM), protecting neurons that express TrkB from apoptosis.1 7,8-DHF is neuroprotective in an animal model of Parkinson’s disease.1 It supports emotional learning in mice and reverses memory deficits in a mouse model of Alzheimer’s disease.2,3 It also improves motor function and extends survival in an animal model of Huntington’s disease.4 7,8-DHF inhibits the cytochrome P450 aromatase (IC50 = 10 µM) and, in this way, alters estrogen metabolism.5 It also has antioxidant action that increases intracellular glutathione synthesis and scavenges reactive oxygen species.


7,8-Dihydroxyflavone powder History

In 2017, evidence was published suggesting that tropoflavin and various other reported small-molecule TrkB agonists might not actually be direct agonists of the TrkB and might be mediating their observed effects by other means.


7,8-Dihydroxyflavone powder Mechanism Of Action

7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)—such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease—without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.

7,8-Dihydroxyflavone (7,8-DHF) may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving, memory, vasorelaxation and hypertension. 7,8-DHF elicits protection in scopolamine induced Alzheimer-like pathologic dysfunction.


7,8-Dihydroxyflavone powder Application

7,8-Dihydroxyflavone hydrate has been used as tropomyosin-receptor-kinase B (TrkB) agonist in mice and to inhibit TrkB for monitoring evoked excitatory postsynaptic currents (eEPSCs).


7,8-Dihydroxyflavone powder More research

A variety of close structural analogues of tropoflavin have also been found to act as TrkB agonists in vitro, including diosmetin (5,7,3′-trihydroxy-4′-methoxyflavone), norwogonin (5,7,8-trihydroxyflavone), eutropoflavin (4′-dimethylamino-7,8-dihydroxyflavone), 7,8,3′-trihydroxyflavone, 7,3′-dihydroxyflavone, 7,8,2′-trihydroxyflavone, 3,7,8,2′-tetrahydroxyflavone, and 3,7-dihydroxyflavone.[37] The highly hydroxylated analogue gossypetin (3,5,7,8,3′,4′-hexahydroxyflavone), conversely, appears to be an antagonist of TrkB in vitro.

Tropoflavin was also found to decrease mouse sleep in dark phase and reduce hypothalamus level of orexin A but not orexin B in mice.



  1. Andero et al (2012) 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilzation stress in rats. Hippocampus 22 399
  2. Jang et al (2010) A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proc.Natl.Acad.Sci.USA 107 268
  3. Boltaev U, Meyer Y, Tolibzoda F, Jacques T, Gassaway M, Xu Q, Wagner F, Zhang YL, Palmer M, Holson E, Sames D (2017). “Multiplex quantitative assays indicate a need for reevaluating reported small-molecule TrkB agonists”. Sci Signal.
  4. Jiang Small-molecule TrkB receptor agonists improve motor function and extend survival in a mouse model of Huntington’s disease. Hum.Mol.Genet. 2013