Amino Tadalafil powder (385769-84-6)

Amino Tadalafil powder (385769-84-6) video

 

 

Amino Tadalafil powder Base Information

Name	Amino Tadalafil powder
CAS	385769-84-6
Purity	98%
Chemical name	Amino Tadalafil
Synonyms	Aminotadalafil
Molecular Formula	C21H18N4O4
Molecular Weight	390.4 g/mol
Melting Point
InChI Key	VUKJGAVIWMPOOJ-UHFFFAOYSA-N
Form	Solid
Appearance	White to off-white Crystalline powder
Half Life
Solubility
Storage Condition	Store in a sealed airtight container, keep the air out, protected from heat, light and humidity.
Application	Used in the treatmen of erectile dysfunction(ED)
Testing Document	Available

 

Amino Tadalafil powder General Description

Amino tadalafil powder is a potent inhibitor of phosphodiesterase 5 (PDE5). PDE5, an enzyme found primarily in the smooth muscle of the corpus cavernosum, selectively cleaves and degrades cGMP to 5′-GMP. PDE5 inhibitors are similar in structure to cGMP and they competitively bind to PDE5 and inhibit cGMP hydrolysis, thus enhancing the effects of NO, resulting in prolonging an erection.

 

Amino Tadalafil powder (385769-84-6) History

Amino tadalafil vs tadalafil, Amino tadalafil is a drug analog of tadalafil.

 

Amino Tadalafil powder Mechanism Of Action

Inhibitor of phosphodiesterase 5 (PDE5). PDE5, an enzyme found primarily in the smooth muscle of the corpus cavernosum, selectively cleaves and degrades cGMP to 5′-GMP. PDE5 inhibitors are similar in structure to cGMP and they competitively bind to PDE5 and inhibit cGMP hydrolysis, thus enhancing the effects of NO, resulting in prolonging an erection.

 

Amino Tadalafil powder (385769-84-6) Application

Amino tadalafil is an analog of tadalafil, a potent inhibitor of phosphodiesterase 5 with applications in several conditions, including used in the treatmen of erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction.

 

Amino Tadalafil powder More research

In rats treated with both melatonin and tadalafil, the recoveries were more pronounced than in rats given either melatonin or tadalafil alone. The ICP/mean arterial pressure value in vehicle-treated rats was significantly higher than in the control group, while in the tadalafil- and tadalafil + melatonin-treated groups have returned this value had returned to control levels. In addition, as an individual treatment, and especially when combined with tadalafil, melatonin prevented spinal cord injury (SCI)-induced oxidative damage to cavernosal tissues and restored ED, most likely due to its anti-oxidant effects

 

Amino Tadalafil powder (385769-84-6) Reference

• Kim, D., et al.: Bioorg. Med. Chem., 9, 1895 (2001), Tseng, M., et al.: J. Food Drug. Anal., 10, 112 (2002), Blount, M., et al.: Mol. Pharmacol., 66, 144 (2004),

 

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