Triamterene powder is a potassium-sparing diuretic (water pill) that prevents your body fromabsorbing too much salt and keeps your potassium levels from getting too low. Triamterene powder is used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney condition called nephrotic syndrome. Triamterene powder is also used to treat edema caused by using steroid medicine or having too much aldosterone in your body. Aldosterone is a hormone produced by the adrenal glands to help regulate the salt and water balance in your body.
02 Triamterene powder (396-01-0) video
03 Triamterene powder Base Information
|Half Life||4-6 hours|
|Solubility||formic acid: soluble200 mg + 4 mL warm Formic Acid, clear, yellow-green, <0.1 G/100 ML AT 20 ºC|
|Application||Triamterene is a weak diuretic with potassium sparingproperties; blocks Na+ reuptake in the kidneys.|
04 Triamterene powderGeneral Description
Triamterene powder is used alone or with other medications to treat edema (fluid retention; excess fluid held in body tissues) caused by various conditions, including liver and heart disease. Triamterene is in a class of medications called diuretics (‘water pills’). It causes the kidneys to eliminate unneeded water and sodium from the body into the urine, but reduces the loss of potassium.
Triamterene powder comes as a capsule to take by mouth. It usually is taken once a day in the morning after breakfast or twice a day after breakfast and lunch. It is best to take triamterene powder earlier in the day so that frequent trips to the bathroom do not interfere with nighttime sleep. Take triamterene at around the same time(s) every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take triamterene exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
05 Triamterene (396-01-0) History
Triamterene powder (trye am’ ter een) is an inhibitor of renal epithelial sodium channels in the late distal tubule and collecting ducts of the kidney. As a result, triamterene powder promotes a mild sodium diuresis, but maintains body potassium levels. Triamterene powder is used largely in therapy of edema and can be safely used in patients with cirrhosis. Because of its potassium-sparing actions, triamterene is also used in combination with thiazide or loop diuretics in an attempt to prevent hypokalemia. Triamterene powder was approved for use in the United States in 1964 and continues to be widely used with more than 20 million prescriptions filled yearly. Triamterene is available in tablets and capsules of 50 and 100 mg in generic forms and under the brand name of Dyrenium. The typical dose of triamterene is 50 to 200 mg daily in one or two divided doses. Triamterene is also available in fixed dose combinations with hydrochlorothiazide (Maxide, Dyazide and generically). The major side effects of triamterene powder are dizziness, fatigue, headache, dry mouth, hyperkalemia and dehydration.
06 Triamterene (396-01-0) Mechanism Of Action
Triamterene powder inhibits the epithelial sodium channels (ENaC) located on the lumenal side in the late distal convoluted tubule and collecting tubule, which are transmembrane channels that normally promotes sodium uptake and potassium secretion.In the late distal tubule to the collecting duct, sodium ions are actively reabsorbed via ENaC on the lumnial membrane and are extruded out of the cell into the peritubular medium by a sodium-potassium exchange pump, the Na-K-ATPase,with water following passively.Triamterene exerts a diuretic effect on the distal renal tubule to inhibit the reabsorption of sodium ions in exchange for potassium and hydrogen ions and its natriuretic activity is limited by the amount of sodium reaching its site of action.Its action is antagonistic to that of adrenal mineralocorticoids, such as aldosterone, but it is not an inhibitor or antagonist of aldosterone.Label Triamterene powder maintains or increases the sodium excretionm, thereby increasing the excretion of water, and reduces the excess loss of potassium, hydrogen and chloride ions by inhibiting the distal tubular exchange mechanism.Due to its diuretic effect, triamterene powder rapidly and reversibly reduces the lumen-negative transepithelial potential difference by almost complete abolition of Na+ conductance without altering K+ conductance.This reduces the driving force for potassium movement into the tubular lumen and thus decreases potassium excretion.Triamterene powder is similar in action to amiloride but, unlike amiloride, increases the urinary excretion of magnesium.
07 Triamterene (396-01-0) Application
Triamterene is a “water pill” (diuretic) that works in your kidneys to increase the amount of urine you make. This helps your body get rid of extra water. This medication is used to decrease swelling (edema) caused by conditions such as cancer, congestive heart failure, liver disease, and kidney disease. This effect can help your kidneys work better and lessen symptoms such as trouble breathing and swelling in your ankles, feet, hands, or belly.
08 Triamterene (396-01-0) More research
Triamterene powder can be used in the treatment of congestive heart failure, cirrhosis, and the edema caused by secondary hyperaldosteronism. It is frequently used in combination with other diuretics except spironolactone. Amiloride, but not triamterene, possesses antihypertensive effects that can add to those of the thiazides. These K+-sparing diuretics have low efficacy when used alone, since only a small amount of total Na reabsorption occurs at more distal sites of the nephron.
These compounds are used primarily in combination with other diuretics, such as the thiazides and loop diuretics, to prevent or correct hypokalemia. The availability of fixed-dose mixtures of thiazides with nonsteroidal K+-sparing compounds has proved a rational form of drug therapy. Both triamterene and amiloride are available alone or in combination with hydrochlorothiazide.
09 Triamterene (396-01-0) Document Download
10 Triamterene (396-01-0) Reference
- Crosley AP; et al. (1962). “Triamterene, A New Natruretic Agent: Preliminary Observations in Man”. Ann Intern Med. 56 (2): 241–251. doi:10.7326/0003-4819-56-2-241. PMID 13882367.
- Strickland, Carol (15 October 1989). “Bolar: A Drug Company Under Siege”. The New York Times.
- Swartz R; Longwell P (March 2005). “Treatment of vertigo” (PDF). Am Fam Physician. 71 (6): 1115–22. PMID 15791890.
- Shaw, Donna (February 27, 1991). “U.s. Charges Bolar Pharmaceutical With Misrepresenting Its Products”. The Philadelphia Inquirer.
- 01. Overview
- 02. Triamterene powder (396-01-0) video
- 03. Triamterene powder Base Information
- 04. Triamterene powderGeneral Description
- 05. Triamterene (396-01-0) History
- 06. Triamterene (396-01-0) Mechanism Of Action
- 07. Triamterene (396-01-0) Application
- 08. Triamterene (396-01-0) More research
- 09. Triamterene (396-01-0) Document Download
- 10. Triamterene (396-01-0) Reference