Glycine Propionyl-L-Carnitine HCl powder is a form of Propionyl-L-Carnitine bonded at the molecular level to the amino acid Glycine. Propionyl L-Carnitine is a derivative of the popular amino acid L-Carnitine, which is used to metabolise and transport stored body fat for use as energy. It helps the body produce energy. It is important for heart function, muscle movement, and many other body processes.
02 Glycine Propionyl-L-Carnitine powder video
03 (423152-20-9) Base Information
|Name||Glycine Propionyl-L-Carnitine powder|
|Chemical name||Glycine Propionyl-L-Carnitine|
|Synonyms||Propionyl-L-carnitine chloride glycinate;Glycine propionyl L-carnitine hydrochloride;GPLC|
|Molecular Weight||292.332 g/mol|
|Appearance||White Crystalline Powder|
|Application||Propionyl-L-carnitine is commonly used for treatingleg pain (intermittent claudication) and congestive heart failure (CHF), chest pain (angina), and somebowel problems such as ulcerative colitis.|
04 (423152-20-9) General Description
Glycine Propionyl-L-Carnitine powder is an amino acid that is naturally produced in the body. Amino acids are the building blocks of proteins. L-carnitine and acetyl-L-carnitine are also amino acids, and they are chemically related to Glycine Propionyl-L-Carnitine powder. In fact, the body can convert L-carnitine to propionyl-L-carnitine and acetyl-L-carnitine. But, no one knows whether the benefits of carnitines are interchangeable. Until more is known, don’t substitute one form of carnitine for another.
Glycine Propionyl-L-Carnitine powder is commonly used for treating leg pain (intermittent claudication) due to poor blood circulation (peripheral vascular disease, PVD), to improve wound healing in people with PVD. PVD is often caused by diabetes or “hardening of the arteries” (atherosclerosis). Glycine Propionyl-L-Carnitine powder is also used to treat congestive heart failure (CHF), chest pain (angina), and some bowel problems such as ulcerative colitis. A specific kind of propionyl-L-carnitine, called glycine propionyl-L-carnitine, is often used to improve athletic ability. There is limited scientific research that supports taking propionyl-L-carnitine by mouth for other uses.
Beside, men with sexual performance problems (erectile dysfunction, ED) due to diabetes or poor circulation sometimes use propionyl-L-carnitine along with prescription medications. Older men who have symptoms of low testosterone levels sometimes use propionyl-L-carnitine in combination with acetyl-L-carnitine.
05 (423152-20-9) History
The following doses have been studied in scientific research:
For disorders of the blood vessels: 500-1500 mg Glycine Propionyl-L-Carnitine twice daily.
For congestive heart failure and chest pain due to blood circulation problems (chronic angina): A dose of 500 mg of Glycine Propionyl-L-Carnitine three times daily.
For symptoms in older men caused by insufficient levels of testosterone: A dose of 2 grams of acetyl-L-carnitine plus 2 grams of p Glycine Propionyl-L-Carnitine daily has been used.
For ED (erectile dysfunction): A daily dose of 2 grams of Glycine Propionyl-L-Carnitine has been used in combination with 50 mg of sildenafil (Viagra) given twice weekly.
For Peyronie’s disease: 2 grams of Glycine Propionyl-L-Carnitine daily has been used in combination with injections of a medication called verapamil.
For blood vessel disorders and heart disease: Healthcare providers give Glycine Propionyl-L-Carnitine intravenously (by IV).
06 (423152-20-9) Mechanism Of Action
As a potent form of L-Carnitine, GPLC helps the body produce energy from stored body fat by shuttling fatty acids from fat cells into the mitochondria of muscle cells where the fatty acids can be metabolised and used to produce energy. This process is known as fat metabolism. An increase in the use of stored body fat for energy will result in a reduction of stored body fat.
Glycine Propionyl-L-Carnitine also enhances the level of nitric oxide in the bloodstream, which leads to an increase in blood flow and an increase in oxygen and nutrient delivery to working muscles. Consequently, users may experience an increase in vascularity and an increase in muscle pump when supplementing with GPLC. As a result, GPLC has the ability to increase performance during training. It has also been shown to reduce markers of muscular damage following anaerobic exercise by increasing the oxygenation of muscles and eliminating lactic acid and other metabolic waste, hence increasing post-workout muscle recovery.
Combined with a sensible diet and workout regime, GLPC can assist fat loss, increase vascularity and muscle pump, improve performance and enhance recovery.
07 (423152-20-9) Application
♦ Congestive heart failure (CHF).
♦ Sexual performance problems (erectile dysfunction, ED)
♦ Chest pain (angina).
♦ Treating symptoms of “male menopause,” low levels of testosterone due to aging.
♦ A type of heart disease called chronic ischemic heart disease.
♦ Poor circulation (peripheral vascular disease) that causes leg pain while walking (intermittent claudication).
♦ An increase in hard tissue in the penis (Peyronie’s disease).
♦ A disease of the bowels called ulcerative colitis.
08 (423152-20-9) More research
Developing research suggests that Glycine Propionyl-L-Carnitine powder might improve general fatigue in patients with Chronic fatigue syndrome (CFS) . Interestingly, the combination of propionyl-L-carnitine and acetyl-L-carnitine appears to be less effective than either supplement alone.
Beside, not enough is known about the use of Glycine Propionyl-L-Carnitine during pregnancy and breast-feeding. Stay on the safe side and avoid use.
09 (423152-20-9) Document Download
10 (423152-20-9) Reference
- Bloomer, RJ; Tschume, LC; Smith, WA (2009). “Glycine propionyl-L-carnitine modulates lipid peroxidation and nitric oxide in human subjects”. Int J Vitam Nutr Res. 79 (3): 131– doi:10.1024/0300-98126.96.36.199.
- Bloomer, RJ; Smith, WA; Fisher-Wellman, KH (2007). “Glycine propionyl-L-carnitine increases plasma nitrate/nitrite in resistance trained men”. J Int Soc Sports Nutr. 4 (1): 22. doi:10.1186/1550-2783-4-22. PMC 2211291.
- Reznick, AZ; Kagan, VE; Ramsey, R (1992). “Antiradical effects in L-propionyl carnitine protection of the heart against ischemia-reperfusion injury: the possible role of iron chelation”. Arch Biochem Biophys. 296: 394– doi:10.1016/0003-9861(92)90589-o.
- Smith, WA; Fry, AC; Tschume, LC; Bloomer, RJ (2008). “Effect of glycine propionyl-L-carnitine on aerobic and anaerobic exercise performance”. Int J Sport. Nutr Exerc Metab. 18(1): 19–
- 01. Overview
- 02. Glycine Propionyl-L-Carnitine powder video
- 03. (423152-20-9) Base Information
- 04. (423152-20-9) General Description
- 05. (423152-20-9) History
- 06. (423152-20-9) Mechanism Of Action
- 07. (423152-20-9) Application
- 08. (423152-20-9) More research
- 09. (423152-20-9) Document Download
- 10. (423152-20-9) Reference