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Sulforaphane Powder (4478-93-7)
Sulforaphane Powder (4478-93-7) video
Sulforaphane Powder Base Information
| Name | Sulforaphane Powder |
| CAS | 4478-93-7 |
| Purity | 1%，10% |
| Chemical name | D,L-Sulforaphane |
| Synonyms | sulforafan; sulforaphan; sulforaphane; R-SULFORAPHANE; R,S-SULFORAPHANE; SULFORAPHANE, L-; SULFORAPHANE, DL-; SULFORAPHANE, D- |
| Molecular Formula | C6H11NOS2 |
| Molecular Weight | 177.3 |
| Melting Point | 68.93° C (Predicted) |
| InChI Key | SUVMJBTUFCVSAD-UHFFFAOYSA-N |
| Form | Powder |
| Appearance | Colourless to Yellow |
| Half Life | / |
| Solubility | Chloroform (Sparingly), Methanol (Slightly) |
| Storage Condition | −20°C |
| Application | Potent, selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Occurs naturally in broccoli. It was found to inhibit chemically induced mammary tumor formation in rats. Antitumor agent. Sulforaphane is reported to a small study to alleviate the symptoms associated with autism. |
| Testing Document | Available |
Sulforaphane Powder General Description
Sulforaphane, that is isolated from the seeds of Brassica oleracea L. var. botrytis L, is a cruciferous vegetable-derived isothiocyanate with promising chemopreventive and therapeutic activities. Sulforaphane powder has antitumor effects against bladder cancer cells through an ROS-mediated intrinsic apoptotic pathway, and suggest that ER stress and Nrf2 may represent strategic targets for Sulforaphane-induced apoptosis. Sulforaphane might exert a significant neuroprotective effect on cholinergic deficit and cognitive impairment. Broccoli sprouts contain large amounts of sulforaphane, which is also found in other cruciferous vegetables including cabbage and kale.
Sulforaphane Powder (4478-93-7) History
Sulforaphane powder is an isothiocyanate present naturally in widely consumed vegetables; has shown anticancer and cardioprotective activities.
In Vitro:Sulforaphane induces a cell cycle arrest in a dose-dependent manner, followed by cell death. This sulforaphane-induced cell cycle arrest was correlated with an increased expression of cyclins A and B1. Sulforaphane induces cell death via an apoptotic process. Sulforaphane inhibits the reinitiation of growth and diminishes cellular viability in quiescent colon carcinoma cells (HT29) and has a lower toxicity on differentiated CaCo2 cells. Pre-treatment of H9c2 rat myoblasts with sulforaphane decreases the apoptotic cell number and the expression of pro-apoptotic proteins (Bax, caspase-3 and cytochrome c), as well as the doxorubicin-induced increase in mitochondrial membrane potential. Furthermore, sulforaphane increases the mRNA and protein expression of heme oxygenase-1, which consequently reduces the levels of reactive oxygen species (ROS, measured using MitoSOX Red reagent) in the mitochondria which are induced by doxorubicin.
In Vivo:Sulforaphane can block the formation of ammary tumors in Sprague-Dawley rats treated with single doses of 9,10-dimethyl-1,2-benzanthracene. Administration of sulforaphane reduces the incidence, multiplicity, and weights and delays the development of the mammary tumors evoked by a single dose of DMBA in female Sprague-Dawley rats.
Sulforaphane Powder Mechanism Of Action
Biochem/physiol Actions
Selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli.
Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables.It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.
Sulforaphane Powder (4478-93-7) Application
Sulforaphane can prevent skin cancer when applied directly to the skin. Sulforaphane is a Potent, selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Occurs naturally in broccoli. It was found to inhibit chemically induced mammary tumor formation in rats. Antitumor agent.
Sulforaphane is reported to a small study to alleviate the symptoms associated with autism.
Sulforaphane Powder (4478-93-7) More research
Sulforaphane exhibits anticancer, antidiabetic, and antimicrobial properties in experimental models. It is obtained from cruciferous vegetables such as broccoli, Brussels sprouts or cabbages. The enzyme myrosinase transforms glucoraphanin, a glucosinolate, into sulforaphane upon damage to the plant (such as from chewing). Young sprouts of broccoli and cauliflower are particularly rich in glucoraphanin.
Sulforaphane Powder (4478-93-7) Reference
- Kunugi A, Tajima Y, Kuno H, Sogabe S, Kimura H. HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production. J Pharmacol Exp Ther. 2018 Mar;364(3):377-389. doi: 10.1124/jpet.117.245050. Epub 2018 Jan 3. PubMed PMID: 29298820.
- Zhang, Y., et al.: Proc. Natl. Acad. Sci. USA, 89, 2399 (1992), Shikita, M., et al.: Biochem. J., 341, 725 (1999), Wittich, S., et al.: J. Med. Chem., 45, 3296 (2002), Lee, J., et al.: Cancer Lett., 224, 171 (2005); Chem. and Eng. News, p 11, Oct. 20 (2014)
- Gamet-Payrastre L, et al. Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res. 2000 Mar 1;60(5):1426-33.
- Li B, et al. Sulforaphane prevents doxorubicin-induced oxidative stress and cell death in rat H9c2 cells. Int J Mol Med. 2015 Jul;36(1):53-64. [3]. Zhang Y, et al. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornylisothiocyanates. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3147-50.
- 2020 Glucoraphanin Vs. Sulforaphane: The Best Antioxidant and Key Nutrient In Broccoli
