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Taxifolin (dihydroquercetin) powder 480-18-2

Taxifolin (3,5,7,3,4-pentahydroxy flavanone or dihydroquercetin) powder is a flavonoid commonly found in onion, milk thistle, French maritime pine bark and Douglas fir bark.There is evidence that taxifolin protects bmMSCs from ⋅OH-induced damage and inhibits free radical formation at key stages of apoptosis in cellular mitochondria . It was reported that taxifolin displayed anticancer and neuroprotective properties.

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Taxifolin (dihydroquercetin) powder Chemical Base Information

Name Taxifolin (dihydroquercetin)
CAS 480-18-2
Purity 98%
Chemical name 5,7,3′,4′-flavan-on-ol
Synonyms Dihydroquercetin

Taxifoliol

Distylin

(+)-Taxifolin

trans-Dihydroquercetin

(+)-Dihydroquercetin

Molecular Formula C15H12O7
Molecular Weight 304.25
Boling Point /
InChI Key CXQWRCVTCMQVQX-LSDHHAIUSA-N
Form powder
Appearance yellow
Half Life /
Solubility (±)-Taxifolin has a solubility of approximately 0.5 mg/ml in a 1:1 solution of DMSO:PBS (pH 7.2) using this method.
Storage Condition RT
Application dietary supplements ingredient
Testing Document Available

 

Taxifolin (dihydroquercetin) powder 480-18-2 History

Raw Taxifolin is a powerful flavonoid.

In the mid-1950s, scientists first isolated this compound and described taxifoline or dihydroquercetin, which is chemically analogous to quercetin or rutin, but with slightly different properties.

 

Taxifolin (dihydroquercetin) powder 480-18-2 Mechanism Of Action

Taxifolin is not mutagenic and less toxic than the related compound quercetin. It acts as a potential chemopreventive agent by regulating genes via an ARE-dependent mechanism.Taxifolin has shown to inhibit the ovarian cancer cell growth in a dose-dependent manner.However, in this same study, taxifolin was the least effective flavonoid in the inhibition of VEGF expression.There is also a strong correlation (with a correlation coefficient of 0.93) between the antiproliferative effects of taxifolin derivatives on murine skin fibroblasts and human breast cancer cells.

Taxifolin has shown to have anti-proliferative effects on many types of cancer cells by inhibiting cancer cell lipogenesis. By inhibiting the fatty acid synthase in cancer cells, taxifolin is able to prevent the growth and spread of cancer cells.

The capacity of taxifolin to stimulate fibril formation and promote stabilization of fibrillar forms of collagen can be used in medicine. Also taxifolin inhibited the cellular melanogenesis as effectively as arbutin, one of the most widely used hypopigmenting agents in cosmetics. However, arbutin acts as quercetin extremely mutagenic, carcinogenic and toxic.

 

Taxifolin (dihydroquercetin) powder 480-18-2 Application

Taxifolin (dihydroquercetin) powder has been shown to have very good effects on some changes in the body’s cells, especially those that are not desirable. Nearly 600 studies have been published – most of them in Russia, and they talk about the positive effects of taxifolin, a powerful flavonoid derived from Siberian larch. So, what are the benefits of Taxifolin (dihydroquercetin) in dietary supplements and medical?

Taxifolin (Dihydroquercetin) is a potent flavonoid that can also be found and buy on the market in a raw powder form.

Much effort is put into verifying and demonstrating the action of dihydroquercetin – the main areas of this type of research are mainly the following:

Effect of taxifolin on inflammatory mediators and diseases such as cancer.

Effect of taxifoline and myeloperoxidase removal effect

Effect of taxifolin on dermal fibroblast damage

Effect of taxifoline on the regulation of collagenase I in UVB-treated skin cells

Effect of taxifolin on cells and its potential cytoprotective effect

General data from a number of studies suggest that: quercetin,  taxifolin (Dihydroquercetin), and quercitrin may benefit in slowing skin aging in humans.

 

Other Taxifolin benefits in medical and dietary supplements may include:

  1. Taxifolin (Dihydroquercetin)is a powerful flavonoid

It was in the mid-1950s that scientists for the first time extracted and described taxifolin, or dihydroquercetin, which is an analogue of quercetin or rutin but with somewhat different properties. It displays vitamin P activities, boosting vascular membranes and reducing allergic and inflammatory reactions, and also has many properties not shared by the majority of other bioflavonoids. Taxifolin therefore exerts a much more potent antioxidant effect than most flavonoids.

 

  1. Taxifolin (Dihydroquercetin)inhibits oxidative stress and inflammation

Taxifolin or Dihydroquercetin has been shown to be a powerful neutraliser of free radicals, capable of destroying two of the most dangerous forms present in the human body: the superoxide and peroxide radicals. It also works to protect red and white blood cells. Studies show that it protects white blood cells from environmental damage, and that in red blood cells it prevents oxidative cell death.

 

  1. Taxifolin (Dihydroquercetin)beneficial in the treatment of cancer

Numerous studies have shown that taxifolin has the ability to restrict the growth of cancer cell lines. Breast cancer cells and ovarian cancer cells are two types of malignancies that taxifolin has demonstrated the potential to kill.

 

  1. Taxifolin (Dihydroquercetin)dietary supplement effects relate to COVID Pneumonia

Russian researchers are investigating the effects of the dietary supplement Taxifolin on people recovering from COVID-related pneumonia. Launched in 2021, this clinical trial involves the use of 30 milligrams (mg) daily of Taxifolin Aqua for 100 patients. The researchers hope to elucidate how the dietary supplement could impact respiratory function, the condition of the arterial wall, and overall quality of life.

 

  1. Taxifolin (Dihydroquercetin)benefits on hypertension

Taxifolin has various properties likely to be of benefit to those with hypertension. Clinical studies have shown that it improves the elasticity of erythrocytes such that they are able to easily penetrate even the most delicate blood vessels. Elevations in pressure no longer occur as a matter of course and thus the risk of stroke is drastically reduced. Taxifolin also decreases blood viscosity and improves microcirculation at capillary level.

 

Various studies have been conducted in this context in Russia. Taxifolin’s effects were investigated in two groups of 40 patients with neuro-circulatory asthenia (a form of tachycardia) with hypertonia and arterial hypertension. While both groups were given a hypotensive, the second group also received an additional daily dose of 40mg of taxifolin. In the first group, a clear hypotensive effect was observed between the third and fourth days of treatment but 17% of participants needed an increase in their dose of medication. The same hypotensive effect was seen in the second group but sooner – between the first and second days of treatment – and none of this group needed their medication increased.

 

  1. Taxifolin (Dihydroquercetin)beneficial in the treatment of cerebrovascular disease

Taxifolin supplementation was shown to improve certain problems, particularly headaches, insomnia, asthenic and vascular-vegetative problems as well as vertigo. Improvements were more significant in patients with encephalopathy linked to stroke-associated posterior vascular problems. It also reduced emotional lability, irritability, anxiety, low mood, hypochondria and fixation on personal feelings. Again, with the exception of low mood and hypochondria, these improvements were greater in stroke patients. Indices of intellectual memory activity were better in two thirds of patients following administration of taxifolin, as were concentration and attention. Patients’ memory improved by 70% and volume of operational memory increased in 66.7% of cases.

The data obtained from studies on middle-aged patients with discirculatory encephalopathy shows that taxifolin exerts moderate effects in relation to the central mechanisms of functional vegetative and psycho-emotional regulation.

Two clinical studies were conducted on 52 patients to evaluate the effects of 21 days’ administration of taxifolin combined with vitamin C on patients with cerebral circulation problems. The supplementation resulted in decreased blood viscosity and clot-forming tendencies, improved memory, attention and mental performance, reduced vertigo, normalised sleep patterns, relief from headaches and less fatigue. No such changes were observed in a placebo group.

 

Taxifolin (Dihydroquercetin) other health benefits and uses

-Taxifolin and cardiovascular disease, taxifolin inhibited peroxidation of serum and hepatic lipids following toxic ionising radiation.

-Prevents complications of diabetes,taxifolin inhibits the pro-inflammatory activity of neutrophils in type 2 diabetics and may therefore help protect the vascular system from the disease’s harmful effects.

-Maintains a healthy central nervous system,Taxifolin offers essential protection to the brain and neurons.

-Protection against liver damage and hepatitis, due to Taxifolin significant antioxidant potency, taxifolin may protect the liver against exposure both to these toxins and as well as to viruses.

-Boosts the immune system,studies suggest that taxifolin may help combat serious infections such as pneumonia or HIV.

 

Taxifolin (dihydroquercetin) powder 480-18-2 More research

Taxifolin (dihydroquercetin) Vs Quercetin: Which one is powerful? Is Taxifolin the same as quercetin?

1. The first difference between quercetin and dihydroquercetin is that they tend to come from different plant sources.Taxifoline (dihydroquercetin) and Quercetin are both flavonoids. Flavonoids are plant pigments found in many foods and plants such as citrus plants, tea, red wine, richly colored berries, and even dark chocolate. They can even make vitamin C even more potent and longer lasting in the body.

Flavonoids comprise about 60% of the 8,000 known polyphenols, the plant compounds that act as antioxidants in your body, fighting harmful free radicals. Without enough antioxidants protection to neutralize excess free radicals, they can damage your cells.

Quercetin is found in the bitter, fuzzy inner rind of citrus fruits, other fruits like cherries and apples, vegetables like kale and broccoli, seeds, grains, and red onions. Dihydroquercetin, also known as taxifolin, is commonly found in onions, milk thistle, grapes, green tea, olive oil, and the tree bark of some conifers.

2. The second biggest difference between Taxifolin (dihydroquercetin)and quercetin is that they have different chemical makeups. Dihydroquercetin has two additional atoms of hydrogen per molecule, which makes it a more powerful antioxidant, according to pre-clinical studies.

3. Taxifolin (dihydroquercetin)is not mutagenic and less toxic than the quercetin. It acts as a potential chemopreventive agent by regulating genes via an ARE-dependent mechanism. Taxifolin has shown to inhibit the ovarian cancer cell growth in a dose-dependent manner.

 

What are the side effects of Taxifolin (dihydroquercetin)?

Despite the health benefits of taxifolin, side effects may also occur in some people, especially those who take the flavonoid as a dietary supplement. The side effects of taxifolin may include:

-Abdominal pain

-Nausea and diarrhea

-Rash or contact dermatitis

-Increased risk of blood clots and bleeding (in some people)

Consult with your doctor before taking taxifolin supplements.

 

How do Vitamin C and Taxifolin Dihydroquercetin work together?

Taxifolin boosts the beneficial effects of vitamin C by increasing the duration of its biological activity, stimulating its regeneration and slowing down its elimination from the body. In Russia, a complex of taxifolin and vitamin C is a popular treatment for many diseases where oxidative stress is the underlying mechanism.

 

Buy Taxifolin (dihydroquercetin) powder online

Taxifolin (dihydroquercetin) is a bioflavonoid with potent anti-inflammatory and antioxidant effects. The flavonoid is found in foods and beverages like wine, tea, cocoa and vinegar, alongside many fruits and vegetables. Taxifolin  may serve a number of health purposes as an anti-inflammatory and anticancer agent.

Taxifolin (dihydroquercetin) can be found and buy on the market in a raw powder form. Wisepowder has capability to produce and supply large quantity of Taxifolin (Dihydroquercetin) powder. Wisepowder has independent lab and

professional scientific research team, strict quality management system, equipped with imported advanced instruments from Germany, Japan and U.S. for analysis and synthesis of the content of active ingredients, guarantee the best quality products and service. You are welcome contact to discuss more details and build long time cooperation.

 

Taxifolin (dihydroquercetin) powder 480-18-2 Reference

  1. 1. Angelis A, et al. Bio-Guided Isolation of Methanol-Soluble Metabolites of Common Spruce (Picea abies) Bark by-Products and Investigation of Their Dermo-Cosmetic Properties. Molecules. 2016 Nov 21;21(11):1586.
  2. Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radic. Biol. Med. 20, 933 (1996), (Review), Abstract;
  3. Lei Ren, et al. Dissecting Efficacy and Metabolic Characteristic Mechanism of Taxifolin on Renal Fibrosis by Multivariate Approach and Ultra-Performance Liquid Chromatography Coupled With Mass Spectrometry-Based Metabolomics Strategy. Front Pharmacol. 2021 Jan 14;11:608511.
  4. Suppression of hydroperoxide-induced cytotoxicity by polyphenols: T. Nakayama; Cancer Res. 54, 1991s (1994), Abstract;Suppression of active oxygen-induced cytotoxicity by flavonoids: T. Nakayama, et al.; Biochem. Pharmacol. 45, 265 (1993), Abstract;
  1. Luo, Haitao; Jiang, Bing-Hua; King, Sarah; Chen, Yi Charlie (2008). “Inhibition of Cell Growth and VEGF Expression in Ovarian Cancer Cells by Flavonoids”. Nutrition and Cancer. 60 (6): 800–9. doi:10.1080/01635580802100851. PMID 19005980. S2CID 43576449