Chrysin powder (480-40-0) video

Chrysin powder Base Information

What is Chrysin?

Chrysin, also called 5,7-dihydroxyflavone, is a flavonoid found in honey, propolis, and a few species of passion flowers. It is also found in carrots, silver linden, some geranium species, and chamomile. Chrysin has multiple therapeutic effects and works as an antioxidant and anti-inflammatory substance. It also has antiviral and anticancer properties. It is extracted from various plants, especially the blue passionflower (Passiflora caerulea).

Chrysin, however, has low bioavailability and chance of rapid excretion in the human body. Hence it is poorly absorbed by the body. Chrysin needs to be taken in higher doses to get the maximum effects.

How Does Chrysin Work?

Chrysin is a type of flavonoid. Flavonoids are natural pigments found in plants, fruits, vegetables, and honey. They help to regulate cellular activity and help to get rid of the radicals that can cause oxidative stress in the body. They may also possess antimicrobial properties.

Chrysin has got anti-inflammatory and antioxidant properties. Chrysin mainly decreases cell proliferation, induces cell death by apoptosis in cancer cells, and reduces inflammation.

Its anti-inflammatory actions are connected to the inflammatory cytokine regulation, most probably due to the inhibition of cytokines such as IFN-c and TNF-α. It does this by activating the macrophages via the NF-κB pathway. Chrysin may also inhibit the levels of major inflammatory cytokines such as prostaglandin-E2, COX-2, and the activity of NO and the iNOS plasma level.

Chrysin also has antioxidative properties. Antioxidants are substances that can prevent damage to the cells caused by various free radicals. Chrysin prevents the damage done by the free radicals in the body [1].

It has also been shown to improve the status of lipid peroxidases and antioxidants, especially during carcinogenesis. It can inhibit the growth of tumors via apoptosis by activating the Notch1 signaling pathway [2].

Chrysin’s ability to increase the levels of testosterone in the human body seems to be a misleading claim as it has been shown that it does not have such effects. Hence its use as a testosterone enhancing product in body building must be reviewed [3].

Natural sources of chrysin are mint plant, bee glue or propolis, honey, passionflower, and oyster mushrooms.

Benefits of Chrysin

Chrysin does not have enough evidence to show its complete effects on the body. However, several studies have shown that chrysin has potential health benefits.

Some of the health benefits of Chrysin are:

Neuroprotective Effect

Chrysin may help in protecting the nerves from degeneration due to old age and toxins. This is largely due to its antioxidant properties [4]. It has shown to be effective in treating inflammation of the nerves caused by hyperammonemia.

Effect on Prostate Cancer

Chrysin can reduce proliferation and induce cell death in cancer cells in prostate cancer [5]. Hence, it may be a useful measure to treat this condition.

Cardiovascular Effects

Chrysin can decrease lipid synthesis and can increase the bioavailability of nitric oxide (NO). So it can help in modulating vascular function. It may also inhibit the development of atherosclerosis by decreasing the inflammation in the vessels. Thus, it may help in preventing and treating cardiovascular diseases [6].

Effect on Kidneys

Chrysin has been shown to reduce renal damage due to medications and toxins. A study conducted on cisplatin-induced nephrotoxicity in rats showed that using chrysin in these test subjects helped to increase their renal functions [7]. Thus, chrysin may have a nephroprotective function as well.

Hepatoprotective Effect

A study conducted on the mice with liver damage caused by carbon tetrachloride (CCl4) showed that using chrysin on these test subjects improved their hepatic function and reduced the liver enzymes that are the biomarkers of hepatic function [8]. Thus, chrysin has got hepatoprotective abilities.

Effects on Asthma

Chrysin has shown to be effective in treating bronchoalveolar hyperresponsiveness in ovalbumin (OVA) induced rats [9]. It was able to reduce the inflammation in the lungs and relieve the symptoms. This may be because of the alteration of Th1/Th2 polarization due to the suppression of inducible nitric oxide synthase, nuclear factor-κB, and activation protein. Hence, chrysin may also help in treating asthma as well.

Effects on Diabetes

Chrysin may be able to decrease the effects of diabetes. It may also help to treat the complications due to diabetes [10].

Effects as Antioxidant

Chrysin’s antioxidant properties may help to counteract the effects of aging, cell damage due to toxins and pollutants, etc. This may even help in treating skin and hair conditions.

Effect on Anxiety

Chrysin may be able to treat anxiety due to its anxiolytic-like effects. A study showed that giving chrysin to post-surgical menopausal rats with anxiety-like symptoms can help to decrease their symptoms [11]. This may be because of its effect on the GABAA receptors.

Effect on Estrogen

One of the properties of chrysin is that it can decrease the levels of estrogen in the body by suppressing the enzyme aromatase (CYP19) [12]. This means it may help inhibit the aromatase enzyme and thus help in preventing and treating hormone-dependent breast cancer. It may also work in treating estrogen-dependent diseases.

Side Effects of Chrysin

There have been no reported events about the side effects of using chrysin powder up to now.

Who Should Avoid Chrysin?

There are some conditions where chrysin should be avoided. This is because the effects of this drug on patients with these conditions are not well established.

Some of these conditions are:

In pregnancy and lactating mothers — Since there is not enough information about the effects of Chrysin in pregnant and lactating mothers, it is best to avoid use during these times.

Bleeding disorders —  There are some concerns that chrysin may aggravate bleeding in those with bleeding disorders.

Surgery — There is a possibility that chrysin may slow down blood clotting in the body. So it may be a good thing to avoid it for at least 2 weeks before surgery.

Drugs That Can Interact With Chrysin

There are some medications that may interact with chrysin.

They are:

Aromatase Inhibitors

These medications include aminoglutethimide, anastrozole, exemestane, letrozole, etc. These are used in treating estrogen-sensitive cancers, which get affected by the levels of estrogen in the body. Aromatase inhibitors decrease the levels of estrogen in the body. This same property is exhibited by chrysin powder as well. Hence, taking these medications with chrysin could lead to the body level of estrogen decreasing rapidly, causing several side effects.

Glucuronidated Drugs

These are medications that get metabolized by the liver. Chrysin powder could hasten the rate of metabolism of these drugs, causing them to last for a shorter duration in the body. This action could lead to less effectiveness of these drugs. Glucuronidated drugs include acetaminophen, atorvastatin, diazepam, digoxin, entacapone, estrogen, irinotecan, lamotrigine, lorazepam, lovastatin, meprobamate, morphine, oxazepam, etc.

Cytochrome P450 1A2 (CYP1A2) Substrates

Chrysin could lower the metabolic rate of these medications, causing them to last for a longer time in the body. This action could cause the level of these drugs in the bloodstream to rise and stay that way for a longer time, leading to more side effects. These medications include clozapine, cyclobenzaprine, fluvoxamine, haloperidol, imipramine, mexiletine, olanzapine, propranolol, theophylline, etc.

Dosage of Chrysin

A daily dosage of 0.5 to 3g chrysin powder is considered safe. However, this may alter according to the condition and needs of the user.

Where Can You Buy Chrysin?

You can buy chrysin directly from the chrysin powder manufacturer company. It comes in packages of 1kg per packet or 25kg per drum. However, customization of the order is possible according to your need. This product is made with the best ingredients. It is produced under strict guidelines and using proper safety measures. This drug needs to be stored at a room temperature, away from direct sunlight and humidity, in an airtight container. This is to prevent it from interacting with other chemicals in the environment.

References

1. Mani, R., & Natesan, V. (2018). Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action. Phytochemistry, 145, 187-196. https://pubmed.ncbi.nlm.nih.gov/29161583/
2. Yu, X. M., Phan, T., Patel, P. N., Jaskula‐Sztul, R., & Chen, H. (2013). Chrysin activates Notch1 signaling and suppresses tumor growth of anaplastic thyroid carcinoma in vitro and in vivo. Cancer, 119(4), 774-781. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528831/
3. Gambelunghe, C., Rossi, R., Sommavilla, M., Ferranti, C., Rossi, R., Ciculi, C., … & Rufini, S. (2003). Effects of chrysin on urinary testosterone levels in human males. Journal of medicinal food, 6(4), 387-390. https://pubmed.ncbi.nlm.nih.gov/14977449/
4. Mani, R., Natesan, V., & Arumugam, R. (2017). Neuroprotective effect of chrysin on hyperammonemia mediated neuroinflammatory responses and altered expression of the astrocytic protein in the hippocampus. Biomedicine & Pharmacotherapy, 88, 762-769. https://www.sciencedirect.com/science/article/abs/pii/S0753332216320480
5. Samarghandian, S., Afshari, J. T., & Davoodi, S. (2011). Chrysin reduces proliferation and induces apoptosis in the human prostate cancer cell line pc-3. Clinics, 66, 1073-1079. https://www.scielo.br/j/clin/a/KKS4gNtfLkMdT9RZzbwRkJF/?lang=en
6. Farkhondeh, T., Samarghandian, S., & Bafandeh, F. (2019). The cardiovascular protective effects of chrysin: a narrative review on experimental researches. Cardiovascular & Hematological Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Cardiovascular & Hematological Agents), 17(1), 17-27. https://pubmed.ncbi.nlm.nih.gov/30648526/
7. Sultana, S., Verma, K., & Khan, R. (2012). Nephroprotective efficacy of chrysin against cisplatin-induced toxicity via attenuation of oxidative stress. Journal of Pharmacy and Pharmacology, 64(6), 872-881.
8. Hermenean, A., Mariasiu, T., Navarro‑González, I., Vegara‑Meseguer, J., Miuțescu, E., Chakraborty, S., & Pérez‑Sánchez, H. (2017). Hepatoprotective activity of chrysin is mediated through TNF-α in chemically-induced acute liver damage: An in vivo study and molecular modeling. Experimental and therapeutic medicine, 13(5), 1671-1680. https://www.spandidos-publications.com/10.3892/etm.2017.4181
9. Wadibhasme, P. G., Ghaisas, M. M., & Thakurdesai, P. A. (2011). Anti-asthmatic potential of chrysin on ovalbumin-induced bronchoalveolar hyperresponsiveness in rats. Pharmaceutical biology, 49(5), 508-515. https://www.tandfonline.com/doi/full/10.3109/13880209.2010.521754
10. Samarghandian, S., Azimi-Nezhad, M., Samini, F., & Farkhondeh, T. (2016). Chrysin treatment improves diabetes and its complications in liver, brain, and pancreas in streptozotocin-induced diabetic rats. Canadian journal of physiology and pharmacology, 94(4), 388-393. https://pubmed.ncbi.nlm.nih.gov/26863330/
11. Rodríguez-Landa, J. F., Hernández-López, F., Cueto-Escobedo, J., Herrera-Huerta, E. V., Rivadeneyra-Domínguez, E., Bernal-Morales, B., & Romero-Avendaño, E. (2019). Chrysin (5, 7-dihydroxyflavone) exerts anxiolytic-like effects through GABAA receptors in a surgical menopause model in rats. Biomedicine & Pharmacotherapy, 109, 2387-2395. https://pubmed.ncbi.nlm.nih.gov/30551498/
12. Balam, F. H., Ahmadi, Z. S., & Ghorbani, A. (2020). Inhibitory effect of chrysin on estrogen biosynthesis by suppression of enzyme aromatase (CYP19): A systematic review. Heliyon, 6(3), e03557. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7063143/