Acacetin powder (480-44-4)

Acacetin (5,7-dihydroxy-4-methoxyflavone) is widespread throughout the Plant Kingdom, but is particularly abundant in the Asteraceae, Euphorbiaceae, Passifloraceae, Lamiaceae and Malvaceae families. It has been shown to exhibit strong inhibitory effects against glutathione reductase, cyclo-oxygenase, acetylcholinesterase, aldose reductase and xanthine oxidase enzymes.

Acacetin powder 480-44-4 Chemical Base Information

Acacetin powder 480-44-4 General Description

Acacetin powder is raw material of Acacetin, which is an O-methylated flavone naturally found in safflower seeds and several plants such as Saussurea involucrata or other members of the Asteraceae family. In primary mesencephalic culture exposed to MPP+, acacetin  was reported to protect dopaminergic cells, and this was associated with a decrease of NO, prostaglandin E2, and TNF-α . In addition, acacetin treatment administered to MPTP-lesioned mice improved motor deficits induced by MPTP and protected dopaminergic cells in the striatum and the SN. MPTP-induced increased microglia activation, as reflected by an elevation of iNOS and COX-2 expression in the striatum and the SN, was attenuated by acacetin treatment.

Acacetin powder 480-44-4 History

Acacetin(5,7-dihydroxy-4-methoxyflavone), a dietary component, is abundant in acacia honey and has superior anticancer activities. Acacetin, apigenin, chrysin, and pinocembrin are flavonoid aglycones found in foods such as parsley, honey, celery, and chamomile tea. Flavonoids can act as substrates and inhibitors of the CYP3A4 enzyme, a heme containing enzyme responsible for the metabolism of one third of drugs on the market.

Acacetin powder 480-44-4 Mechanism Of Action

Acacetin(5,7-dihydroxy-4-methoxyflavone) reduced αβ production by interfering with BACE-1 activity and APP synthesis, resulting in a decrease in the levels of the APP carboxy-terminal fragments and the APP intracellular domain. Therefore, the protective effect of acacetin on αβ production is mediated by transcriptional regulation of BACE-1 and APP, resulting in decreased APP protein expression and BACE-1 activity. Acacetin also inhibited APP synthesis, resulting in a decrease in the number of amyloid plaques.

Acacetin powder 480-44-4 Application

1.A Potential Protective Compound against Cardiovascular Diseases

Acacetin (5,7-dihydroxy-4′-methoxyflavone) is the major bioactive component of the traditional Chinese medicine “Snow lotus”. As a natural flavonoid compound, it has been shown to have good pharmacological effects such as anti-inflammatory, anticancer, and anti-obesity. Among them, its prominent role in cardiovascular diseases (CVD) has received extensive attention from scholars in recent years.

2.Superior Anticancer Activities

Acacetin (5,7-dihydroxy-4′-methoxyflavone) is a flavonoid compound with antimutagenic, antiplasmodial, antiperoxidant, anti-inflammatory and anticancer effects.

Study show that acacetin suppressed the viability of DU145 cells by inducing apoptosis. Western blot anlaysis of various markers of signaling pathways revealed that acacetin targets the Akt and nuclear factor (NF)-κB signaling pathways by inhibiting the phosphorylation of IκBα and NF-κB in a dose-dependent manner. Consistent with its ability to induce apoptosis, the acacetin-mediated inhibition of the pro-survival pathway, Akt, and of the NF-κB pathway was accompanied by a marked reduction in the levels of the NF-κB‑regulated anti-apoptotic proteins, Bcl-2 and X-linked inhibitor of apoptosis protein (XIAP), as well as of the proliferative protein, cyclooxygenase (COX)-2.

Acacetin exerts antitumor effects by targeting the Akt/NF-κB signaling pathway.

3.Potentially exerts anti-inflammatory  and antioxidative effects on sepsis

Acacetin is a natural flavonoid found in various plants, including Sparganii rhizoma, Sargentodoxa cuneata and Patrinia scabiosifolia. Sepsis is a dysregulated systemic response to infection, and no effective treatment options are available.  Studies have revealed that acacetin potentially exerts anti-inflammatory and antioxidative effects on sepsis.

4.Acacetin effects on Alzheimer’s disease

Alzheimer’s disease (AD) is a neurodegenerative disorder and the most prevalent form of dementia in developed and developing countries. Study show that acacetin has good effects on Alzheimer’s disease.

5.Anti-inflammatory/antinociceptive activities

Acacetin is a bioflavonoid with pharmacological properties such as antinociceptive/anti-inflammatory activities. However, scientific evidence of its spectrum activity and mechanisms of action is unknown. Study show that acacetin to be potentially useful in the therapy of pain-related diseases.

Reference

1.Zhao, J; Dasmahapatra, AK; Khan, SI; Khan, IA (December 2008). “Anti-aromatase activity of the constituents from damiana (Turnera diffusa)”. Journal of Ethnopharmacology. 120 (3): 387–393. doi:10.1016/j.jep.2008.09.016. PMID 18948180.

2.Valkama, E; Salminen, J-P; Koricheva, J; Pihlaja, K (2004). “Changes in leaf trichomes and epicuticular flavonoids during leaf development in three birch taxa”. Annals of Botany. 94 (2): 233–242. doi:10.1093/aob/mch131. PMC 4242156. PMID 15238348.

3.UmiKalsom, Yusuf; Harborne, Jeffrey B. (1991). “Flavonoid distribution in asplenioid ferns”. Pertanika. 14 (3): 297–300.