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HBT1 Powder (489408-02-8)

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HBT1 Powder (489408-02-8)

HBT1 powder is an AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.

Manufacture: Batch Production

Package: 1KG/bag, 25KG/drum

Category: Supplements

Description

HBT1 Powder (489408-02-8) video

HBT1 Powder (489408-02-8) Base Information

Name	HBT1 powder
CAS	489408-02-8
Purity	98%
Chemical name	2-(((5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetyl)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
Synonyms	HBT1; HBT-1; HBT 1
Molecular Formula	C16H17F3N4O2S
Molecular Weight	386.39
Melting Point	/
InChI Key	PHLXSNIEQIKENK-UHFFFAOYSA-N
Form	powder
Appearance	white to beige
Half Life	/
Solubility	DMSO: 2 mg/mL, clear
Storage Condition	0 – 4 C for short term (days to weeks), or -20 C for long term (months).
Application	AMPA receptor potentiator
Testing Document	Available

HBT1 Powder (489408-02-8) General Description

HBT1 powder is an AMPA receptor potentiator with lower agonistic effect, avoiding bell-shaped response in vitro BDNF production. It is an AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.

HBT1 Powder (489408-02-8) Reference

[1] Kunugi A, Tajima Y, Kuno H, Sogabe S, Kimura H. HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production. J Pharmacol Exp Ther. 2018 Mar;364(3):377-389. doi: 10.1124/jpet.117.245050. Epub 2018 Jan 3. PubMed PMID: 29298820.

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