HBT1 Powder (489408-02-8)
01 Overview
HBT1 powder is an AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.
02 HBT1 Powder (489408-02-8) video
03 HBT1 Powder (489408-02-8) Base Information
| Name | HBT1 powder |
| CAS | 489408-02-8 |
| Purity | 98% |
| Chemical name | 2-(((5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetyl)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide |
| Synonyms | HBT1; HBT-1; HBT 1 |
| Molecular Formula | C16H17F3N4O2S |
| Molecular Weight | 386.39 |
| Melting Point | / |
| InChI Key | PHLXSNIEQIKENK-UHFFFAOYSA-N |
| Form | powder |
| Appearance | white to beige |
| Half Life | / |
| Solubility | DMSO: 2 mg/mL, clear |
| Storage Condition | 0 – 4 C for short term (days to weeks), or -20 C for long term (months). |
| Application | AMPA receptor potentiator |
| Testing Document | Available |
04 HBT1 Powder (489408-02-8) General Description
HBT1 powder is an AMPA receptor potentiator with lower agonistic effect, avoiding bell-shaped response in vitro BDNF production. It is an AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.
05 HBT1 Powder (489408-02-8) History
06 HBT1 Powder (489408-02-8) Mechanism Of Action
07 HBT1 Powder (489408-02-8) Application
08 HBT1 Powder (489408-02-8) More research
09 HBT1 Powder (489408-02-8) Document Download
COA
10 HBT1 Powder (489408-02-8) Reference
[1] Kunugi A, Tajima Y, Kuno H, Sogabe S, Kimura H. HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production. J Pharmacol Exp Ther. 2018 Mar;364(3):377-389. doi: 10.1124/jpet.117.245050. Epub 2018 Jan 3. PubMed PMID: 29298820.