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HBT1 Powder (489408-02-8)

HBT1 powder is an AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.

Manufacture:  Batch Production
Package:  1KG/bag, 25KG/drum
Wisepowder has the capability to produce and supply large quantity. All production under cGMP condition and strict quality control system, all testing documents and sample available.
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HBT1 Powder (489408-02-8) video

 

HBT1 Powder (489408-02-8) Base Information

Name HBT1 powder
CAS 489408-02-8
Purity 98%
Chemical name 2-(((5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetyl)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
Synonyms HBT1; HBT-1; HBT 1
Molecular Formula C16H17F3N4O2S
Molecular Weight 386.39
Melting Point /
InChI Key PHLXSNIEQIKENK-UHFFFAOYSA-N
Form powder
Appearance white to beige
Half Life /
Solubility DMSO: 2 mg/mL, clear
Storage Condition 0 – 4 C for short term (days to weeks), or -20 C for long term (months).
Application AMPA receptor potentiator
Testing Document Available

 

HBT1 Powder (489408-02-8) General Description

HBT1 powder is an AMPA receptor potentiator with lower agonistic effect, avoiding bell-shaped response in vitro BDNF production. It is an AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.

 

HBT1 Powder (489408-02-8) Reference

[1] Kunugi A, Tajima Y, Kuno H, Sogabe S, Kimura H. HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production. J Pharmacol Exp Ther. 2018 Mar;364(3):377-389. doi: 10.1124/jpet.117.245050. Epub 2018 Jan 3. PubMed PMID: 29298820.
 

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