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HBT1 Powder (489408-02-8) video
HBT1 Powder (489408-02-8) Base Information
Name | HBT1 powder |
CAS | 489408-02-8 |
Purity | 98% |
Chemical name | 2-(((5-Methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetyl)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide |
Synonyms | HBT1; HBT-1; HBT 1 |
Molecular Formula | C16H17F3N4O2S |
Molecular Weight | 386.39 |
Melting Point | / |
InChI Key | PHLXSNIEQIKENK-UHFFFAOYSA-N |
Form | powder |
Appearance | white to beige |
Half Life | / |
Solubility | DMSO: 2 mg/mL, clear |
Storage Condition | 0 – 4 C for short term (days to weeks), or -20 C for long term (months). |
Application | AMPA receptor potentiator |
Testing Document | Available |
HBT1 Powder (489408-02-8) General Description
HBT1 powder is an AMPA receptor potentiator with lower agonistic effect, avoiding bell-shaped response in vitro BDNF production. It is an AMPA-R [alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor] potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate dependent manner.
HBT1 Powder (489408-02-8) Reference
[1] Kunugi A, Tajima Y, Kuno H, Sogabe S, Kimura H. HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production. J Pharmacol Exp Ther. 2018 Mar;364(3):377-389. doi: 10.1124/jpet.117.245050. Epub 2018 Jan 3. PubMed PMID: 29298820.
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