Diosmetin powder

Diosmetin powder (520-34-3) video

Diosmetin Base Information

What is Diosmetin?

Diosmetin is a type of flavone. It belongs to the O-methylated flavonoids class. It is naturally found in citrus fruits. Its IUPAC name is 5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one. Diosmetin was initially identified from the plant Amphilophium crucigerum.

Diosmetin has uses as an anticancer medication. It also has antioxidant and anti-inflammatory properties. It can also help to preserve cognition and memory in neurodegenerative conditions.

Natural sources of diosmetin are citrus fruits like oranges, mandarins, lemons, grapefruits, etc.

How Does Diosmetin Work?

Diosmetin is formed when a compound called diosmin gets hydrolyzed to the aglycone form by the intestinal flora. This action occurs to make it easier for its absorption in the body. It also works as a weak TrkB receptor agonist.

Hence, diosmin is a flavone glycoside of diosmetin. It is used to treat different blood vessel disorders such as hemorrhoids, varicose veins, venous stasis, hemorrhage, etc.

One of diosmetin’s properties is its ability to work against cancer cells. Different tumors are known to express an excess amount of CYP1 family enzymes of cytochrome P450. Diosmetin gets converted to luteolin in HepG2 cells after 12 and 30hr of incubation in the presence of CYP1A inhibitor alpha-naphthoflavone. Luteolin is much more effective as it is cytotoxic. The antiproliferative effect of diosmetin in HepG2 cells can block the G2/M phase of the cell cycle. Along with this, there is also the up-regulation of the phospho-extracellular-signal-regulated kinase (p-ERK), phospho-c-jun N-terminal kinase, p53, and p21 proteins. Hence, diosmetin is capable of showing anticancer abilities.

Diosmetin is capable of suppressing CYP1A1 and CYP1B1. These two extrahepatic enzymes are carcinogenic and cause cancer progression.

Diosmetin can also work in treating osteoporosis by affecting the survival of osteoblasts. Diosmetin can cause differentiation in the osteoblasts, and this may help in treating the condition of osteoporosis.

History of Diosmetin

Diosmetin’s research began after its precursor diosmin was isolated from figwort in the 1920s. Diosmin was introduced as a medication in 1969. Then in the 1960s, it was discovered that this flavone glycoside can help in the treatment of vascular diseases. Currently, there is a great interest in the therapeutic potential of this drug. It may be a possible alternative treatment for certain cancers.

Diosmetin has not received approval for use from the FDA. However, it is available as a food additive and supplement. It can be bought as an over-the-counter supplement without prescription.

Benefits of Diosmetin

There are several uses of diosmetin. Most of these uses are still under study and have not been finalized yet. However, diosmetin has been showing plenty of potential to be a standard treatment in dealing with various conditions and diseases.

The benefits of diosmetin are:

Effect on Cancer

Diosmetin is capable of halting the progress of cell growth and development especially those of the cancer cells. It is effective in stopping the progression and growth of cancer cells [1]. It can convert the enzymes CYP1A1 and CYP1B1 into the flavone luteolin. These are enzymes that can contribute to the development of cancer. By stopping the enzymes that are needed for the cancer cells to proliferate and grow, diosmetin can halt the progression of cancer. Hence, diosmetin has the potential to be used as an anticancer drug.

Effect as Antioxidant

Diosmetin also has antioxidant properties.Oxidation and the actions of various radicals in the body are responsible for aging and development of various diseases. Diosmetin has been shown to have antiradical properties, thus tackling the oxygen-free radicals that occur in the process of oxidation in the body [2]. It also has effects as a chelating agent, especially as an iron-chelating agent. It has also been shown to have cytoprotective properties. Hence, diosmetin has a chance of being used as an antioxidant in clinical practice.

Effect on Dyslipidemia

Diosmetin and diosmin can reduce the effects of hyperlipidemia. A study was conducted where mice fed a high sucrose diet were treated with diosmetin and diosmin [3]. The results showed that there was a decrease in body weight of the test subjects. Diosmetin even reduced the lipid levels in these mice with hyperlipidemia. Thus, they are capable of decreasing the fat accumulation in the liver and epididymal tissues. They are also capable of improving glucose intolerance by lowering glucose levels. They are more effective when taken together, with diosmin having better abilities as an antidyslipidemic.

Effects on Cognitive and Memory Impairment

Diosmetin can lessen cognitive and memory impairment. A study was conducted on mice with unpredictable stress [4]. They were supplied with diosmetin and reviewed after 28 days. It showed that using diosmetin helped to improve serum corticosterone levels and provide more antioxidants to the brain. This means diosmetin could help as a memory-enhancing substance.

Effects on Alzheimer’s disease

Diosmetin and diosmin are effective in Alzheimer’s disease. Diosmetin has shown to be able to reduce the pathology caused by amyloid-beta (Aβ) in mice with Alzheimer’s disease [5]. Diosmetin  can reduce the levels of cerebral amyloid-beta levels, tau-hyperphosphorylation, and cognitive impairment. So it may be able to slow down the effects of Alzheimer’s disease.

Effects on Skin Disorders

Diosmetin has shown to be effective in decreasing the effects of atopic dermatitis. Its anti-inflammatory properties may assist in decreasing the cytokines that are raised in this condition [6]. Hence, it may be an effective treatment for inflammatory skin diseases.

Effect on Bones

Diosmetin is effective in strengthening the bones. It is capable of preventing osteoporosis by facilitating osteoblast differentiation [7]. This differentiation occurs in MG-63 and hFOB cells. It also increases the secretions of osteocalcin. It also helps in the synthesis of type I collagen. So diosmetin could help to prevent bone loss and osteoclastogenesis.

Effect on Cardiovascular System

Diosmetin also shows antiplatelet abilities. It can suppress platelet activation and may help in treating various cardiovascular diseases [8].

Side Effects of Diosmetin

• Stomach upset
• Diarrhea
• Dizziness
• Headache
• Skin redness
• Hives
• Hypersensitivity to Diosmetin
• Muscle pains
• Abnormal heart rate

Drug Interactions With Diosmetin

There are no known reports of drug interactions with diosmetin to date.

The effects of diosmetin on users with specific conditions and diseases are not known.

In pregnancy and breastfeeding women, it is best to not use this supplement as there is no research about diosmetin’s effects on pregnant and breastfeeding mothers.

Dosage of Diosmetin

The dosage of diosmetin powder is about 1000mg per day. However, it can reach a maximum dosage of 3000mg per day, depending on the condition.

Where to buy Diosmetin in 2021?

You can buy diosmetin powder directly from the diosmetin powder manufacturers company. It is available in a solid form as a light yellow to yellow colored powder. It is packed in a package of 1 kg per packet and 25kg per drum. However, this can be customized according to the needs of the buyer.

It needs to be stored at a temperature of 2 to 8°C. It needs a cold, dark, and dry place for storage. This is to prevent it from reacting with other chemicals in the environment. This product is made from the best ingredients following proper protocols under strict observation.

References Cited

1. Androutsopoulos, V. P., Mahale, S., Arroo, R. R., & Potter, G. (2009). Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 breast cancer cells due to CYP1 activation. Oncology reports, 21(6), 1525-1528.
2. Morel, I., Lescoat, G., Cogrel, P., Sergent, O., Pasdeloup, N., Brissot, P., … & Cillard, J. (1993). Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin, and diosmetin on iron-loaded rat hepatocyte cultures. Biochemical pharmacology, 45(1), 13-19.
3. Chung, S., Kim, H. J., Choi, H. K., Park, J. H., & Hwang, J. T. (2020). Comparative study of the effects of diosmin and diosmetin on fat accumulation, dyslipidemia, and glucose intolerance in mice fed a high‐fat high‐sucrose diet. Food Science & Nutrition, 8(11), 5976-5984.
4. Saghaei, E., Nasiri Boroujeni, S., Safavi, P., Borjian Boroujeni, Z., & Bijad, E. (2020). Diosmetin Mitigates Cognitive and Memory Impairment Provoked by Chronic Unpredictable Mild Stress in Mice. Evidence-Based Complementary and Alternative Medicine, 2020.
5. Sawmiller, D., Habib, A., Li, S., Darlington, D., Hou, H., Tian, J., … & Tan, J. (2016). Diosmin reduces cerebral Aβ levels, tau hyperphosphorylation, neuroinflammation, and cognitive impairment in the 3xTg-AD mice. Journal of neuroimmunology, 299, 98-106.
6. Lee, D. H., Park, J. K., Choi, J., Jang, H., & Seol, J. W. (2020). Anti-inflammatory effects of natural flavonoid diosmetin in IL-4 and LPS-induced macrophage activation and atopic dermatitis model. International Immunopharmacology, 89, 107046.
7. Hsu, Y. L., & Kuo, P. L. (2008). Diosmetin induces human osteoblastic differentiation through the protein kinase C/p38 and extracellular signal‐regulated kinase 1/2 pathway. Journal of Bone and Mineral Research, 23(6), 949-960.
8. Zaragozá, C., Monserrat, J., Mantecón, C., Villaescusa, L., Álvarez-Mon, M. Á., Zaragozá, F., & Álvarez-Mon, M. (2021). Binding and antiplatelet activity of quercetin, rutin, diosmetin, and diosmin flavonoids. Biomedicine & Pharmacotherapy, 141, 111867.

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