Diosmetin powder is a flavone belonging to the class of O-methylated flavonoids. The compound is an aglycone of diosmin (diosmetin 7-o-rutinoside), which presents naturally in citrus fruits such as lemons.
Diosmetin exhibits anti-cancer, anti-inflammatory, antinociceptive, and anti-oxidant properties. In the research corridors, scientists identify it as 3’,5,7-trihydroxy-4’-methoxyflavone. Both Diosmetin and chrysoeriol are methylated metabolites of luteolin. Diosmetin solubility in water is 0.075 g/L.
|Synonyms||Cyanidenon-4′-methyl ether 1479, Luteolin-4′-methyl ether|
|Molecular Weight||300.26 g/mol|
|Appearance||light yellow to yellow powder|
|Half Life||22.9 to 40.1 hours|
|Solubility||Sparingly soluble in water (<1 mg/ml). Soluble in acetonitrile, DMSO (60 mg/ml), and ethanol (17 mg/ml).|
|Application||dietary supplements, food additives|
The inception of Diosmetin powder research dates back to the 1920s, when its precursor, diosmin, was taken out of figwort. Four decades later, research scientists identified this flavone glycoside as a therapeutic agent in the treatment of vascular diseases. You should note that diosmin is a precursor of this flavanoid. However, you can distinguish their structures using diosmetin NMR analysis.
At the onset of the 21st century, the scientific interest and pharmacological values of diosmetin powder has been at the peak. Research scientists are now considering the compound to be an alternative treatment for certain cancers.
Over time, diosmetin is used as a food additive and in dietary supplements.
Cancerous tumors are responsible for the overexpression of the CYP1 enzymes.
Diosmetin powder converts to luteolin in the human cancer cell lines. This step occurs after about 12 and 30 hours after administering the drug. According to research scientists, luteolin has potent cytotoxic properties.
Diosmetin blocks the G2-M phase, leading to the upregulation of p53, p51, and p-ERK (phospho-extracellular signal-regulated kinase). These proteins are significant in tumor or and cancer suppression.
One of the diosmetin uses is in the management of various cancers such as colon, prostate, breast, hepatocellular, bladder, and urinary carcinomas. The plus of resolving to this treatment is that it is has minimal adverse effects compared with chemotherapy. What’s more, it is quite inexpensive and it will have no effect on normal cells.
Diosmetin exhibits the anti-carcinogenic effects by inducing apoptosis and holding back proliferation on cancerous cells. In the hepatocellular carcinoma cells, HepG2, diosmetin induces G2-M arrest and the expression of the P53 proteins.
For acute myeloid leukemia, treatment with disometin delayed tumor growth due to increase in cytokine TNFα and caspases 8 and 3/7, which are cofactors of apoptosis of cancerous cells.
Recent studies have confirmed the potentiality of diosmetin in strengthening of bones. Just like apigenin, this flavonoid prevents osteoporosis. It works by facilitating osteoblast differentiation in MG-63 and hFOB cells. Besides, diosmetin causes maturation in the bone marrow stromal cells.
Diosmetin increases the secretion of osteocalcin, mineralization, production of osteopontin, and synthesis of type I collagen. These factors play significant roles in bone metabolism.
Diosmetin protects the body tissues against oxidative stress by inhibiting ROS (reactive oxygen species). Just like naringenin, scientists are considering this flavonoid as an ideal therapeutic agent for managing liver diseases, which are as a result of oxidative stress.
A typical diosmetin dosage is about 1000mg per day. However, the amount can go as high as 3000mg, subject to the condition you wish to treat. The drug is taken in two separate doses for at most six months.
Diosmetin is majorly present in citrus fruits including oranges, mandarin, lemons, grape fruits, and pummelos.
To quantify and establish the amount present in these products, scientists use diosmetin uv spectrum.
There are countless research studies that have elucidated the pharmacological value of diosmetin metabolism powder. Researchers have tested the flavonoid on murine models to ascertain its role in the fight against cancerous tumors. In all the studies, diosmetin would exhibit anti-cancer properties on breast, blood, colon, liver, and prostate carcinomas.
Studies also confirm that this flavone protects against ischemia/reperfusion due to renal injury. Besides, it aids in air remodeling in chronic asthma.
Although there are numerous preclinical trials to back up the efficiency of diosmetin in cancer treatment and bone growth, its safety in human remains unknown.
For analytical testing and quantification, researchers use diosmetin d3.
In the US and some European countries, diosmetin is commercially available as a dietary supplement. The drug is nonprescription. This product is also present in citrus bioflavonoids and formulations.
You can also buy diosmetin powder for research purposes.
1.Oak, C., Khalifa, O.A., et al. (2018). Diosmetin Suppresses Human Prostate Cancer Cell Proliferation Through the Induction of Apoptosis and Cell Cycle Arrest. International Journal of Oncology.
2.Patel, K., Gadewar, M., Tahilyani, V., and Patel, D.K. (2013). A Review on Pharmacological and Analytical Aspects of Diosmetin: A Consice Report. Chinese Journal of Integrative Medicine.
3.Ya-Ling Hsu and Po-Lin Kuo. (2008). Diosmetin Induces Human Osteoblastic Differentiation Through the Protein Kinase C/p38 and Extracellular Signal-Regulayed Kinase 1/2 Pathway. Journal of Bone and Mineral Research.
4.Androutsopoulos, V.P., Mahale, S., Arrooo, R.R., and Potter, G. (2009). Anticancer Effects of the Flavonoid Diosmetin on Cell Cycle Progression and Proliferation of MDA-MB 468 Breast Cancer Cells Due to CPY1 Activation. Oncology Reports.