Dehydroepiandrosterone (DHEA) powder (53-43-0)

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Category: SKU: N/A

Name:Dehydroepiandrosterone (DHEA)

CAS:53-43-0

Molecular Formula:C19H28O2

STORAGE:Store in a cool and dry place. Keep away from direct sunlight and heat.

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Dehydroepiandrosterone (DHEA) (53-43-0) video

 

DHEA powder (53-43-0) Base Information

Name Dehydroepiandrosterone(DHEA) powder
CAS 53-43-0
Purity 98%
Chemical name Dehydroepiandrosterone
Synonyms dehydroepiandrosterone,dhea,prasterone,dehydroisoandrosterone,androstenolone,trans-dehydroandrosterone,3beta-hydroxyandrost-5-en-17-one,diandron,diandrone,psicosterone
Molecular Formula C19H28O2
Molecular Weight 288.42
Melting Point 146.0°C to 151.0°C
InChI Key FMGSKLZLMKYGDP-USOAJAOKSA-N
Form Powder
Appearance White to Off-white powder
Half Life 7-22 hours
Solubility 63.5 mg/L (at 25 °C)
Storage Condition +15 °C to +30 °C
Application It has undergone extensive clinical research on treating menopausal syndrom, chorionitis, coronary heart disease, gout, psoriasis, AIDS and so on.
Testing Document Available

 

DHEA Powder: Uses, Benefits, and Side Effects

Hormone levels in the body naturally begin to decrease with age, resulting in negative physiological changes. Supplementing these hormones is believed to improve the health of people over the age of 25 years to 27 years. One of the most important hormones that are recommended as a supplement is Dehydroepiandrosterone or DHEA. This anti-aging supplement can be purchased wholesale as dehydroepiandrosterone powder from DHEA powder manufacturers.

 

What is DHEA powder?

Dehydroepiandrosterone is a naturally occurring hormone in the human body, synthesized and released from adrenal glands, gonads, and the brain. The brain and these glands synthesize this precursor hormone to increase the levels of androgens and estrogen in the body.

DHEA is the most abundant steroid precursor in the human body and a decrease in its levels in the body is indicative of severe adrenal insufficiency. DHEA levels are frequently used in the medical field as a biomarker for the analysis of the function and health of adrenal glands and pituitary glands. This is because almost all of DHEA in the human body is synthesized from the adrenal gland. Due to the importance of the levels of the hormone and the physiological difference of levels amongst different genders and age groups, doctors have to thoroughly follow up and check them regularly to ensure proper health.

DHEA powder is a potent source of exogenous dehydroepiandrosterone which can be used to replenish the body’s DHEA levels. It is most commonly used by people to improve their athletic abilities and for its anti-aging features, amongst other potential uses.

The hormone in the human body was initially isolated from urine in 1934 by two German biochemists;  Adolf Butenandt and Kurt Tscherning. After more information was known about the chemical compound and its potential benefits, the manufacturing of synthetic versions of DHEA was attempted. With several trials, DHEA powder was synthesized and it is now one of the most commonly used hormonal supplements in the world.

It can be used in powder form, which can be purchased wholesale, to either be consumed as is or for the manufacturing of the pill form of the supplement. It can also be found in injection, pill, and cream form, with the bioavailability and metabolism rates differing for all types. The bioavailability of this steroid hormone precursor, however, is low overall as it is only 50 percent. Moreover, DHEA, generally, has a half-life of 25 minutes, after which it is metabolized in the liver and excreted completely through the urine.

However, DHEA powder doesn’t stay in the human body as DHEA itself, but rather gets converted to male and female sex hormones, namely, testosterone and estrogen, and continues to produce effects indirectly. The effect of these hormones may last longer than that of the DHEA powder itself.

 

What are the uses of DHEA?

DHEA powder has several uses and most of these uses are the same as those of endogenous DHEA. Naturally occurring DHEA has different functions in the human body, such as those mentioned below:

  • Synthesis of Testosterone and Dihydrotestosterone (DHT)
  • Synthesis of Estrogen
  • Inhibition of G6PDH to lower NADPH induced free radical formation
  • Binding to neurotrophin receptors to reduce the incidence of neurodegenerative diseases
  • Agonist, negative allosteric modulator, and a positive allosteric modulator of different neurotransmitters
  • Antiglucocorticoid effects

These are the main functions of DHEA with a couple of them only being discovered recently. DHEA powder is believed to have the same uses and some more as well, as the uses of DHEA itself are still being studied and not all are yet known.

 

It is generally safe to use Dehydroepiandrosterone powder, although its use is not approved by the Food and Drug Authority or FDA for any medical conditions and disorders that people may use it for. However, people claim to see the benefits of DHEA in managing the symptoms of the following disorders:

  • Alzheimer’s disease
  • Chronic fatigue syndrome
  • Depression
  • Erectile dysfunction
  • Fatigue
  • Fibromyalgia
  • Lupus
  • Menopausal symptoms
  • Metabolic syndrome
  • Multiple sclerosis
  • Parkinson’s disease

Moreover, the mechanism of DHEA powder and supplements in the human body through which they produce the positive effects is relatively the same as the mechanism of action of the DHEA hormone in the body. This explains some of the uses of DHEA powder, especially for certain disorders as they are the result of relatively low DHEA levels which decreases steroid hormone levels as well.

 

Benefits of DHEA

Dehydroepiandrosterone powder is a widely used supplement with several benefits, which are supported by scientific evidence and proof. The use of DHEA powder has been known to produce several benefits, which were discovered through thorough scientific analysis.

 

● Manage Adrenal Disorders and Diseases

DHEA is primarily synthesized in the adrenal glands in the body, which are located on top of the kidneys. These glands are important for the normal endocrinology of the human body, however, their function can be impaired either as an action of congenital malformation or due to acquired disorders. Those result in a specific disorder namely, Adrenal Insufficiency.

Supplementation with DHEA is believed to help manage the symptoms of adrenal insufficiency such as fatigue, weakness, and fluctuations in blood pressure. Although the symptoms of the disorder do not seem to be serious, the disorder can be life-threatening without treatment.

Recent studies have shown that not only can DHEA powder help women with adrenal insufficiency manage their symptoms but it can also help increase their quality of life significantly. In a meta-analysis study of ten different randomized, placebo-controlled clinical trials, it was found that women who took DHEA powder to improve their symptoms of adrenal insufficiency, had decreased anxiety and depression. These can occur with adrenal insufficiency and negatively affect the quality of life. Moreover, the subjects reported an increased libido that improved different aspects of their sexual lives.

Similar studies have proven that DHEA supplementation may be able to combat the effects of androgen deficiency as a result of chronic adrenal gland failure, hence, improving the quality of life and the general mood of the patients. In the same study, it was found that consumption of the DHEA powder has the ability to increase IGF-1 levels, which points towards the hypothesized immunomodulatory effects of the hormonal precursor, however, it cannot be proven unless Phase III clinical trials are performed.

 

● Treat Infertility

Infertility is managed and treated using Assisted Reproductive Techniques (ART) such as in vitro fertilization or IVF. Recent studies have shown that DHEA supplementation may be beneficial in increasing the success rates of IVF in women battling infertility. A systematic review of studies performed on DHEA supplementation in women suffering from diminished ovarian reserve found that these women responded better to infertility treatment when combined with DHEA powder.

In one of the randomized, placebo-controlled clinical trials it was found that the rates of live birth after IVF/ICSI procedures increased to 23 percent, compared to the rates of 4 percent, without the DHEA supplementation. This points towards the efficacy of DHEA powder in the treatment of infertility.

Similar studies focused on the causes of infertility such as Polycystic Ovarian Syndrome or PCOS and how DHEA supplementation may affect those conditions. It was found that DHEA powder may help manage PCOS and eventually reduce the extent to which it can affect the fertility of a woman.

 

● Manage Sexual function and Improve Libido

Several studies have shown replenishing DHEA levels in the body can improve sexual function and libido as a result of the functioning of the hormone. This improvement is seen in both genders, unlike the fertility benefits of the hormonal supplement which are only seen in women.

A systematic review performed and published in 2017 focused on the efficiency of DHEA in improving sexual function by tackling the issues of sexual frequency, impaired sexual function, and libido. Based on the results of the study, subjects taking DHEA powder claimed to see a significant improvement in sexual function overall, with changes in the sexual frequency along with libido. The results of this study were especially pronounced in the perimenopausal and postmenopausal women. Postmenopausal women also noticed an improvement in lubrication hence reducing vaginal dryness often associated with menopause.

However, it was noticed that the best results with DHEA supplementation were seen in patients with sexual disorders rather than for the maintenance of good health.

 

● Contribute to the Management of Depression

Treatment and management of depression by DHEA powder works in multiple ways. Indirectly, improvement of menopausal symptoms in perimenopausal and postmenopausal women is associated with decreased depression and anxiety rates in these age groups.

Direct effects of DHEA powder on depression are yet not understood but are believed to be dose-dependent. It was found, through the comparison of multiple different pieces of research, that low doses of DHEA powder may help manage depression to an extent, although it is believed that high levels of DHEA can cause a significant increase in depression rates amongst consumers. Some studies also claim to see no significant results in the treatment of depression in the young and healthy individuals taking DHEA supplements.

 

● Increased Muscle Size and Muscle Strength

The effects of DHEA powder on muscle strength are both directly and indirectly, much like its effect on the management of depression. While DHEA gets converted to testosterone in the body, it can help increase muscle strength and size through the actions of the sex hormone. However, apart from that, muscle size and strength remain unchanged in healthy young adults and adults with even high doses of DHEA powder.

An important distinction in the change of muscle size with DHEA powder is that this benefit is seen in elderly individuals with impaired muscle strength and structure, as a result of age or several other disorders. Most effects of DHEA supplementation are only seen when health is impaired as they help treat and manage disorders.DHEA cannot be used as a pre-workout or other form of a muscle-enhancing product by healthy and young individuals.

 

● Increased Bone Density

One of the main side effects of low levels of DHEA in the body, as a result of aging, is that the bone density decreases, significantly. DHEA supplementation in these individuals is associated with increased DHEA levels, which in turn, increases bone density through the normal mechanisms of the hormone.

This increase in bone density is also seen mostly in postmenopausal women who already suffer from osteoporosis or reduced bone density due to a lack of estrogen. Multiple pieces of research have shown that bone density increases as a result of DHEA supplements is exaggerated inwomen and not as pronounced in men.

 

Dosage of DHEA Powder

While several scientific studies and researches were performed to study the efficacy and benefits of the hormone, these studies also helped determine the appropriate dosage of DHEA powder and supplements. The well-tolerated and generally safe dosage of dehydroepiandrosterone powder lies between the 25mg and 50 mg range. However, dosages of up to 500mg are considered to be safe and the lowest effective dose is considered to be 10mg.

A specific study type showed that 25mg of DHEA powder can be consumed every day, for up to two years and 50mg can be consumed every day for up to a year, without any reported toxicities and/or overdose.

 

Side Effects of DHEA Powder

DHEA powder is considered to be relatively safe with no toxicities or severe adverse effects being reported yet. However, this hormonal supplement can interact with certain medications and produce adverse effects, hence why these interactions should be avoided. Moreover, the use of DHEA powder is strictly contraindicated in patients with cancer, especially those that are effect by the sex hormone levels in the body.

Mild adverse effects of the product include acne, oily skin, and excessive hair growth in the armpits and the groin region. These side effects are self-limited and almost always resolve spontaneously, without any medical intervention.

 

Why buy DHEA Powder from our DHEA Powder Manufacturers?

DHEA powder should be manufactured and processed in special conditions to ensure the safety of the hormonal supplement. Our DHEA Powder Manufacturers guarantee that the supplement is produced by following all safety guidelines and protocols, with precision. This is important as the slightest contamination could result in the final product losing its efficacy and potency. Moreover, contaminants are not safe for human health.

After the manufacturing process is complete, all products manufactured are subjected to quality control and further testing to ensure that the products manufactured have the same benefits as shown by the research. If the products pass quality control tests, they are then sent forward for delivery or to the storage facility. The storage system at our DHEA Powder Manufacturers is equipped with the necessary temperature controls along with other controls to ensure appropriate storage of DHEA powder that does not lead to reactions of the supplement prior to delivery.

Even after the products leave the facility, there are systems in place for quality control tracking which allow the DHEA powder manufacturers to track down a faulty product, and to easily identify which batch it belongs to. This helps recall all products if needed and to check the manufacturing process along with the storage and transportation of that specific batch to identify the mistake, if any.

 

 

References

  • Peixoto, C., Carrilho, C. G., Barros, J. A., Ribeiro, T. T., Silva, L. M., Nardi, A. E., Cardoso, A., & Veras, A. B. (2017). The effects of dehydroepiandrosterone on sexual function: a systematic review. Climacteric : the journal of the International Menopause Society, 20(2), 129–137. https://doi.org/10.1080/13697137.2017.1279141
  • Peixoto, C., Grande, A. J., Mallmann, M. B., Nardi, A. E., Cardoso, A., & Veras, A. B. (2018). Dehydroepiandrosterone (DHEA) for Depression: A Systematic Review and Meta-Analysis. CNS & neurological disorders drug targets, 17(9), 706–711. https://doi.org/10.2174/1871527317666180817153914
  • Lang, K., Burger-Stritt, S., & Hahner, S. (2015). Is DHEA replacement beneficial in chronic adrenal failure?. Best practice & research. Clinical endocrinology & metabolism, 29(1), 25–32. https://doi.org/10.1016/j.beem.2014.09.007
  • Dou, L., Zheng, Y., Li, L., Gui, X., Chen, Y., Yu, M., & Guo, Y. (2018). The effect of cinnamon on polycystic ovary syndrome in a mouse model. Reproductive biology and endocrinology : RB&E, 16(1), 99. https://doi.org/10.1186/s12958-018-0418-y
  • Morales, A. J., Haubrich, R. H., Hwang, J. Y., Asakura, H., & Yen, S. S. (1998). The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clinical endocrinology, 49(4), 421–432. https://doi.org/10.1046/j.1365-2265.1998.00507.x

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