Dehydroepiandrosterone(DHEA) powder is an important endogenous steroid hormone, which is an androgen receptor antagonist and an estrogen receptor agonist. It is a natural compound that promotes cognitive, reproductive and dietary health. It may also support the muscles, making Dehydroepiandrosterone (DHEA) powder a popular bodybuilding supplement.
|Melting Point||146.0°C to 151.0°C|
|Appearance||White to Off-white powder|
|Half Life||7-22 hours|
|Solubility||63.5 mg/L (at 25 °C)|
|Storage Condition||+15 °C to +30 °C|
|Application||It has undergone extensive clinical research on treating menopausal syndrom, chorionitis, coronary heart disease, gout, psoriasis, AIDS and so on.|
Dehydroepiandrosterone(DHEA) powder is a precursor hormone, which means it has little biological effect on its own, but has powerful effects when converted into other hormones such as testosterone and oestradiol. Dehydroepiandrosterone(DHEA) is produced from cholesterol mainly by the outer layer of the adrenal glands, known as the adrenal cortex, although it is also made by the testes and ovaries in small amounts. It circulates in the blood, mainly attached to sulphur as dehydroepiandrosterone sulphate, which prevents the hormone being broken down. In women, dehydroepiandrosterone(DHEA) is an important source of oestrogens in the body – it provides about 75% of oestrogens before the menopause, and 100% of oestrogens in the body after menopause.
Dehydroepiandrosterone(DHEA) powder production increases from around nine or ten years of age, peaks during the 20s and gradually decreases into old age. Dehydroepiandrosterone(DHEA) is also produced in small amounts by the brain, although its precise role there is not clear.
Dehydroepiandrosterone(DHEA) was first isolated from human urine in 1934 by Adolf Butenandt and Kurt Tscherning.
Dehydroepiandrosterone(DHEA) powder has a thyroid stimulating effect inhibiting food and fat intake and reducing fat accumulation, etc. It improves glucose tolerance, increases insulin level and fights diabetes. It can enhance endocrine system actiity, reduce cortisol levels, and resist a variety of pathological processes. It can help the body obtain cortical antibodies. Dehydroepiandrosterone(DHEA) has a strong protective and synergistic effect when used to treat tumors, becuase it inhibits ribose 5-phosphate. Inhibits cancer by inhibiting excessive mitochondria (NADPH) and ribose 5-phosphate esters. Regulates the growth of pancreatic cancer cells by regulating the concentration of estrogen in blood plasma. A decline in GnRH gene expression leads to aging, and DHEA can restore GnRH neuronal activity, stopping or improving certain diseases associated with declines in DHEA by stimulating GnRH biosynthesis. Restores impaired immune response, improves T- and B-cell function, and plays an important role in enhancing the physiological activity of insulin-like growth factor (IGF-1,) and is a potentially useful drug for immunodeficiency. DHEA alone cannot directly affect the growth and differential of osteoblasts, but it can do so by influencing 1,25-dihydroxyvitamin D3. The effects of Dehydroepiandrosterone(DHEA) on bone mass depend on the presence and form of sex hormones in bone cells and their endrocine effects on osteoblasts. Dehydroepiandrosterone(DHEA) is an anabolic protein hormone which promotes protein synthesis. According to the findings of Marrero and others, feeding DHEA (0.45%) to mice increased liver weight, increasing liver mitochondria by guiding liver protein restoring RNA and protein synthesis.
Dehydroepiandrosterone(DHEA) is said to aid in the treatment or prevention of the following health problems:
chronic fatigue syndrome
DHEA powder is also said to slow up the aging process, improve sports performance,enhance libido, promote weight loss, and bolster the immune system.
In addition, DHEA supplements are frequently marketed as testosterone-boosting agents and used for such purposes as increasing muscle mass and reducing fat mass.
DHEA is produced in the zona reticularis of the adrenal cortex under the control of adrenocorticotropic hormone (ACTH) and by the gonads under the control of gonadotropin-releasing hormone (GnRH). It is also produced in the brain. DHEA is synthesized from cholesterol via the enzymes cholesterol side-chain cleavage enzyme (CYP11A1; P450scc) and 17α-hydroxylase/17,20-lyase (CYP17A1), with pregnenolone and 17α-hydroxypregnenolone as intermediates. It is derived mostly from the adrenal cortex, with only about 10% being secreted from the gonads. Approximately 50 to 70% of circulating DHEA originates from desulfation of DHEA-S in peripheral tissues. DHEA-S itself originates almost exclusively from the adrenal cortex, with 95 to 100% being secreted from the adrenal cortex in women.
Increasing endogenous production
Regular exercise is known to increase DHEA production in the body. Calorie restriction has also been shown to increase DHEA in primates. Some theorize that the increase in endogenous DHEA brought about by calorie restriction is partially responsible for the longer life expectancy known to be associated with calorie restriction. Catalpol and a combination of acetyl-carnitine and propionyl-carnitine on 1:1 ratio also improves endogenous DHEA production and release due to direct cholinergic stimulation of CRH release and an increase of IGF-1 expression respectively.