N-Methyl-D-Aspartic Acid (NMDA) powder is an amino acid derivative. The acid is designed to mimic the action of glutamate. NMDA powder is a water-soluble substance in biological tissue. Instead, it is ingested orally. N-Methyl-D-Aspartic Acid (NMDA) powder was first synthesized in a lab in the early 1960s. It has however grown in popularity over the years. In the bodybuilding sphere, NMDA has often been explored for its testosterone boosting properties. NMDA powder also has a number of different names too. The drug may also be referred to as N-Methyl-D Aspartate. Other names used to identify it include N –Methyl aspartic acid, succinic acid, and (R)-2 Methylamino.
02 (6384-92-5) video
03 (6384-92-5) Base Information
|Name||N-Methyl-D-Aspartic Acid (NMDA) powder|
|Chemical name||N-Methyl-D-aspartic acid|
|Synonyms||LC488A; LC 488A; LC-488A|
|Molecular Weight||147.13 g/mol|
|Melting Point||189 to 190 °C|
|Solubility||Soluble in DMSO|
|Storage Condition||Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).|
|Application||N-methyl-D-aspartic acid is an aspartic acid derivative having an N-methyl substituent and D-configuration. It has a role as a neurotransmitter agent. It is a D-alpha-amino acid, a D-aspartic acid derivative, an amino dicarboxylic acid and a secondary amino compound.|
04 What is NMDA?
As we have already noted above, N-Methyl-D-Aspartic Acid (NMDA) powder is basically an amino acid derivative. NMDA will mimic the actions of glutamate, a very powerful neurotransmitter in the brain. A neurotransmitter is a chemical that is used by nerve cells to send signals. Glutamate is one of the most abundant excitatory neurotransmitters in the human nervous system. Its action is very important in enhancing cognitive function including sharp memory and increased attention.
05 How Does NMDA Work?
N-Methyl-D-Aspartic Acid (NMDA) will trigger and mimic the action of glutamate when ingested in the body. The amino acid does this by binding into glutamate receptors in the nervous system. However, it is important to note that there are several glutamate receptors in the body. NMDA does not bind to all of them in fact it only binds to one receptor referred to as the NMDA Glutamate receptor. The receptor is one of the most common excitatory neurotransmitters in the human nervous system. It is responsible for transiting signals across the nervous system.
The action of N-Methyl-D-Aspartic Acid (NMDA) in the brain may also lead to increased production of testosterone hormones. You see, before binding to the receptors, N-Methyl-D-Aspartic Acid (NMDA) will, first of all, break down through a methyl transference process called NMDA Synthetase. The amino acid breaks down into a substance referred to as N-Methyl D-Asperate which will stimulate the hypothalamus Pituitary. This may help to enhance the production of testosterone. This is why n-methyl-d-aspartic acid bodybuilding is very popular in muscle development.
06 What Does the NMDA Receptor Do?
The N-methyl-D-aspartate receptor often shortened to NMDA or sometimes NMDAR is one of the naturally occurring glutamate receptors in the human nervous system. NMDA is also classified as an ion channel protein. NMDA is, in fact, one of three types of ionotropic glutamate receptors. Ionotropic glutamate receptors are very crucial in memory and learning in humans. The activity of the NMDA receptor may be affected by several psychoactive drugs including alcohol, phencyclidine, and others.
07 N-Methyl-D-Aspartic Acid (NMDA) Benefits
Biologically, NMDA is used in the body as an excitotoxin. In other words, it simply kills nerve cells by overexciting them. However, when introduced in lower quantities, NMDA will not act as a neurotoxin. Low quantities of NMDA are known to mimic the action of glutamate and this may offer a number of benefits. Here they are:
Improved Cognitive Function and Testosterone Production
The action of glutamate in the human nervous system is very important. N-methyl-d-aspartic acid testosterone is also a key area of benefits for this amino acid. In addition to this, there are also claims that glutamate may be used to treat a number of issues. Even though these claims have not been proven by any research or clinical trials, there is a theoretical basis for them.
Here they are:
- Glutamate may assist to treat people with personality and childhood behavioral issues
- Can be used to treat intellectual disorders
- Can be used as a possible treatment for epilepsy and muscular dystrophy
- Glutamate may also be used to treat low blood sugar among diabetes patients
- It may aloes help to reduce the risk of nerve damage in people having chemotherapy.
It is important to stress that NMDA is not glutamate. It’s simply a chemical that mimics the action of glutamate and therefore it may be associated with all the benefits that come with glutamate.
08 N-Methyl-D-Aspartic Acid (NMDA) Research
There is a lot of N-Methyl-D-Aspartic Acid receptor research right now but so far very little information is known about it. First of all, it is a known fact within the neuroscience community that NMDA is an excitotoxin. This means that it kills nerve cells by overexciting them. This trait has found a lot of applications in behavioral neuroscience research in recent years. In essence, researchers are trying to see whether the introduction of NMDA in the brain or spinal cord may cause any behavioral changes in test subjects.
There is also some research trying to see whether n methyl d aspartic acid receptor structure and function may have any positive effect in enhancing memory, learning, and other important cognitive functions. Theoretically, NMDA plays an important role in a wide range of psychological functions including memory and learning. However, the extent of this role is still not yet clear based on the research out there so far.
09 How to Take N-Methyl-D-Aspartic Acid (NMDA)?
N-Methyl-D-Aspartic Acid is normally sold in the form of a powder online these days. However, information about the dosage is still scanty. It may be a good idea to consult widely before taking the powder. If you have any existing chronic conditions talk to your doctor first and see whether the powder will be safe for you. Pregnant women are also advised to stay away from NMDA. Even though N-Methyl-D-Aspartic Acid is generally considered a safe supplement, it should only be administered under the supervision and advice of a medical practitioner.
10 N-Methyl-D-Aspartic Acid (NMDA) Side Effects
As we have already noted above, research on n-methyl-d-aspartic acid (NMDA) receptor antagonist and its effects are very scanty right now. It is very hard to pinpoint specific side effects. However, NMDA supplements are generally considered safe to use. Even in cases where n-methyl-d-aspartic acid side effects are reported, they are very minimal. Additionally, the effects of NMDA will vary a lot from one person to the next. A good rule would be to consult with your doctor and see if you qualify for N-Methyl-D-Aspartic Acid. If for some reason your side effects don’t go away after a few hours, visit a doctor as well.
11 Buy NMDA Powder online
Well, in case you feel you could really use an NMDA supplement and all the n-methyl-d-aspartic acid benefits it has to offer then there are a few N-Methyl-D-Aspartic Acid(NMDA) suppliers online you can go to and buy the product. However, you may want to take your time. There are so many sites out there claiming to sell N-Methyl-D-Aspartic Acid supplements.
Do not just buy from anyone and anywhere. Check out each N-Methyl-D-Aspartic Acid(NMDA) vendor and do some background research to avoid any disappointments.
Here are some tips that may help:
- Reviews are very crucial. Vendors that have hundreds of positive customer reviews from other users will most likely offer a quality product.
- Check out the years the vendor has sold N-Methyl-D-Aspartic Acid. Companies that have done this for a while often carry quality products.
- See if the vendor can give you more information about NMDA before you buy. Ask about dosage, side effects, interactions, and any other information you may need.
- Ask about shipping as well. The last thing you want is to wait for ages before getting your powder.
- Finally, do not buy cheap products. It’s better to spend extra dollars and get a top-quality product.
N-Methyl-D-Aspartic Acid powder is a powerful protein that has several applications in the nervous system and the brain. The guide above should give you a basic understanding of it including what does NMDA stand for.
12 NMDA (6384-92-5) Reference
- “N-Methylaspartate – Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 24 June 2005. Identification. Retrieved 9 January 2012.
- Dingledine, R; Borges K (Mar 1999). “The glutamate receptor ion channels”. Pharmacol. Rev. 51 (1): 7–61. PMID 10049997.
- Liu, Y; Zhang J (Oct 2000). “Recent development in NMDA receptors”. Chin Med J (Engl). 113 (10): 948–56. PMID 11775847.
- Cull-Candy, S; Brickley S (Jun 2001). “NMDA receptor subunits: diversity, development and disease”. Current Opinion in Neurobiology. 11 (3): 327–35. doi:10.1016/S0959-4388(00)00215-4. PMID 11399431.
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- 01. Overview
- 02. (6384-92-5) video
- 03. (6384-92-5) Base Information
- 04. What is NMDA?
- 05. How Does NMDA Work?
- 06. What Does the NMDA Receptor Do?
- 07. N-Methyl-D-Aspartic Acid (NMDA) Benefits
- 08. N-Methyl-D-Aspartic Acid (NMDA) Research
- 09. How to Take N-Methyl-D-Aspartic Acid (NMDA)?
- 10. N-Methyl-D-Aspartic Acid (NMDA) Side Effects
- 11. Buy NMDA Powder online
- 12. NMDA (6384-92-5) Reference