N-Methyl-D-aspartic acid powder or N-Methyl-D-aspartate (NMDA) is an amino acid derivative that acts as a specific agonist at the NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Unlike glutamate, NMDA only binds to and regulates the NMDA receptor and has no effect on other glutamate receptors (such as those for AMPA and kainate). NMDA receptors are particularly important when they become overactive during withdrawal from alcohol as this causes symptoms such as agitation and, sometimes, epileptiform seizures.
02 (6384-92-5) video
03 (6384-92-5) Base Information
|Name||N-Methyl-D-Aspartic Acid (NMDA) powder|
|Chemical name||N-Methyl-D-aspartic acid|
|Synonyms||LC488A; LC 488A; LC-488A|
|Molecular Weight||147.13 g/mol|
|Melting Point||189 to 190 °C|
|Solubility||Soluble in DMSO|
|Storage Condition||Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).|
|Application||N-methyl-D-aspartic acid is an aspartic acid derivative having an N-methyl substituent and D-configuration. It has a role as a neurotransmitter agent. It is a D-alpha-amino acid, a D-aspartic acid derivative, an amino dicarboxylic acid and a secondary amino compound.|
04 NMDA (6384-92-5) General Description
N-Methyl-D-aspartic acid (NMDA) powder is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase.
05 NMDA (6384-92-5) powder History
N-Methyl-D-aspartic acid powder is an amino acid derivative acting as a specific agonist at the NMDA receptor, and therefore mimics the action of the neurotransmitter glutamate on that receptor. In contrast to glutamate, NMDA binds to and regulates the above receptor only, but not other glutamate receptors. NMDA is a water-soluble synthetic substance that is not normally found in biological tissue. It was first synthesized in the 1960’s.
NMDA is an excitotoxin; this trait has applications in behavioral neuroscience research. The body of work utilizing this technique falls under the term “lesion studies.” Researchers apply NMDA to specific regions of an (animal) subject’s brain or spinal cord and subsequently test for the behavior of interest, such as operant behavior.
If the behavior is compromised, it suggests the destroyed tissue was part of a brain region that made an important contribution to the normal expression of that behavior. Examples of antagonists of the NMDA receptor are APV, dextromethorphan, ketamine, phencyclidine (PCP), riluzole, and memantine. They are commonly referred to as NMDA receptor antagonists.
06 NMDA (6384-92-5) Mechanism Of Action
How does n-methyl-d-aspartic acid work? There is no much scientific information on this area, but we are to explain the acts in a simple way.
N-methyl-D-aspartic acid (NMDA) acts as a specific agonist at the NMDA receptor, and therefore mimics the action of the neurotransmitter glutamate on that receptor. As we know, glutamate is the excitatory neurotransmitter found in most synapses of the central nervous system, and pharmacologists made this analogue to activate a sub-type of glutamate receptors. Since there are multiple glutamate receptors, you can distinguish between them pharmacologically with different drugs, and NMDA is one of those drugs. In contrast to glutamate, NMDA binds to and regulates the NMDA receptor only, with no effect on other glutamate receptors.
D-Aspartic Acid breaks down into N-Methyl-D-Aspartic acid via a methyl transference reaction called NMDA Synthetase. N-Methyl-D-Aspartate then stimulates the Hypothalamus-Pituitary and testes to produce hormones. Therefore, if you take D-Aspartic Acid, it is the N-Methyl-D-Aspartic Acid, which gets there through conversion that actually does the work by increasing testosterone levels as well as growth hormone and luteinizing hormone.
07 NMDA (6384-92-5) Application
What is n-methyl-d-aspartic acid? N-methyl-d-aspartic acid is well-known in sports nutrition industry among bodybuilders and fitness lovers for its testosterone-boosting benefits. N-methyl-d-aspartic acid, abbreviated as NMDA, has several other names such as N-Methyl-D-aspartate, N-Methyl aspartic acid, (R)-2-(Methylamino) succinic acid, etc.
08 NMDA (6384-92-5) More research
When we talk about N-methyl-d-aspartic acid, you can never forget D-Aspartic acid (DAA). DAA is an excitatory amino acid while N-methyl-d-aspartic acid (NMDA) is deemed to be 100 times more potent than D-aspartic acid at stimulating the NMDA receptor. patrick Arnold is believe to be an active chemist inventor with DAA and NMDA.
09 NMDA (6384-92-5) Document Download
10 NMDA (6384-92-5) Reference
- “N-Methylaspartate – Compound Summary”. PubChem Compound. USA: National Center for Biotechnology Information. 24 June 2005. Identification. Retrieved 9 January 2012.
- Dingledine, R; Borges K (Mar 1999). “The glutamate receptor ion channels”. Pharmacol. Rev. 51 (1): 7–61. PMID 10049997.
- Liu, Y; Zhang J (Oct 2000). “Recent development in NMDA receptors”. Chin Med J (Engl). 113 (10): 948–56. PMID 11775847.
- Cull-Candy, S; Brickley S (Jun 2001). “NMDA receptor subunits: diversity, development and disease”. Current Opinion in Neurobiology. 11 (3): 327–35. doi:10.1016/S0959-4388(00)00215-4. PMID 11399431.
- 2019 L-theanine Nootropics: Everything You Need To Know About
- 01. Overview
- 02. (6384-92-5) video
- 03. (6384-92-5) Base Information
- 04. NMDA (6384-92-5) General Description
- 05. NMDA (6384-92-5) powder History
- 06. NMDA (6384-92-5) Mechanism Of Action
- 07. NMDA (6384-92-5) Application
- 08. NMDA (6384-92-5) More research
- 09. NMDA (6384-92-5) Document Download
- 10. NMDA (6384-92-5) Reference