N-Methyl-D-Aspartic Acid (NMDA) powder (6384-92-5)

N-Methyl-D-aspartic acid (NMDA) powder is an endogenously generated molecule in rat nervous system and endocrine glands. NMDA is present at low level (nmol/g) in the adenohypophysis, hypothalamus, brain, and testis. NMDA is derived from D-Asp by an S-adenosylmethionine-dependent enzyme also referred to as NMDA synthase.

N-Methyl-D-aspartic acid powder is an amino acid derivative acting as a specific agonist at the NMDA receptor, and therefore mimics the action of the neurotransmitter glutamate on that receptor. In contrast to glutamate, NMDA binds to and regulates the above receptor only, but not other glutamate receptors. NMDA is a water-soluble synthetic substance that is not normally found in biological tissue. It was first synthesized in the 1960’s.

NMDA is an excitotoxin; this trait has applications in behavioral neuroscience research. The body of work utilizing this technique falls under the term “lesion studies.” Researchers apply NMDA to specific regions of an (animal) subject’s brain or spinal cord and subsequently test for the behavior of interest, such as operant behavior.

If the behavior is compromised, it suggests the destroyed tissue was part of a brain region that made an important contribution to the normal expression of that behavior. Examples of antagonists of the NMDA receptor are APV, dextromethorphan, ketamine, phencyclidine (PCP), riluzole, and memantine. They are commonly referred to as NMDA receptor antagonists.

How does n-methyl-d-aspartic acid work? There is no much scientific information on this area, but we are to explain the acts in a simple way.

N-methyl-D-aspartic acid (NMDA) acts as a specific agonist at the NMDA receptor, and therefore mimics the action of the neurotransmitter glutamate on that receptor. As we know, glutamate is the excitatory neurotransmitter found in most synapses of the central nervous system, and pharmacologists made this analogue to activate a sub-type of glutamate receptors. Since there are multiple glutamate receptors, you can distinguish between them pharmacologically with different drugs, and NMDA is one of those drugs. In contrast to glutamate, NMDA binds to and regulates the NMDA receptor only, with no effect on other glutamate receptors.

D-Aspartic Acid breaks down into N-Methyl-D-Aspartic acid via a methyl transference reaction called NMDA Synthetase. N-Methyl-D-Aspartate then stimulates the Hypothalamus-Pituitary and testes to produce hormones. Therefore, if you take D-Aspartic Acid, it is the N-Methyl-D-Aspartic Acid, which gets there through conversion that actually does the work by increasing testosterone levels as well as growth hormone and luteinizing hormone.

What is n-methyl-d-aspartic acid? N-methyl-d-aspartic acid is well-known in sports nutrition industry among bodybuilders and fitness lovers for its testosterone-boosting benefits. N-methyl-d-aspartic acid, abbreviated as NMDA, has several other names such as N-Methyl-D-aspartate, N-Methyl aspartic acid, (R)-2-(Methylamino) succinic acid, etc.

When we talk about N-methyl-d-aspartic acid, you can never forget D-Aspartic acid (DAA). DAA is an excitatory amino acid while N-methyl-d-aspartic acid (NMDA) is deemed to be 100 times more potent than D-aspartic acid at stimulating the NMDA receptor. patrick Arnold is believe to be an active chemist inventor with DAA and NMDA.

COA

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