Tianeptine powder (66981-73-5)

$39.99
Free shipping for order over US$249 (USA and Asia)
Free shipping for order over US$349 (Europe)
5-10 hours(in business day) fast shipping
Clear
Only 7 left! 81 people are viewing this and 28 people have it in their cart.
No your quantity? Click here
Warning: If you are pregnant, nursing, taking any medications or have any medical condition consult your physician before use. Keep out of reach of children.
Category: SKU: N/A

Name:Tianeptine

CAS:66981-73-5

Molecular Formula: C21H25ClN2O4S

STORAGE:Store in a cool and dry place. Keep away from direct sunlight and heat.

How To Place Order?
[1]. Choose quantity you need, then add to cart

[2]. Proceed to check out

[3]. Fill in your detail information, the *is required, choose your payment method. There are different payment methods include:
-Direct Bank Transfer
-Coinpayments: Bitcoin,Ether,USDT
Then click “Place order”
Tips: the email address must correct, the tracking information will keep update through email notice

[4]. If choose “Coinpayment”, after click “Place order”, then will show as below to pay

[5]. If Choose “Direct Bank Transfer”, after click “Place order”, then will show as below, will appear the bank account details, after make bank transfer (please use your order number as the reference), send a bank slip to us

[6]. Payment confirmed
[7]. Parcel send out about 5-10 hours (in business day)
[8]. Tracking number provided
[9]. Parcel arrived
[10]. Re-order

Tianeptine powder (66981-73-5) video

 

 

Tianeptine powder (66981-73-5) Base Information

Name Tianeptine powder
CAS 66981-73-5
Purity 98%
Chemical name 7-[(3-chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid
Synonyms S-1574; JNJ-39823277; TPI-1062
Molecular Formula C21H25ClN2O4S
Molecular Weight 436.95
Melting Point 129-131°C
InChI Key JICJBGPOMZQUBB-UHFFFAOYSA-N
Form Powder
Appearance White Color
Half Life 4 to 9 hours
Solubility Freely soluble in water, in methanol and in methylene chloride.
Storage Condition Store at 4° C
Application Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant
Testing Document Available

 

Tianeptine powder (66981-73-5) General Description

Tianeptine is a drug used primarily in the treatment of major depressive disorder and has been studied in the treatment of irritable bowel syndrome (IBS).Structurally, Tianeptine, is an atypical antidepressant which is used mainly in the treatment of major depressive disorder, although it may also be used to treat anxiety, asthma, and irritable bowel syndrome.

Tianeptine has antidepressant and anxiolytic effect with a relative lack of sedative, anticholinergic, and cardiovascular side effects. It has been found to act as an atypical agonist of the μ-opioid receptor with clinically negligible effects on the δ- and κ-opioid receptors as do most tricyclic antidepressants (TCA).

 

Tianeptine powder (66981-73-5) History

Tianeptine was discovered and patented by the French Society of Medical Research in the 1960s. Currently, tianeptine is approved in France and manufactured and marketed by Laboratories Servier SA; it is also marketed in a number of other European countries under the trade name Coaxil as well as in Asia (including Singapore) and Latin America as Stablon and Tatinol but it is not available in Australia, Canada, New Zealand, the United Kingdom, or the United States.

 

Tianeptine powder (66981-73-5) Mechanism Of Action

Recent studies suggest that tianeptine acts as a full agonist at the mu-type opioid receptor (MOR) [A33314], [A33316]. The mu opioid receptors are currently being studied as effective targets for antidepressant therapies. It is believed that the clinical effects of tianeptine are owed to its modulation of these receptors.

Many demonstrate that the mechanism of action of tianeptine is distinct from SSRIs and support the hypothesis that the mechanism of action of tianeptine relates to alteration of glutaminergic activity in the amygdala and the hippocampus [A31971, A431969, A31986]. In addition to the above mechanisms, tianeptine is a unique antidepressant and anxiolytic medication that stimulates the uptake of serotonin (5-hydroxytryptamine; 5-HT), and 5-hydroxyindoleacetic acid (5-HIAA) in brain tissue [A31971]. Although the monoaminergic neurotransmitters serotonin (5-HT), noradrenaline (NA) and dopamine (DA) are proven to be related to the occurrence of depressive disorders, it is now recognized that monoamine deficits are not sufficient to explain the mechanism of action of antidepressant.

 

Tianeptine powder (66981-73-5) Application

  • 1) Tianeptine Improves Depressive Symptoms
  • 2) Tianeptine Lessens Anxiety, Stress, and PTSD and Symptoms From Stress.
  • 3) Tianeptine Benefits Memory and Learning
  • 4) Tianeptine is an Anti-inflammatory
  • 5) Tianeptine decreases pain
  • 6) Tianeptine Helps Treat Irritable bowel Syndrome
  • 7) Tianeptine Reduces Asthma

 

Tianeptine powder (66981-73-5) More research

A clinical trial comparing its efficacy and tolerability with amitriptyline in the treatment of irritable bowel syndrome showed that tianeptine was at least as effective as amitriptyline and produced less prominent adverse effects such as dry mouth and constipation.Tianeptine has been reported to be very effective for asthma. In August 1998, Dr. Fuad Lechin and colleagues at the Central University of Venezuela Institute of Experimental Medicine in Caracas published the results of a 52-week randomized controlled trial of asthmatic children; the children in the groups that received tianeptine had a sharp decrease in clinical rating and increased lung function. Two years earlier, they had found a close, positive association between free serotonin in plasma and severity of asthma in symptomatic persons. As tianeptine was the only agent known to both reduce free serotonin in plasma and enhance uptake in platelets, they decided to use it to see if reducing free serotonin levels in plasma would help. By November 2004, there had been two double-blind placebo-controlled crossover trials and a >25,000 person open-label study lasting over seven years, all showing effectiveness. Tianeptine also has anticonvulsant and analgesic effects, and a clinical trial in Spain that ended in January 2007 has shown that tianeptine is effective in treating pain due to fibromyalgia. Tianeptine has been shown to have efficacy with minimal side effects in the treatment of attention-deficit hyperactivity disorder.

 

Tianeptine powder (66981-73-5) Reference

  • Mennini, T., et al. 1987. Naunyn Schmiedebergs Arch. Pharmacol. 336: 478-482. PMID: 3437921
  • Kato, G. and Weitsch, A.F. 1988. Clin Neuropharmacol. 11: S43-S50. PMID: 3052825
  • Tianeptine Sodium. Martindale: The Complete Drug Reference. London, UK: Pharmaceutical Press. 5 December 2011. Retrieved 2 December 2013.
  • J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1195–. ISBN 978-1-4757-2085-3.

Reviews

There are no reviews yet.

Be the first to review “Tianeptine powder (66981-73-5)”

Your email address will not be published. Required fields are marked *

Login

Lost your password?

Cart

Your cart is currently empty.