Aniracetam powder (72432-10-1)

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Category: SKU: N/A

Name: Aniracetam

CAS:72432-10-1

Molecular Formula:  C12H13NO3

STORAGE:Store in a cool and dry place. Keep away from direct sunlight and heat.

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Aniracetam powder (72432-10-1) video

 

Aniracetam powder Base Information

Name Aniracetam powder
CAS 72432-10-1
Purity 98%
Chemical name 1-(4-methoxybenzoyl)pyrrolidin-2-one
Synonyms Aniracetam; Ampamet; Ro-13-5057; Ro 13 5057; Ro135057; Draganon; Sarpul
Molecular Formula C12H13NO3
Molecular Weight 219.237 g/mol
Melting Point 121-122°C
InChI Key ZXNRTKGTQJPIJK-UHFFFAOYSA-N
Form Solid
Appearance White to Off-white powder
Half Life 1-2.5 hours
Solubility Aniracetam powder is fat soluble and is better taken with meals or fats like fish oil. During our test, aniracetam was not soluble in any solvent when at room temperature. However, when heated to85° C, aniracetam displayed high solubility in oil.
Storage Condition 0 – 4 C for short term (days to weeks), or -20 C for long term (months).
Application Aniracetam used in the treatment of behavioral and psychological symptoms of dementia following stroke and in Alzheimer’s disease.
Testing Document Available

 

Aniracetam: What is it? What are its Benefits?

Aniracetam is a drug used in the treatment of memory and attention disorders. These are usually due to degenerative or cerebrovascular diseases. It is a synthetically derived nootropic from the racetam family. It may be useful to treat cognitive impairment, dementia, Alzheimer’s disease, ADHD, and depression.

 

What is Aniracetam?

Aniracetam is a drug of the racetam family. It is a fat-soluble nootropic drug. It works as a stimulant as well as a mental enhancer.

Aniracetam may improve the memory, creativity, motivation, and sharpness of the mind. It also has anxiolytic properties. It is available in the form of a white or off-white colored powder.

Aniracetam was first made by Hoffmann-La Roche in the 1970s. It was patented by the Swiss-based pharmaceutical company F. Hoffmann-La Roche AG in 1978.

Aniracetam’s core consists of a pyrrolidine nucleus. This drug can be manufactured by mixing 2-pyrrolidone with anisoyl chloride in the presence of triethylamine. Or in an alternate way, by mixing gamma-aminobutyric acid with anisoyl chloride. Aniracetam is a cholinergic compound, thus affecting the acetylcholine levels in the brain.

It is not approved for use in the USA by the FDA, though it is available as a dietary supplement. It is available as a prescription drug in Europe.

 

What does Aniracetam Do?

To understand the workings of aniracetam, we must first talk about its parent class nootropics.

Nootropics are called ‘smart drugs’ and can increase the performance of the brain. They can also make the memory better and enhance cognition. They usually have a stimulant-like effect, similar to coffee. Nootropics can also increase mental alertness and concentration. They consist of both natural and synthetic substances.

Aniracetam works on the part of the neuron in the brain called alpha-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid (AMPA). AMPA receptors are ionotropic glutamate receptor channels.

AMPA receptors allow fast synaptic transmission between the neurons in the central nervous system. They are capable of controlling cell excitability. AMPA does this by allowing a controlled movement of calcium and sodium ions into the cell. They also help the signals to move quickly between the neurons.

The exact mechanism of action of Aniracetam is still relatively unknown. One of the ways how aniracetam works in the brain is by modulating the AMPA receptors in the brain. The main metabolite of aniracetam is N-anisoyl-GABA. This metabolite has many effects.

Aniracetam can slow down the rate of closing of the channels of the receptors. It also desensitizes the partially liganded receptors [1]. Aniracetam showed to be capable of deactivating receptors even at lower concentrations. It means this drug reduces the desensitization of glutamate (AMPA) receptors in the brain. Thus, it leads to a boost in neural signaling. It is because of the increasing effectiveness of glutamate. In the end, it causes glutamate to be more available in the brain, thus allowing for better cognition and memory.

Aniracetam can increase the levels of dopamine and serotonin in the prefrontal cortex, similar to GABA. This action leads to a better mood and may reduce depression.

Aniracetam also has anxiolytic properties. This property can be attributed to its actions on the cholinergic, dopaminergic, and serotonergic systems.

Aniracetam is fat-soluble. It means that it can cross the blood-brain barrier more easily than water-soluble molecules like piracetam, another nootropic. Because of this, it works faster in the brain and gets absorbed faster too. Its side effects do not last as long as other nootropics. It can also reduce anxiety and depression.

It may be used to treat clinical depression, Alzheimer’s disease, attention deficit hyperactivity disorder (ADHD), sleep disorders, and motion sickness.

 

Uses of Aniracetam

There are several benefits of Aniracetam powder. However, the studies and human research are still limited and much needed. Most of the studies about this drug are from animal research and experiments.

Some of the benefits of this drug are:

 

Effects on Cognition

Aniracetam can increase the cognitive abilities of the brain, especially in aged people who have dementia. Dementia is a cognitive disorder that occurs in many people as they age. It can cause memory loss, which can have detrimental effects on the daily life of the person.

A study was conducted in 2011 in which Aniracetam was given to 276 patients with cognitive disorders. It was given as both a single drug therapy or combined with cholinesterase inhibitors (ChEIs). After months of treatment, it was found that the cognitive functions, mood, and functionality of the patients improved significantly [2].

Therefore, Aniracetam powder may be a good choice to better the symptoms in those with cognitive impairment.

 

Effect on Depression

Aniracetam may be effective in treating symptoms of depression. Aniracetam can enhance the levels of dopamine and serotonin in the prefrontal cortex, amygdala, and hippocampus regions of rats with high blood pressure and prone to stroke [3]. These same abilities were shown by the N-anisoyl-gamma-aminobutyric acid (N-anisoyl-GABA), a metabolite of aniracetam. This means it may be possible for it to be effective in the treatment of depression as well.

Effect on Sleep

Aniracetam, like other nootropics, may help treat different sleep disorders and insomnia. A study on stroke-prone rats with hypertension showed that giving aniracetam for five consecutive days increased their REM sleep [4]. So, it may be helpful in sleep disorders caused by vascular dementia.

 

Effects on Memory

Aniracetam’s effects on improving memory are still under speculation. It can reverse memory impairment in rats [5]. Providing aniracetam in the female rats with ameliorated scopolamine-induced amnesia resulted in these animals showing better memory. So it may be able to improve memory in humans as well.

 

Effect on Dementia

Aniracetam is effective in lowering the effects of dementia. In a study involving 109 elderly patients with dementia, aniracetam was given for six months after dividing the patients into two groups [6]. At the end of the experiment, it was found that those who received aniracetam showed an improvement in the psycho behavior patterns. It also showed a slowing of the deterioration. Hence, it may be possible for aniracetam to lessen the problematic behavior and loss of cognition that can occur with dementia in the aging population.

 

Effect on Brain Recovery

Aniracetam is effective in the recovery of the brain after an injury caused by trauma. A study conducted on rats with traumatic brain injury has shown that aniracetam is helpful in the treatment of cognitive impairment caused by trauma over the brain [7].

 

Effect on Alertness and Focus

Aniracetam may help the user to stay more focused and alert to their environment or the task at hand. Thus it may be useful in students and users with ADHD.

 

Effect as a Neuroprotective Agent

Aniracetam has been shown as an effective neuroprotective agent. It is capable of preserving the neuropsychological parameters of patients with dementia. So it may be useful for patients with memory loss.

 

Side Effects of Aniracetam

Aniracetam powder, like most other drugs, has its own set of side effects. Most of these may be due to incorrect or overdosing on the medication. While most of the side effects are not very serious, others can be dangerous. So it is advised to exercise caution while taking this medication.

The commonly reported side effects of aniracetam are:

  • Anxiety
  • Increased heart rate
  • Weight loss
  • Incontinence
  • Sexual dysfunction
  • Insomnia
  • Headaches
  • Irritability
  • Vertigo
  • Nausea
  • Diarrhea
  • Allergies or Hypersensitivity

 

Interactions of Aniracetam With Other Medications

There are several medications that aniracetam can interact with. In most cases, it can amplify the effects of the other drugs. It can also cause some of these drugs to remain in the system for a longer duration.

Some of the drugs that can interact with Aniracetam are:

  • Anticoagulants like warfarin
  • Anticonvulsants like gabapentin
  • Antidepressants like bupropion
  • Anesthetics like propofol
  • Benzodiazepines such as diazepam, alprazolam
  • Opiates like oxycodone

 

Dosage of Aniracetam

The recommended dosage of aniracetam powder is 1500mg per day, taken in doses of 750mg in the morning and 750mg in the evening.

 

Where Can You Buy Aniracetam?

If you would like to purchase Aniracetam powder the best option is to get it directly from the Aniracetam powder manufacturer company. Since this drug is made with the finest ingredients by the best production team, you will get the finest product. Aniracetam powder comes in packages of 1kg per packet or 25kg per drum, but it can be customized according to your needs. The drug needs to be stored and transported in dry and cold conditions. It can be stored at 0 to 4° C for a short term and -20 °C for a long term. This is to prevent damaging the drug and keep it from interacting with the chemicals in the environment.

 

References

  1. Lawrence, J. J., Brenowitz, S., & Trussell, L. O. (2003). The mechanism of action of aniracetam at synaptic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors: indirect and direct effects on desensitization. Molecular Pharmacology, 64(2), 269-278. https://molpharm.aspetjournals.org/content/64/2/269
  2. Koliaki, C. C., Messini, C., & Tsolaki, M. (2012). Clinical efficacy of aniracetam, either as monotherapy or combined with cholinesterase inhibitors, in patients with cognitive impairment: a comparative open study. CNS neuroscience & therapeutics, 18(4), 302-312. https://onlinelibrary.wiley.com/doi/10.1111/j.1755-5949.2010.00244.x
  3. Shirane, M., & Nakamura, K. (2001). Aniracetam enhances cortical dopamine and serotonin release via cholinergic and glutamatergic mechanisms in SHRSP. Brain Research, 916(1-2), 211-221. https://pubmed.ncbi.nlm.nih.gov/11597608/
  4. Kimura, M., Okano, S., & InouÉ, S. (2000). Effects of aniracetam on impaired sleep patterns in stroke‐prone spontaneously hypertensive rats. Psychiatry and clinical neurosciences, 54(3), 314-316. https://pubmed.ncbi.nlm.nih.gov/11186092/
  5. Martin, J. R., Moreau, J. L., & Jenck, F. (1995). Aniracetam reverses memory impairment in rats. Pharmacological Research, 31(2), 133-136. https://pubmed.ncbi.nlm.nih.gov/7596957/
  6. Senin, U., Abate, G., Fieschi, C., Gori, G., Guala, A., Marini, G., … & Parnetti, L. (1991). Aniracetam (Ro 13-5057) in the treatment of senile dementia of Alzheimer type (SDAT): results of a placebo-controlled multicentre clinical study. European Neuropsychopharmacology, 1(4), 511-517. https://pubmed.ncbi.nlm.nih.gov/1822317/
  7. Baranova, A. I., Whiting, M. D., & Hamm, R. J. (2006). Delayed, post-injury treatment with aniracetam improves cognitive performance after traumatic brain injury in rats. Journal of neurotrauma, 23(8), 1233-1240. https://pubmed.ncbi.nlm.nih.gov/16928181/

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