03 Enobosarm (MK2866) Base Information
|Name||Enobosarm (MK2866) powder|
|Synonyms||MK2866; MK 2866; MK-2866; GTX024; GTX 024; GTX-024; Ostarine; Enobosarm.|
|Molecular Weight||389.334 g/mol|
|Melting Point||132 to 136 °C (270 to 277 °F)|
|Appearance||White to Off-white|
|Half Life||24 hours|
|Solubility||Soluble in DMSO, not in water|
|Storage Condition||0 – 4 C for short term (days to weeks), or -20 C for long term (months).|
|Application||Ostarine, aslo known as Enobosarm, and MK-2866 and GTX-024, is selective androgen receptor modulator with anabolic activity.|
04 Enobosarm(MK2866) General Description
Ostarine powder, aslo known as Enobosarm, and MK-2866 powder and GTX-024, is selective androgen receptor modulator with anabolic activity. Selective androgen receptor modulator (SARM) GTx-024 powder is designed to work like testosterone, thus promoting and/or maintaining libido, fertility, prostate growth, and muscle growth and strength. Mimicking testosterone’s action, this agent may increase lean body mass, thereby ameliorating muscle wasting in the hypermetabolic state of cancer cachexia.
05 Enobosarm (MK2866) History
GTx Incorporated was founded in Memphis in 1997 and licensed rights to enobosarm from the University of Tennessee Research Foundation; the SARM compounds were invented by James T. Dalton, Duane D. Miller, Karen A. Veverka and their research teams at Ohio State University, the University of Tennessee and GTx, respectively.
By 2007, enobosarm was in a Phase II trial, and that year GTx signed an exclusive license agreement for its SARM program with Merck & Co.The companies ended the deal in 2010.
In August 2013, GTx announced that enobosarm had failed in two Phase III clinical trials to treat wasting in people with lung cancer.The company had invested around $35 million in the development of the drug. The company said at that time that is planned to pursue approval of enobosarm in Europe; the company was also still developing GTx-758 for castration-resistant prostate cancer.
In 2016, GTx began Phase II trials, to see if enosobarm might be effective to treat stress urinary incontinence in women.
06 Enobosarm (MK2866) Mechanism Of Action
Ostarine MK-2866 powder is a Selective Androgen Receptor Modulator (SARM CAS 1202044-20-9). It was developed by a pharmaceutical company known as GTX to help people to fight against the muscle wasting conditions. It achieves the end result by binding your androgen receptors in the same manner as prohormones or anabolic steroids.
But the benefit of the ostarine is that it will affect only certain tissues, unlike the steroids. Though many of us as men may not have it, deep inside almost each one of us would crave for those strong and shaped muscles and six-pack abs. However, this will remain wishful thinking unless we get up and do something about it. While exercise, good nutrition with the best of proteins are quite vital, there are a few others things too that one must take into account.
It works by targeting the androgen receptors that are found in the bone and muscles without affecting the other organs of your body. Moreover, it will not be converted into unwanted hormones that you can expect from steroids. It does not offer any severe side effect as well.
07 Enobosarm(MK2866) (841205-47-8) Application
Ostarine MK-2866 is designed for the increased lean mass gain. While having this supplement, you can expect noticeable lean mass gains. In addition, you will have better strength and you will feel active and dynamic. You will have more endurance. If you have joint pain, you will feel better. This product has joint healing abilities. It will help in weight loss, recomposition, and bulking.
The functioning will not be different from the steroids. It will cause the muscle growth similar to the steroids. But the difference is that it will not offer any severe side effects that you find in the anabolic steroids. You can say thatostarine(MK-2866) is safe and offer a natural result without affecting many tissues and other organs of your body.
It uses the anabolic effects on your muscle tissues fully. This ability makes it a good choice to treat the muscle wasting ailments. In addition to curing, it is very effective to build the muscles.
GTx has done many research and experiments for this product before introducing it into the market. It has conducted a four months IIb trial with 159 patients. All of them have shown a significant difference. They have got a complete boost in total muscle mass in comparison to the other supplements and the methods.
When it comes to the bodybuilding, the users found it very helpful as it helps to improve the lean muscle mass and even the muscle strength. The product is highly appreciated by the users for the muscle building and more endurance.
08 Enobosarm(MK2866) (841205-47-8) More research
Ostarine (also known as GTx-024 and MK-2866) is an investigational selective androgen receptor modulator (SARM) from GTX, Inc for treatment of conditions such as muscle wasting and osteoporosis, formerly under development by Merck & Company. GTx and Merck had clinical development plans to evaluate Ostarine for the treatment of muscle loss in patients with COPD and for the treatment of chronic sarcopenia.
09 Enobosarm(MK2866) (841205-47-8) Reference
1: Girgis CM, Mokbel N, Digirolamo DJ. Therapies for musculoskeletal disease: can we treat two birds with one stone? Curr Osteoporos Rep. 2014 Jun;12(2):142-53. doi: 10.1007/s11914-014-0204-5. Review. PubMed PMID: 24633910; PubMed Central PMCID: PMC4083371.
2: Srinath R, Dobs A. Enobosarm (GTx-024, S-22): a potential treatment for cachexia. Future Oncol. 2014 Feb;10(2):187-94. doi: 10.2217/fon.13.273. PubMed PMID: 24490605.
4: Nagle, Mike (7 November 2007). “Merck flexes muscle with GTx deal”. Outsourcing Pharma.
- 01. Overview
- 02. Enobosarm
- 03. Enobosarm (MK2866) Base Information
- 04. Enobosarm(MK2866) General Description
- 05. Enobosarm (MK2866) History
- 06. Enobosarm (MK2866) Mechanism Of Action
- 07. Enobosarm(MK2866) (841205-47-8) Application
- 08. Enobosarm(MK2866) (841205-47-8) More research
- 09. Enobosarm(MK2866) (841205-47-8) Reference