Choline Bitartrate is an essential nutrient, generally grouped as a B Vitamin. When taken at a dose of at least 82.5mg it has a number of benefits, including contributing to the maintenance of normal liver function and contributing to normal lipid metabolism. Choline is produced by the body natural and can be obtained via the diet. Foods high in choline include egg yolks, meat, spinach, cauliflower, cabbage, lettuce, nuts, grains, wheat germ and legumes. Bitartrate is synthesised with choline to ensure optimal absorption within the human body.
|Name||Choline Bitartrate powder|
|Chemical name||Choline Bitartrate|
|Synonyms||Choline Bitrate;CHOLINE TARTRATE;Cholini Bitatratis;CHOLINE BITARTRATE;tanedioicacid(1:1);Tartaric acid choline;Cholinebitartrate,98%;CHOLINE BITARTRATE SALT;Choline L-(+)-Bitartrate;CHOLINE BITARTRATE COATED|
|Appearance||White Solid Powder|
|Solubility||Soluble in alcohol and slightly soluble in water.|
|Storage Condition||Room Temperature|
|Application||Medicine, dietary supplement, nutrient.|
Choline, a quaternary ammonium compound, is similar to the B vitamins. It can be made in the liver and found in foods such as liver, muscle meats, fish, nuts, beans, peas, spinach, wheat germ, and eggs. Choline is required to make essential membrane phospholipids. It is an important source of labile methyl groups and a precursor for the biosynthesis of the neurotransmitter acetylcholine which is released by nerve cells to send signals to other cells. Choline is an essential nutrient for humans when excess methionine and folate are not available in the diet. It is used to treat liver diseases, including chronic hepatitis and cirrhosis. It is also used to treat depression, memory loss, Alzheimer-type dementias, Huntington’s chorea, Tourette’s disease, a brain disorder called cerebellar ataxia, certain types of seizures, and a mental condition called schizophrenia. Athletes use choline for bodybuilding and delaying fatigue in endurance sports. Choline is taken by pregnant women to prevent neural tube defects in their babies and is used as a supplement in infant formulas. Other uses include preventing cancer, lowering cholesterol, and controlling asthma. Choline is often linked together with tartaric acid (also known as bitrate) in many brain vitamin supplement formulas to improve its absorption rate into the body’s nervous system and eventually into the brain. A binding of these two brain vitamins together helps to synthesize compounds that are essential for the optimal health of membranes and nerve endings found in cells in the body.
Several mechanisms are suggested for the cancer-promoting effect of a choline-devoid diet. These incl incr cell proliferation related to regeneration after parenchymal cell death occurs in the choline deficient liver, hypomethylation of DNA (alters expression of genes), reactive oxygen species leakage from mitochondria with incr lipid peroxidation in liver, activation of protein kinase C signaling due to accumulation of diacylglycerol in liver, mutation of the fragile histidine triad (FHIT) gene, which is a tumor suppressor gene, and defective cell-suicide (apoptosis) mechanisms. Loss of phposphatidylethanolamine N-methyl-transferase (PEMT) function may also contribute to malignant transformation of hepatocytes.
Acetylcholine is one of the most important neurotransmitters used by neuronsin the memory centers of the brain (hippocampus and septum). Choline accelerates the synth and release of acetylcholine in nerve cells.
Choline deficiency in cell culture causes apoptosis or programmed cell death. This appears to be due to abnormalities in cell membrane phosphatidylcholine content and an incr in ceramide, a precursor, as well as a metabolite of sphingomyelin. Ceramide accumulation, which is caused by choline deficiency, appears to activate a caspase, a type of enzyme that mediates apoptosis.
Choline bitartrate has been used as one of the components in experimental diets to study the effects on reproductive processes and on bone genes during gestation and lactation.
Health Benefits of Choline Bitartrate:
Being a product of vitamin, it can be applied to medicine, healthcare productand food.
It is a nutritious additive and fat remover, enhance fatty metabolism and eliminate the accumulation of fat in liver.
Influence muscle contractions, movement, coordination and enhance memory.
Involved in higher level brain functions like memory, thought and intellect.
Is vital to the structural integrity of cell walls, the production of amino acids and proteins and the metabolism of fats.
Aid in the treatment of Alzheimer’s Disease, manic depression and improve the symptoms of Parkinson’s Disease.