Anandamide Powder is an endogenous occurring cannabinoid neurotransmitter in the brain, which means that the human brain is able to produce anandamide without intaking foods containing AEA. The brains of mammal species and raw cacao are confirmed to contain some amount of anandamide.
Soluble in DMSO (~30 mg/ml), DMF (~10 mg/ml), anhydrous ethanol (5 mg/ml), PBS, pH 7.2 (~100 mg/ml), and water (<0.1 mg/ml at 25° C).
An endogenous cannabinoid receptor ligand
Anandamide (AEA) General Description
Anandamide, also known as N-arachidonoylethanolamine (AEA), is a fatty acid neurotransmitter derived from the non-oxidative metabolism of eicosatetraenoic acid (arachidonic acid), an essential omega-6 fatty acid. The name is taken from the Sanskrit word ananda, which means “joy, bliss, delight”, and amide. It is synthesized from N-arachidonoyl phosphatidylethanolamine by multiple pathways.
Beyond creativity, anandamide has a host of benefits as well, here is general description on them.
Working Memory – This is one of the key components of creativity. As mentioned above, anandamide helps gather many pieces of information in order to create new ideas. There are few studies on healthy adults, but one model showed that rats afflicted with working memory deficits improved this cognitive measure with only anandamide.
From this evidence, it is clear anandamide interacts with working memory and various mechanisms. The change is scientifically proven, but for healthy adults the magnitude is still unknown.
Neurogenesis – According to Dr. Gary Wenk, anandamide can be a powerful chemical associated with neurogenesis especially in the elderly. As a researcher of neuroscience, he has insights into the effects of anandamide and the interactions with the brain.
Until recently, scientists believed that neurogenesis (the growing of new brain cells) only happened in youth and adolescents. Today it is well known that neurogenesis continues long into adulthood and the better we can manage it, the less risk we have of neurodegenerative problems like memory issues and dementia.
Anti-Depressive – Beyond the cognitive benefits, there are several mood and quality of life enhancements with anandamide as well. Studies of rat brain models suggest anandamide has strong anti-depressive effects in the brain, which can help those with a poor mood.
Anandamide (AEA) powder (94421-68-8) History
Anandamide was first described (and named) in 1992 by Raphael Mechoulam and his lab members W. A. Devane and Lumír Hanuš.
Anandamide (AEA) powder Application
Anandamide is synthesized enzymatically in the areas of the brain that are important in memory, thought processes and control of movement. Research suggests that anandamide plays a role in the making and breaking of short-term connections between nerve cells, and this is related to learning and memory. Animal studies suggest that too much anandamide induces forgetfulness. This suggests that if substances could be developed that keep anandamide from binding to its receptor, these might be used to treat memory loss or even to enhance existing memory!
Anandamide (AEA) More research
Black pepper contains the alkaloid guineesine, which is an anandamide reuptake inhibitor. It may therefore increase anandamide’s physiological effects.
Low dose intake of anandamide has an anxiolytic effect, but high dose intake in mice shows evident hippocampus death.
A Scottish woman with a rare genetic mutation in her FAAH gene with resultant elevated anandamide levels was reported to be immune to anxiety, unable to experience fear and insensitive to pain. The frequent burns and cuts she suffered due to her hypoalgesia healed quicker than average.
Anandamide (AEA) powder (94421-68-8) Reference
Devane, W.; Hanus, L; Breuer, A; Pertwee, R.; Stevenson, L.; Griffin, G; Gibson, D; Mandelbaum, A; Etinger, A; Mechoulam, R (18 December 1992). “Isolation and structure of a brain constituent that binds to the cannabinoid receptor”. Science. 258 (5090): 1946–
Mechoulam R, Fride E (1995). “The unpaved road to the endogenous brain cannabinoid ligands, the anandamides”. In Pertwee RG (ed.). Cannabinoid receptors. Boston: Academic Press. pp. 233–
Battista, N., and Maccarrone, M. (2017). “Basic mechanisms of synthesis and hydrolysis of major endocannabinoids,” in The Endocannabinoid System: Genetics, Biochemistry, Brain Disorders, and Therapy, ed. E. Murillo-Rodriguez ( Amsterdam: Elsevier), 1–24.
Devane et al. (1992), Isolation and structure of a brain constituent that binds to the cannabinoid receptor; Science, 258 1946.