3,4-Dihydroxybenzoic acid powder 99-50-3

3,4-Dihydroxybenzoic acid powder Chemical Base Information Name 3,4-Dihydroxybenzoic acid CAS 99-50-3 Purity 99% Chemical name 3,4-Dihydroxybenzoic acid Synonyms 3,4-DIHYDROXYBENZOIC ACID protocatechuic acid 99-50-3 Protocatehuic acid 4-Carboxy-1,2-dihydroxybenzene Molecular Formula C7H6O4 Molecular […]

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3,4-Dihydroxybenzoic acid powder Chemical Base Information

Name 3,4-Dihydroxybenzoic acid
CAS 99-50-3
Purity 99%
Chemical name 3,4-Dihydroxybenzoic acid

protocatechuic acid


Protocatehuic acid


Molecular Formula C7H6O4
Molecular Weight 154.12
Boling Point /
Form powder
Appearance White or almost white crystalline powder
Half Life /
Solubility soluble in hot water
Storage Condition RT
Application Dietary supplements
Testing Document Available


3,4-Dihydroxybenzoic acid powder 99-50-3 General Description

Powder 3,4-dihydroxybenzoic acid also well known as Protocatechuic acid (PCA), it is a dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4. It has a role as a human xenobiotic metabolite, a plant metabolite, an antineoplastic agent, an EC (shikimate dehydrogenase) inhibitor and an EC (procollagen-proline dioxygenase) inhibitor. It is a member of catechols and a dihydroxybenzoic acid. It derives from a benzoic acid. It is a conjugate acid of a 3,4-dihydroxybenzoate.


3,4-Dihydroxybenzoic acid powder 99-50-3 Mechanism Of Action

3,4-Dihydroxybenzoic acid has been reported to induce apoptosis of human leukemia cells, as well as malignant HSG1 cells taken from human oral cavities,but 3,4-Dihydroxybenzoic acid was found to have mixed effects on TPA-induced mouse skin tumours. Depending on the amount of PCA and the time before application, PCA could reduce or enhance tumour growth. Similarly, 3,4-Dihydroxybenzoic acid was reported to increase proliferation and inhibit apoptosis of neural stem cells. In an in vitro model using HL-60 leukemia cells, protocatechuic acid showed an antigenotoxic effect and tumoricidal activity.In two preclinical investigations, protocatechuic acid from Hibiscus sabdariffa showed an excellent ability to effectively inhibit the replication of herpes simplex virus type 2 and to potently deactivate the catalytic activity of urease.


What Is 3,4-Dihydroxybenzoic acid powder Use For?

3,4-Dihydroxybenzoic acid powder is use to make the dietary supplements for body health. 17 benefits of of 3,4-Dihydroxybenzoic acid are:

  1. Strong antioxidant

3,4-Dihydroxybenzoic acid is considered as an active component of some traditional Chinese herbal medicines such as Cibotium barometz (L.)  J.S, Stenoloma chusanum (L.) Ching, Ilex chinensis Sims. Fruits of Ficus species are rich source of polyphenolic compounds and flavanoids which are responsible for strong antioxidant properties that help in prevention and therapy of various oxidative stress related diseases such as neurodegenerative and hepatic diseases. Acai oil, obtained from the fruit of the Acaí palm (Euterpe oleracea) [20], is rich in protocatechuic acid (630  36 mg/kg). Acai oil has a relatively high content of polyphenols, which in turn has been linked to a range of reported (mostly in vitro) antioxidant, anti-inflammatory, antiproliferative, and cardioprotective properties. PCA also occurs in rich quantity in various multiple fruits such as berries (raspberry, blueberry, mulberry, strawberry, cranberry, and gooseberry). It is also known to occur in Loquat fruit, wine, honey, and soybean.


  1. Resist onion smudge

3,4-Dihydroxybenzoic acid occurs in pigmented onion scales Allium cepa  which enables them resist onion smudge, a fungal disease due to Colletotrichum circinans.


  1. Good chemopreventive properties

3,4-Dihydroxybenzoic acid is also found in Carrot (Daucus carota) and in mushrooms such as Agaricus bisporus (White Button Mushroom) or Phellinus linteus and has shown good chemopreventive properties.


  1. Antibacterial Activity

Roselle calyx (Hibiscus sabdariffa L.) extract and protocatechuic acid were both found to decrease lipid oxidation levels in ground beef tissue. Protocatechuic acid also exhibited dose-dependent effect.


  1. Antidiabetic Activity

Protocatechuic acid at 1% and 2% when given to d-galactose treated mice for 8 weeks decreased reactive oxygen species levels, protein carbonyl, carboxymethyllysine, pentosidine, sorbitol, fructose, and methylglyoxal.


  1. Anticancer Activity

PCA seems to have chemopreventive potential because it inhibits the in vitro chemical carcinogenesis and exerts proapoptotic and antiproliferative effects in different tissues


  1. Antiulcer Activity

The mechanism of action of PCA ethyl ester may be due to either cytoprotective action of the drug or by strengthening the gastric mucosa thereby enhancing mucosal defense. Similarly protocatechuic acid may also possess a certain level of antiulcer properties.


  1. Antiageing Activity

Protocatechuic acid derived from the dried fruits of Alpinia oxyphylla has proved to be a potential antiageing compound on spleen and liver antioxidant system in aged rats.


  1. Antifibrotic Activity

Studies have shown protocatechuic aldehyde to possess beneficial antifibrogenic effects. Transforming growth factor-β1 (TGF-β1) and connective transforming growth factor (CTGF) are associated with the pathophysiology of liver fibrosis.


  1. Other benefits

Hibiscus protocatechuic acid (PCA) is a simple phenolic compound isolated from the dried flowers of Hibiscus sabdariffa L. , a Chinese herbal medicine, which is reported to be:














and tonic

Also this is a folk remedy for abscesses, bilious conditions, cancer, cough, debility, dyspepsia, dysuria, fever, hangover, heart ailments, hypertension , neurosis, scurvy, and strangury.

  1. Antiviral Activity
  2. Anti-Inflammatory, Analgesic, and Antiseptic Properties
  3. Antiatherosclerotic and Hyperlipidemic Activities
  4. Cardiac Activity
  5. Hepatoprotective Activity
  6. Neurological Effects
  7. Effects on Reproductive System


3,4-Dihydroxybenzoic acid powder 99-50-3 Application

Dietary supplements, antioxidant


3,4-Dihydroxybenzoic acid powder 99-50-3 More research

Protocatechuic acid, also known as protocatechuate or 3,4-dihydroxybenzoate, belongs to the class of organic compounds known as hydroxybenzoic acid derivatives. Hydroxybenzoic acid derivatives are compounds containing a hydroxybenzoic acid (or a derivative), which is a benzene ring bearing a carboxyl and a hydroxyl groups. The enzyme protocatechuate 3,4-dioxygenase uses 3,4-dihydroxybenzoate and O2 to produce 3-carboxy-cis,cis-muconate. Protocatechuic acid is a drug. In the analogous hardening of the cockroach ootheca, the phenolic substance concerned is protocatechuic acid. Protocatechuic acid is a mild, balsamic, and phenolic tasting compound. Outside of the human body, protocatechuic acid is found, on average, in the highest concentration in a few different foods, such as garden onions, cocoa powders, and star anises and in a lower concentration in lentils, liquors, and red raspberries. Protocatechuic acid has also been detected, but not quantified in several different foods, such as cloud ear fungus, american pokeweeds, common mushrooms, fruits, and feijoa. This could make protocatechuic acid a potential biomarker for the consumption of these foods. It is also found in Allium cepa (17,540 ppm). It is a major metabolite of antioxidant polyphenols found in green tea. Similarly, PCA was reported to increase proliferation and inhibit apoptosis of neural stem cells. In vitro testing documented antioxidant and anti-inflammatory activity of PCA, while liver protection in vivo was measured by chemical markers and histological assessment.


3,4-Dihydroxybenzoic acid Sources

  1. 3,4-Dihydroxybenzoic acidcan be isolated from the stem bark of Boswellia dalzielii. and from leaves of Diospyros melanoxylon.
  2. Açaí oil, obtained from the fruit of the açaí palm (Euterpe oleracea), is rich in protocatechuic acid (630±36 mg/kg). 3,4-Dihydroxybenzoic acidalso exists in the skins of some strains of onion as an antifungal mechanism, increasing endogenous resistance against smudge fungus. It is also found in Allium cepa (17,540 ppm).
  3. 3,4-Dihydroxybenzoic acidoccurs in roselle (Hibiscus sabdariffa), which is used worldwide as a food and beverage.
  4. 3,4-Dihydroxybenzoic acidis also found in mushrooms such as Agaricus bisporus or Phellinus linteus.
  5. 3,4-Dihydroxybenzoic acidis regarded as an active component in traditional Chinese herbal medicine such as Stenoloma chusanum (L.) Ching, Ilex chinensis Sims, Cibotium barometz (L.) J.Sm.


Buy 3,4-Dihydroxybenzoic acid Powder

3,4-Dihydroxybenzoic acid Powder as the ingredient use to make dietary supplements, is popular sell online in the anti aging market. Wisepowder produce and supply large quantity of 3,4-Dihydroxybenzoic acid powder, purity no less than 98%, sample and testing documents available.


3,4-Dihydroxybenzoic acid powder 99-50-3 Reference

  1. Anter, J.; Romero Jiménez, M.; Fernández Bedmar, Z.; Villatoro Pulido, M.; Analla, M.; Alonso Moraga, A.; Muñoz Serrano, A. (March 2011). “Antigenotoxicity, cytotoxicity, and apoptosis induction by apigenin, bisabolol, and protocatechuic acid”. Journal of Medicinal Food. 14 (3): 276–
  2. Hassan, S. T. S.; Švajdlenka, E. (October 2017). “Biological evaluation and molecular docking of protocatechuic acid from Hibiscus sabdariffa L. as a potent urease inhibitor by an ESI–MS based method”. Molecules. 22 (10): 1696.
  3. Lee, Y.-S.; Kang, Y. H.; Jung, J. Y.; et al. (October 2008). “Protein glycation inhibitors from the fruiting body of Phellinus linteus”. Biological & Pharmaceutical Bulletin. 31 (10): 1968–72. doi:10.1248/bpb.31.1968. PMID 18827365.
  4. Babich, H.; Sedletcaia, A.; Kenigsberg, B. (November 2002). “In vitro cytotoxicity of protocatechuic acid to cultured human cells from oral tissue: involvement in oxidative stress”. Pharmacology & Toxicology. 91 (5): 245–253. doi:10.1034/j.1600-0773.2002.910505.x. PMID 12570031