Cannabidiol (CBD) is a naturally occurring compound found in the resinous flower of cannabis, a plant with a rich history as a medicine going back thousands of years. Today the therapeutic properties of CBD are being tested and confirmed by scientists and doctors around the world. A safe, non-addictive substance, CBD is one of more than a hundred “phytocannabinoids,” which are unique to cannabis and endow the plant with its robust therapeutic profile.
Chemical Base Information
|Purity||99% Isolate / Extrapure Isolate (CBD≥99.5%）|
|Synonyms||CBD; C07578; CBD oil; CBD crystal; CANNABIDIOL;CBD Isolate; (1r-trans)-;CBD powder 99%; CBD,CANNABIDIOL; (-)-CANNABIDIOL|
|Appearance||White to light yellow crystalline powder|
|Half Life||18–32 hours|
|Solubility||Soluble in oil, extremely soluble in ethanol and methanol, insoluble in water|
|Storage Condition||Room temperature, keep dry and away from light|
|Application||For scientific research purposes only, or as raw materials for downstream product development, or for sale in legitimate countries and regions abroad. Please note these products should not be directly consumed or used for clinical treatment in China mainland|
Cannabidiol(CBD) powder 13956-29-1 General Description
Cannabidiol[CBD] is the main non-psychotropic component of the glandular hairs of Cannabis sativa. It displays a plethora of actions including anticonvulsive, sedative, hypnotic, antipsychotic, and anti-inflammatory and neuroprotective properties. It is a major phyto-cannabinoid, accounting for up to 40% of the Cannabis plant’s extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical implications are currently being investigated, CBD has shown promise as a therapeutic and pharmaceutical drug target. In particular, CBD has shown promise as an analgesic, anticonvulsant, muscle relaxant, anxiolytic, antipsychotic and has shown neuroprotective, anti-inflammatory, and antioxidant activity, among other currently investigated uses.
CBD is closely related to another important medicinally active phytocannabinoid: tetrahydrocannabinol (THC), the compound that causes the high that cannabis is famous for. These are the two components of cannabis that have been most studied by scientists.
Both CBD and THC have significant therapeutic attributes. But unlike THC, CBD does not make a person feel “stoned” or intoxicated. That’s because CBD and THC act in different ways on different receptors in the brain and body.
CBD can actually lessen or neutralize the psychoactive effects of THC, depending on how much of each compound is consumed. Many people want the health benefits of cannabis without the high – or with less of a high. The fact that CBD is therapeutically potent as well as non-intoxicating, and easy to take as a CBD oil, makes it an appealing treatment option for those who are cautious about trying cannabis for the first time.
Efforts to isolate the active ingredients in cannabis were made in the 19th century. Cannabidiol was studied in 1940 from Minnesota wild hemp and Egyptian Cannabis indica resin. The chemical formula of CBD was proposed from a method for isolating it from wild hemp. Its structure and stereochemistry were determined in 1963.
Mechanism Of Action
Cannabidiol has effects on the brain. The exact cause for these effects is not clear. However, cannabidiol seems to prevent the breakdown of a chemical in the brain that affects pain, mood, and mental function. Preventing the breakdown of this chemical and increasing its levels in the blood seems to reduce psychotic symptoms associated with conditions such as schizophrenia. Cannabidiol might also block some of the psychoactive effects of delta-9-tetrahydrocannabinol (THC). Also, cannabidiol seems to reduce pain and anxiety.
Analgesic and anti-inflammatory: Cannabidiol can produce analgesic effects. The pharmacological mechanism of analgesia is mainly related to CB1 and CB2 receptors.CB1 receptors achieve analgesic effects by directly inhibiting the release of gamma-aminobutyric acid, gray matter and RVM (GABA), and glutamate in the spinal cord in the periaquapular.
GABA neurotransmitters in the human brain have a calming effect, inhibiting excitability in the brain’s centers.Cannabidiol can help control the consumption of GABA neurotransmitters, inhibit brain excitement, reduce seizures, and improve the effectiveness of other antiepileptic drugs.
Endocannabinoids is an important substance in the body that helps depression patients reduce anxiety. Cannabidiol helps keep endocannabinoids at a reasonable level, making patients feel good and happy, but patients will not reply on this CBD powder.
Cannabidiol(CBD) powder 13956-29-1 More research
Research on other uses for cannabidiol includes several neurological disorders, but the findings have not been confirmed to establish such uses in clinical practice. In October 2019, the FDA issued an advisory warning that the effects of CBD during pregnancy or breastfeeding are unknown, indicating that the safety, doses, interactions with other drugs or foods, and side effects of CBD are not clinically defined, and may pose a risk to the mother and infant.
Many claims are made for the therapeutic benefit of cannabidiol that are not backed by sound evidence. Some claims – for example that cannabidiol can be used to treat cancer – fall into the realm of pseudoscience.
In 2020, the label for Epidiolex in the US was expanded to include treatment of seizures associated with tuberous sclerosis complex.
- “FDA Regulation of Cannabis and Cannabis-Derived Products, Including Cannabidiol (CBD) (General)”. US Food and Drug Administration (FDA). January 22, 2021. Retrieved April 14, 2021.
- Campos AC, Moreira FA, Gomes FV, Del Bel EA, Guimarães FS (December 2012). “Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders”. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences (Review). 367 (1607): 3364–
- Izgelov D, Davidson E, Barasch D, Regev A, Domb AJ, Hoffman A. Pharmacokinetic investigation of synthetic cannabidiol oral formulations in healthy volunteers. Eur J Pharm Biopharm. 2020;154:108-115.
- Gurley BJ, Murphy TP, Gul W, Walker LA, ElSohly M. Content versus Label Claims in Cannabidiol (CBD)-Containing Products Obtained from Commercial Outlets in the State of Mississippi. J Diet Suppl. 2020;17:599-607.