Fisetin Powder (528-48-3)
Fisetin is a common botanical polyphenol and flavonoid found in a wide variety of plants, fruits and vegetables including strawberries, apples, persimmons, onions and cucumbers. Fisetin is considered a plant pigment imparting many fruits and vegetables, such as strawberries, with their characteristic color and appearance. Fisetin has a very similar molecular structure as the more popular plant flavonoid and dietary supplement Quercetin. Unlike Quercetin, however, Fisetin may be a senolytic and perhaps one of the most powerful senolytics known.
Manufacture: Batch Production
Package: 1KG/bag, 25KG/drum
Fisetin Chemical Base Information Base Information
|Synonyms||2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one , 3,3′,4′,7-Tetrahydroxyflavone , 5-Deoxyquercetin , Natural Brown 1 , CI-75620 , NSC 407010 , NSC 656275 , BRN 0292829 , Cotinin , 528-48-3 (anhydrous)|
|Melting Point||330° C (dec.)|
|Solubility||Soluble to 100 mM in DMSO and to 10 mM in ethanol|
|Storage Condition||−20°C for long time|
|Application||Fisetin is a potent sirtuin activating compound (STAC), antiinflammatory and anticancer agent|
Flavonoid polyphenols are commonly used for their antioxidant properties. Their main source is fruits and vegetables that are consumed regularly, by millions worldwide. Due to their health benefits, flavonoids have also become key ingredients in different dietary supplements, especially resveratrol. Recent studies have found a new flavonoid namely fisetin, which is believed to be the most potent among the other flavonoids used as a dietary supplement. Fisetin powder or Fisetin supplements have since increased in demand due to their health benefits.
What is Fisetin?
Fisetin is a flavonoid polyphenol that acts as a yellow pigment in plants. Originally discovered in 1891, fisetin is found in many fruits and vegetables such as persimmon and strawberries. Although it has been around for a long time, it was only recently that the fisetin benefits were discovered and made it stand out compared to other supplements. Moreover, it was the potential medicinal benefits of fisetin powder that encouraged research into the topic. Although it has been studied and the fisetic benefits and fisetin side effects have been realized, there is still a lot that scientists haven’t been able to understand about the flavonoid.
The Mechanism Of Action of Fisetin: How does Fisetin work?
Fisetin powder works through multiple pathways in the human body. Fisetin especially works on the antioxidants levels in the body and this is one of its major benefits. It fights against free radicals, which are unstable ions that will participate in harmful chemical reactions to harm the body. Fisetin’s antioxidant properties allow it to neutralize these free radicals and hence, reduce the oxidative stress that the body is under.
Another mechanism of action of fisetin is that it blocks the NF-KB pathway. This pathway is important for the production and release of pro-inflammatory cytokines and eventually, inflammation. NF-KB is a pro-inflammatory pathway that induces gene transcription to synthesize the inflammatory proteins. When overtly activated, the NF-KB pathway plays an important role in cancer development, allergies, and autoimmune diseases. Fisetin powder blocks this pathway, hence, acting as an anti-inflammatory supplement.
Fisetin powder also blocks the action of the mTOR pathway. This pathway, much like the NF-KB pathway, is involved in the development of cancer, diabetes mellitus, obesity, and neurodegenerative diseases. mTOR pathway causes the cells to panic as they struggle to meet the energy demands of the pathway, resulting in an excessive workload on the cells. What this means is that cells are overworking and producing metabolic waste but there isn’t sufficient time to clean up the waste resulting in the accumulation of waste. This can be detrimental to cellular health and the blockage of this pathway by fisetin supplement is how fisetin helps manage obesity, diabetes, and cancer.
Apart from these major mechanisms of action, fisetin is also able to inhibit the activity of lipid-degrading enzymes, lipoxygenases. It also inhibits matrix metalloproteinases or the MMP family of enzymes. These enzymes are crucial for cancerous cells to be able to invade other tissues, however, with the use of fisetin powder, that is no longer possible.
What food contains Fisetin?
Fisetin is a plant-based flavone that is primarily extracted from apples and strawberries. It is a pigment of yellow and ochre color in plants, meaning that most fruits and vegetables of that color are rich in fisetin. Fisetin, in plants, is synthesized from the amino acid phenylalanine, and the accumulation of this flavone in plants is highly dependent on the environment of the plant. If the plant is exposed to shorter wavelengths of UV rays, then there is an increase in the production of fisetin. Fisetin powder is made from the isolation of fisetin from the following plant sources.
|Plant sources||Amount of Fisetin
What are the benefits of Fisetin?
Fisetin benefits are quite a few, and they have all been seen on animal models. No research has been able to conclusively determine these benefits in humans as most studies are still in the clinical phase. The different benefits of fisetin include:
Aging of the body is marked by a net increase in senescent cells, that are no longer able to divide. These cells release inflammatory signals, which results in the complications of aging most commonly seen. Most age-related disorders are due to abhorrent inflammation in the body promoted by the senescent cells. Fisetin powder consumption targets these cells and removes them from the body, hence, reducing inflammation and slowing down the aging process.
In animal models, fisetin supplement has been shown to reduce blood sugar levels significantly. This effect of fisetin comes from the flavonoid’s ability to increase insulin levels, increase glycogen synthesis, and decrease the liver’s ability to initiate gluconeogenesis. Basically, fisetin acts on every pathway in the body that results in glucose production and stops those while activating the pathways that either store or use up the glucose in the bloodstream.
The anti-cancer effects of fisetin powder differ based on the type of cancer. In a study performed on prostate cancer, fisetin was able to reduce the growth of cancer by blocking testosterone and DHT receptors, which are important for the growth of prostate cancer. In another study where the cancer being studied was lung cancer, fisetin supplements were able to increase antioxidants in the blood that had been reduced by tobacco use. Fisetin was also able to reduce the growth of lung cancer by 67 percent on its own, and 92 percent when combined with a chemotherapy drug. When used in colon cancer, fisetin significantly reduced the inflammation associated with colon cancer. The study, however, did not mention any effect of fisetin on cancer growth.
When older rats with age-related decline in cognition were given fisetin supplement, there was a significant improvement in their cognitive skills and memory. In another study, animal models were exposed to neurotoxic substances and then given a fisetin supplement. The test subjects were found to have not experienced any memory loss due to the supplement. However, it is not known if fisetin can cross the human blood-brain barrier with the same efficiency as the mice blood-brain barrier.
Fisetin is also neuroprotective in the sense that it prevents the development of neurodegenerative disorders such as Alzheimer’s by reducing the accumulation of harmful proteins in the brain. Similarly, mice with ALS showed an improvement in their balance and muscle coordination after being given fisetin powder. They also experienced a prolonged life span than what was expected.
Researchers studied the effect of fisetin powder on the cholesterol levels of rats who were fed a high-fat diet. Total cholesterol and LDL levels were found to have decreased significantly whereas HDL levels almost doubled. The hypothesized mechanism through which fisetin rids the body of cholesterol is believed to be increased release of it into bile. The reduced cholesterol, overall, has a cardioprotective effect.
All these fisetin benefits point toward anti-aging and longevity of life which should be enough to promote more clinical studies so that the compound can be approved for medicinal use.
Fisetin Vs Quercetin: is fisetin the same as quercetin?
Quercetin and Fisetin are both plant flavonoids or pigments that are well known for their anti-inflammatory and anti-oxidant properties. They both also have significant anti-aging properties, which they perform by clearing senescent cells from the body. Fisetin powder, however, has been shown to clear out the cells with increased efficacy and potency than quercetin.
Fisetin Vs Resveratrol: is fisetin better than resveratrol?
Resveratrol is a polyphenol that is also quite popular for its anti-oxidant properties. Taking quercetin and resveratrol results in a synergistic effect on the body, although quercetin is more potent at mediating inflammation and managing insulin resistance. Since Fisetin is better at performing these functions than quercetin, it can be concluded that fisetin supplement is better than resveratrol supplements.
Fisetin and weight loss
Researchers studied the effect of fisetin powder on fat accumulation in the body and it was found that it blocks certain pathways to reduce diet-related obesity. It targets the mTORC1 signaling pathway. This pathway is important for cell growth and lipid synthesis, hence, inducing fat accumulation in the body.
How much fisetin should I take: The fisetin dosage?
Fisetin dosage ranges between 2 mg to 5 mg, per kilogram of weight, however, this is not the recommended guideline for the dosage. There is no specific dosage recommendation for fisetin usage, and speaking to a medical professional would help in determining a fisetin dosage range, specific to one’s own conditions. In one of the studies conducted with the purpose of assessing the effect of fisetin powder on inflammation caused by colon cancer, 100 mg per day was required to notice a significant reduction in inflammation.
What are the side effects of fisetin?
Fisetin only recently became the subject of multiple studies and different pieces of research. This late interest in the flavonoid means that most studies performed have been on animal models or in a lab setting. Not many human studies have been performed to conclusively determine the potential side effects and toxicities of the supplement. Animal models on exposure to high doses of fisetin supplement did not show any adverse effects, pointing towards the safety of the supplement.
However, it is important to remember that lack of side effects in animal models does not mean that the risk of side effects in humans does not exist. To reach that conclusion, more clinical studies need to be performed. In one study that was performed on cancer patients to assess the efficacy of fisetin powder in managing the symptoms of cancer, both placebo and control groups reported gastric discomfort. Since the side effect was present in both groups, and both groups were undergoing chemotherapy at the same time, it is hard to conclude that fisetin powder consumption can cause gastric discomfort.
Fisetin powder may not have any reported side effects but it does interact with certain drugs, resulting in altered metabolism of those drugs. Fisetin was found to reduce the blood sugar levels in animal models, which is quite a benefit on its own. But when taken in conjunction with anti-diabetic medications, the glucose-reducing effect of both, the supplement and the drug could be exaggerated. This could result in several health complications.
Fisetin powder is metabolized by the liver, in the same way, that blood thinners are metabolized. Due to this, it is hypothesized that these two would interact with each other and Fisetin powder would increase the effects of blood-thinning agents.
Fisetin powder and fisetin supplements online
Fisetin powder can be bought online from different fisetin powder manufacturers, in quantities based on the specific need. Buying fisetin bulk amounts can help with the pricing as well. Fisetin’s price is not that out of range, and it is in the same range as other flavonoid supplements.
When looking to buy a fisetin supplement, it is important to thoroughly look through fisetin powder manufacturers and their manufacturing process. This is to ensure that proper safety guidelines and manufacturing protocols are followed during the production of the fisetin supplement. It is crucial to buy pure fisetin powder as it makes for the best fisetin supplement. If the supplier does not follow safety protocols in the extractions and synthesis of fisetin, the end-product can be contaminated or tainted with ingredients that are either harmful to human health or have no effect on human health, whatsoever. Either way, the fisetin benefits would not be experienced despite taking the supplement for a long time.
It is always important to look into the ingredients of the fisetin powder being purchased and the concentration ratio of these ingredients to ensure that pure fisetin powder is being purchased. If this distinction is not made, then there is a huge likelihood of increased fisetin side effects and/or reduced fisetin benefits, overall.