Fisetin is a common botanical polyphenol and flavonoid found in a wide variety of plants, fruits and vegetables including strawberries, apples, persimmons, onions and cucumbers. Fisetin is considered a plant pigment imparting many fruits and vegetables, such as strawberries, with their characteristic color and appearance. Fisetin has a very similar molecular structure as the more popular plant flavonoid and dietary supplement Quercetin. Unlike Quercetin, however, Fisetin may be a senolytic and perhaps one of the most powerful senolytics known.
|Synonyms||2-(3,4-dihydroxyphenyl)-3,7-dihydroxychromen-4-one , 3,3′,4′,7-Tetrahydroxyflavone , 5-Deoxyquercetin , Natural Brown 1 , CI-75620 , NSC 407010 , NSC 656275 , BRN 0292829 , Cotinin , 528-48-3 (anhydrous)|
|Melting Point||330° C (dec.)|
|Solubility||Soluble to 100 mM in DMSO and to 10 mM in ethanol|
|Storage Condition||−20°C for long time|
|Application||Fisetin is a potent sirtuin activating compound (STAC), antiinflammatory and anticancer agent|
Fisetin can be found in a wide variety of plants. It is found in Eudicotyledons, such as trees and shrubs in the family Fabaceae, such as the acacias Acacia greggii and Acacia berlandieri, the parrot tree (Butea frondosa), the honey locust (Gleditsia triacanthos), members of the family Anacardiaceae such as the Quebracho colorado and species of the genus Rhus, which contains the sumacs.Along with myricetin, fisetin provides the color of the traditional yellow dye young fustic, which was extracted from the Eurasian smoketree (Rhus cotinus). Many fruits and vegetables also contain fisetin, including strawberriesapples, and grapes. Fisetin can be extracted from fruit and herbal sources in juices, wines, and infusions such as teas. It is also found in Monocotyledons such as onions. It is also present in Pinophyta species such as the yellow cypress (Callitropsis nootkatensis).
Fisetin is shown to exhibit anti-cancer, anti-inflammatory, antioxidant activities and also enhance the memory.
Fisetin is a plant polyphenol and part of the flavonoid group in the flavonol sub-category. The earliest record of isolated fisetin dates back to 1833 from the smoke bush (Rhus cotinus). Its basic chemical characteristics were later defined by J. Schmidt in 1886, but it was not until the 1890s when S. Kostanecki defined its chemical structure and confirmed it via synthesis. Kostanecki launched a study of plant pigments during this period and coined group names for sub-categories, including flavones, flavonol, chromones, and chalcones.
Fisetin, like many plant polyphenols, is known to have antioxidant properties and demonstrates the specific biological activity of protecting functional macromolecules against stress, resulting in a benefit to cellular cytoprotection. It is also known to have anti-inflammatory, chemopreventive, and chemotherapeutic properties.
Finally, more recently, it has also shown promise as a senolytic, a compound that encourages aged or damaged senescent cells to destroy themselves rather than lingering in the body and contributing to the chronic, age-related inflammation known as “inflammaging”, which is associated with a wide range of age-related diseases.
Fisetin is a naturally occurring therapeutically active flavonol which has been used in the synthesis of pharmaceutically active anti-inflammatory, anticonvulsant and antiproliferative agents.
Numerous scientific studies over the past 10-15 years have established that Fisetin has beneficial effects on brain cells. It is a small molecule that is easily able to cross the blood-brain barrier. In the brain, it supports the removal of senescent cells. By selectively removing the senescent cells (and the spreading inflammation they foster), Fisetin can improve overall brain functioning and help restore mental alertness.
In June 2019, scientists published the results of an experiment in which they injected mice with a harmful ‘neuro-toxin’ substance that promptly caused their brain cells to enter that inflamed senescent state. Their behavior, balance, muscle control, etc. changed markedly, and the mice could no longer handle the “maze tests” that they’d been good at before. When those same unfortunate mice were then given doses of FISETIN, they recovered and regained their ability to navigate the maze tests, etc. In performing this radical type of test (which obviously can only be performed on very simple lab animals like mice), the scientists demonstrated the amazing effectiveness of FISETIN.
 Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., … & McGuckian, C. (2018). Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine, 36, 18-28.
 Schubert, D., Currais, A., Goldberg, J., Finley, K., Petrascheck, M., & Maher, P. (2018). Geroneuroprotectors: Effective Geroprotectors for the Brain. Trends in pharmacological sciences, 39(12), 1004-1007.
 Forbes TDA, Clement BA. “Chemistry of Acacia’s from South Texas” (PDF). Texas A&M Agricultural Research and Extension Center at. Archived from the original (PDF) on May 15, 2011. Retrieved 2010-04-14.