Hydroxypinacolone Retinoate Powder

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What are the benefits of Hydroxypinacolone Retinoate(HPR) powder?

  1. Anti-aging
  2. Belongs to the “royal family” of skincare which are a collection of potent retinoids
  3. Reduce pigmentation and blemishes
  4. Binds directly to the retinoid receptors of the skin cells to enable it to work its magic
  5. Improve fine lines and wrinkles
  6. Has similar results as active retinoic acid without the irritation
  7. Reduce sebum production, shrink pores and improve texture
  8. Increase hydration and improve skin luster
  9. Highly recommended for addressing acne due to its ability to regulate oil production
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Chemical Base Information

Name Hydroxypinacolone Retinoate powder
CAS 893412-73-2
Purity 98%
Chemical name Hydroxypinacolone Retinoate
Synonyms Fat-Soluble HPR; Water-Soluble HPR; Hydroxypinacolone Retinoate; Hydroxypinacolone Retinoate,HPR; Hydroxyl pinacone retinoate Liposome; Liposomal Hydroxypinacolone Retinoate; Retinoic acid
Molecular Formula C26H38O3
Molecular Weight 398.58
Boling Point 508.5±33.0 °C(Predicted)
InChI Key XLPLFRLIWKRQFT-XUJYDZMUSA-N
Form Solid
Appearance Yellow powder or crystal
Half Life /
Solubility insoluble in water, and easily hydrolyzed under strong acid and alkali
Storage Condition Store in a cool, ventilated warehouse. The storage temperature should not exceed 37 ° C. It should be stored separately from oxidants and edible chemicals, and avoid mixed storage.
Application Used as an antioxidant.

Used as a conditioner, antioxidant, etc. in the field of personal care products.

Testing Document Available

 

What is Hydroxypinacolone Retinoate(HPR) powder 893412-73-2?

Hydroxypinacolone retinoate(HPR) is milder and less irritating than retinol and can be effectively used in skin care products. Hydroxypinacolone retinoate has a larger molecular weight than retinol, so the skin will absorb it relatively slowly, and it will take longer to effect the skin. Hydroxypinacolone retinoate is also suitable for treating acne, while it can effectively treat melasma. Hydroxypinacolone retinoate is different from other retinoic acid (retinoic acid) derivatives. It does not need to be converted to directly act. Compared with retinoic acid, its irritation is much reduced. It is safer to use around the eyes, and the transdermal rate is also better. It is more stable than other retinoic acid compounds. Hydroxypinacolone retinoate has a particle size of less than 100nm, which can stably disperse the active substance in the formula, and at the same time, it can effectively penetrate the skin to function and effectively control the release rate of the active substance.

Hydroxypinacolone retinoate(HPR) as a member of the skincare royal family, hydoxypinacolone retinoate is able to provide the same results to the skin as retinoic acid when applied, without the irritation associated with 0.5% retinol. You can also expect to see a dramatic reduction in fine lines and wrinkles when applying 0.2% of HPR around the eye area for 14 days. There are also many promising claims in regards to collagen production, cell renewal and combating blemishes.

 

Hydroxypinacolone Retinoate(HPR) Mechanism Of Action

Hydroxypinacolone retinoate(HPR) stimulates the proliferation and renewal of skin cells, restores the skin thickness that has become thinner with age, fills fine lines and wrinkles on the skin, while protecting the skin from further damage by wrinkles, and restores skin fullness And elasticity, making the skin younger and younger.

One of the significant advantages of Hydroxypinacolone retinoate(HPR) over retinol and other vitamin A derivatives currently widely used in cosmetics is that it does not need to be converted to retinoic acid to fill fine lines, lighten wrinkles, and protect the skin. When you apply it to the skin, it can directly bind to the receptor and start working, so that the epidermal cells on the skin begin to proliferate, fill fine lines, and lighten the original wrinkles and reduce pigmentation, improve your skin condition, make the skin look more compact, shiny, elastic, you will look younger.

The second significant advantage of Hydroxypinacolone retinoate(HPR) powder is its stable composition. Thermal stress tests have shown that it can work effectively on the skin for up to 15h.

 

What are the benefits of Hydroxypinacolone Retinoate(HPR) powder?

A retinol derivative, which has the function of regulating the metabolism of the epidermis and stratum corneum, can resist aging, can reduce sebum spillage, dilute epidermal pigments, play a role in preventing skin aging, preventing acne, whitening and light spots. While ensuring the powerful effect of retinol, it also greatly reduces its irritation. It is currently used for anti-aging and prevention of acne recurrence.

Other Hydroxypinacolone Retinoate(HPR) benefits are:

  1. Anti-aging
  2. Belongs to the “royal family” of skincare which are a collection of potent retinoids
  3. Reduce pigmentation and blemishes
  4. Binds directly to the retinoid receptors of the skin cells to enable it to work its magic
  5. Improve fine lines and wrinkles
  6. Has similar results as active retinoic acid without the irritation
  7. Reduce sebum production, shrink pores and improve texture
  8. Increase hydration and improve skin luster
  9. Highly recommended for addressing acne due to its ability to regulate oil production

Hydroxypinacolone retinoate(HPR) is the newest member of the superhero vitamin A ingredient family. Hydroxypinacolone retinoate(HPR) is an ester of retinoic acid and works similar to tretinoin (or prescription strength Retin–A) but with little to no skin irritation.

Both retinol and hydroxypinacolone retinoate are excellent ingredients for the skin, however there are some significant differences when choosing which to use in your routine.

Retinol needs to be broken down over several steps to be converted into a retinoic acid. The breakdown process can cause skin irritability and produce unwanted side effects such as:

Dermatitis

Itchiness or pruritis

Dry or flaky skin

Sensitivity reactions

Red or inflamed skin

Uncomfortable sensations

One of the significant advantages hydroxypinacolone retinoate has over retinol and other vitamin A derivatives used in active ingredient cosmeceuticals today is that it does not require a conversion to retinoic acid. Once applied to the skin it can bind directly to the receptors allowing a cascade of events to take place which produce the antiaging effects, reduction in pigmentation marks and blemishes, improving the appearance of fine lines and wrinkles, reducing sebum production, minimising pores and improving skin texture. Furthermore, increased hydration and an improvement in the glow of the skin can also be expected.

The second significant advantage hydroxypinacolone retinoate has over other forms of Vitamin A is ingredient stability. Thermal stress tests have shown that hydroxypinacolone retinoate will remain stable and effective in the skin for up to 15 hours.

 

Hydroxypinacolone Retinoate powder(HPR) application

Hydroxypinacolone Retinoate powder applicable Products:

Anti-aging products: Promote collagen synthesis in the dermis, prevent collagen from degrading too quickly, and improvement of fine lines can be observed within a week.

Whitening products: Inhibit tyrosinase, promote metabolism, and accelerate the disappearance of melanin. The literature shows that the combination with VC is also effective in treating acne skin.

Acne products: Not only can reduce acne, but also reduce oil secretion and lighten the pigmentation left over from acne.

Sunscreen products: suppress the increase of MMP activity caused by ultraviolet rays, protect elastin and dermal collagen, and improve wrinkles and fine lines caused by ultraviolet rays.

Repair products: promote the synthesis of hyaluronic acid in the body, reduce the skin TEWL, promote the activity of keratinocytes, increase the thickness of the epidermal layer, and make the epidermal layer stronger.

 

Hydroxypinacolone Retinoate(HPR) dosage

Who can use hydroxypinacolone retinoate(HPR) dosage? Anyone who has consulted with a doctor or dermatologist to ensure it will be safe to use on the skin with no signs of irritation.

 

Hydroxypinacolone Retinoate(HPR) side effects

The true results of hydroxypinacolone retinoate is yet to be fully understood so it would be advisable to seek the help of a doctor or dermatologist before applying it all over the skin.

 

Where to Buy hydroxypinacolone retinoate Powder

Wisepowder offers hydroxypinacolone retinoate bulk powder in 1g package, and offers wholesale different quantity according to your need. Wisepowder’s hydroxypinacolone retinoate powder has been lab-tested and verified for both product purity and identity.

 

Hydroxypinacolone Retinoate(HPR) powder Reference

[1] Efficacy and safety of a 12-month treatment with a combination of hydroxypinacolone retinoate and retinol glycospheres as maintenance therapy in acne patients after oral isotretinoin.Bettoli V, Zauli S, Borghi A, Toni G, Ricci M, Bertoldi AM, Virgili A.G Ital Dermatol Venereol. 2017 Feb;152(1):13-17.

[2] Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres.Veraldi S, Barbareschi M, Guanziroli E, Bettoli V, Minghetti S, Capitanio B, Sinagra JL, Sedona P, Schianchi R.G Ital Dermatol Venereol. 2015 Apr;150(2):143-7.

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