Hydroxypinacolone Retinoate powder

Hydroxypinacolone retinoate (short as HPR), also known as granactive retinoid, is an oxidized derivative of retinol, which can directly bind to retinoic acid receptors (RARs). It has the function of regulating the metabolism of epidermal cells and the stratum corneum. It can reduce sebum overflow, lighten epidermal pigments, prevent skin aging, Prevent acne, whitening spots, etc. While ensuring strong efficacy, it greatly reduces its irritation. At present, it is mainly used for anti-aging and preventing acne recurrence.

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Hydroxypinacolone Retinoate(HPR) powder Base Information

Name Hydroxypinacolone Retinoate powder
CAS 893412-73-2
Purity 98%
Chemical name Hydroxypinacolone Retinoate
Synonyms Fat-Soluble HPR; Water-Soluble HPR; Hydroxypinacolone Retinoate; Hydroxypinacolone Retinoate,HPR; Hydroxyl pinacone retinoate Liposome; Liposomal Hydroxypinacolone Retinoate; Retinoic acid
Molecular Formula C26H38O3
Molecular Weight 398.58
Boling Point 508.5±33.0 °C(Predicted)
Form Solid
Appearance Yellow powder or crystal
Half Life /
Solubility insoluble in water, and easily hydrolyzed under strong acid and alkali
Storage Condition Store in a cool, ventilated warehouse. The storage temperature should not exceed 37 ° C. It should be stored separately from oxidants and edible chemicals, and avoid mixed storage.
Application Used as an antioxidant.

Used as a conditioner, antioxidant, etc. in the field of personal care products.

Testing Document Available


Hydroxypinacolone Retinoate powder 893412-73-2 General Description

Hydroxypinacolone retinoate is milder and less irritating than retinol and can be effectively used in skin care products. Hydroxypinacolone retinoate has a larger molecular weight than retinol, so the skin will absorb it relatively slowly, and it will take longer to effect the skin. Hydroxypinacolone retinoate is also suitable for treating acne, while it can effectively treat melasma. Hydroxypinacolone retinoate is different from other retinoic acid (retinoic acid) derivatives. It does not need to be converted to directly act. Compared with retinoic acid, its irritation is much reduced. It is safer to use around the eyes, and the transdermal rate is also better. It is more stable than other retinoic acid compounds. Hydroxypinacolone retinoate has a particle size of less than 100nm, which can stably disperse the active substance in the formula, and at the same time, it can effectively penetrate the skin to function and effectively control the release rate of the active substance.


Hydroxypinacolone Retinoate powder 893412-73-2 Mechanism Of Action

Hydroxypinacolone retinoate stimulates the proliferation and renewal of skin cells, restores the skin thickness that has become thinner with age, fills fine lines and wrinkles on the skin, while protecting the skin from further damage by wrinkles, and restores skin fullness And elasticity, making the skin younger and younger.

One of the significant advantages of Hydroxypinacolone retinoate over retinol and other vitamin A derivatives currently widely used in cosmetics is that it does not need to be converted to retinoic acid to fill fine lines, lighten wrinkles, and protect the skin. When you apply it to the skin, it can directly bind to the receptor and start working, so that the epidermal cells on the skin begin to proliferate, fill fine lines, and lighten the original wrinkles and reduce pigmentation, improve your skin condition, make the skin look more compact, shiny, elastic, you will look younger.

The second significant advantage of Hydroxypinacolone retinoate is its stable composition. Thermal stress tests have shown that it can work effectively on the skin for up to 15h.


Hydroxypinacolone Retinoate powder 893412-73-2 Application

A retinol derivative, which has the function of regulating the metabolism of the epidermis and stratum corneum, can resist aging, can reduce sebum spillage, dilute epidermal pigments, play a role in preventing skin aging, preventing acne, whitening and light spots. While ensuring the powerful effect of retinol, it also greatly reduces its irritation. It is currently used for anti-aging and prevention of acne recurrence.


Hydroxypinacolone Retinoate powder 893412-73-2 More research

Hydroxypinacolone Retinoate powder applicable Products

Anti-aging products: Promote collagen synthesis in the dermis, prevent collagen from degrading too quickly, and improvement of fine lines can be observed within a week.

Whitening products: Inhibit tyrosinase, promote metabolism, and accelerate the disappearance of melanin. The literature shows that the combination with VC is also effective in treating acne skin.

Acne products: Not only can reduce acne, but also reduce oil secretion and lighten the pigmentation left over from acne.

Sunscreen products: suppress the increase of MMP activity caused by ultraviolet rays, protect elastin and dermal collagen, and improve wrinkles and fine lines caused by ultraviolet rays.

Repair products: promote the synthesis of hyaluronic acid in the body, reduce the skin TEWL, promote the activity of keratinocytes, increase the thickness of the epidermal layer, and make the epidermal layer stronger.



[1] Efficacy and safety of a 12-month treatment with a combination of hydroxypinacolone retinoate and retinol glycospheres as maintenance therapy in acne patients after oral isotretinoin.Bettoli V, Zauli S, Borghi A, Toni G, Ricci M, Bertoldi AM, Virgili A.G Ital Dermatol Venereol. 2017 Feb;152(1):13-17.

[2] Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres.Veraldi S, Barbareschi M, Guanziroli E, Bettoli V, Minghetti S, Capitanio B, Sinagra JL, Sedona P, Schianchi R.G Ital Dermatol Venereol. 2015 Apr;150(2):143-7.

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