Urolithin A Powder

Urolithin A powder Base Information

Urolithin A Powder General Description

Urolithin A powder is a metabolite compound resulting from the transformation of ellagitannins by the gut bacteria and is an inducer of mitophagy. Urolithin A shifts mitochondria from CI- to CII-driven respiration, extends lifespan and improves muscle function. It belongs to the class of organic compounds known as benzo-coumarins or dibenzo-α-pyrones. Its precursors – ellagic acids and ellagitannins – are ubiquitous in nature, including edible plants, such as pomegranates, strawberries, raspberries, and walnuts. Since the 2000s, urolithin A has been subject of preliminary studies regarding its possible biological effects.

Urolithin A powder can improve the quality and function of mitochondria, and increase the strength and endurance of aging muscles. It is the only natural product that has been proven to restart mitochondrial autophagy and reverse muscle aging.

Urolithins are microflora human metabolites of dietary ellagic acid derivatives，such as ellagitannins. They are produced in the

human gut, and found in the urine in the form of urolithin B glucuronide after absorption of ellagitannins-containing food such as

pomegranate, strawberries, red raspberries, walnuts or oak-aged red wine.

During intestinal metabolism by bacteria, ellagitannins and punicalagins are converted to urolithins, which have unknown

biological activity in vivo in humans. Urolithins metabolites of pomegranate juice ellagitannins localize specifically in

the prostate gland, colon, and intestinal tissues of mice.

Ellagitannins exhibit low bioavailability and are transformed in the gut to ellagic acid and its microbiota metabolites.

Urolithins are found in plasma mostly as glucuronides at low concentrations.

Urolithins production is dependent on the gut microbiome enterotype. Individuals producing urolithins show a much higher abundance

of the Clostridium leptum group of Firmicutes phylum than Bacteroides or Prevotella

Urolithin A powder History

In laboratory studies, urolithin A powder was shown to induce mitophagy, which is a selective recycling of mitochondria by autophagy, a process that cleans defective mitochondria following damage or stress, and tends to become less efficient during aging.[14] This effect has been observed in different animal species (mammalian cells, rodents and C. elegans).

Urolithin A powder Application

Urolithin A powder is intended for use as an ingredient in select foods or for special dietary uses in meal replacement products based on its nutritive activity in supporting general mitochondrial health.

Urolithin A powder More research

Urolithin A is not known to be found in any food. It forms as the result of transformation of ellagic acids and ellagitannins by the gut microflora in humans. Ellagic acid itself results from the hydrolysis of ellagitannins in the gut in the presence of water.[citation needed]

Sources of ellagitannins are: pomegranates, nuts, some berries (raspberries, strawberries, blackberries, cloudberries), tea, muscadine grapes, many tropical fruits, and oak-aged wines (table below).

The conversion of the ellagic acids into urolithin A depends on individual microflora composition and can vary significantly.

Urolithin A Powder Reference

1. Paller CJ, Pantuck A, Carducci MA. A review of pomegranate in prostate cancer. Prostate Cancer Prostatic Dis. 2017 Apr 25. doi: 10.1038/pcan.2017.19. [Epub ahead of print] Review. PubMed PMID: 28440320.
2. Ito H. Metabolites of the ellagitannin geraniin and their antioxidant activities. Planta Med. 2011 Jul;77(11):1110-5. doi: 10.1055/s-0030-1270749. Epub 2011 Feb 3. Review. PubMed PMID: 21294073.
3. Ishimoto H, et al. In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A. Bioorg Med Chem Lett. 2011 Oct 1;21(19):5901-4.

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