What Is S-Adenosyl-L-methionine (SAM) Powder?

Powder S-adenosyl-L-methionine (commonly called "SAM-e" "SAM") is a naturally-occurring chemical component present in all cells of the body where it is essential in more than 200 metabolic pathways. It is CAS number is 29908-03-0.

S-adenosyl-L-methionine (SAM) is involved in the formation, activation, and breakdown of other chemicals in the body, including hormones, proteins, and certain drugs. The body uses it to make certain chemicals that play a role in pain, depression, liver disease, and other conditions.

People most commonly take SAMe for depression and osteoarthritis. It is also used for anxiety, liver disease, fibromyalgia, schizophrenia, and many other conditions, but there is no good scientific evidence to support these uses.

SAMe has been available as a dietary supplement in the US since 1999, but it has been used as a prescription drug in Italy, Spain, and Germany for many decades. It is available without a prescription in the United States and some other countries.



What Is S-Adenosyl-L-methionine Disulfate Tosylate Powder?

Powder S-Adenosyl-L-methionine Disulfate Tosylate is the Disulfate Tosylate form of S-Adenosyl-L-methionine (SAM), its CAS number is 97540-22-2, also well known as Ademetionine disulfate tosylate, S-Adenosyl methionine disulfate tosylate, AdoMet disulfate tosylate.

It is a White to off-white hygroscopic powder, freely soluble in water, practically insoluble in hexane and acetone. S-Adenosyl-L-methionine disulfate tosylate (Ademetionine disulfate tosylate) is the principal biological methyl donor synthesized in all mammalian cells but most abundantly in the liver. The Ademetionine disulfate tosylate powder is popular use in dietary supplements as the main ingredient.



How Does S-Adenosyl-L-methionine (SAM) and S-Adenosyl-L-methionine Disulfate Tosylate Work?

How does S-Adenosyl-L-methionine (SAM) and Ademetionine disulfate tosylate work in the body? What is the mechanism of action? S-Adenosyl-L-methionine (SAM) is a naturally-occurring compound found in almost every tissue and fluid in the body. It is involved in many important processes. SAMe plays a role in the immune system, maintains cell membranes, and helps produce and break down brain chemicals, such as serotonin, melatonin, and dopamine. It works with vitamin B12 and folate (vitamin B9). Being deficient in either vitamin B12 or folate may reduce levels of SAMe in your body.

Several studies show that SAMe helps relieve the pain of osteoarthritis. Other studies suggest that SAMe may help treat depression. Researchers have also examined SAMe's use in the treatment of fibromyalgia and liver disease with mixed results. Many of the early studies used SAMe given intravenously or as an injection. Only recently have researchers been able to look at the effects of SAMe taken by mouth.

The body uses Ademetionine disulfate tosylate to make certain chemicals in the body that play a role in pain, depression, liver disease, and other conditions. People who don't make enough Ademetionine disulfate tosylate naturally may be helped by taking Ademetionine disulfate tosylate as a supplement.



What Are The Benefits Of S-Adenosyl-L-methionine (SAM) and S-Adenosyl-L-methionine Disulfate Tosylate powder?

S-adenosyl-L-methionine (SAM) is a compound found naturally in the body. SAMe helps produce and regulate hormones and maintain cell membranes. SAM is popular sell in world as dietary supplement. What are the benefits of use S-Adenosyl-L-methionine (SAM)?


Clinical studies performed as early as 1973 indicated that S-adenosyl-L-methionine (SAM) had antidepressant effects. Over the next 2 decades, the efficacy of S-adenosyl-L-methionine (SAM) in treating depressive disorders was confirmed in > 40 clinical trials. Several review articles that summarize these studies were published in 1988, 1989 , 1994, and 2000.

-Help with Osteoarthritis

Many studies comparing the use of S-adenosyl-L-methionine (SAM) with nonsteroidal anti-inflammatory drugs showed that each provided similar pain relief and improvement in joint function, but S-adenosyl-L-methionine (SAM) produced fewer side effects. A smaller number of studies haven't shown the same results.


S-adenosyl-L-methionine (SAM) can be effective in reducing symptoms of fibromyalgia, including pain, fatigue, morning stiffness, and depressed mood. But most studies used an injectable form of S-adenosyl-L-methionine (SAM). Among studies that examined doses of S-adenosyl-L-methionine (SAM) by mouth, some found it was effective at reducing these symptoms while others found no benefit.

-Liver disease

People with liver disease often cannot synthesize S-adenosyl-L-methionine (SAM) in their bodies. Preliminary studies suggest that taking S-adenosyl-L-methionine (SAM) may help treat chronic liver disease caused by medications or alcoholism.


Preliminary evidence suggests that S-adenosyl-L-methionine (SAM) may improve cognitive symptoms, such as the ability to recall information and remember words. Researchers suspect S-adenosyl-L-methionine (SAM) acts on regions of the brain that regulate gene expression of amyloid proteins, one of the hallmarks of Alzheimer disease.



How Long Does It Take For S-Adenosyl-L-methionine (SAM) To Work?

Most currently available antidepressants have a delayed onset of action, thus consistent improvement in mood may be noticeable only after four to six weeks of daily use. In contrast, S-Adenosyl-L-methionine (SAM) has a relatively rapid onset of action, usually within one week of starting treatment



What Are The Side Effects Of Taking S-Adenosyl-L-methionine (SAM) Powder

S-adenosyl-L-methionine (SAM) appears to be safe and might be effective in treating depression and osteoarthritis. However, S-adenosyl-L-methionine (SAM) might interact with antidepressants. Don't use S-adenosyl-L-methionine (SAM) and prescription antidepressants together.

The common side effects of taking S-adenosyl-L-methionine (SAM) may:
-headache, dizziness;
-feeling anxious or nervous;
-vomiting, upset stomach;
-diarrhea, constipation;
-increased sweating; or.
-sleep problems (insomnia).



Can I get S-Adenosyl-L-methionine (SAM) From Food Source?

S-Adenosyl-L-methionine (SAM) is not found in food. It is produced by the body from the amino acid methionine and ATP which serves as the major energy source for cells throughout the body.



How Much S-Adenosyl-L-methionine(SAM) Dose Can I Take?

When considering the use of S-Adenosyl-L-methionine supplements, seek the advice of your doctor. You may also consider consulting a practitioner who is trained in the use of herbal/health supplements.

If you choose to use S-Adenosyl-L-methionine, use it as directed on the package or as directed by your doctor, pharmacist, or other healthcare provider. Do not use more of this product than is recommended on the label.

Call your doctor if the condition you are treating with S-Adenosyl-L-methionine does not improve, or if it gets worse while using this product.

SAMe has most often been used by adults in doses of 400-1600 mg by mouth daily for up to 12 weeks. Speak with a healthcare provider to find out what dose might be best for a specific condition.



What Happen If I Missed A S-Adenosyl-L-methionine Dosage

Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra SAMe to make up the missed dose.



What Happen If I Over Dose?

Seek emergency medical attention if over dose.



What Is S-Adenosyl-L-methionine Drug Reaction?

If you are being treated with any of the following medications, you should not use S-Adenosyl-L-methionine without first talking to your health care provider.

Taking S-Adenosyl-L-methionine at the same time as these drugs may increase the risk of serotonin syndrome (a potentially dangerous condition caused by having too much serotonin in your body):

Dextromethorphan (Robitussin DM, other cough syrups)
Meperidine (Demerol)
Pentazocine (Talwin)
Tramadol (Ultram)

Antidepressant medications

S-Adenosyl-L-methionine may interact with antidepressant medications, increasing the potential for side effects including headache, irregular or accelerated heart rate, anxiety, and restlessness, as well as the potential fatal condition called Serotonin Syndrome, mentioned above. Some experts theorize that taking SAMe increases the levels of serotonin in the brain, and many antidepressants do the same. The concern is that combining the two may increase serotonin to dangerous levels. Talk to your doctor before using SAMe if you are taking any medications for depression or anxiety.

Levodopa (L-dopa)

S-Adenosyl-L-methionine may reduce the effectiveness of this medication for Parkinson disease.

Medications for diabetes

S-Adenosyl-L-methionine may reduce levels of blood sugar and may strengthen the effect of diabetes medications, which increases the risk of hypoglycemia (low blood sugar).



Buy S-Adenosyl-L-methionine (SAM) and S-Adenosyl-L-methionine Disulfate Tosylate Powder In Bulk

S-Adenosyl-L-methionine (also known as SAMe,SAM) is a manmade form of a chemical that occurs naturally in the body. S-Adenosyl-L-methionine Disulfate Tosylate is the Disulfate Tosylate format of S-Adenosyl-L-methionine.

S-Adenosyl-L-methionine has been used in alternative medicine as a likely effective aid in reducing the symptoms of depression, and in treating osteoarthritis. Other uses not proven with research have included treating liver disease, heart disease, schizophrenia, anxiety, tendonitis, chronic back pain, migraine headaches, seizures, premenstrual syndrome, and chronic fatigue syndrome.

S-Adenosyl-L-methionine Disulfate Tosylate is often sold as dietary supplement in the market. Wisepowder as the manufacturer of S-Adenosyl-L-methionine (SAM) powder and S-Adenosyl-L-methionine Disulfate Tosylate Powder, has capability to produce and supply high quality S-Adenosyl-L-methionine powder for S-Adenosyl-L-methionine (SAM) supplement use.



S-Adenosyl-L-methionine (SAM) powder and S-Adenosyl-L-methionine Disulfate Tosylate powder Reference

  1. Galizia, I; Oldani, L; Macritchie, K; Amari, E; Dougall, D; Jones, TN; Lam, RW; Massei, GJ; Yatham, LN; Young, AH (10 October 2016). "S-Adenosyl methionine (SAMe) for depression in adults". The Cochrane Database of Systematic Reviews. 2016 (10): CD011286. doi:10.1002/14651858.CD011286.pub2. PMC 6457972. PMID 27727432
  2. Anstee, QM; Day, CP (November 2012). "S-Adenosylmethionine (SAMe) therapy in liver disease: a review of current evidence and clinical utility". Journal of Hepatology. 57 (5): 1097–109. doi:10.1016/j.jhep.2012.04.041. PMID 22659519.
  3. Födinger M, Hörl W, Sunder-Plassmann G (Jan–Feb 2000). "Molecular biology of 5,10-methylenetetrahydrofolate reductase". J Nephrol. 13 (1): 20–33. PMID 10720211.
  4. McKie, Robin (10 April 2022). "Biologists warn against toxic SAMe 'health' supplement". The Observer.

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